Effect of Corticoids on the Resistance of the Kidney to an Excess of Phosphates

1956 ◽  
Vol 187 (1) ◽  
pp. 41-44 ◽  
Author(s):  
Hans Selye ◽  
Pierre Bois
Keyword(s):  
Drinking Water ◽  
Renal Calculus ◽  
Calcium Deposition ◽  
Pars Intermedia ◽  
Phosphate Solution ◽  
Concurrent Treatment ◽  
Calculus Formation ◽  
Desoxycorticosterone Acetate

In unilaterally nephrectomized rats, the substitution of 1.2% NaH2PO4 for drinking water rapidly produced marked calcium deposition in the pars intermedia of the kidney. This effect of the phosphate solution is enhanced by concurrent treatment with desoxycorticosterone acetate (DCA) and inhibited by cortisol acetate (COLA). The possible rôle of corticoids in the production of clinical nephrocalcinosis and renal calculus formation is briefly discussed.

ROLE OF SCIENCE IN POLICY, SYSTEMS STRENGTHENING AND SUSTAINABLE SERVICE DELIVERY OF ARSENIC SAFE DRINKING WATER

2019 ◽  
Author(s):  
Prosun Bhattacharya ◽  
◽  
Md. Tahmidul Islam ◽  
Dara Johnston ◽  
Nargis Akter ◽  
...  
Keyword(s):  
Drinking Water ◽  
Service Delivery ◽  
Safe Drinking Water ◽  
Policy Systems

scholarly journals The Dual Role of Vitamin K2 in “Bone-Vascular Crosstalk”: Opposite Effects on Bone Loss and Vascular Calcification

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1222
Author(s):  
Domitilla Mandatori ◽  
Letizia Pelusi ◽  
Valeria Schiavone ◽  
Caterina Pipino ◽  
Natalia Di Pietro ◽  
...  
Keyword(s):  
Bone Loss ◽  
Vascular Calcification ◽  
Vascular System ◽  
The Elderly ◽  
Food Supplement ◽  
Vitamin K2 ◽  
Bioactive Molecules ◽  
Calcium Deposition ◽  
Age Related

Osteoporosis (OP) and vascular calcification (VC) represent relevant health problems that frequently coexist in the elderly population. Traditionally, they have been considered independent processes, and mainly age-related. However, an increasing number of studies have reported their possible direct correlation, commonly defined as “bone-vascular crosstalk”. Vitamin K2 (VitK2), a family of several natural isoforms also known as menaquinones (MK), has recently received particular attention for its role in maintaining calcium homeostasis. In particular, VitK2 deficiency seems to be responsible of the so-called “calcium paradox” phenomenon, characterized by low calcium deposition in the bone and its accumulation in the vessel wall. Since these events may have important clinical consequences, and the role of VitK2 in bone-vascular crosstalk has only partially been explained, this review focuses on its effects on the bone and vascular system by providing a more recent literature update. Overall, the findings reported here propose the VitK2 family as natural bioactive molecules that could be able to play an important role in the prevention of bone loss and vascular calcification, thus encouraging further in-depth studies to achieve its use as a dietary food supplement.

scholarly journals Water contamination events in UK drinking-water supply systems

2008 ◽  
Vol 6 (S1) ◽  
pp. 21-26 ◽  
Author(s):  
John Gray
Keyword(s):  
Drinking Water ◽  
Water Supply ◽  
Water Supply Systems ◽  
Water Company ◽  
Health Authorities ◽  
The Uk ◽  
Contamination Events ◽  
Supply Systems

Water supply companies in the UK have a duty under prime UK legislation to notify the Drinking Water Inspectorate of events affecting or potentially affecting the quality of drinking-water supplies. Under the same legislation, the Inspectorate has a duty to investigate each event. After assessing all of the information available, including companies' reports, the Inspectorate advises on the way in which the event was handled and whether any statutory requirements were contravened. If appropriate, a prosecution of the water company may be initiated. Copies of the assessment are sent to the water company, relevant local and health authorities, Ofwat (the economic regulator), the regional Consumer Council for Water and any other interested parties, including consumers who request it. Generic guidance may be issued to the industry on matters of wider concern. This paper considers the role of the Inspectorate, the powers available to it and reporting arrangements. An overview is presented of events that occurred between 1990 and 2005 and common features are identified. Causes of different types of event are discussed. The importance of well-established contacts between the various interested parties involved in protecting public health is emphasised through discussion of example incidents.

