Temperature Profiles During Cryolipolysis
Abstract Cryolipolysis is a noninvasive clinical procedure for the local reduction of adipose tissue. Paddles as cold as ~10 °C are placed in good thermal contact the epidermis. The goal is to cool the subcutaneous adipose tissue to ~10 °C, which induces apoptosis and an inflammatory response in the adipocytes. The dermis is, of course, cooler than the adipocytes, but the triglyceride in the adipocytes are thought to crystalize, causing apoptosis. The clinical procedure have been developed empirically. A mathematical model could aid in understanding the mechanisms of response and improving the design of the procedure. Here, the Pennes equation is used to model the temperature of the tissue during cooling. The two parameters identified are the thermal diffusivity of the tissue and a blood perfusion parameter, which also gives the characteristic length. Green's functions are used to solve the Pennes equation, which simplifies to a transient fin equation.