scholarly journals One-Year Outcome of Small-Vessel Disease Treated with Sirolimus-Eluting Stents: A Subgroup Analysis of the e-SELECT Registry

2012 ◽  
Vol 26 (2) ◽  
pp. 163-172 ◽  
Author(s):  
RUNLIN GAO ◽  
ALEXANDRE ABIZAID ◽  
ADRIAN BANNING ◽  
ANTONIO L. BARTORELLI ◽  
VLADIMÍR DŽAVÍK ◽  
...  
Keyword(s):  
Subgroup Analysis ◽  
Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
One Year

scholarly journals ONE-YEAR OUTCOME OF SMALL-VESSEL DISEASE TREATED WITH SIROLIMUS-ELUTING STENTS: A SUBGROUP ANALYSIS OF THE E-SELECT REGISTRY

2011 ◽  
Vol 57 (14) ◽  
pp. E1840
Author(s):  
Runlin Gao ◽  
Alexander Abizaid ◽  
Adrian Banning ◽  
Antonio. L. Bartorelli ◽  
Vladimír Džavík ◽  
...  
Keyword(s):  
Subgroup Analysis ◽  
Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
One Year

scholarly journals Non-Simultaneous Bilateral Ischemic Optic Neuropathy Related to High Altitude and Airplane Flight in a Patient with Cerebral Small Vessel Disease

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2325
Author(s):  
Ana Boned-Murillo ◽  
Olivia Esteban-Floria ◽  
Mireya Martinez-Velez ◽  
Javier Mateo Gabas ◽  
Francisco Javier Ascaso Puyuelo
Keyword(s):  
Computed Tomography ◽  
Optic Neuropathy ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Cranial Computed Tomography ◽  
Ischemic Optic Neuropathy ◽  
Inadequate Response ◽  
Vessel Disease ◽  
One Year

Non-arteritic anterior ischemic optic neuropathy (NA-AION) is considered the most frequent type of acute optic neuropathy. A 61-year-old woman presented with a NA-AION in her right eye within 24 h following an airplane flight. One year later, after driving for 10 days with a daily accumulated altitude of 1500 m, she developed a NA-AION in her left eye. Systemic disorders were investigated, and cerebral small vessel disease was observed via cranial computed tomography. An inadequate response to hypoxia, in a patient with individual susceptibility, could lead to reduced blood supply to the optic nerve head, which could represent an underlying cause of NA-AION.

scholarly journals Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack

2016 ◽  
Vol 13 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Francesco Arba ◽  
Terence J Quinn ◽  
Graeme J Hankey ◽  
Kennedy R Lees ◽  
Joanna M Wardlaw ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Cognitive Impairment ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Small Vessel Disease ◽  
Small Vessel ◽  
Perivascular Spaces ◽  
Vessel Disease ◽  
One Year

Background Previous studies suggested that enlarged perivascular spaces are neuroimaging markers of cerebral small vessel disease. However, it is not clear whether enlarged perivascular spaces are associated with cognitive impairment. We aimed to determine the cross-sectional relationship between enlarged perivascular spaces and small vessel disease, and to investigate the relationship between enlarged perivascular spaces and subsequent cognitive impairment in patients with recent cerebral ischemic event. Methods Anonymized data were accessed from the virtual international stroke trial archive. We rated number of lacunes, white matter hyperintensities, brain atrophy, and enlarged perivascular spaces with validated scales on magnetic resonance brain images after the index stroke. We defined cognitive impairment as a mini mental state examination score of ≤26, recorded at one year post stroke. We examined the associations between enlarged perivascular spaces and clinical and imaging markers of small vessel disease at presentation and clinical evidence of cognitive impairment at one year using linear and logistic regression models. Results We analyzed data on 430 patients with mean (±SD) age 64.7 (±12.7) years, 276 (64%) males. In linear regression analysis, age (β = 0.24; p < 0.001), hypertension (β = 0.09; p = 0.025), and deep white matter hyperintensities (β = 0.31; p < 0.001) were associated with enlarged perivascular spaces. In logistic regression analysis, basal ganglia enlarged perivascular spaces were independently associated with cognitive impairment at one year after adjusting for clinical confounders (OR = 1.72, 95% CI = 1.22–2.42) and for clinical and imaging confounders (OR = 1.54; 95% CI = 1.03–2.31). Conclusions Our data show that in patients with ischemic cerebral events, enlarged perivascular spaces are cross-sectionally associated with age, hypertension, and white matter hyperintensities and suggest that enlarged perivascular spaces in the basal ganglia are associated with cognitive impairment after one year.

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