Novel approach for pericapsular radiofrequency ablation of sacrococcygeal junction for patients with coccydynia

2022 ◽  
pp. rapm-2021-103183
Author(s):  
Guy Feigin ◽  
Ning Nan Wang ◽  
Vitaliano Di Grazia ◽  
Philip Peng
Keyword(s):  
Conservative Therapy ◽  
Case Series ◽  
Rf Ablation ◽  
New Approach ◽  
Novel Approach ◽  
Different Types ◽  
History Of ◽  
Sacrococcygeal Joint ◽  
Fluoroscopy Guidance ◽  
Large Case

IntroductionCoccydynia is a multifactorial complex clinical challenge. A multimodal approach with both conservative measures and procedural interventions is often recommended. We described a novel approach of radiofrequency (RF) ablation for the management of coccydynia.MethodsThree patients with known history of coccydynia refractory to conservative therapy were referred to our clinic. All received different types of RF ablation before: one with anterior bipolar lesion with no analgesia benefit, one with posterior stripped lesion with good benefit but only after 8 weeks of pain flare and one received anterior monopolar lesion with 50% pain reduction for 2–3 months. All subjects underwent a novel RF ablation to the anterior surface of the sacrococcygeal and intercoccygeal joints with two bipolar lesions using multi-tined needles under fluoroscopy guidance. One bipolar lesion was between two needles: one in the sacrococcygeal and another in the intercoccygeal (between first and second coccyx) joints. Another bipolar lesion was between needles on both side of the sacrococcygeal joint.ResultsAll experienced at least 65% pain relief for 6 months. The sitting endurance increased from less than 5 min to an average of 70 min. No adverse effect was observed in two and in the patient who used to have pain flare after lesioning, the pain flare lasted only for 2 weeks.DiscussionThe configuration of the two bipolar lesions with multi-tined needles in this case series stimulates the thinking of new approach for the ablation technique for pain from coccyx. Further prospective large case cohort study is needed.

The PediSedate® device, a novel approach to pediatric sedation that provides distraction and inhaled nitrous oxide: clinical evaluation in a large case series

2006 ◽  
Vol 17 (2) ◽  
pp. 162-166 ◽  
Author(s):  
WILLIAM T. DENMAN ◽  
PACIFICO M. TUASON ◽  
MOHAMMED I. AHMED ◽  
LORALIE M. BRENNEN ◽  
M. SOLEDAD CEPEDA ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Clinical Evaluation ◽  
Case Series ◽  
Novel Approach ◽  
Large Case Series ◽  
Pediatric Sedation ◽  
Large Case

scholarly journals A Hybrid Method of Hiding The Text Information Using Stegnography

2013 ◽  
pp. 21-25
Author(s):  
M.Grace Vennice ◽  
M. Swapna ◽  
MD.Ahmad Ali ◽  
T.Dharma Reddy
Keyword(s):  
Hybrid Method ◽  
Information Hiding ◽  
Secret Message ◽  
Privacy And Security ◽  
New Approach ◽  
Novel Approach ◽  
Text Steganography ◽  
Suitable Amount ◽  
History Of ◽  
Text Information

The Often Distribution of encrypted messages will depict the concentration of third parties. The attempts can be made to break and expose the actual messages by the hackers and cracker crackers. To conceal the subsistence of message steganography is introduced by hiding a secret message inside another credulous message.Steganography along with cryptograph y is used and offers suitable amount of privacy and security over the communication cha channel. nnel. In this paper along with various existing text text-based steganography techniques, an overview of text steganography and a concise history of steganography can be presented. The problems present in the text steganography and issues with existing solution solutionss are highlighted. In information hiding, a novel approach is proposed by using inter-word word spacing and inter inter-paragraph paragraph spacing as a hybrid method. Based on the length of the secret message, the proposed method provides dynamic generated stego stego-text with six ix options of maximum capacity. The considerable drawbacks of every existing method and how our new approach might be recommended as a solution can be analyzed in this paper.

scholarly journals What Frequency of Technical Activity Is Needed to Improve Results? New Approach to Analysis of Match Status in Professional Soccer

2019 ◽  
Vol 16 (12) ◽  
pp. 2233 ◽  
Author(s):  
Marek Konefał ◽  
Paweł Chmura ◽  
Kacper Rybka ◽  
Jan Chmura ◽  
Maciej Huzarski ◽  
...  
Keyword(s):  
High Frequency ◽  
Effect Sizes ◽  
Large Impact ◽  
Football Players ◽  
Frequency Of Occurrence ◽  
New Approach ◽  
Professional Soccer ◽  
Novel Approach ◽  
Different Types ◽  
Moderate Effect

