scholarly journals The effect of diet in infancy on asthma in young adults: the Merthyr Allergy Prevention Study

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-215040
Author(s):  
Sadiyah Hand ◽  
Frank Dunstan ◽  
Ken Jones ◽  
Iolo Doull
Keyword(s):  
High Risk ◽  
Allergic Disease ◽  
Clinical Assessment ◽  
Intervention Group ◽  
Cow’S Milk ◽  
Allergy Prevention ◽  
Prevention Study ◽  
Cow's Milk ◽  
Soya Milk ◽  
Increased Risk

IntroductionEarly infant diet might influence the risk of subsequent allergic disease.MethodsThe Merthyr Allergy Prevention Study (MAPS) was a randomised controlled trial in infants at high risk of allergic disease. The trial determined whether a cow’s milk exclusion diet for the first 4 months of life decreased the risk of allergic disease including asthma compared with a normal diet. A soya milk preparation was offered to those in the intervention group. A standardised questionnaire for allergic disease was completed at ages 1, 7, 15 and 23 years, with clinical assessment at 1, 7 and 23 years. The effect of the intervention on the risk of atopy, asthma and wheeze at age 23 years was determined.Findings487 subjects entered the study; at age 23 years 299 completed the questionnaire, of which 119 attended clinical assessment. Subjects randomised to the intervention group had a significantly increased risk of atopy (adjusted OR 2.97, 95% CI 1.30 to 6.80; p=0.01) and asthma (OR 2.07, 95%CI 1.09 to 3.91; p=0.03) at age 23 years, but not wheeze (OR 1.43, 95%CI 0.87 to 2.37; p=0.16). Earlier exposure to cow’s milk was associated with a decreased risk of wheeze and asthma at age 23 years, while earlier exposure to soya milk was associated with an increased risk of atopy and asthma.InterpretationIn infants at high risk of allergic disease, either cow’s milk exclusion or early soya milk introduction for the first 4 months of life increases the risk of atopy, wheeze and asthma in adulthood.

scholarly journals Should we continue to counsel families to use hydrolyzed formulas as a means of allergy prevention in high-risk infants?

2019 ◽  
Vol 25 (2) ◽  
pp. 79-81
Author(s):  
Megan Burke ◽  
Edmond S Chan ◽  
Elissa M Abrams
Keyword(s):  
High Risk ◽  
Position Statement ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Allergy Prevention ◽  
Recent Systematic Review ◽  
Cow's Milk ◽  
High Risk Infants ◽  
Hydrolyzed Formula ◽  
Over Time

Abstract The prevalence of food allergy in North America is high, and has increased over time. As a result, focus has shifted from treatment to allergy prevention. Previous studies have suggested that hydrolyzed formula may prevent atopic dermatitis in high-risk infants. As a result, multiple international guidelines including the Canadian Paediatric Society (CPS) position statement on allergy prevention recommend the use of hydrolyzed formula as a means of allergy prevention in mothers who are not breastfeeding or using donor breastmilk. However, a recent systematic review has not supported an association between use of hydrolyzed formula and allergy prevention. In addition, studies are emerging supporting the use of early and regular cow’s milk formula as a means of cow’s milk allergy prevention.

Management of neonatal cow’s milk allergy in high-risk neonates

2009 ◽  
Vol 51 (4) ◽  
pp. 544-547 ◽  
Author(s):  
Tokuo Miyazawa ◽  
Kazuo Itahashi ◽  
Takanori Imai
Keyword(s):  
High Risk ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy

Growth of Escherichia coli and Concentration of Iron in an Infant Feeding Formula

PEDIATRICS ◽  
1978 ◽  
Vol 62 (6) ◽  
pp. 1072-1074
Author(s):  
Robert S. Baltimore ◽  
John S. Vecchitto ◽  
Howard A. Pearson
Keyword(s):  
Escherichia Coli ◽  
Iron Deficiency ◽  
Low Socioeconomic Status ◽  
Iron Supplementation ◽  
Cow’S Milk ◽  
Iron Fortification ◽  
Low Socioeconomic ◽  
Cow's Milk ◽  
Serious Infection ◽  
Increased Risk

