SAT0434 Recurrence rates in patients with dupuytren’s contracture 3 years after successful treatment with collagenase clostridium histolyticum

To assess the efficacy, safety and pharmacokinetics of 0.58 mg collagenase Clostridium histolyticum injections for the treatment of Dupuytren’s contracture in Japanese patients, we conducted a phase III, multicentre, uncontrolled, open-label clinical study in patients with Dupuytren’s contracture. Of the 77 patients, 66 achieved clinical success in the primary treated joint (86%; 95% confidence interval: 76% to 93%), confirming the efficacy of collagenase Clostridium histolyticum injections. More improvement was seen in the metacarpophalangeal joints than in the proximal interphalangeal joints (94% versus 73%). The main adverse reaction was a local reaction in the injected hand. No tendon rupture or anaphylactic reactions were seen. The concentrations of collagenase Clostridium histolyticum were below the lower limit of quantification in plasma samples at all time points. As seen in global studies in Caucasian patients, a corrective effect on Dupuytren’s contracture and good tolerance were observed in most non-Caucasian (Asian) Japanese patients. Level of Evidence: Level 3

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A single injection of collagenase clostridium histolyticum for the treatment of moderate Dupuytren’s contracture: a 2 year follow-up of 47 patients

Journal of Hand Surgery (European Volume) ◽

10.1177/1753193415597421 ◽

2015 ◽

Vol 41 (6) ◽

pp. 664-665 ◽

Cited By ~ 6

Author(s):

J. McFarlane ◽

A. M. Syed ◽

T.F. Sibly

Keyword(s):

Single Injection ◽

Dupuytren’S Contracture ◽

Collagenase Clostridium Histolyticum ◽

Dupuytren's Contracture ◽

Clostridium Histolyticum

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Injectable Collagenase Clostridium Histolyticum for Dupuytren's Contracture

Yearbook of Plastic and Aesthetic Surgery ◽

10.1016/s1535-1513(10)79549-7 ◽

2011 ◽

Vol 2011 ◽

pp. 102-103

Author(s):

D.J. Smith

Keyword(s):

Dupuytren’S Contracture ◽

Collagenase Clostridium Histolyticum ◽

Dupuytren's Contracture ◽

Clostridium Histolyticum

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The efficacies and limitations of fasciectomy and collagenase clostridium histolyticum in Dupuytren’s contracture management: A meta-analysis

Journal of Orthopaedic Surgery ◽

10.1177/2309499020921747 ◽

2020 ◽

Vol 28 (2) ◽

pp. 230949902092174 ◽

Cited By ~ 1

Author(s):

Tokai B Cooper ◽

Keshav Poonit ◽

Chenglun Yao ◽

Zeyuan Jin ◽

Jingwei Zheng ◽

...

Keyword(s):

Meta Analysis ◽

Treatment Algorithm ◽

Cochrane Library ◽

Dupuytren’S Contracture ◽

Collagenase Clostridium Histolyticum ◽

Dupuytren's Contracture ◽

Clostridium Histolyticum ◽

Palmar Aponeurosis ◽

The Mean

Background: We intend to assess the efficacies and limitations of collagenase clostridium histolyticum (CCH) and fasciectomy in treating Dupuytren’s contracture, and the associated complications and rate of recurrences aiming to present a treatment algorithm. Methods: A literature search within the PubMed, Web of Sciences, Cochrane Library, and EMBASE databases was performed using the combined key words ‘Dupuytren, palmar aponeurosis contracture, collagenase clostridium histolyticum and fasciectomy’, including all possible studies with a set of predefined inclusion and exclusion criteria. Results: Thirty studies were assessed for eligibility from 215 identified records. Seventeen publications satisfied the inclusion criteria including 2142 joints in 1784 patients. The mean follow-up time was 18.0 months (3–60). Conclusion: Acceptable contractures release was obtained in both techniques. Severe complications associated with fasciectomy outrank those of CCH, whereas the low rate of recurrence favors the fasciectomy technique.

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