The aim of the research detailed here has been to assess the frequency with which football players engage in technical activity of various different types, in relation to seven phases of a game associated with changes in match status. To this end, 2016–2017 domestic-season matches in Germany’s Bundesliga were analyzed, the relevant data being retrieved using an Opta Sportsdata Company system. Technical activity taken into consideration included shots, passes, ball possession, dribbles, and tackles. It was found that there was a large impact of frequency of shots on target (H = 466.999(6); p = 0.001) in relation to the different match-status phases. Furthermore, moderate effect sizes were then obtained for frequency of shots (H = 187.073(6); p = 0.001), frequency of passes (H = 133.547(6); p = 0.001), and percentage of ball possession (H = 123.401(6); p = 0.001). The implication would be that a team trying to change the match score of a game experienced at a given moment in a more favorable direction will need to raise the frequency and accuracy of passes, the percentage of ball possession, and the percentage of tackles ending in success. The maintenance of a winning match status requires a high frequency of occurrence of shots and shots on target as well as greater frequency and effectiveness of dribbling. The main finding from our work is that consideration of the consequences of a game presented in relation to seven potential phases to match status can point to a novel approach to analysis.

scholarly journals HCC Heterogeneity: Molecular Pathogenesis and Clinical Implications

2009 ◽  
Vol 31 (3) ◽  
pp. 227-233
Author(s):  
Emilia Fransvea ◽  
Angelo Paradiso ◽  
Salvatore Antonaci ◽  
Gianluigi Giannelli
Keyword(s):  
Growth Factors ◽  
Clinical Outcome ◽  
Kinase Inhibitor ◽  
Clinical Aspects ◽  
Clinical Implications ◽  
New Approach ◽  
Tissue Microenvironment ◽  
Novel Approach ◽  
History Of ◽  
Extreme Variability

Background: Hepatocellular carcinoma (HCC) poses a major challenge because of the extreme variability of the clinical outcome, which makes it difficult to properly stage the disease and thereby estimate the prognosis. There is growing evidence that this heterogeneous clinical behavior is attributable to several different biological pathways. A novel approach to mapping these differences is by investigating the epigenetics associated with certain clinical aspects.Design: Herein, the relevance of these molecular differences in combination with the biological and molecular pathways regulating the clinical outcome will be discussed. Use of a mechanistic and pathogenic approach to clarify the natural history of HCC is not just an academic speculation but should help to develop new therapies and to tailor these therapies to each individual patient.Conclusion: New biological therapies targeting components of the tumoral or peritumoral microenvironment are crucial to the fight against HCC. However, biological redundancies and the presence of several growth factors, hormones, cytokines, etc., potentially involved in HCC tumor progression make it difficult to assess the best target. Sorafenib, a multi-tyrosine kinase inhibitor, blocks the functions of different growth factors present in the tissue microenvironment. The use of Sorafenib in patients with HCC offers a new approach to the therapy of this disease, stimulating research focusing on the development of drugs based on new molecular and pathogenic insights.

Basicity or Ionicity – A New Approach for Understanding Glass Properties

2008 ◽  
Vol 39-40 ◽  
pp. 129-134
Author(s):  
Adrian Volceanov
Keyword(s):  
Energy Levels ◽  
Electronic Energy ◽  
New Approach ◽  
Novel Approach ◽  
History Of ◽  
Chemical Character ◽  
Electronic Energy Levels ◽  
Major Adjustment ◽  
Global Mean ◽  
Glass Properties

Basicity of glass is still a challenge in spite of various attempts to measure or calculate it. The values assigned for basicity of glasses, either calculated or experimentally determined, are not always in full agreement with actual facts, and discrepancies among the theoretical ones are not unusual. For instance, SiO2 is described by a single basicity value even if the polymorphs of SiO2 are quite different. Only few attempts were made to face this challenge. Present paper deals with a novel approach on theoretical ionicity / basicity based on electronic energy levels or band structure of solids. Another major adjustment takes into account the possibility of decomposing ionicity of complex chemical bondings into a sum of binary bondings. Considering the distribution of the interbonding angles specific for vitreous systems, it is possible to estimate both a local ionicity (basicity) of bondings and a global (mean) basicity of glass. The variation of basicity (ionicity) with temperature is also presented, this finding being able to open a new view on thermal history of glass considered through chemical character of bondings.

Introduction

2020 ◽  
pp. 1-16
Author(s):  
David Faflik
Keyword(s):  
Urban Studies ◽  
Final Analysis ◽  
New Approach ◽  
Urban Forms ◽  
Modern City ◽  
Actual Existence ◽  
The Past ◽  
Novel Approach ◽  
History Of ◽  
The City

This book rests upon a pair of related propositions that have far-reaching consequences for the work of urban studies. The first is that the history of the modern city is a history of urban forms. The second is that the interpretive turn to formalism represents a wholly new approach to thinking about urbanism and historicism. In other words, this book argues that to conceive of the city “formally” is not only to revise our understanding of the city’s actual existence. It is to argue for an alternative way of apprehending the conditions through which knowledge of the city is even possible. Forms alter our sense of what the historical city was. Forms change how we perceive the very practice of urban perception, whether we’re talking about the perceptual habits of historical observers from the past or anyone who is mindful, today, of how forms function in the present century. In the final analysis, the twin claims on which this book depends suggest a different kind of urban being even as they propose a novel approach to city “reading.” In forms, we’ll never know the city the same way again.

