Expression of αvβ6 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications

2013 ◽  
Vol 42 (7) ◽  
pp. 547-556 ◽  
Author(s):  
Hai-Xia Li ◽  
Jin-Hua Zheng ◽  
Hai-Xia Fan ◽  
Hui-Ping Li ◽  
Zhong-Xiuzi Gao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Outcomes ◽  
Squamous Cell ◽  
Collagen Fibre ◽  
Prognostic Implications ◽  
Αvβ6 Integrin

αvβ6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells

2005 ◽  
Vol 309 (2) ◽  
pp. 273-283 ◽  
Author(s):  
M YLIPALOSAARI ◽  
G THOMAS ◽  
M NYSTROM ◽  
S SALHIMI ◽  
J MARSHALL ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Αvβ6 Integrin

scholarly journals COMPARISON OF IMMUNOHISTOCHEMICAL MARKER WITH SPECIAL STAINS IN THE PROGNOSIS OF THE DIFFERENT GRADES OF ORAL SQUAMOUS CELL CARCINOMA

2019 ◽  
Vol 8 (4) ◽  
Author(s):  
Dr. Parthiban Nallaiyan ◽  
Dr. Bharathi Ramakrishnan ◽  
Dr. Gnanadeepam Santigo ◽  
Dr. Dhanalakshmi Jeyasivanesan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Periodic Acid ◽  
Collagen Fibre ◽  
Ki 67 ◽  
Periodic Acid Schiff ◽  
Schiff Reagent ◽  
Neutral Mucin

Objectives: The aim of the study is to compare the efficiency of Ki-67 with special stains in the stroma of different grades of Oral Squamous Cell Carcinoma (OSCC) and to evaluate the influence of these changes in predicting the prognosis of these tumors. Materials and Methods: A total of 30 cases of different grades of Oral Squamous Cell Carcinoma and 6 cases of control were sections and stained with Picrosirus red (PR), combined Alcian blue-periodic acid Schiff reagent (AB-PAS) and Immunohistochemical (IHC) marker Ki-67. Results: Collagen fibre nature using PR stain and proliferative activity of malignant epithelial cells using IHC marker Ki-67 was found to be statistically significant. Mucin presence using AB-PAS was statistically insignificant. Conclusion: Prognosis in different grades of oral squamous cell carcinoma can be accessed by change in collagen fibres birefringence, as the tumour progresses there is change from mature to immature collagen. Ki-67 is a good proliferative marker and shows that there is positive correlation with histological grading of oral squamous cell carcinoma. Presence of acidic or neutral mucin in OSCC needed to be further studied. For assessing the prognosis in different grades of OSCC, special stains can also be used. Keywords: Collagen, Mucin, Squamous cell carcinoma, Ki-67.

Sign in / Sign up

Export Citation Format

Share Document