scholarly journals RETROSPECTIVE STUDY TOTAL SERUM IMMUNOGLOBULIN E, ALLERGEN-SPECIFIC IGE PROFILE AND PERIPHERAL BLOOD EOSINOPHILIA PERCENTAGE IN MODERATE TO SEVERE ASTHMATIC PATIENTS IN RESPIRATORY CLINIC, TAIPING HOSPITAL

Respirology ◽  
2018 ◽  
Vol 23 ◽  
pp. 97-97
Keyword(s):  
Retrospective Study ◽  
Peripheral Blood ◽  
Immunoglobulin E ◽  
Specific Ige ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Blood Eosinophilia ◽  
Asthmatic Patients ◽  
Severe Asthmatic ◽  
Peripheral Blood Eosinophilia

The Association of Skin Test Reactivity, Total Serum IgE Levels, and Peripheral Blood Eosinophilia with Asthma in Kuwait

2000 ◽  
Vol 37 (6) ◽  
pp. 481-488 ◽  
Author(s):  
Mousa Khadadah ◽  
B. O. Onadeko ◽  
C. I. Ezeamuzie ◽  
H. T. Mustafa ◽  
R. Marouf ◽  
...  
Keyword(s):  
Skin Test ◽  
Peripheral Blood ◽  
Total Serum ◽  
Skin Test Reactivity ◽  
Blood Eosinophilia ◽  
Serum Ige ◽  
Peripheral Blood Eosinophilia

LINKAGE ANALYSIS OF IL-4 AND OTHER CHROMOSOME 5q31.1 MARKERS AND TOTAL SERUM IMMUNOGLOBULIN E (IgE) CONCENTRATIONS

PEDIATRICS ◽  
1995 ◽  
Vol 96 (2) ◽  
pp. 379-379
Author(s):  
Arden Levy
Keyword(s):  
Linkage Analysis ◽  
Immunoglobulin E ◽  
Specific Ige ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Serum Ige ◽  
Sib Pair Analysis ◽  
Pair Analysis

This group found evidence linking five markers in chromosome 5q31.1 with a gene modulating total serum IgE concentration in a sib-pair analysis of 170 individuals in 11 Amish families. Evidence was found for the linkage of 5q31. I and the IL-4 gene. Specific IgE concentrations were not linked to these markers. Thus, this study suggests that IL-4 or a nearby gene in 5q31.1 regulates overall IgE production.

scholarly journals The effect of peripheral blood eosinophilia on inflammatory markers in asthmatic patients with lower respiratory tract infections

2019 ◽  
Vol 47 (6) ◽  
pp. 2452-2460 ◽  
Author(s):  
Yakup Cag ◽  
Yakup Pacal ◽  
Mehmet Gunduz ◽  
Sakine Isik ◽  
Birgul Altinsoy Kertmen ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Peripheral Blood ◽  
Lower Respiratory Tract ◽  
Inflammatory Marker ◽  
Blood Eosinophilia ◽  
Asthmatic Patients ◽  
Reactive Protein ◽  
Asthma Patients ◽  
Tract Infections ◽  
Peripheral Blood Eosinophilia

Background To investigate the behaviour of the inflammatory marker neutrophil-to-lymphocyte ratio (NLR) in the presence of peripheral blood eosinophilia (PBE) in paediatric asthma patients with lower respiratory tract (LRT) infections. Methods This retrospective study enrolled consecutive patients aged ≥5 years who were diagnosed with asthma and whose haemogram values were available. The patients were further subdivided based on the presence or absence of LRT infections and allergies. NLR and C-reactive protein (CRP) were evaluated in relation to the presence or absence of PBE (≥4% eosinophils). Results A total of 991 patients were enrolled in the study. Patients with LRT infections had significantly higher leucocyte and neutrophil counts, a greater NLR and a higher level of CRP compared with patients without LRT infections. Overall, patients with PBE had significantly lower NLRs and CRP regardless of the presence or absence of an LRT infection. The PBE percentage showed moderate inverse correlations with NLR ( r = −0.34) and CRP ( r = −0.20). Conclusion The presence of PBE was significantly associated with lower NLR and CRP regardless of the presence or absence of an infectious condition.