Geochemical modeling and multivariate statistical approach for assessing the groundwater quality, and mechanism of arsenic mobilization in Bahraich region, Indo-Gangetic plains, India

2021 ◽  
Author(s):  
Mohd Usman Khan ◽  
Nachiketa Rai ◽  
Mukesh Kumar Sharma
Keyword(s):  
Heavy Metal ◽  
Drinking Water ◽  
Heavy Metal Contamination ◽  
Geochemical Modeling ◽  
Sulfide Oxidation ◽  
Dissolution Mechanism ◽  
Multivariate Statistical ◽  
Gangetic Plains ◽  
Groundwater Samples

<p>As contamination in groundwater has been reported from various regions of the Indian subcontinent but no data related to heavy metal contamination of groundwater has been reported for the Bahraich area in the Indo-Gangetic plains. We report the first dataset on arsenic contamination and groundwater hydrogeochemistry, in Bahraich. This includes concentrations of heavy metal such as As, Mn, and Fe, along with major cations (Na<sup>+</sup>, K<sup>+</sup>, Ca<sup>2+</sup>and Mg<sup>2+</sup>) and anions (F<sup>-</sup>, Cl<sup>-</sup>, NO<sub>3</sub><sup>-</sup>, SO<sub>4</sub><sup>2-</sup> and PO<sub>4</sub><sup>3-</sup>), and dissolved organic carbon (DOC), along with various physico-chemical parameters such as EC, pH, and Eh from samples collected during two extensive field campaigns conducted during pre-monsoon, and post-monsoon seasons respectively. The combined use of geochemical modeling and multivariate statistical approaches such as principal component analysis (PCA) and correlation analysis (CA) suggest several processes affecting the geochemistry of groundwater including the lithological characteristics of aquifers and anthropogenic activities.</p><p>The groundwater of the study area predominantly belongs to the Ca-Mg-HCO<sub>3</sub> type hydrochemical facies. HCO<sub>3</sub><sup>−</sup>/Na<sup>+</sup> and Ca<sup>2+</sup>/Na<sup>+</sup> signatures of groundwater indicate the influence of silicate weathering and carbonate dissolution processes with the insignificant role of evaporate dissolution mechanism. As concentration was found to range from 0.6 μg/L to ~100 μg/L with almost 40% of the collected samples exceeding the WHO defined limit of 10 μg/L for drinking water. 70 % of the groundwater samples were found to have very high Fe concentrations exceeding the WHO guideline of 0.3 mg/l in drinking water. Mn concentrations in the groundwater samples were relatively low with only ~10 % of the samples exceeding the WHO defined limit for Mn (400 μg/L). The majority of the groundwater samples were found to be anoxic in nature showing low NO<sub>3</sub><sup>−</sup> & SO<sub>4</sub><sup>2-</sup> concentrations, high Fe & Mn and DOC concentrations, and negative Eh values.</p><p>Results from this study show that the reductive dissolution mechanism of iron oxyhydroxide is the dominant mechanism responsible for arsenic release in groundwater of the region, ruling out any role of sulfide oxidation and alkali desorption.</p><p> </p><p> </p>

scholarly journals Drinking water and diarrhoeal disease due to Escherichia coli

2003 ◽  
Vol 1 (2) ◽  
pp. 65-72 ◽  
Author(s):  
Paul R. Hunter
Keyword(s):  
Escherichia Coli ◽  
Drinking Water ◽  
Clinical Presentation ◽  
Diarrhoeal Disease ◽  
Central Place ◽  
E Coli ◽  
Related Disease ◽  
Direct Damage ◽  
Water Microbiology