Iron deficiency reaches epidemic proportions in infants, particularly those of low socioeconomic status.1 In an attempt to decrease the frequency of this deficiency, iron fortification of infant cereals and cow's milk formulas has been advocated.2 Although the prevention of iron deficiency is a valid nutritional goal, concern has recently been voiced about possible detrimental effects of iron supplementation.3,1 This concern has been based on studies indicating an association between hyperferremia and serious infection,3,6 and also by denionstrations that the bacteriostatic properties of serum and milk can be abolished by the addition of iron.7,8 These findings have been extrapolated into suggestions that the iron supplementation of cow's milk formulas might predispose the infants consuming them to an increased risk of bacterial infection and even that ironcontaining formulas might be contraindicated.4

scholarly journals Nottingham Eczema Severity Scoring tool can identify children at high risk of food allergy to cow’s milk, egg and peanut

2015 ◽  
Vol 5 (S3) ◽  
Author(s):  
Lizalet Oosthuizen ◽  
M. A. Mc Aleer ◽  
R. M. Watson ◽  
G. M. O’Regan ◽  
A. Byrne ◽  
...  
Keyword(s):  
Food Allergy ◽  
High Risk ◽  
Cow’S Milk ◽  
Severity Scoring ◽  
Cow's Milk ◽  
Scoring Tool

Children who avoid drinking cow’s milk are at increased risk for prepubertal bone fractures

2004 ◽  
Vol 104 (2) ◽  
pp. 250-253 ◽  
Author(s):  
Ailsa Goulding ◽  
Jennifer E.P. Rockell ◽  
Ruth E. Black ◽  
Andrea M. Grant ◽  
Ianthe E. Jones ◽  
...  
Keyword(s):  
Bone Fractures ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Increased Risk

scholarly journals Safety of Cow’s Milk-Derived Fortifiers Used with an All-Human Milk Base Diet in Very Low Birthweight Preterm Infants

2020 ◽  
Vol 15 (7) ◽  
pp. 3-13
Author(s):  
Alan Lucas ◽  
Maushumi Assad ◽  
Jan Sherman ◽  
John Boscardin ◽  
Steven Abrams
Keyword(s):  
Human Milk ◽  
Preterm Infants ◽  
Low Birthweight ◽  
Ductus Arteriosus ◽  
Cow’S Milk ◽  
Very Low Birthweight ◽  
Cow's Milk ◽  
Increased Risk ◽  
Preterm Formula ◽  
The Impact

Background: Very low birthweight (VLBW) preterm infants fed mothers own milk (MOM) need nutritional supplementation, traditionally achieved with cow’s milk derived fortifier (CMDF) and preterm formula (PTF) if MOM is insufficient. CM products have been associated with diverse major morbidities. The current recommendation is to preferentially replace PTF with donor milk (DM) to produce a 100% human milk (HM) base diet, usually fortified with CMDF. Objective: To identify whether CMDF, even when fed with a 100% HM base diet, is related to an increased risk of major morbidities. Methods: We identified a randomized trial with an all-HM base diet, comparing CMDF with a fortifier derived from human milk (HMDF), and two additional studies of this design were generated from raw data as subgroup analyses of a randomized controlled trial and a quasi-experimental study. Using these studies, we calculated the impact of CMDF on major morbidities of death, necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), sepsis, bronchopulmonary dysplasia (BPD) and patent ductus arteriosus (PDA). Results: Each study individually provided support for an increase in major morbidities with CMDF. Meta-analyses of pooled data showed that compared to HMDF, the CMDF group had large in- creases in NEC (RR = 3.3; P = .001), ROP (RR = 2.2; P = .007), PDA (RR = 1.6; P = .009), interruption of feeding (RR = 3.4; P = .001) and a positive mortality/morbidity index based on one or more of death, NEC, sepsis, ROP and BPD (RR = 1.4; P = .006). Conclusions: Despite the increased use of HM in modern neonatal care as a base diet, we found a greater risk of critical morbidities with CMDF compared with HMDF. This burden of morbidity provides evidence that the benefits of an HM base diet, might be, in part, counteracted by multiple adverse outcomes relating to the use of CMDF.

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