Effect of mifepristone and lithospermum combination regimen on medical abortion in early pregnancy rats

Author(s):  
Qiong Yu ◽  
Shihong Hu ◽  
Shifu Hu
2021 ◽  
Vol 104 (10) ◽  
pp. 1626-1631

Objective: To compare the complete abortion rate, the induction-to-abortion time, and side effects between 600 mcg and 800 mcg misoprostol sublingually. Materials and Methods: Total, of 108 pregnant women with gestational age less than 12 weeks with early pregnancy loss from March 2020 to February 2021 at the Department of Obstetrics and Gynecology, Queen Savang Vadhana Memorial Hospital, were included. For group 1 (n=54), 600 mcg misoprostol was administrated sublingually. For group 2 (n=54), 800 mcg misoprostol was administrated sublingually. If the abortion did not occur, the repeated misoprostol in the same dose would be administrated sublingually every 6 hours for a maximum of three doses. Results: There was no significant difference in the complete abortion rate between the two groups (55.6% in the 600 mcg misoprostol group, 64.7% in the 800 mcg misoprostol group, p=0.339, and 95% CI 0.082 to 1.862). The induction-to-abortion time was 9.5 hours (IQR 6.75 to 48.00) in the 600 mcg misoprostol group and 10 hours (IQR 6.00 to 60.00) in the 800 mcg misoprostol group. The side effects of both groups were similar, included abdominal pain, diarrhea, nausea and vomiting, fever, heavy bleeding, and headache. Conclusion: The efficacy of the 600 mcg misoprostol was noninferior to 800 mcg misoprostol. The adverse effects were similar in both groups. Mean induction-to-abortion time was also similar in both groups. Keywords: Early pregnancy loss; Misoprostol; Medical abortion


Author(s):  
Mitchell D. Creinin ◽  
Kristina Gemzell Danielsson

1970 ◽  
Vol 2 (2) ◽  
pp. 54-58 ◽  
Author(s):  
Veena Shrivastava

Unsafe abortion is a major health issue. Therefore safe abortion services which is effective. acceptable and techniquely easy to perform should be available. Aim- To confirm effectiveness, side effects, safety and patient satisfaction with medical termination of early pregnancy. Methods- It was a prospective study 150 women who were less than 63 days pregnant and consented for medical termination of pregnancy were given! 200mg 0 Mefepristone orally and 48 hrs later 800 micro gram Misoprostol was inserted vaginally. They were followed up in 14 days. Bleeding, pain G.I symptoms any other side effects were recorded. Abortion was complete or not was confirmed clinically and by USG. Failure and success was documented depending upon need for surgical evacuation. Results- The success rate with this regime was 92.6% and failure rate was 7.3%. There were no major side effects with Mifepristone. The average bleeding after misoprostol insertion was 10 days and 80% women had more bleeding than normal period. All of them had pain. Only 13.3% needed analgesic. women (96%) were satisfied with the method. Conclusion- combination of mifepristone and misoprostol is a safe and effective of early pregnancy Keywords- medical termination, pregnancy, mifepristone, misoprostol.   doi:10.3126/njog.v2i2.1456 N. J. Obstet. Gynaecol 2007 Nov-Dec; 2 (2): 54 - 58


2020 ◽  
Vol 99 (12) ◽  
pp. 1603-1610 ◽  
Author(s):  
Venla Kemppainen ◽  
Maarit Mentula ◽  
Vilja Palkama ◽  
Oskari Heikinheimo

2017 ◽  
Vol 16 (05) ◽  
pp. 19-21
Author(s):  
Dr. Chirom Pritam Kumar Singh ◽  
Dr. Ruma Sarkar

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