scholarly journals PTU-172 Oesophageal cancer risk: results of a prospective cohort with Barrett's oesophagus

Gut ◽  
2012 ◽  
Vol 61 (Suppl 2) ◽  
pp. A255.1-A255
Author(s):  
B T Theron ◽  
H Padmanabhan ◽  
H Aladin ◽  
B T Cooper ◽  
N Trudgill
Keyword(s):  
Cancer Risk ◽  
Oesophageal Cancer ◽  
Prospective Cohort ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus

scholarly journals Derivation of genetic biomarkers for cancer risk stratification in Barrett’s oesophagus: a prospective cohort study

Gut ◽  
2015 ◽  
Vol 65 (10) ◽  
pp. 1602-1610 ◽  
Author(s):  
Margriet R Timmer ◽  
Pierre Martinez ◽  
Chiu T Lau ◽  
Wytske M Westra ◽  
Silvia Calpe ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Risk ◽  
Risk Stratification ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus ◽  
Genetic Biomarkers

scholarly journals Comparative quantitative survey of patient experience in Barrett’s oesophagus and other gastrointestinal disorders

2020 ◽  
Vol 7 (1) ◽  
pp. e000357
Author(s):  
James Britton ◽  
Paraskevi Taxiarchi ◽  
Glen Martin ◽  
Robert Willert ◽  
Maria Horne ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Symptom Control ◽  
Rank Correlation ◽  
Colonic Polyps ◽  
Colonic Polyp ◽  
Barrett’S Oesophagus ◽  
Cancer Worry ◽  
Barrett's Oesophagus ◽  
Acid Regurgitation ◽  
Spearman’S Rank Correlation

ObjectiveTo assess health-related quality of life in patients with non-dysplastic Barrett’s oesophagus (NDBO) and endoscopically treated dysplastic Barrett’s oesophagus (DBO).DesignThis quantitative, self-administered questionnaire study was conducted across three National Health Service hospitals. Data were collected from three other cohorts; gastro-oesophageal reflux disease (GORD), colonic polyp surveillance and healthy individuals. Fisher’s exact and Spearman’s rank correlation tests were used for analysis. Propensity score matching adjusted for age, sex and comorbidities.Results687 participants were eligible for analysis (NDBO n=306, DBO n=49, GORD n=132, colonic polyps n=152 and healthy n=48). 53% of NDBO participants reported similarly high cancer worry, comparable to DBO (50%, p=0.933) and colonic polyp participants (51%, p=0.355). Less cancer worry was reported in GORD participants (43.4%, p=0.01 vs NDBO). NDBO participants reported anxiety in 15.8% and depression in 8.6% of cases, which was similar to the other disease cohorts. Moderate or severe heartburn or acid regurgitation was found in 11% and 10%, respectively, in the NDBO cohort, comparable to DBO participants (heartburn 2% p=0.172, acid regurgitation 4% p=0.31) but lower (better) than GORD participants (heartburn 31% p=<0.001, acid regurgitation 25% p=0.001). NDBO participants with moderate or severe GORD symptoms were associated with higher rates of anxiety (p=<0.001), depression (p=<0.001) and cancer worry (p=<0.001). NDBO patients appropriately perceiving their cancer risk as low had lower rates of cancer worry (p=<0.001).ConclusionThis study provides insight into the problems Barrett’s oesophagus patients may face. Future care pathways must be more patient focussed to address misconceptions of cancer risk, oesophageal cancer related worry and GORD symptom control.

scholarly journals Barrett's oesophagus: epidemiology, cancer risk and implications for management

Gut ◽  
2013 ◽  
Vol 63 (1) ◽  
pp. 191-202 ◽  
Author(s):  
Pieter Jan F de Jonge ◽  
Mark van Blankenstein ◽  
William M Grady ◽  
Ernst J Kuipers
Keyword(s):  
Cancer Risk ◽  
Barrett’S Oesophagus ◽  
Barrett's Oesophagus

scholarly journals Risk of oesophageal cancer in Barrett's oesophagus and in gastro-oesophageal reflux

2003 ◽  
Vol 124 (4) ◽  
pp. A33 ◽  
Author(s):  
Masoud Solaymani-Dodaran ◽  
Carol Coupland ◽  
Richard F.A. Logan
Keyword(s):  
Oesophageal Cancer ◽  
Barrett’S Oesophagus ◽  
Oesophageal Reflux ◽  
Barrett's Oesophagus

scholarly journals Cancer incidence and mortality risks in a large US Barrett's oesophagus cohort

Gut ◽  
2017 ◽  
Vol 67 (3) ◽  
pp. 418-529 ◽  
Author(s):  
Michael B Cook ◽  
Sally B Coburn ◽  
Jameson R Lam ◽  
Philip R Taylor ◽  
Jennifer L Schneider ◽  
...  
Keyword(s):  
Oesophageal Cancer ◽  
Absolute Risk ◽  
Barrett’S Oesophagus ◽  
Oesophageal Adenocarcinoma ◽  
Kaiser Permanente ◽  
Barrett's Oesophagus ◽  
Relative Risks ◽  
Incidence And Mortality ◽  
The Usa ◽  
Prostate Cancers

ObjectiveBarrett's oesophagus (BE) increases the risk of oesophageal adenocarcinoma by 10–55 times that of the general population, but no community-based cancer-specific incidence and cause-specific mortality risk estimates exist for large cohorts in the USA.DesignWithin Kaiser Permanente Northern California (KPNC), we identified patients with BE diagnosed during 1995–2012. KPNC cancer registry and mortality files were used to estimate standardised incidence ratios (SIR), standardised mortality ratios (SMR) and excess absolute risks.ResultsThere were 8929 patients with BE providing 50 147 person-years of follow-up. Compared with the greater KPNC population, patients with BE had increased risks of any cancer (SIR=1.40, 95% CI 1.31 to 1.49), which slightly decreased after excluding oesophageal cancer. Oesophageal adenocarcinoma risk was increased 24 times, which translated into an excess absolute risk of 24 cases per 10 000 person-years. Although oesophageal adenocarcinoma risk decreased with time since BE diagnosis, oesophageal cancer mortality did not, indicating that the true risk is stable and persistent with time. Relative risks of cardia and stomach cancers were increased, but excess absolute risks were modest. Risks of colorectal, lung and prostate cancers were unaltered. All-cause mortality was slightly increased after excluding oesophageal cancer (SMR=1.24, 95% CI 1.18 to 1.31), but time-stratified analyses indicated that this was likely attributable to diagnostic bias. Cause-specific SMRs were elevated for ischaemic heart disease (SMR=1.39, 95% CI 1.18 to 1.63), respiratory system diseases (SMR=1.51, 95% CI 1.29 to 1.75) and digestive system diseases (SMR=2.20 95% CI 1.75 to 2.75).ConclusionsPatients with BE had a persistent excess risk of oesophageal adenocarcinoma over time, although their absolute excess risks for this cancer, any cancer and overall mortality were modest.

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