scholarly journals What keeps an island community COVID ‐19 free in a global pandemic?

2021 ◽  
Author(s):  
Pam Oliver ◽  
Neil Lindsay ◽  
Robin Kearns
Keyword(s):  
Global Pandemic ◽  
Island Community

Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity and Pathogenesis?

2020 ◽  
Author(s):  
Angelo Spinello ◽  
Andrea Saltalamacchia ◽  
Alessandra Magistrato
Keyword(s):  
Health Economic ◽  
Global Health ◽  
Receptor Binding ◽  
Binding Motif ◽  
Spike Glycoprotein ◽  
High Affinity ◽  
Global Pandemic ◽  
Medical Countermeasures ◽  
High Infectivity ◽  
Human Receptor

<p>The latest outbreak of a new pathogenic coronavirus (SARS-CoV-2) is provoking a global health, economic and societal crisis. All-atom simulations enabled us to uncover the key molecular traits underlying the high affinity of SARS-CoV-2 spike glycoprotein towards its human receptor, providing a rationale to its high infectivity. Harnessing this knowledge can boost developing effective medical countermeasures to fight the current global pandemic.</p>

The Structural Landscape of SARS-CoV-2 Main Protease: Hints for Inhibitor Search.

2020 ◽  
Author(s):  
Luigi Leonardo Palese
Keyword(s):  
Comparative Analysis ◽  
Global Health ◽  
Binding Site ◽  
Causative Agent ◽  
Data Set ◽  
Substrate Binding Site ◽  
Global Pandemic ◽  
Main Protease ◽  
Crystallographic Structures ◽  
Structural Aspects

In 2019, an outbreak occurred which resulted in a global pandemic. The causative agent of this serious global health threat was a coronavirus similar to the agent of SARS, referred to as SARS-CoV-2. In this work an analysis of the available structures of the SARS-CoV-2 main protease has been performed. From a data set of crystallographic structures the dynamics of the protease has been obtained. Furthermore, a comparative analysis of the structures of SARS-CoV-2 with those of the main protease of the coronavirus responsible of SARS (SARS-CoV) was carried out. The results of these studies suggest that, although main proteases of SARS-CoV and SARS-CoV-2 are similar at the backbone level, some plasticity at the substrate binding site can be observed. The consequences of these structural aspects on the search for effective inhibitors of these enzymes are discussed, with a focus on already known compounds. The results obtained show that compounds containing an oxirane ring could be considered as inhibitors of the main protease of SARS-CoV-2.

The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 748-752
Author(s):  
Swapnali Khabade ◽  
Bharat Rathi ◽  
Renu Rathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthy Person ◽  
World Health ◽  
Physical And Mental Health ◽  
Leading Role ◽  
Global Pandemic ◽  
The People ◽  
The World ◽  
Health Organization ◽  
The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

Dietary and living regimen of covid-19 with special reference to Ayurveda Varsha and Sharad Ritucharya

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 758-762
Author(s):  
Amit Biswas ◽  
KunalChandankhede
Keyword(s):  
Environmental Changes ◽  
World Health ◽  
Human Beings ◽  
Dietary Regimen ◽  
Global Pandemic ◽  
The World ◽  
Health Organization ◽  
Disease Free ◽  
Individual Disease ◽  
Morbid Conditions

Wuhan originated Covid-19 disease is caused by SARC-COV 2 virus. It is a contagious disease it spread all over the world. World health organization declared a global pandemic disease. In Covid-19 immunity plays an important role. In old age people or having other co-morbid conditions the mortality rate is more. Ayurveda has a big role in improved immunity or to intact immunity. The principle of Ayurveda is to keep individual swastha (diseases free). To maintain individual disease-free Ritucharya is one of the important subjects of Ayurveda. Aimed of study is to find out Ritucharya literature from the Ayurveda and modern research specifically Varsha and Sharad ritu. Ritucharya contains dietary regimen, living modification, common medicine, and contraindicated things those changing according to environmental change. Upcoming season in India is Varsha and Sharad ritu. Environmental changes are huge in this season and it directly affected human beings. So this study reveals property of ritu, dietary regimen, living modification, common medicine and contraindicated things in upcoming varsha and sharad ritu.

Analisis Hidrolis dan Jejak Karbon Jaringan Distribusi Air Bersih di Pulau Kecil Padat Penduduk (Pulau Lengkang Kecil, Kota Batam)

2020 ◽  
Vol 21 (2) ◽  
pp. 227-235
Author(s):  
Muhammad Rizki Apritama ◽  
I Wayan Koko Suryawan ◽  
Yosef Adicita
Keyword(s):  
Water Supply ◽  
Distribution System ◽  
Water Distribution ◽  
Treatment Plant ◽  
Primary Source ◽  
Distribution Networks ◽  
Clean Water ◽  
Island Community ◽  
Dug Wells ◽  
Centralized Wastewater Treatment

