scholarly journals Synthesis, Spectral Characterization and Biocidal Studies of Copper(II) Complexes of Chromen-2-one-3-carboxy Hydrazide and 2-(Chromen-3'-onyl)-5-(aryl)-1,3,4-oxadiazole Derivatives

2011 ◽  
Vol 8 (3) ◽  
pp. 1346-1354
Author(s):  
Glory Mathew ◽  
R. Krishnan ◽  
Molly Antony ◽  
M. S. Suseelan
Keyword(s):  
Magnetic Susceptibility ◽  
Bacterial Species ◽  
Geometry Optimization ◽  
Structural Features ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Distorted Octahedral Geometry ◽  
H Nmr ◽  
Oxadiazole Derivatives

Copper(II) complexes of chromen-2-one-3-carboxyhydrazide and 2-(chromen-3'-onyl)-5-(aryl)-1,3,4-oxadiazole derivatives have been synthesized. The structural features have been determined from their microanalytical, magnetic susceptibility, molar conductance, IR, UV Vis,1H NMR and ESR spectral data. All the Cu(II) complexes exhibit the composition Cu(Ln)2X2; where L1= chromen-2-one-3-carboxy hydrazide, L2 = 2-(chromen-3'-onyl)-5-(2ʺ-hydroxy phenyl)-1,3,4-oxadiazole, L3 = 2-(chromen-3'-onyl)-5-(4ʺ-nitrophenyl)-1,3,4 -oxadiazole and L4 = 2-(chromen-3'-onyl)-5-(4ʺ-chlorophenyl)-1,3,4-oxadiazole; X = Cl-, Br-, NO3-, CH3COO-, ClO4-and CNS-. The N, O donor ligands act as a bidentate ligand in all the complexes. Distorted octahedral geometry for all the Cu(II) complexes is proposed. Molecular modeling studies have been made for the rapid structure building, geometry optimization and molecular display. These complexes show the conductance values, supporting their non-electrolytic nature. The monomeric nature of the complexes was confirmed from their magnetic susceptibility values. These complexes have been screened for their antimicrobial activities against some bacterial species likeS.aureus, E.coli, Pseudomonas aeruginosaand few fungal strainsC.albicansandCryptococcus neoformans.

scholarly journals Structural and Biological Studies on Transition Metal Complexes of 4-Aminoantipyrine Derivative

2020 ◽  
Vol 32 (11) ◽  
pp. 2846-2854
Author(s):  
V. Soundaranayaki ◽  
A. Kulandaisamy
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Antimicrobial Activities ◽  
Esr Spectra ◽  
Molar Conductance ◽  
Schiff Base Complexes ◽  
Binding Potential ◽  
Planar Geometry ◽  
Pyramidal Geometry ◽  
Biological Studies

Novel tetra dentate Cu(II), Ni(II), Co(II), VO(II) and Zn(II) Schiff base complexes have been synthesized from salicylidene-4-iminoantipyrine and tyrosine. The synthesized Schiff base complexes was characterized by powder X-ray diffraction studies (XRD), scanning electron microscopy (SEM), FT-IR, ESR, 1H NMR, 13C NMR, UV-vis, molar conductance and magnetic susceptibility measurements. The general formula of complexes was confirmed as [ML] type [M = Cu(II), Co(II), Zn(II), Ni(II) and VO(II); L = C27H24N4O4]. Magnetic susceptibility, IR and UV-vis, spectral data showed that all the complexes have square planar geometry except vanadyl complex which suggests square pyramidal geometry. Lower molar conductance values proved that all the chelates were non-electrolytic nature. The X-band ESR spectra of [CuL] and [VOL] complexes in DMSO solution suggest that the complexes were predominant covalent character. Powder XRD and SEM image pattern evidenced that all the compounds were crystalline in nature and their size ranges from 100-40 nm. Calf thymus DNA binding potential of [CuL] and [VOL] complexes shows that the binding occurs through intercalation mode with low binding constant. The analgesic, CNS, antiulcer and antimicrobial activities of the investigated compounds report reveals that the chelates were significant effect than free Schiff base.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of N1-[(1E)-1-(2-Hydroxyphenyl) ethylidene]-2-oxo-2H-chromene-3-carbohydrazide and its Metal Complexes

