scholarly journals Proteins — a celebration of consilience

2021 ◽  
Author(s):  
Tatjana Škrbić ◽  
Trinh Xuan Hoang ◽  
Achille Giacometti ◽  
Amos Maritan ◽  
Jayanth R. Banavar
Keyword(s):  
Molecular Machines ◽  
Living Cells ◽  
State Structure ◽  
Native State ◽  
Sequence Structure ◽  
Interdisciplinary Framework ◽  
The Common ◽  
The Rich ◽  
Mathematics And Physics

Proteins are the common constituents of all living cells. They are molecular machines that interact with each other as well as with other cell products and carry out a dizzying array of functions with distinction. These interactions follow from their native state structures and therefore understanding sequence-structure relationships is of fundamental importance. What is quite remarkable about proteins is that their understanding necessarily straddles several disciplines. The importance of geometry in defining protein native state structure, the constraints placed on protein behavior by mathematics and physics, the need for proteins to obey the laws of quantum chemistry, and the rich role of evolution and biology all come together in defining protein science. Here we review ideas from the literature and present an interdisciplinary framework that aims to marry ideas from Plato and Darwin and demonstrates an astonishing consilience between disciplines in describing proteins. We discuss the consequences of this framework on protein behavior.

Role of Native-State Structure in Rubredoxin Native-State Hydrogen Exchange†

Biochemistry ◽  
2006 ◽  
Vol 45 (33) ◽  
pp. 9956-9963 ◽  
Author(s):  
David M. LeMaster ◽  
Janet S. Anderson ◽  
Griselda Hernández
Keyword(s):  
Hydrogen Exchange ◽  
State Structure ◽  
Native State

scholarly journals Common Functions of Disordered Proteins across Evolutionary Distant Organisms

2020 ◽  
Vol 21 (6) ◽  
pp. 2105 ◽  
Author(s):  
Arndt Wallmann ◽  
Christopher Kesten
Keyword(s):  
Protein Function ◽  
Intrinsically Disordered Proteins ◽  
Disordered Proteins ◽  
Plant Proteins ◽  
Sequence Structure ◽  
Intrinsically Disordered ◽  
Bioinformatic Approaches ◽  
The Common ◽  
Function Relationship

Intrinsically disordered proteins and regions typically lack a well-defined structure and thus fall outside the scope of the classic sequence–structure–function relationship. Hence, classic sequence- or structure-based bioinformatic approaches are often not well suited to identify homology or predict the function of unknown intrinsically disordered proteins. Here, we give selected examples of intrinsic disorder in plant proteins and present how protein function is shared, altered or distinct in evolutionary distant organisms. Furthermore, we explore how examining the specific role of disorder across different phyla can provide a better understanding of the common features that protein disorder contributes to the respective biological mechanism.

scholarly journals Going beyond Faith: Kierkegaard’s Critical Contribution to Public Theology

2019 ◽  
Vol 32 (4) ◽  
pp. 527-540
Author(s):  
Joshua Furnal
Keyword(s):  
Common Good ◽  
Basic Question ◽  
Public Theology ◽  
Faith And Reason ◽  
The Common Good ◽  
Testimonial Knowledge ◽  
The Common ◽  
The Rich ◽  
Definition Of

In this article, I argue that Kierkegaard’s distinction between a genius and an apostle sheds light on the role of public theology in society. For Kierkegaard, the act and content of faith are rooted in testimonial knowledge which can be shared, and yet also bear witness to divine authority in word and deed. In the first section, I suggest that the contemporary conflict of approaches in public theology is rooted in a basic question in theology regarding the primacy of faith or reason when justifying a concrete, non-theological definition of the common good. In the second section, I rehearse Kierkegaard’s famous distinction between a genius and an apostle to draw attention to how the role of the public theologian in society is regulated by the theological negotiation of faith and reason for the common good in the form of testimony. The upshot of my argument is to uncover the unjustified neglect of the rich resources in Kierkegaard’s writings for current debates about public theology.

On everyday academic research

2017 ◽  
pp. 98-134 ◽  
Author(s):  
J. Tirole
Keyword(s):  
Common Good ◽  
Academic Research ◽  
Research Quality ◽  
Economic Research ◽  
Relevant Research ◽  
The Common ◽  
Verification Of Models ◽  
Science And Research

In the fourth chapter of the book “The economy of the common good”, the nature of economics as a science and research practices in their theoretical and empirical aspects are discussed. The author considers the processes of modeling, empirical verification of models and evaluation of research quality. In addition, the features of economic cognition and the role of mathematics in economic research are analyzed, including the example of relevant research in game theory and information theory.