A Case of Allergic Granulomatous Angiitis with Peripheral Blood Eosinophilia Revealing Resistance to Systemic Steroid

2006 ◽  
Vol 68 (1) ◽  
pp. 19-23
Author(s):  
Yuki SUZUKI ◽  
Hideaki WATANABE ◽  
Amane KITAMI ◽  
Hirohiko SUEKI ◽  
Masafumi IIJIMA ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Systemic Steroid ◽  
Granulomatous Angiitis ◽  
Blood Eosinophilia ◽  
Allergic Granulomatous Angiitis ◽  
Peripheral Blood Eosinophilia

Malignant Fibrous Histiocytoma Associated with Peripheral Blood Eosinophilia

Oncology ◽  
1986 ◽  
Vol 43 (4) ◽  
pp. 230-233 ◽  
Author(s):  
Stefan Serke ◽  
Monika Brenner ◽  
Robert Zimmermann ◽  
Hartmut Lobeck
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Peripheral Blood ◽  
Fibrous Histiocytoma ◽  
Blood Eosinophilia ◽  
Peripheral Blood Eosinophilia

Allergic altered reactivity in the early neonatal period

1982 ◽  
Vol 63 (4) ◽  
pp. 11-13
Author(s):  
A. G. Shamova ◽  
R. M. Bakhtiarova
Keyword(s):  
Enzymatic Activity ◽  
Social Factors ◽  
Peripheral Blood ◽  
Neonatal Period ◽  
Allergic Reactions ◽  
Blood Eosinophilia ◽  
Early Neonatal Period ◽  
Peripheral Blood Eosinophilia

In 138 newborns with toxic (allergic) erythema, the mediation of allergic reactions by social factors was established. On the 2nd day of life, an allergically altered reactivity is clinically manifested, which is also expressed by an altered picture of peripheral blood (eosinophilia, lymphocytosis) and indicators of the enzymatic activity of leukocytes.

scholarly journals Toxocariasis in children: epidemiological, clinical and laboratory aspects

2020 ◽  
Vol 4 (11) ◽  
pp. 670-675
Author(s):  
A.O. Andreeva ◽  
◽  
N.V. Golovchenko ◽  
A.S. Zhuravlev ◽  
◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Laboratory Data ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Eosinophilia ◽  
Rights Protection ◽  
Human Wellbeing ◽  
Consumer Rights ◽  
Positive Rate ◽  
Peripheral Blood Eosinophilia ◽  
Research Institute

Aim: to optimize the diagnosis of toxocariasis based on the analysis of epidemiological, clinical and laboratory data in children with the infestation. Patients and Methods: the analysis of official statistical data for the period of 2014–2018, literature sources, a retrospective analysis of 57 medical records of patients (40 children and 17 adults) who received treatment and diagnostic in the clinic of the Rostov Research Institute of Microbiology and Parasitology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing in 2015–2018 was conducted. Results: a decrease in the incidence of newly diagnosed infestation cases was revealed (registered in the clinic of the Rostov Research Institute of Microbiology and Parasitology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing). It correlated with official statistics (r=0.9, p=0.05). Based on clinical and laboratory examination, the diagnosis was established in 26 patients (45.6%). Among patients with a verified diagnosis of toxocariasis, the proportion of children aged 1 years and 1 months to 10 years old, was 96%. An analysis of epidemiological data showed that 76% of children had close contact with the soil. The infestation occurred in the form of latent toxocariasis in 36% of patients. In more than half of the cases, the disease was clinically manifested by geophagy (56.0%). A permanent laboratory parameter was the eosinophilic leukemoid reaction in patients with toxocariasis. Peripheral blood eosinophilia ranged from 15.66.2±9.31% in latent toxocariasis to 25.5±15.0 % in visceral toxocariasis. The positive rate in ELISA with Toxocara antigen was higher than that in the group of patients with visceral toxocariasis. However, there was no correlation between the eosinophilia level and positive rate (r=0.1, p=0.05). Conclusion: in areas where the incidence of toxocariasis and environmental contamination with invasive helminth eggs are high, it is advisable to perform tests of the peripheral blood in children at least one time per year in the autumn for timely diagnosis of infestation. The use of ELISA with Toxocara antigen is reasonable in the cases of peripheral blood eosinophilia. KEYWORDS: toxocariasis, statistics, incidence, eosinophilia, enzyme-linked immunosorbent assay, Toxocara antigen. FOR CITATION: Andreeva A.O., Golovchenko N.V., Zhuravlev A.S. Toxocariasis in children: epidemiological, clinical and laboratory aspects. Russian Medical Inquiry. 2020;4(11):670–675. DOI: 10.32364/2587-6821-2020-4-11-670-675.

