scholarly journals Glycemic Index and Glycemic Load and Their Association with C-Reactive Protein and Incident Type 2 Diabetes

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Geertruida J. van Woudenbergh ◽  
Anneleen Kuijsten ◽  
Eric J. G. Sijbrands ◽  
Albert Hofman ◽  
Jacqueline C. M. Witteman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Index ◽  
Glycemic Load ◽  
Positive Association ◽  
Diabetes Incidence ◽  
Linear Regression Models ◽  
C Reactive Protein ◽  
Incident Type ◽  
Reactive Protein

Objective. To investigate whether the Glycemic Index (GI) or Glycemic Load (GL) of a diet is associated with C-reactive Protein (CRP) and risk of type 2 diabetes in a prospective study.Materials and Methods. Our analysis included 4,366 participants who did not have diabetes at baseline. During follow-up 456 diabetes cases were confirmed. Dietary GI and GL were derived from a food-frequency questionnaire and its association with CRP was examined cross-sectionally using linear regression models. The association of GI and GL with diabetes incidence was examined using Cox proportional hazard models.Results. GL, but not GI, was associated with lnCRP at baseline (bGL=0.11per 50 units;P=.01). When comparing the highest to the lowest tertile of GI with respect to diabetes incidence, a Relative Risk (RR) of 0.95 [95%CI 0.75, 1.21] was found after adjustment for lifestyle and nutritional factors. For GL the RR for diabetes incidence was 1.00 [95%CI 0.74, 1.36]. Additional adjustment for CRP did not change RRs.Conclusion. Since GI was not associated with CRP and risk of type 2 diabetes, it is unlikely that a high GI diet induces the previously shown positive association between CRP and risk of type 2 diabetes by increasing CRP concentrations.

scholarly journals Association of c-reactive protein and uric acid with Type 2 diabetes

1970 ◽  
Vol 20 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Md Safiqul Islam ◽  
Md Saiful Islam ◽  
Yearul Kabir
Keyword(s):  
Type 2 Diabetes ◽  
Uric Acid ◽  
Colorimetric Method ◽  
Positive Association ◽  
C Reactive Protein ◽  
High Blood Glucose ◽  
Male And Female ◽  
Reactive Protein ◽  
Bangladeshi Population

Diabetes mellitus is a group of metabolic diseases characterized by high blood glucose levels that result from defects in insulin secretion or action or both. Some recent studies had shown that elevated level of C?reactive protein (CRP) and uric acid are involved in the pathogenesis of type 2 diabetes, regardless of other characteristics of subjects. Our aim was to investigate the association between CRP and uric acid levels with diabetes in Bangladeshi population. Two hundred type 2 diabetic subjects (male 110, female 90) and 60 non diabetic subjects (30 male, 30 female) were included in the study over six months. CRP and uric acid were measured by Latex Agglutination method and enzymatic colorimetric method, respectively. CRP was significantly higher (p < 0.01) in diabetic compared to non-diabetic subjects for both male and female subjects. The level of uric acid was also significantly higher in male and female diabetic subjects (p < 0.05 and p < 0.01) compared to non-diabetic subjects, respectively. In multiple regression analysis, CRP showed a positive association with uric acid and BMI in both diabetic and non-diabetic subjects. On the other hand, uric acid showed positive association with fasting blood sugar (FBS), diastolic blood pressure, HbA1c and CRP in case of diabetic subjects, but with age, BMI, CRP, HbA1c and creatinine in non-diabetic subject. Uric acid also shows a significantly (p < 0.001) positive Pearson correlation with CRP. These data strongly suggest that compared to non-diabetic subjects, diabetic subjects have significantly higher level of CRP and uric acid. Key words: C-reactive protein; Uric acid; Type 2 diabetes; Bangladeshi population DOI: http://dx.doi.org/10.3329/dujbs.v20i2.8980 DUJBS 2011; 20(2): 191-199

scholarly journals Mediation Role of C-Reactive Protein on the Association between Smoking Quantity and Type 2 Diabetes in Current Chinese Smokers

