Age and gender dependency of baroreflex sensitivity in healthy subjects

1998 ◽  
Vol 84 (2) ◽  
pp. 576-583 ◽  
Author(s):  
Tomi Laitinen ◽  
Juha Hartikainen ◽  
Esko Vanninen ◽  
Leo Niskanen ◽  
Ghislaine Geelen ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Healthy Subjects ◽  
Baroreflex Sensitivity ◽  
Plasma Renin ◽  
Frequency Component ◽  
High Frequency Component ◽  
Plasma Norepinephrine ◽  
Age And Gender ◽  
And Gender

Laitinen, Tomi, Juha Hartikainen, Esko Vanninen, Leo Niskanen, Ghislaine Geelen, and Esko Länsimies. Age and gender dependency of baroreflex sensitivity in healthy subjects. J. Appl. Physiol. 84(2): 576–583, 1998.—We evaluated the correlates of baroreflex sensitivity (BRS) in healthy subjects. The study consisted of 117 healthy, normal-weight, nonsmoking male and female subjects aged 23–77 yr. Baroreflex control of heart rate was measured by using the phenylephrine bolus-injection technique. Frequency- and time-domain analysis of heart rate variability and an exercise test were performed. Plasma norepinephrine, epinephrine, insulin, and arginine vasopressin concentrations and plasma renin activity were measured. In the univariate analysis, BRS correlated with age ( r = −0.65, P < 0.001), diastolic blood pressure ( r = −0.47, P < 0.001), exercise capacity ( r = 0.60, P < 0.001), and the high-frequency component of heart rate variability ( r= 0.64, P < 0.001). There was also a significant correlation between BRS and plasma norepinephrine concentration ( r = −0.22, P < 0.05) and plasma renin activity ( r = 0.32, P < 0.001). According to the multivariate analysis, age and gender were the most important physiological correlates of BRS. They accounted for 52% of interindividual BRS variation. In addition, diastolic blood pressure and high-frequency component of heart rate variability were significant independent correlates of BRS. BRS was significantly higher in men than in women (15.0 ± 1.2 vs. 10.2 ± 1.1 ms/mmHg, respectively; P < 0.01). Twenty-four percent of women >40 yr old and 18% of men >60 yr old had markedly depressed BRS (<3 ms/mmHg). We conclude that physiological factors, particularly age and gender, have significant impact on BRS in healthy subjects. In addition, we demonstrate that BRS values that have been proposed to be useful in identifying postinfarction patients at high risk of sudden death are frequently found in healthy subjects.

scholarly journals A single dose of dark chocolate increases parasympathetic modulation and heart rate variability in healthy subjects

2016 ◽  
Vol 29 (6) ◽  
pp. 765-773 ◽  
Author(s):  
Ana Amélia Machado DUARTE ◽  
Cristiano MOSTARDA ◽  
Maria Claudia IRIGOYEN ◽  
Katya RIGATTO
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Single Dose ◽  
Standard Deviation ◽  
Healthy Subjects ◽  
Frequency Component ◽  
Dark Chocolate ◽  
High Frequency Component ◽  
Rr Intervals

ABSTRACT Objective: The aim of this study was to investigate the acute effect of a single dose of dark chocolate (70% cocoa) on blood pressure and heart rate variability. Methods: Thirty-one healthy subjects (aged 18-25 years; both sexes) were divided into two groups: 10 subjects in the white chocolate (7.4 g) group and 21 in the dark chocolate (10 g) group; measurements were performed at the university's physiology lab. An electrocardiogram measured the sympathovagal balance by spectral and symbolic analysis. Results: A single dose of dark chocolate significantly reduced systolic blood pressure and heart rate. After consuming 10 g of dark chocolate, significant increases were observed for heart rate variability, standard deviation of RR intervals standard deviation of all NN intervals, square root of the mean squared differences between adjacent normal RR intervals root mean square of successive differences, and an increase in the high frequency component in absolute values, representing the parasympathetic modulation. Conclusion: In conclusion the importance of our results lies in the magnitude of the response provoked by a single dose of cocoa. Just 10 g of cocoa triggered a significant increase in parasympathetic modulation and heart rate variability. These combined effects can potentially increase life expectancy because a reduction in heart rate variability is associated with several cardiovascular diseases and higher mortality.

Heart rate variability in healthy subjects is related to age and gender

1997 ◽  
Vol 160 (3) ◽  
pp. 235-241 ◽  
Author(s):  
K. JENSEN‐URSTAD ◽  
N. STORCK ◽  
F. BOUVIER ◽  
M. ERICSON ◽  
L. E. LINDBLAND ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Healthy Subjects ◽  
Age And Gender ◽  
And Gender

scholarly journals Heart Rate Variability Duration: Expanding the Ability of Wearable Technology to Improve Outpatient Monitoring?

