Epidural electrical stimulation to facilitate locomotor recovery after spinal cord injury

2021 ◽  
Author(s):  
Johannie Audet ◽  
Charly G. Lecomte
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Clinical Implementation ◽  
Preclinical Models ◽  
Lumbosacral Region ◽  
Locomotor Recovery ◽  
Promising Therapeutic Approach ◽  
Cord Injury ◽  
Stimulation Of

Tonic or phasic electrical epidural stimulation of the lumbosacral region of the spinal cord facilitates locomotion and standing in a variety of preclinical models with severe spinal cord injury. However, the mechanisms of epidural electrical stimulation that facilitate sensorimotor functions remain largely unknown. This review aims to address how epidural electrical stimulation interacts with spinal sensorimotor circuits and discusses the limitations that currently restrict the clinical implementation of this promising therapeutic approach.

Effect of Electrical Stimulation of Hamstrings and L3/4 Dermatome on Gait in Spinal Cord Injury

2006 ◽  
Vol 9 (1) ◽  
pp. 48-55 ◽  
Author(s):  
Arjan van der Salm ◽  
Peter H. Veltink ◽  
Hermie J. Hermens ◽  
Anand V. Nene ◽  
Maarten J. IJzerman
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Cord Injury ◽  
Stimulation Of

scholarly journals Acute effect of electrical stimulation of the dorsal genital nerve on rectal capacity in patients with spinal cord injury

Spinal Cord ◽  
2012 ◽  
Vol 50 (6) ◽  
pp. 462-466 ◽  
Author(s):  
J Worsøe ◽  
L Fynne ◽  
S Laurberg ◽  
K Krogh ◽  
N J M Rijkhoff
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Acute Effect ◽  
Cord Injury ◽  
Rectal Capacity ◽  
Stimulation Of

scholarly journals Electrical Stimulation Of The Cervical Dorsal Roots Enables Functional Arm And Hand Movements In Monkeys With Cervical Spinal Cord Injury

2020 ◽  
Author(s):  
B. Barra ◽  
S. Conti ◽  
M.G. Perich ◽  
K. Zhuang ◽  
G. Schiavone ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Motor Control ◽  
Cervical Spinal Cord ◽  
Three Dimensional ◽  
Arm Movements ◽  
Cervical Spinal Cord Injury ◽  
Cord Injury ◽  
Stimulation Of

SUMMARYRegaining arm motor control is a high priority for people with cervical spinal cord injury1. Unfortunately, no therapy can reverse upper limb paralysis. Promising neurotechnologies stimulating muscles to bypass the injury enabled grasping in humans with SCI2,3 but failed to sustain whole arm functional movements that are necessary for daily living activities. Here, we show that electrical stimulation of the cervical spinal cord enabled three monkeys with cervical SCI to execute functional, three-dimensional, arm movements. We designed a lateralized epidural interface that targeted motoneurons through the recruitment of sensory afferents within the dorsal roots and was adapted to the specific anatomy of each monkey. Simple stimulation bursts engaging single roots produced selective joint movements. We then triggered these bursts using movement-related intracortical signals, which enabled monkeys with arm motor deficits to perform an unconstrained, three-dimensional reach and grasp task. Our technology increased muscle activity, forces, task performance and quality of arm movements. Finally, analysis of intra-cortical neural data showed that a synergistic interaction between spared descending pathways and electrical stimulation enabled this restoration of voluntary motor control. Spinal cord stimulation is a mature clinical technology4–7, which suggests a realistic path for our approach to clinical applications.

scholarly journals Interlimb Reflexes Induced by Electrical Stimulation of Cutaneous Nerves after Spinal Cord Injury

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153063 ◽  
Author(s):  
Jane E. Butler ◽  
Sharlene Godfrey ◽  
Christine K. Thomas
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Cord Injury ◽  
Stimulation Of

scholarly journals Electrical Stimulation of the Urethra Evokes Bladder Contractions in a Woman With Spinal Cord Injury

2010 ◽  
Vol 33 (3) ◽  
pp. 261-265 ◽  
Author(s):  
Michael J. Kennelly ◽  
Kimberly C. Arena ◽  
Nell Shaffer ◽  
Maria E. Bennett ◽  
Warren M. Grill ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Cord Injury ◽  
Stimulation Of
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