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Dan Feng ◽  
Tao Liu ◽  
Hui Wang ◽  
Emma Karp ◽  
Wenhua Ling ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Binary Logistic Regression ◽  
Positive Association ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Smoking Quantity ◽  
Develop Type ◽  
Who 1999 Criteria

Objective. Previous studies have indicated that cigarette smokers are more likely to develop type 2 diabetes and that both smoking and type 2 diabetes are associated with C-reactive protein (CRP). This study examined whether CRP mediates the association between smoking quantity and type 2 diabetes.Methods. Nine hundred and eighty-four current Chinese smokers were selected from a community-based chronic disease survey conducted in Guangzhou and Zhuhai. Type 2 diabetes was defined according to the WHO 1999 criteria. CRP was measured with flow cytometry. Binary logistic regression was performed to assess the mediation.Results. A positive association was observed between smoking quantity and type 2 diabetes (P<0.05). After controlling for potential confounders, daily cigarette consumption was significantly associated with higher CRP levels. Current smokers with type 2 diabetes had higher CRP levels than smokers without type 2 diabetes. The association between the smoking quantity and type 2 diabetes was mediated by CRP, which accounted for 50.77% of the association.Conclusions. This study provides further evidence that smoking quantity is positively associated with type 2 diabetes and suggests that the association between smoking and type 2 diabetes might be mediated by CRP.

scholarly journals Meat Consumption and Its Association With C-Reactive Protein and Incident Type 2 Diabetes: The Rotterdam Study

Diabetes Care ◽  
2012 ◽  
Vol 35 (7) ◽  
pp. 1499-1505 ◽  
Author(s):  
G. J. van Woudenbergh ◽  
A. Kuijsten ◽  
B. Tigcheler ◽  
E. J. G. Sijbrands ◽  
F. J. A. van Rooij ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Meat Consumption ◽  
Rotterdam Study ◽  
C Reactive Protein ◽  
Incident Type ◽  
Reactive Protein ◽  
Incident Type 2 Diabetes

scholarly journals Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes: A Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1280 ◽  
Author(s):  
Geoffrey Livesey ◽  
Richard Taylor ◽  
Helen F. Livesey ◽  
Anette E. Buyken ◽  
David J. A. Jenkins ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Index ◽  
Meta Analysis ◽  
Glycemic Load ◽  
Good Health ◽  
European Ancestry ◽  
Incident Type ◽  
Dietary Glycemic Index ◽  
Meta Analyses

Published meta-analyses indicate significant but inconsistent incident type-2 diabetes (T2D)-dietary glycemic index (GI) and glycemic load (GL) risk ratios or risk relations (RR). It is now over a decade ago that a published meta-analysis used a predefined standard to identify valid studies. Considering valid studies only, and using random effects dose–response meta-analysis (DRM) while withdrawing spurious results (p < 0.05), we ascertained whether these relations would support nutrition guidance, specifically for an RR > 1.20 with a lower 95% confidence limit >1.10 across typical intakes (approximately 10th to 90th percentiles of population intakes). The combined T2D–GI RR was 1.27 (1.15–1.40) (p < 0.001, n = 10 studies) per 10 units GI, while that for the T2D–GL RR was 1.26 (1.15–1.37) (p < 0.001, n = 15) per 80 g/d GL in a 2000 kcal (8400 kJ) diet. The corresponding global DRM using restricted cubic splines were 1.87 (1.56–2.25) (p < 0.001, n = 10) and 1.89 (1.66–2.16) (p < 0.001, n = 15) from 47.6 to 76.1 units GI and 73 to 257 g/d GL in a 2000 kcal diet, respectively. In conclusion, among adults initially in good health, diets higher in GI or GL were robustly associated with incident T2D. Together with mechanistic and other data, this supports that consideration should be given to these dietary risk factors in nutrition advice. Concerning the public health relevance at the global level, our evidence indicates that GI and GL are substantial food markers predicting the development of T2D worldwide, for persons of European ancestry and of East Asian ancestry.

