scholarly journals Polymyalgia rheumatica-like syndrome from checkpoint inhibitor therapy: case series and systematic review of the literature

RMD Open ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. e000906 ◽  
Author(s):  
Cassandra Calabrese ◽  
Laura C Cappelli ◽  
Marie Kostine ◽  
Elizabeth Kirchner ◽  
Tawnie Braaten ◽  
...  

ObjectiveTo assess whether the polymyalgia rheumatica (PMR)-like syndrome reported as an immune related adverse event (irAE) from checkpoint inhibitor therapy is consistent with the 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) provisional criteria for PMR.MethodsThe cases were derived from two sources. Group 1 represents reported cases from three contributing centres. Group 2 was derived from a systematic review of the literature searching for all cases reported as PMR or PMR-like illness associated with checkpoint inhibitor therapy. Cases were assessed for the quality of reporting and then analysed to determine whether they fulfilled the 2012 EULAR/ACR provisional criteria for PMR.ResultsA total of 49 patients were included for analysis. Among the entire group, 37 (75%) were designated ‘complete’ indicating that they had sufficient data to reliably apply the 2012 EULAR/ACR criteria. 28 (75%) cases fulfilled complete criteria for PMR. A number of cases also demonstrated some clinical features unusual for idiopathic PMR.ConclusionThis study suggests a high proportion of reported cases of checkpoint inhibitor-related PMR fulfil preliminary criteria for PMR, yet in one quarter clinical details were incomplete making verification problematic. Furthermore, in the absence of a gold standard for the diagnosis of PMR, the relationship of checkpoint inhibitor-related PMR to the idiopathic form remains unclear.

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 204-LB ◽  
Author(s):  
KARA R. MIZOKAMI-STOUT ◽  
ROMA GIANCHANDANI ◽  
MARK MACEACHERN ◽  
RAVI M. IYENGAR ◽  
SARAH YENTZ ◽  
...  

2020 ◽  
pp. annrheumdis-2020-217225 ◽  
Author(s):  
Gregoire Martin de Fremont ◽  
Rakiba Belkhir ◽  
Julien Henry ◽  
Anne Laure Voisin ◽  
Olivier Lambotte ◽  
...  

2019 ◽  
Vol 145 (6) ◽  
pp. 1527-1557 ◽  
Author(s):  
Suheil Albert Atallah-Yunes ◽  
Anis John Kadado ◽  
Gregory P. Kaufman ◽  
Jaime Hernandez-Montfort

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