Escherichia coli has had a central place in water microbiology for decades as an indicator of faecal pollution. It is only relatively recently that the role of E. coli as pathogen, rather than indicator, in drinking water has begun to be stressed. Interest in the role of E. coli as a cause of diarrhoeal disease has increased because of the emergence of E. coli O157:H7 and other enterohaemorrhagic E. coli, due to the severity of the related disease. There are enterotoxigenic, enteropathogenic, enterohaemorrhagic, enteroinvasive, enteroaggregative and diffusely adherent strains of E. coli. Each type of E. coli causes diarrhoeal disease through different mechanisms and each causes a different clinical presentation. Several of the types cause diarrhoea by the elaboration of one or more toxins, others by some other form of direct damage to epithelial cells. This paper discusses each of these types in turn and also describes their epidemiology, with particular reference to whether they are waterborne or not.

scholarly journals Spinal Tolerance and Dependence: Some Observations on the Role of SpinalN-Methyl-D-Aspartate Receptors and Phosphorylation in the Loss of Opioid Analgesic Responses

2000 ◽  
Vol 5 (1) ◽  
pp. 33-39
Author(s):  
Tony L Yaksh ◽  
Xiao-Ying Hua
Keyword(s):  
Nmda Receptor ◽  
Opioid Analgesic ◽  
Dose Effect ◽  
Concurrent Treatment ◽  
Analgesic Effects ◽  
Delta Opioids ◽  
Probable Role ◽  
Pkc Isozymes ◽  
The Right

The continuous delivery of opiates can lead to a reduction in analgesic effects. In humans, as in other animals, some component of this change in sensitivity seems likely to have a strong pharmacodynamic component. Such loss of effect, deemed to be tolerance in the present article, can be readily demonstrated in animals with repeated bolus and continuous intrathecal infusion of mu and delta opioids and alpha-2 adrenergic agonists. Research has shown that this loss of effect can be diminished by concurrent treatment withN-methyl-D-aspartate (NMDA) receptor antagonists and by the suppression of the activity of spinal protein kinase C (PKC). This suggests in part the probable role of PKC-mediated phosphorylation in the right shift in the dose-effect curves observed with continuous opiate or adrenergic exposure. Importantly, this right shift is seen to occur in parallel with an increase in the phosphorylating activity in the dorsal horn and in the expression of several PKC isozymes. The target of this phosphorylation is not certain. Phosphorylation of the NMDA receptor enhances its functionality, while phosphorylation of the opioid receptor or associated channels seems to diminish their activity or to enhance internalization. While the focus is on several specific components, the accumulating data emphasize the biological complexity of these changes in spinal drug reactivity.

scholarly journals Harapan Baru Atas Pengelolaan Sumber Daya Air terkait Putusan MK Nomor 85/PUU-XI/2013

2016 ◽  
Vol 12 (3) ◽  
pp. 422
Author(s):  
Izzatin Kamala
Keyword(s):  
Drinking Water ◽  
Water Resources ◽  
Private Sector ◽  
The State ◽  
Constitutional Court ◽  
Resources Management ◽  
Household Level ◽  
Role Of The State ◽  
Water Value

The Decision of Constitutional Court No.85/PUU-XI/2013 (The Decision of CC 2013) has canceled Law No. 7 Year 2004 on Water Resources (Law on WR 2014). The cancellation is a new hope for improving the management of water resources. During the implementation of Law WR 2004, there is mismanagement in the provision of drinking water. This paper has two focus issues, namely: first, how the low responsibility of the state for managing water resources impacts the fulfillment of drinking water for the citizens? Second, how are the improvements of water resources management expected to be realized through the Decision of CC 2013? From the discussion, the author has two conclusions. First, the negligence of the state caused that the role of the state in providing drinking water for the citizens was  lost by the role of private sector. For example, a year before judicial review (2012), the number of consumers of drinking water supplied by the national sector in in the counting unit of household level is only the part of 11.79 percent. The number was lost by the supply of private sector covering 38.85 percent of households nationally. Second, the Decision of CC 2013 brings a new hope. Some basic thought are the improvement of state’s responsibility for managing water resources, termination  on the private’s monopoly and termination on commercialization of water value.

Sign in / Sign up

Export Citation Format

Share Document