2009 ◽  
Vol 6 (3) ◽  
pp. 615-624 ◽  
Author(s):  
K. Siddappa ◽  
K. Mallikarjun ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML, MʹL and M″L [where M=Cu(II), Co(II), Ni(II) and Mn(II), Mʹ=Fe(III) and M″=Zn(II), Cd(II) and Hg(II) and L=N1-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-oxo-2H-chromene- 3-carbohydrazide (HL)] Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HL acts as doubly monodentate bridge for metal ions and form mononuclear complexes. The complexes Ni(II), Co(II), Cu(II) Mn(II) and Fe(III) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal complexes were screened for their antimicrobial activity.

scholarly journals Synthesis, Characterization and Antifungal Studies of Adducts of p- Ethylphenyldithiocarbonates of Copper(II)

2019 ◽  
Vol 31 (8) ◽  
pp. 1819-1824
Author(s):  
Shivangi Sharma ◽  
Renu Sachar ◽  
G.D. Bajju ◽  
Vikas Sharma
Keyword(s):  
Magnetic Susceptibility ◽  
Electron Spin Resonance ◽  
Room Temperature ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Distorted Octahedral Geometry ◽  
Distorted Octahedral ◽  
Spin Resonance

A series of adducts of p-ethylphenyldithiocarbonates of copper(II) [(p-C2H5C6H4OCS2)2Cu] with ethyl pyridines and chloro pyridines have been synthesized in 1:2 molar ratio. They were characterized by elemental analysis, magnetic susceptibility and molar conductance measurements, infrared, electronic, electron spin resonance and mass spectroscopy, NMR and thermogravimetric analysis. In addition, antifungal studies of these adducts were also performed. The results revealed that the adducts have 1:2 stoichiometry, non-electrolytic and paramagnetic at room temperature. On the basis of spectral studies, a distorted octahedral geometry is proposed around copper(II) ion. ESR studies depicted elongated axial symmetry of Cu(II)adducts with nitrogen donors. Moreover, the adducts also showed potential antifungal activity against Fusarium oxysporium.

scholarly journals Spectral, Magnetic and Biological Studie on Some Bivalent 3d Metal Complexes of Hydrazine Derived Schiff-Base Ligands

1997 ◽  
Vol 4 (2) ◽  
pp. 65-68 ◽  
Author(s):  
Zahid H. Chohan ◽  
Syed K. A. Sherazi
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Magnetic Moment ◽  
Bacterial Species ◽  
Biological Properties ◽  
Molar Conductance ◽  
Schiff Base Ligands ◽  
H Nmr ◽  
3D Metal Complexes

Metal(II) complexes of hydrazine derived Schiff-base ligands of the type M(L)2Cl2 where M = Co, Cu, Ni and Zn and L = L1 and L2 have been prepared and characterised by molar conductance, magnetic moment, elemental analysis and electronic, IR, H-NMR and C13 spectral data.The different modes of chelation of the ligands and their comparative biological properties against different bacterial species are reported.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of 3-[(2-Hydroxy-quinolin-3-ylmethylene)-amino]-2-phenyl-3H-quinazolin-4-one and its Metal(II) Complexes

2008 ◽  
Vol 5 (1) ◽  
pp. 155-162 ◽  
Author(s):  
K. Siddappa ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Elemental Analysis ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML2 and M′L [where M=Cu(II), Co(II), and Ni(II) and M′= Zn(II), Cd(II) and Hg(II)]. L = 3-[(2-hydroxy-quinolin-3-ylmethylene)-amino]-2-phenyl-3H-quinazolin-4-one, (HQMAPQ) Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HQMAPQ acts as doubly monodentate bridge for metal(II) ions and form mononuclear complexes. The complexes Ni(II), Co(II) and Cu(II) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal(II) complexes were screened for their antimicrobial activity.

scholarly journals Synthesis, characterisation and antimicrobial activities of mixed ligand complexes of Mn (II), Fe (II) and Co(II) containing N,N'-bis (o-anisaldehyde) p-phenylenediamine (tetradentate schiff base) and gylcine