ABSTRACTThe clean water supply system network on Lengkang Kecil Island was developed in 2019. A small portion of the community's freshwater comes from harvesting rainwater and dug wells, which are only obtained during the rainy season. The primary source of clean water used by the community comes from underwater pipelines with a daily discharge of 0.86 l/sec. The water supply of the Lengkang Kecil Island community is 74.3 m3/day, with 146 House Connections (HCs) and to serve public facilities such as elementary schools, primary health centers, and mosques. Hydraulic evaluation of clean water distribution using EPANET 2.0 software on flow velocity shows the lowest rate of 0.29 m/s and the highest of 1.21 m/s. The lowest pressure value in the distribution system is 6.94-6.96 m and headloss units in the range 0.08-0.25 m/km. These three criteria are still within the distribution network design criteria (feasible). A carbon footprint can be calculated from each activity from the analysis of the evaluation of clean water distribution networks. The most massive emissions came from pumping activities with 131 kg CO2-eq, followed by emissions from wastewater 62.5 kgCO2-eq. Further research is needed to determine the quality of wastewater and the design for a centralized wastewater treatment plant (IPALT) to improve Lengkang Kecil Island residents' living standards.Keywords: Lengkang Kecil Island, water, EPANET, carbon footprintABSTRAKJaringan sistem penyediaan air bersih pada Pulau Lengkang Kecil dimulai pada tahun 2019. Sebagian kecil air bersih yang digunakan masyarakat berasal dari pemanenan air hujan dan sumur gali yang hanya didapat pada musim hujan. Sumber air bersih utama yang digunakan masyarakat berasal dari pengaliran perpipaan bawah laut dengan debit harian 0,86 l/detik. Kebutuhan air masyarakat Pulau Lengkang Kecil adalah 74,3 m3/hari dengan 146 Sambungan Rumah (SR) serta untuk melayani fasilitas umum seperti sekolah dasar (SD), puskesmas, dan masjid. Evaluasi hidrolis distribusi air bersih dengan menggunakan software EPANET 2.0 terhadap kriteria kecepatan aliran menunjukkan nilai terendah 0,29 m/s dan tertinggi 1,21 m/s. Nilai sisa tekan dalam sistem distribusi adalah 6,94–6,96 m dan unit headloss pada kisaran 0,08–0,25 m/km. Ketiga kriteria ini masih berada dalam kriteria desain jaringan distribusi (layak). Dari analisis evaluasi jaringan distribusi air bersih, dapat dihitung jejak karbon yang dihasilkan dari setiap kegiatannya. Emisi terbesar berasal dari kegiatan pemompaan dengan nilai 131 kgCO2-eq, diikuti dengan emisi yang berasal dari air limbah dengan nilai 62,5 kgCO2-eq. Penelitian lanjutan diperlukan untuk mengetahui kualitas dari air limbah dan desain untuk instalasi pengolahan air limbah terpusat (IPALT) untuk meningkatkan taraf hidup penduduk Pulau Lengkang Kecil.Kata kunci: Pulau Lengkang Kecil, air, EPANET, jejak karbon

Too WEIRD, Too Fast: Preprints about COVID-19 in the Psychological Sciences

2020 ◽  
Author(s):  
Arathy Puthillam
Keyword(s):  
Overwhelming Majority ◽  
Global Pandemic ◽  
The Us ◽  
The World ◽  
The Face ◽  
Conducting Research ◽  
Psychological Studies

That American and European participants are overrepresented in psychological studies has been previously established. In addition, researchers also often tend to be similarly homogenous. This continues to be alarming, especially given that this research is being used to inform policies across the world. In the face of a global pandemic where behavioral scientists propose solutions, we ask who is conducting research and on what samples. Forty papers on COVID-19 published in PsyArxiV were analyzed; the nationalities of the authors and the samples they recruited were assessed. Findings suggest that an overwhelming majority of the samples recruited were from the US and the authors were based in US and German institutions. Next, men constituted a large proportion of primary and sole authors. The implications of these findings are discussed.

OnPoint: A package for online experiments in motor control and motor learning

2020 ◽  
Author(s):  
Jonathan Sanching Tsay ◽  
Alan S. Lee ◽  
Guy Avraham ◽  
Darius E. Parvin ◽  
Jeremy Ho ◽  
...  
Keyword(s):  
Motor Control ◽  
Motor Learning ◽  
Open Source Software ◽  
Research Progress ◽  
Global Pandemic ◽  
Large N ◽  
Open Source Software Package ◽  
Potential Applications ◽  
Temporal And Spatial ◽  
The One

Motor learning experiments are typically run in-person, exploiting finely calibrated setups (digitizing tablets, robotic manipulandum, full VR displays) that provide high temporal and spatial resolution. However, these experiments come at a cost, not limited to the one-time expense of purchasing equipment but also the substantial time devoted to recruiting participants and administering the experiment. Moreover, exceptional circumstances that limit in-person testing, such as a global pandemic, may halt research progress. These limitations of in-person motor learning research have motivated the design of OnPoint, an open-source software package for motor control and motor learning researchers. As with all online studies, OnPoint offers an opportunity to conduct large-N motor learning studies, with potential applications to do faster pilot testing, replicate previous findings, and conduct longitudinal studies (GitHub repository: https://github.com/alan-s-lee/OnPoint).

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