scholarly journals Multiyear prospective cohort study to evaluate the risk potential of MERS-CoV infection among Malaysian Hajj pilgrims (MERCURIAL): a study protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e050901
Author(s):  
Jefree Johari ◽  
Robert D Hontz ◽  
Brian L Pike ◽  
Tupur Husain ◽  
Chee-Kheong Chong ◽  
...  
Keyword(s):  
Cohort Study ◽  
Middle East ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Global Public Health ◽  
Serum Samples ◽  
Potential Threat ◽  
Mass Gatherings ◽  
Viral Respiratory Infection ◽  
Scientific Meetings

IntroductionMiddle East respiratory syndrome (MERS) is a viral respiratory infection caused by the MERS-CoV. MERS was first reported in the Kingdom of Saudi Arabia in 2012. Every year, the Hajj pilgrimage to Mecca attracts more than two million pilgrims from 184 countries, making it one of the largest annual religious mass gatherings (MGs) worldwide. MGs in confined areas with a high number of pilgrims’ movements worldwide continues to elicit significant global public health concerns. MERCURIAL was designed by adopting a seroconversion surveillance approach to provide multiyear evidence of MG-associated MERS-CoV seroconversion among the Malaysian Hajj pilgrims.Methods and analysisMERCURIAL is an ongoing multiyear prospective cohort study. Every year, for the next 5 years, a cohort of 1000 Hajj pilgrims was enrolled beginning in the 2016 Hajj pilgrimage season. Pre-Hajj and post-Hajj serum samples were obtained and serologically analysed for evidence of MERS-CoV seroconversion. Sociodemographic data, underlying medical conditions, symptoms experienced during Hajj pilgrimage, and exposure to camel and untreated camel products were recorded using structured pre-Hajj and post-Hajj questionnaires. The possible risk factors associated with the seroconversion data were analysed using univariate and multivariate logistic regression. The primary outcome of this study is to better enhance our understanding of the potential threat of MERS-CoV spreading through MG beyond the Middle East.Ethics and disseminationThis study has obtained ethical approval from the Medical Research and Ethics Committee (MREC), Ministry of Health Malaysia. Results from the study will be submitted for publication in peer-reviewed journals and presented in conferences and scientific meetings.Trial registration numberNMRR-15-1640-25391.

scholarly journals Maternal COVID-19 infection, clinical characteristics, pregnancy and neonatal outcome: a prospective cohort study at a tertiary care center in Central India

2021 ◽  
Vol 9 (6) ◽  
pp. 1633
Author(s):  
Moushmi S. Parpillewar Tadas ◽  
Prashanthi S. ◽  
Mrunmayi Tankhiwale ◽  
Monika Singh
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Neonatal Outcome ◽  
Care Center ◽  
Tertiary Care ◽  
Central India ◽  
Family Welfare ◽  
Global Public Health ◽  
Severity Of Disease

Background: COVID-19 caused by severe acute respiratory syndrome coronavirus-2 is a global public health emergency as declared by WHO. Currently how it affects pregnancy very little is known. To identify maternal and neonatal risks associated with COVID-19 in pregnancy and to describe outcome a prospective cohort study was done. Associations were evaluated for all COVID-19 patients and for disease classified as mild versus moderate/severe disease.Methods: In this study COVID RT-PCR positive women who were admitted from 1 May to 31 August were included. Cases were classified according to their severity, investigations done and treated according to MOHFW (ministry of health and family welfare), India guidelines. Data was collected, analysed in terms of maternal and neonatal outcome.Results: Total 221 COVID-19 cases were admitted and 181 delivered during study period. There were 215 (97.28%) mild, 5 (2.71%) moderate and 1 (0.45%) severe cases. 210 (95.02%) were diagnosed in third trimester. Mean gestational age was 36.79±5.24 weeks and 3 out of 4 in moderate/severe category delivered preterm. 132 (59.73%) were asymptomatic. There was 1 ICU admission and 1 maternal death. Mean birth weight was 2.7±0.59 kg. There were 7 stillbirths, 14 NICU admission and 1 neonatal death.Conclusions: Majority of the covid infected women are asymptomatic are in mild category and there is no adverse maternal and neonatal outcome due to disease. Adversity of maternal and neonatal outcome depends on severity of disease and severity of disease is dependent on presence of co-morbidities.

scholarly journals Systemic immune-inflammation index independently predicts poor survival of older adults with hip fracture: a prospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhi-Cong Wang ◽  
Wei Jiang ◽  
Xi Chen ◽  
Ling Yang ◽  
Hong Wang ◽  
...  
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
Hip Fracture ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Public Health Problem ◽  
Global Public Health ◽  
All Cause Mortality ◽  
Immune Inflammation

Abstract Background The systemic immune-inflammation index (SII), based on peripheral platelet, neutrophil and lymphocyte counts, has been proven to be a promising prognostic indicator in various diseases. Hip fracture is a common injury among the older adults, and has become a global public health problem with high mortality and disability rates. However, the relationship between SII and the prognosis of hip fracture is not yet well-known. The aim of the this study was to explore the predictive value of SII in older adults with hip fracture undergoing surgery. Methods This was a prospective cohort study performed from January 2014 to December 2018 at a orthopaedic center, China. The SII was calculated as platelet×neutrophil/lymphocyte counts. Univariable and multivariable Cox proportional hazard models were used to assess the association between SII and all-cause mortality. Results A total of 290 older adults with hip fracture were included, and the mean (SD) age was 77.6 (8.6) years, and 189 (65.2%) were female. The median (IQR) SII was 759.4 (519.0–1128.7) × 109/L. After a median follow-up time of 33.4 months, 13 (4.5%), 26 (9.0%) and 54 (18.6%) patients died within the 30-day, 1-year and last follow-up, respectively. Multivariable Cox analysis revealed that each increase of 100 units of SII was associated with a 8% increased hazard of death at 1-year follow-up (HR = 1.08, 95% CI: 1.01–1.17, p = 0.033), and 9% increased hazard of death at last follow-up (HR = 1.09, 95% CI: 1.03–1.15, p = 0.003). Conclusions SII is associated with poor all-cause mortality in older adults with hip fracture undergoing surgery, and deserves further investigation and application in clinical practice.

Organizational Justice and Health of Employees: Prospective Cohort Study.

2013 ◽  
Author(s):  
Mika Kivimaki ◽  
Marko Elovainio ◽  
Jussi Vahtera ◽  
Marianna Virtanen ◽  
Jane E. Ferrie
Keyword(s):  
Cohort Study ◽  
Organizational Justice ◽  
Prospective Cohort Study ◽  
Prospective Cohort

Cynical distrust increases breast cancer risk: Evidence from a prospective cohort study

2002 ◽  
Author(s):  
A. R. Aro ◽  
H. J. de Koning ◽  
K. Vehkalahti ◽  
P. Absetz ◽  
M. Schreck ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Prospective Cohort Study ◽  
Prospective Cohort
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