scholarly journals Demographic and clinical characteristics of patients with functional motor disorders: the prospective Salpêtrière cohort

2021 ◽  
Author(s):  
Béatrice Garcin ◽  
Nicolas Villain ◽  
Francine Mesrati ◽  
Lionel Naccache ◽  
Emmanuel Roze ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Psychiatric Comorbidity ◽  
Middle Age ◽  
Case Series ◽  
University Hospital ◽  
Motor Disorders ◽  
Motor Weakness ◽  
History Of ◽  
Large Case Series ◽  
Large Case

AbstractFunctional motor disorders (FMD) are common and disabling. They are known to affect predominantly women and to start at young or middle age but to date, large case series are lacking, and demographic and clinical characteristics of patients with FMD rely on data from small cohorts. The current study aimed at describing the demographic and clinical characteristics of a large cohort of FMD patients.MethodsWe prospectively collected data from FMD patients who were referred to the Neurophysiology Department of the Pitié-Salpêtrière University Hospital between 2008 and 2016 for treatment with repeated transcranial magnetic stimulation.Results482 patients were included. There was a majority of women (73.7%) with a median age of 40 years old at TMS treatment. Median age at symptoms onset was 35.5 years old and symptoms were mostly characterized by an acute (47.3%) or subacute (46%) onset. Only 23% of patients were active workers while 58.3% were unemployed for medical reasons. Half of the patients suffered from functional motor weakness (n= 241) and the other half suffered from movement disorders (n=241), mainly represented by tremor (21.15%) and dystonia (20.5%). 33.6% had no psychiatric comorbidity and 17.4% reported no history of trauma. No significant differences were found in age or gender according to clinical phenotypes.ConclusionWe present the largest cohort of patients with FMD to date. This cohort will contribute to a better understanding of FMDs and their risk factors.

A Novel Approach for Continuous Acoustic Emission Monitoring on Rotating Machinery Without the Use of Slip Ring

2008 ◽  
Vol 130 (6) ◽  
Author(s):  
T. H. Loutas ◽  
J. Kalaitzoglou ◽  
G. Sotiriades ◽  
V. Kostopoulos
Keyword(s):  
Acoustic Emission ◽  
High Frequency ◽  
Damage Development ◽  
New Approach ◽  
Slip Ring ◽  
Novel Approach ◽  
Different Types ◽  
Damage States ◽  
Ae Signals ◽  
Development And Evolution

The acoustic emission (AE) technique is a powerful nondestructive tool for health monitoring of structures and mechanical components, especially due to its sensitivity to capture high frequency signals, which are associated with the early stages of damage development and evolution. The aim of the present work is twofold. The first is the evaluation of a new concept of transducer mounting on rotating structures without the use of the expensive solution of the slip ring. The new concept is realized in a single stage in-house built gearbox setup. The second is the evaluation of the potential of the acquired with the new concept AE signals in distinguishing between different types of artificially induced damage on the gears. Run-in tests were carried out to study the effect of gear damage on the AE recordings. The acoustic emission signature of the healthy gears is first acquired. Then artificial defects are seeded and the acquisition is repeated. The AE signals are analyzed, and their root-mean-square values are calculated. The capability of the new approach of AE acquisition in discriminating between different loading and damage states is shown and discussed. Interesting findings on the effect of the oil temperature on AE recordings only speculated theoretically so far are also presented.

Herpetic Whitlow of the Hand in Infants

2020 ◽  
Author(s):  
Mohammad M. Al-Qattan ◽  
Nada G. AlQadri ◽  
Ghada AlHayaza
Keyword(s):  
Bacterial Infection ◽  
Case Reports ◽  
Case Series ◽  
Individual Case ◽  
Senior Author ◽  
Secondary Bacterial Infection ◽  
Clinical Appearance ◽  
History Of ◽  
Mode Of Transmission ◽  
Time Of Presentation

Abstract Introduction Herpetic whitlows in infants are rare. Previous authors only reported individual case reports. We present a case series of six infants. Materials and Methods This is a retrospective study of six cases of herpetic whitlows in infants seen by the senior author (MMA) over the past 23 years (1995–2017 inclusive). The following data were collected: age, sex, digit involved in the hand, mode of transmission, time of presentation to the author, clinical appearance, presence of secondary bacterial infection, presence of other lesions outside the hand, method of diagnosis, treatment, and outcome. Results All six infants initially presented with classic multiple vesicles of the digital pulp. In all cases, there was a history of active herpes labialis in the mother. Incision and drainage or deroofing of the vesicles (for diagnostic purposes) resulted in secondary bacterial infection. Conclusion The current report is the first series in the literature on herpetic whitlows in infants. We stress on the mode of transmission (from the mother) and establishing the diagnosis clinically. In these cases, no need for obtaining viral cultures or polymerase chain reaction; and no medications are required. Once the vesicles are disrupted, secondary bacterial infection is frequent and a combination of oral acyclovir and intravenous antibiotics will be required.

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