2021 ◽  
Vol 12 ◽  
Author(s):  
David C. Sheridan ◽  
Karyssa N. Domingo ◽  
Ryan Dehart ◽  
Steven D. Baker
Keyword(s):  
Mental Health ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Time Windows ◽  
Low Frequency ◽  
Frequency Component ◽  
Wearable Technology ◽  
Mental Health Research ◽  
High Frequency Component ◽  
Frequency Domains

Heart rate variability (HRV) evaluates beat-to-beat interval (BBI) differences and is a suggested marker of the autonomic nervous system with diagnostic/monitoring capabilities in mental health; especially parasympathetic measures. The standard duration for short-term HRV analysis ranges from 24 h down to 5-min. However, wearable technology, mainly wrist devices, have large amounts of motion at times resulting in need for shorter duration of monitoring. The objective of this study was to evaluate the correlation between 1 and 5 min segments of continuous HRV data collected simultaneously on the same patient. Subjects wore a patch electrocardiograph (Cardea Solo, Inc.) over a 1–7 day period. For every consecutive hour the patch was worn, we selected a 5-min, artifact-free electrocardiogram segment. HRV metric calculation was performed to the entire 5-min segment and the first 1-min from this same 5-min segment. There were 492 h of electrocardiogram data collected allowing calculation of 492 5 min and 1 min segments. 1 min segments of data showed good correlation to 5 min segments in both time and frequency domains: root mean square of successive difference (RMSSD) (R = 0.92), high frequency component (HF) (R = 0.90), low frequency component (LF) (R = 0.71), and standard deviation of NN intervals (SDNN) (R = 0.63). Mental health research focused on parasympathetic HRV metrics, HF and RMSSD, may be accomplished through smaller time windows of recording, making wearable technology possible for monitoring.

scholarly journals Association of cardiac autonomic modulation with physical and clinical features of young people with type 1 diabetes

2016 ◽  
Vol 27 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Anne K. F. Silva ◽  
Diego G. D. Christofaro ◽  
Franciele M. Vanderlei ◽  
Marianne P. C. R. Barbosa ◽  
David M. Garner ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 1 Diabetes ◽  
Standard Deviation ◽  
Young Patients ◽  
Frequency Component ◽  
Parasympathetic Activity ◽  
High Frequency Component ◽  
Rr Intervals

ObjectiveThe objective of this study was to verify possible associations between heart rate variability indices and physical activity, body composition, and metabolic and cardiovascular parameters in individuals with type 1 diabetes.MethodA total of 39 young patients with type 1 diabetes were included. Body composition, physical activity, cardiovascular parameters, and metabolic parameters were assessed. For the heart rate variability analysis, heart rate was recorded beat-by-beat using a Polar S810i heart rate monitor for 30 minutes, with the volunteers in the supine position; subsequently, the following indices were considered: standard deviation of all normal RR intervals; root-mean square of differences between adjacent normal RR intervals in a time interval; percentage of adjacent RR intervals with a difference of duration >50 ms; high frequency component in milliseconds squared; high frequency component in normalised units; standard deviation of the instantaneous variability beat-to-beat; and standard deviation of the long-term variability. The association between the heart rate variability indices and independent variables was verified through linear regression in unadjusted and adjusted models (considering gender and age). The statistical significance was set at 5% and the confidence interval at 95%.ResultsHigh values of at-rest heart rate were associated with reduced parasympathetic activity and global heart rate variability, and higher values of waist-to-hip ratio were related to lower parasympathetic activity, independent of age or gender.ConclusionFor young patients with type 1 diabetes, increases in at-rest heart rate values are associated with reduced parasympathetic activity and global heart rate variability, whereas higher waist-to-hip ratio values are related to lower parasympathetic activity, both independent of age and gender.

scholarly journals Changes in Heart Rate Variability of Depressed Patients after Electroconvulsive Therapy

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Erica B. Royster ◽  
Lisa M. Trimble ◽  
George Cotsonis ◽  
Brian Schmotzer ◽  
Amita Manatunga ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Depressive Symptoms ◽  
Electroconvulsive Therapy ◽  
Low Frequency ◽  
Frequency Component ◽  
High Frequency Component ◽  
Acute Changes ◽  
The Impact

Objective. As few, small studies have examined the impact of electroconvulsive therapy (ECT) upon the heart rate variability of patients with major depressive disorder (MDD), we sought to confirm whether ECT-associated improvement in depressive symptoms would be associated with increases in HRV linear and nonlinear parameters. Methods. After providing consent, depressed study participants (n=21) completed the Beck Depression Index (BDI), and 15-minute Holter monitor recordings, prior to their 1st and 6th ECT treatments. Holter recordings were analyzed for certain HRV indices: root mean square of successive differences (RMSSD), low-frequency component (LF)/high-frequency component (HF) and short-(SD1) versus long-term (SD2) HRV ratios. Results. There were no significant differences in the HRV indices of RMSDD, LF/HF, and SD1/SD2 between the patients who responded, and those who did not, to ECT. Conclusion. In the short term, there appear to be no significant improvement in HRV in ECT-treated patients whose depressive symptoms respond versus those who do not. Future studies will reveal whether diminished depressive symptoms with ECT are reliably associated with improved sympathetic/parasympathetic balance over the long-term, and whether acute changes in sympathetic/parasympathetic balance predict improved mental- and cardiac-related outcomes.

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