Positive Association Between Serum Levels of High-Sensitivity C-Reactive Protein and Depression/Anxiety in Female, but Not Male, Patients With Type 2 Diabetes Mellitus

2019 ◽  
Vol 22 (2) ◽  
pp. 178-187 ◽  
Author(s):  
Qian-Qian Yang ◽  
Di Shao ◽  
Jie Li ◽  
Chun-Ling Yang ◽  
Min-Hua Fan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Positive Association ◽  
High Sensitivity ◽  
Depression And Anxiety ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Symptoms Of Depression ◽  
Hs Crp

Purpose: Patients with Type 2 diabetes (T2D) have increased risk of depression and anxiety. Evidence suggests that a heightened inflammatory state may contribute to this association. Females experience more depression and higher inflammation levels than males. This study compared associations of serum high-sensitivity C-reactive protein (hs-CRP) levels with symptoms of depression and anxiety between men and women with Type 2 diabetes mellitus (T2DM). Method: Cross-sectional data including demographic and disease characteristics, symptoms of depression and anxiety, clinical data, and laboratory values were collected from 392 patients with T2DM recruited from a general hospital in Shandong Province, China. We evaluated associations between serum hs-CRP level and symptoms of depression and anxiety in males and females separately using multiple linear regressions and χ2 tests for trend. Results: Sex moderated the association between serum hs-CRP level and symptoms of depression ( B = .112 [ SE = 0.049]; p = .022) and anxiety ( B = .137 [ SE = 0.053]; p = .011). Among females, hs-CRP level was positively associated with depression ( B = .034, 95% confidence interval [CI] = [.006, .061]; p = .016, false discovery rate [FDR]-adjusted p = .020) and anxiety ( B = .041, 95% CI [.011, .071], p = .007, FDR-adjusted p = .007). Positive trends indicated a higher prevalence of clinically significant symptoms of depression and anxiety in higher serum hs-CRP categories in females. No associations were found in males. Conclusion: Findings demonstrate that associations between serum hs-CRP level and symptoms of depression and anxiety in patients with T2D are sex-specific, with only females demonstrating a significant positive association.

scholarly journals The Association of Serum hsCRP and Urinary Alpha1-Microglobulin in Patients with Type 2 Diabetes Mellitus

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Xiaohua Wan ◽  
Lin Zhang ◽  
Haitong Gu ◽  
Shenglai Wang ◽  
Xiangyi Liu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Renal Damage ◽  
Creatinine Ratio ◽  
Linear Regression Models ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Increasing Risk

This study aimed to investigate the association of serum hsCRP and urinary A1MG in patients with T2DM. Numerous investigations have proven that serum hypersensitive C-reactive protein (hsCRP) concentration in patients with type 2 diabetes mellitus (T2DM) is increased. Also, increased urinary alpha-1 microglobulin (A1MG) can be an early sign of renal damage, primarily on the proximal tubules in T2DM. Little information is available with respect to the associations of serum hsCRP levels and urinary A1MG in T2DM. A total of 520 patients with T2DM were recruited to participate in this study. Serum hsCRP and UA1MG (urinary alpha1-microglobulin to creatinine ratio), UACR (urinary microalbumin to creatinine ratio), UIGG (urinary immunoglobulin G to creatinine ratio), and UTRF (urinary transferrin to creatinine ratio) were obtained. The association of serum hsCRP level and each urinary protein parameter was analyzed by using the regression analysis, respectively. LnhsCRP was positively associated with the lnUA1MG in all three linear regression models (adjusted β in model 3=0.122, SE=0.027, P<0.001). Furthermore, the high hsCRP group (hsCRP > 3mg/L) was associated with increasing risk of high UA1MG (adjusted OR in model 3=1.610, 95% CI 1.037–2.499, P=0.034) by logistic regression. This study suggests that serum hsCRP levels independently associate with UA1MG in patients with T2DM. Further research is warranted to elucidate these interactions.

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