2018 ◽  
Vol 11 (1) ◽  
pp. 32-36
Author(s):  
I.T. Siraj ◽  
M Sule
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
Mixed Ligand Complex ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Ligand Complex ◽  
Tetradentate Schiff Base

Complexes of Mn(II), Fe(II) and Co(II) containing N, N’-bis[o-anisaldehyde]p-phenylenediamine tetradentate Schiff base as primary ligand and glycine as secondary bidentate ligand have been synthesized by reflux in 1:1:1 mole ratio and characterized both analytically and spectroscopically. Molar conductance measurement (69.02 to 86.30Ω–1 cm2 mol–1) of the complexes indicated they are weak electrolyte and magnetic susceptibility measurement shows values in range of 4.53 to 5.59BM indicating their paramagnetism. The infrared data suggested that the Schiff base coordinated via the two nitrogen atoms of the azomethine groups (1628 to 1680 cm-1) and the oxygen atoms of the adjacent methoxy groups (1341 to 1389 cm-1), while glycine coordinated via the nitrogen atom of the amino group (3060-3324 cm-1) and the oxygen atom of the carboxylate anion. Based on the analytical and spectroscopic data the complexes may be assigned an octahedral geometries and molecular formulae of the form [M(L)Gly], where M = Mn, Fe and Co, L=Schiff base and Gly = glycine. The Schiff base and its mixed ligand complexes were screened for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Salmonella typhi, Mucor inducus and Aspergillus fumigatus. The complexes exhibited enhanced antimicrobial activity (10mm to 18mm) at 60 µg/disc as compared to 10mm activity of the uncoordinated Schiff base at the same concentration.Keywords: Mixed ligand complex; Schiff base, Glycine, p-phenylenediamine, o-anisaldehyde

scholarly journals Some Organotellurium(IV) Complexes of 1-Methyl-3-(p-tolylimino)indolin-2-one Schiff Base

2021 ◽  
Vol 33 (6) ◽  
pp. 1236-1244
Author(s):  
Manish Kumar ◽  
K.K. Verma ◽  
Sapana Garg
Keyword(s):  
Schiff Base ◽  
Xanthomonas Campestris ◽  
Computational Study ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Octahedral Geometry ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Distorted Octahedral Geometry ◽  
No Donor

Six new hexa-coordinated organotellurium(IV) complexes of type RTeCl3·NMeIPT and R2TeCl2·NMeIPT (R = 4-hydroxyphenyl, 4-methoxyphenyl or 3-methy-4-hydroxyphenyl; NMeIPT(L) = Schiff base (1-methyl-3-(p-tolylimino)indolin-2-one) derived from condensation of 4-methylisatin and p-toluidine) have been synthesized and characterized by different spectral studies like elemental analyses, molar conductance, infrared, mass spectrometry, 1H NMR, 13C NMR and UV-visible spectroscopy. On the basis of spectroscopic data, it is evident that Schiff base behaves as NO donor bidentate ligand via azomethine nitrogen atom and oxygen atom from carbonyl group for all the tellurium(IV) complexes. The results showed that all the organotellurium(IV) complexes possess distorted octahedral geometry. Geometry of the all organotellurium(IV) complexes was optimized and their theoretical quantum mechanical parameters were calculated. This computational study also suggests octahedral geometry for complexes. The antimicrobial activity of NMeIPT and all the organotellurium(IV) complexes were screened against bacteria i.e. Xanthomonas campestris and Bacillus cereus and fungi i.e. Fusarium oxysporum, Candida albicans and Sclerotinia sclerotium.

scholarly journals Hypercoordinated Organosilicon(IV) and Organotin(IV) Complexes: Syntheses, Spectral Studies, and Antimicrobial Activity In Vitro

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Kiran Singh ◽  
Parvesh Puri ◽  
Yogender Kumar ◽  
Chetan Sharma
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Bases ◽  
Structural Features ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Nmr Studies ◽  
Trigonal Bipyramidal ◽  
Elemental Analyses