Contemplative Principles of a Non-dual Praxis: the Unmediated Practices of the Tibetan ‘Heart Essence’ (sNying thig) Tradition

2015 ◽  
Vol 31 (2) ◽  
pp. 215-240
Author(s):  
Eran Laish
Keyword(s):  
Contemplative Practice ◽  
Tibetan Buddhist ◽  
Buddhist Tradition ◽  
The Common

This article focuses on the main contemplative principles of the ‘Heart Essence’ (sNying thig), a Tibetan Buddhist tradition that is characterized by a vision of non-duality and primordial wholeness. Due to this vision, which asserts an original reality that is not divided into perceiving subject and perceived object, the ‘Heart Essence’ advocates a contemplative practice that undermines the usual intuitions of temporality and enclosed selfhood. Hence, unlike the common principles of intentional praxis, such as deliberate concentration and gradual purification, the ‘Heart Essence’ affirms four contemplative principles of non-objectiveness, openness, spontaneity and singleness. As these principles transcend intentionality, temporality, and multiplicity, they are seen to directly disclose the nature of primordial awareness, in which the meanings of knowing and being are radically transformed. Therefore, the article will also consider the role of these non-dual contemplative principles in deeply changing our understanding of being and knowing alike.

Charles de Gaulle and European Community

2020 ◽  
Vol 2020 (10-3) ◽  
pp. 70-81
Author(s):  
David Ramiro Troitino ◽  
Tanel Kerikmae ◽  
Olga Shumilo
Keyword(s):  
World War Ii ◽  
European Community ◽  
World War ◽  
Charles De Gaulle ◽  
The United Kingdom ◽  
History Of ◽  
The Common ◽  
Post War ◽  
De Gaulle

This article highlights the role of Charles de Gaulle in the history of united post-war Europe, his approaches to the internal and foreign French policies, also vetoing the membership of the United Kingdom in the European Community. The authors describe the emergence of De Gaulle as a politician, his uneasy relationship with Roosevelt and Churchill during World War II, also the roots of developing a “nationalistic” approach to regional policy after the end of the war. The article also considers the emergence of the Common Agricultural Policy (hereinafter - CAP), one of Charles de Gaulle’s biggest achievements in foreign policy, and the reasons for the Fouchet Plan defeat.

“There is such a situation that Comrade Svoboda is under pressure”. The Soviet leadership and the settlement of relations with Czechoslovakia. May 1969

2019 ◽  
pp. 512-519
Author(s):  
Teymur Dzhalilov ◽  
Nikita Pivovarov
Keyword(s):  
Central Committee ◽  
Secretary General ◽  
Political Agenda ◽  
The Political ◽  
Soviet Government ◽  
Soviet Leadership ◽  
Policy Issues ◽  
The World ◽  
The Common

The published document is a part of the working record of The Secretariat of the CPSU Central Committee on May 5, 1969. The employees of The Common Department of the CPSU Central Committee started writing such working records from the end of 1965. In contrast to the protocols, the working notes include speeches of the secretaries of the Central Committee, that allow to deeper analyze the reactions of the top party leadership, to understand their position regarding the political agenda. The peculiarity of the published document is that the Secretariat of the Central Committee did not deal with the most important foreign policy issues. It was the responsibility of the Politburo. However, it was at a meeting of the Secretariat of the Central Committee when Brezhnev raised the question of inviting G. Husák to Moscow. The latter replaced A. Dubček as the first Secretary of the Communist party of Czechoslovakia in April 1969. As follows from the document, Leonid Brezhnev tried to solve this issue at a meeting of the Politburo, but failed. However, even at the Secretariat of the Central Committee the Leonid Brezhnev’s initiative at the invitation of G. Husák was not supported. The published document reveals to us not only new facets in the mechanisms of decision-making in the CPSU Central Committee, the role of the Secretary General in this process, but also reflects the acute discussions within the Soviet government about the future of the world socialist systems.

The Science of Wisdom in a Polarized World: Knowns and Unknowns

2020 ◽  
Author(s):  
Igor Grossmann ◽  
Nic M. Weststrate ◽  
Monika Ardelt ◽  
Justin Peter Brienza ◽  
Mengxi Dong ◽  
...  
Keyword(s):  
Individual Differences ◽  
Problem Solving ◽  
Best Practices ◽  
Cognitive Sciences ◽  
Methodological Challenges ◽  
The Common ◽  
Empirical Approaches ◽  
And Training ◽  
Contextual Differences

Interest in wisdom in the cognitive sciences, psychology, and education has been paralleled by conceptual confusions about its nature and assessment. To clarify these issues and promote consensus in the field, wisdom researchers met in Toronto in July of 2019, resolving disputes through discussion. Guided by a survey of scientists who study wisdom-related constructs, we established a common wisdom model, observing that empirical approaches to wisdom converge on the morally-grounded application of metacognition to reasoning and problem-solving. After outlining the function of relevant metacognitive and moral processes, we critically evaluate existing empirical approaches to measurement and offer recommendations for best practices. In the subsequent sections, we use the common wisdom model to selectively review evidence about the role of individual differences for development and manifestation of wisdom, approaches to wisdom development and training, as well as cultural, subcultural, and social-contextual differences. We conclude by discussing wisdom’s conceptual overlap with a host of other constructs and outline unresolved conceptual and methodological challenges.

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