scholarly journals Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Cheng Peng ◽  
Andres Cardenas ◽  
Sheryl L. Rifas-Shiman ◽  
Marie-France Hivert ◽  
Diane R. Gold ◽  
...  
Keyword(s):  
Life Course ◽  
Association Study ◽  
Immunoglobulin E ◽  
Serum Immunoglobulin ◽  
Total Serum ◽  
Life Course Approach

Proficiency Survey-Based Evaluation of Clinical Total and Allergen-Specific IgE Assay Performance

2010 ◽  
Vol 134 (7) ◽  
pp. 975-982 ◽  
Author(s):  
Robert G. Hamilton
Keyword(s):  
Allergic Disease ◽  
Immunoglobulin E ◽  
Diagnostic Algorithm ◽  
Specific Ige ◽  
Total Serum ◽  
Design Data ◽  
Ige Antibody ◽  
Marked Variability ◽  
Specific Immunoglobulin E ◽  
History Of

Abstract Context.—The diagnostic algorithm for human allergic disease involves confirmation of sensitization by detection of allergen-specific immunoglobulin E (IgE) antibody in individuals suspected of having allergic disease because of a history of allergic symptoms after known allergen exposure. Previous studies showed wide disparity among clinically reported allergen-specific IgE levels from different serologic assays. Objective.—To validate the relative analytic performance (sensitivity, interassay reproducibility, linearity/parallelism, intermethod agreement) of clinically used total and allergen-specific IgE assays by using College of American Pathologists' Diagnostic Allergy “SE” Proficiency Survey data. Design.—Data from 2 SE survey cycles were used to assess relative analytic performance of the ImmunoCAP (Phadia), Immulite (Siemens Healthcare-Diagnostics), and HYTEC 288 (HYCOR-Agilent Technologies) total and allergen-specific IgE assays. In each cycle, 2 recalcified plasma pools from atopic donors were diluted twice with IgE-negative serum and evaluated in approximately 200 federally certified clinical laboratories for total IgE and IgE antibody to 5 allergen specificities. Statistical analysis evaluated analytic sensitivity, linearity, reproducibility, and intermethod agreement. Results.—Interlaboratory intramethod, intermethod, and interdilution agreement of all 6 clinically used total serum IgE assays were excellent, with coefficients of variation (CVs) below 15%. Interlaboratory intramethod, and interdilution agreement of 3 clinically used allergen-specific IgE assays were also excellent with CVs below 15%. However, intermethod CVs identified between-assay disagreement greater than 20% in 80% of allergen-specific IgE measurements. Allergen reagents and patients' immune response heterogeneity are suggested probable causes. Conclusions.—Clinical total and allergen-specific IgE assays display excellent analytic sensitivity, precision, reproducibility, and linearity. Marked variability in quantitative estimates of allergen-specific IgE from clinically used automated immunoassays is a concern that may be ameliorated with component allergen use.

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