This paper deals with the syntheses and structural features of some new diorganosilicon(IV) and diorganotin(IV) complexes having general formulae (CH3)2MCl(L1), (CH3)2MCl(L2), (CH3)2M(L1)2, and (CH3)2M(L2)2 with new Schiff bases (M = Si and Sn). The Schiff bases HL1 and HL2 have been derived from the condensation of 3-bromobenzaldehyde with 4-amino-3-ethyl-5-mercapto-1,2,4-triazole and 4-amino-5-mercapto-3-propyl-1,2,4-triazole, respectively. The compounds have been characterized by the elemental analyses, molar conductance, and spectral (UV, IR, 1H, 13C, 29Si, and 119Sn NMR) studies. The resulting complexes have been proposed to have trigonal bipyramidal and octahedral geometries. In vitro antimicrobial activities of the compounds have been carried out.

scholarly journals Synthesis, Physicochemical Studies and Biological Properties of Mixed-Ligand Nickel(II) Complexes Containing β-Diketones With N-donor Ligands

2018 ◽  
Vol 10 (4) ◽  
pp. 11
Author(s):  
Helen Oluwatola Omoregie
Keyword(s):  
Conductivity Measurement ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Mixed Ligand ◽  
Donor Ligands ◽  
Spectral Measurements ◽  
Physicochemical Studies

Some mixed ligand nickel(II) complexes of thenoyltrifluoroacetone (tta-H) with 2,2ꞌ-bipyridine (bipy), 1,10-phenanthroline (phen) and tetramethylethylenediamine (tmen) [Ni(tta)(N-N)(NO3)]; N-N= bipy, phen, or tmen] have been synthesized and characterized by molar conductance measurements, elemental analysis, mass spectrometry, spectral measurements and antimicrobial activities. Attempt to prepare the mixed ligand nickel(II) complexes containing acetylacetone (acacH), benzoylacetone (bzacH), dibenzoylmethane (dbm-H) and thenoyltrifluoroacetone (tta-H) with ethylenediamine associated with NO3 counter ion led to the formation of [Ni(β-diketone)2en]. The β-diketones enolized acting as bidentate ligand, coordinating to the metal with carbonyl and enolic oxygen, ethylenediamine (en) coordinates to the metal using N, N chromophores. The nickel complexes of the type [Ni(tta)(N-N)NO3)] are five-coordinate square pyramidal in geometry while those of the type [Ni(β-diketone)2en] are six-coordinate octahedral geometry. The conductivity measurement in nitromethane revealed that the [Ni(tta)(N-N)NO3)] complexes are non-electrolyte. The complexes were screened for their in-vitro antimicrobial activity against six microorganisms. A comparison of the complexes with gentamicin showed that most of the complexes are resistant to tested organisms except [Ni(tta)2(en)].H2O, [Ni(bzac)2(en)] and [Ni(bta)2(en)] which compared favourably well in Staphylococcus aureus.

Antimicrobial Properties of Levofloxacin Antibiotic Complexes of Zirconium(IV) and Indium(III)

2020 ◽  
Vol 12 (8) ◽  
pp. 1116-1124
Author(s):  
Maha Abdallah Alnuwaiser
Keyword(s):  
Metal Ion ◽  
Antimicrobial Properties ◽  
Complex Surface ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Bidentate Ligand ◽  
Homogeneous Distribution ◽  
Antibiotic Drug ◽  
Bacteria And Fungi

In this article, there are two new levofloxacin (HLevo) complexes were synthesized and spectroscopically discussed. These complexes were prepared in alkaline state (pH = 8) with the 1:1 stoichiometry between zirconyl(II) or indium(III) chloride and pure HLevo antibiotic drug ligand in mixed solvent equal volumes from methanol and bi-distilled water. The structures interpretation were performed based on the micro analytical (elemental analyses), molar conductance and spectroscopic measurements. It is shown that the deprotonated HLevochelate was coordinated towards ZrIV and InIII metal ions, this occurs as a bidentate ligand through the oxygen atoms of carboxylate and carbonyl group, respectively. Accordingly, these complexes can be speculated as [ZrO(Lev)(Cl)(H2O)] · H2O (1) and [In(Lev)(Cl)2(H2O)2] (2). Through Tranmission Electron Microscopy (TEM) imaging it is demonstrated that the nanoscale particles have a homogeneous distribution across the complex surface. Furthermore, by assessing in vitro antimicrobial activities, the inhibition activity of HLevo drug ligand as well as the associated metal ion complexes were evaluated towards specific types of bacteria and fungi.

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