Obstetric and neonatal outcomes after SARS‐CoV ‐2 infection in the first trimester of pregnancy: A prospective comparative study

Bleeding per vaginum in the first trimester of pregnancy is one of the most common obstetric problems. Bleeding in early pregnancy is an indicator of an abnormality interrupting the normal development and is a common cause of hospital admission. If the viability or non viability of pregnancy can be made on USG, then hormonal therapy and hospitalization can be avoided. This is usually impossible with history and clinical examination and can be established only by USG. Hence based on above findings the present study was planned for Assessment of Vaginal Bleeding in First Trimester of Pregnancy by Comparative Study of Clinical and Ultrasonographic Evaluation. The present study was planned in Department of Obstetrics and Gynaecology, Madhubani Medical College and Hospital, Madhubani, Bihar. In the present study 30 females having history of bleeding per vaginum in the first trimester of pregnancy were enrolled. The data generated from the present study concludes that USG is an extremely valuable non invasive tool in the identifying the causes of first trimester vaginal bleeding. It is also helpful in the decision-making algorithm about the safe continuation of the pregnancy and timely intervention for abnormal pregnancy. High incongruity was seen in our study between clinical diagnosis and USG diagnosis. Keywords: Vaginal Bleeding, First Trimester, Pregnancy, Clinical, Ultrasonographic Evaluation, etc.

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Assessment of free fetal DNA concentration in maternal plasma during the first trimester of pregnancy: comparative study between EDTA and PPT tubes – pilot study

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.3109/14767058.2014.908843 ◽

2014 ◽

Vol 28 (2) ◽

pp. 172-176

Author(s):

Carolina Schneider Chadud ◽

Edward Araujo Júnior ◽

Ciro Dresh Martinhago ◽

Viviane Cristina Mello Andari ◽

Giselle Darahem Tedesco ◽

...

Keyword(s):

Pilot Study ◽

Comparative Study ◽

First Trimester ◽

Maternal Plasma ◽

Dna Concentration ◽

Fetal Dna ◽

First Trimester Of Pregnancy

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Relationship between maternal vitamin D status in the first trimester of pregnancy and maternal and neonatal outcomes: a retrospective single center study

BMC Pediatrics ◽

10.1186/s12887-021-02730-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Meng Ni ◽

Qianqian Zhang ◽

Jiuru Zhao ◽

Qianwen Shen ◽

Dongting Yao ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

First Trimester ◽

Maternal Serum ◽

Neonatal Outcomes ◽

Vitamin D Status ◽

Maternal Vitamin ◽

Serum Vitamin D ◽

First Trimester Of Pregnancy

Abstract Background This study aimed to investigate the relationship between maternal serum vitamin D status in the first trimester of pregnancy and maternal as well as neonatal outcomes, considered the prevalence of vitamin D deficiency (serum 25(OH)D < 50 nmol/L) around the world, especially in the pregnant women. Methods From January 2015 to December 2016, in this cross-sectional retrospective study, we enrolled women receiving regular prenatal examinations and giving birth in the International Peace Maternity and Child Health Hospital. Cases confirmed as multiple pregnancy, incomplete medical records, and vitamin D level recorded after 13 weeks of gestation were excluded. A total of 23,394 mother-infant pairs were included ultimately. Obstetric and neonatal information were extracted from the database. Maternal serum vitamin D concentration was measured by chemiluminescence microparticle immunoassay. Logistic regression analysis (unadjusted and adjusted models) was used to analyze the association between vitamin D and maternal and neonatal outcomes. Results The average 25(OH) D concentration was 43.20 ± 0.10 nmol/L; 67.09% of patients were vitamin D deficient(25(OH) D < 50.00 nmol/L), 29.84% were vitamin D insufficient (50 nmol/L ≤ 25(OH)D < 75 nmol/L), 3.07% were sufficient (25(OH)D ≥ 75 nmol/L). The maternal 25(OH)D levels varied with age, pre-pregnancy BMI, season when blood sample was collected, number of previous-pregnancy. Notably, newborns delivered by women with deficient vitamin D status had a higher incidence rate of admission to NICU (Deficiency: 12.20% vs Insufficiency: 10.90% vs Sufficiency: 11.70%, Pbonferroni = .002) and a longer stay (deficiency: 6.2 ± 4.1 days vs insufficiency: 5.9 ± 3.1 days vs sufficiency: 5.1 ± 2.1 days, Pbonferroni = .010). Moreover, maternal vitamin D deficiency was a dependent risk factor for admission to NICU (unadjusted OR = 1.35, 95% CI,1.05–1.74 Pbonferroni = .022; adjusted OR = 1.31, 95% CI,1.010–1.687 Pbonferroni = .042). Conclusions Maternal vitamin D deficiency (25(OH) D < 50 nmol/L) was prevalent in eastern coastal China. The incidence rate of GDM as well as preeclampsia was higher in vitamin D insufficient group while vitamin D deficiency group was liable to intrauterine infection when compared with the other two groups. Most importantly, low vitamin D status in the first trimester of pregnancy was a dependent risk factor for admission to NICU. More well-designed perspective researches are necessary to clarify the role of vitamin D in the early stage of pregnancy.

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