scholarly journals Periodontal Health and Caries Prevalence Evaluation in Patients Affected by Parkinson's Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Marco Cicciù ◽  
Giacomo Risitano ◽  
Giuseppe Lo Giudice ◽  
Ennio Bramanti
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Oral Health ◽  
Periodontal Disease ◽  
Oral Hygiene ◽  
Neurodegenerative Disorder ◽  
Periodontal Diseases ◽  
Control Group ◽  
Study Group ◽  
Untreated Caries

Parkinson's disease (PD) is a progressive neurodegenerative disorder related to the loss or absence of dopaminergic neurons in the brain. These deficits result in slowness of movement, tremor, rigidity, and dysfunction of behaviour. These symptoms negatively influence the patient’s capability to carry out the daily oral hygiene manoeuvres. The aim of this work is to record the oral health condition of PD patients evaluated at the IRCSS Bonino-Puleio in Messina. The oral health of 45 consecutive PD patients (study group) with neurologic diagnosis based on United Kingdom Brain Bank Criteria has been compared with that of another 45 no PD patients of the same age (control group). The evaluation of the general oral condition was recorded underlining tooth loss, active periodontal disease, and presence of untreated caries. The frequency of untreated caries, periodontal diseases, and missing teeth of the study group was significantly higher than in control group. Based on the data results, clinicians should direct high attention to the oral hygiene of patients with PD, above all at the early stages of the caries or periodontal disease, in order to prevent serious evolution of those pathologic dental conditions that may finally result in the tooth extraction event.

scholarly journals The Relationship between Periodontal Disease and Motor Impairment in the Course of Parkinson’s Disease

2020 ◽  
Vol 74 ◽  
pp. 340-347
Author(s):  
Beata Ledwon ◽  
Andrzej Miskiewicz ◽  
Ewa Grabowska ◽  
Jan Kowalski ◽  
Renata Górska
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Acute Phase Proteins ◽  
Periodontal Diseases ◽  
Motor Impairment ◽  
Lower Number ◽  
Periodontal Treatment ◽  
Control Group ◽  
Study Group ◽  
Timed Up And Go

Introduction: The incidence of Parkinson’s disease and the severity of accompanying motor impairment increase significantly with age. The etiopathogenesis and progression of Parkinson’s disease at the molecular level is associated with the production of cytokines and acute phase proteins, which are also typical for inflammatory diseases, such as periodontitis and gingivitis. Objectives: The aim of the study was to assess the correlation between neurological parameters, the indices of periodontal status and systemic parameters of inflammation, as well as their change after treatment. Patients/Methods: The presented study is a retrospective analysis of data obtained from medical histories and patient charts. Charts of 93 patients diagnosed with Parkinson’s disease and periodontal diseases over the period 2015–2017 were selected. Sixty-one of these patients received periodontal treatment: professional scaling, root planning – SRP and periodontal pockets rinsing with 3% H2O2 and constituted a study group. Additionally, the patients were instructed to use a 0.2% chlorhexidine mouthwash. The other 32 patients, who were not periodontally treated, formed a control group. Both groups continued their anti-parkinsonian treatment. Results: The mean pocket depth at the baseline was 4.0 mm (SD 0.9 mm), mean bleeding index was 56.2%, and 63.9% of patients presented tooth mobility grade II or III. A significant correlation between periodontal and neurological parameters was observed at the baseline. After periodontal treatment, an improvement of both periodontal parameters and those related to the Parkinson’s disease was observed in the study group. Those periodontally treated exhibited lower number of anti-parkinsonian medicines, lower number of falls, as well as better results in10-m walk test and timed-up-and-go test, as compared to the control group. The improvement was observed both 3 and 9 months after the end of treatment.

scholarly journals Oral Health of Parkinson’s Disease Patients: A Case-Control Study

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Marjolein A. E. van Stiphout ◽  
Johan Marinus ◽  
Jacobus J. van Hilten ◽  
Frank Lobbezoo ◽  
Cees de Baat
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Health Status ◽  
Oral Health ◽  
Oral Hygiene ◽  
Oral Health Status ◽  
Control Group ◽  
Tooth Root ◽  
Carious Lesions ◽  
Care Support

The aim of the study was to examine the oral health status of Parkinson’s disease (PD) patients, to compare their oral health status to that of a control group, and to relate it to the duration and severity of PD.Materials and Methods. 74 PD patients and 74 controls were interviewed and orally examined. Among PD patients, the duration and the Hoehn and Yahr stage (HY) of the disease were registered.Results. More PD patients than controls reported oral hygiene care support as well as chewing/biting problems, taste disturbance, tooth mobility, and xerostomia, whereas dentate patients had more teeth with carious lesions, tooth root remnants, and biofilm. Both longer duration and higher HY were associated with more chewing problems and, in dentates, more teeth with restorations. In dentates, longer duration of the disease was associated with higher number of mobile teeth. Higher HY was associated with more oral hygiene care support as well as biting problems and, in dentates, more teeth with carious lesions and tooth root remnants.Conclusions. Comparatively, PD patients had weakened oral health status and reduced oral hygiene care. Both duration and severity of the disease were associated with more oral health and hygiene care problems.

scholarly journals Oral Factors That Impact the Oral Microbiota in Parkinson’s Disease

2021 ◽  
Vol 9 (8) ◽  
pp. 1616
Author(s):  
Natalia S. Rozas ◽  
Gena D. Tribble ◽  
Cameron B. Jeter
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Oral Health ◽  
Soft Tissue ◽  
Oral Hygiene ◽  
Beta Diversity ◽  
Oral Microbiota ◽  
Healthy Controls ◽  
Microbiota Composition ◽  
Salivary Ph

Patients with Parkinson’s disease (PD) are at increased risk of aspiration pneumonia, their primary cause of death. Their oral microbiota differs from healthy controls, exacerbating this risk. Our goal was to explore if poor oral health, poor oral hygiene, and dysphagia status affect the oral microbiota composition of these patients. In this cross-sectional case-control study, the oral microbiota from hard and soft tissues of patients with PD (n = 30) and age-, gender-, and education-matched healthy controls (n = 30) was compared using 16S rRNA gene sequencing for bacterial identification. Study participants completed dietary, oral hygiene, drooling, and dysphagia questionnaires, and an oral health screening. Significant differences in soft tissue beta-diversity (p < 0.005) were found, and a higher abundance of opportunistic oral pathogens was detected in patients with PD. Factors that significantly influenced soft tissue beta-diversity and microbiota composition include dysphagia, drooling (both p < 0.05), and salivary pH (p < 0.005). Thus, patients with PD show significant differences in their oral microbiota compared to the controls, which may be due, in part, to dysphagia, drooling, and salivary pH. Understanding factors that alter their oral microbiota could lead to the development of diagnostic and treatment strategies that improve the quality of life and survivability of these patients.

scholarly journals Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients with Parkinson’s Disease: Study Protocol for a Randomized Controlled Trial

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 314
Author(s):  
Aida Arroyo-Ferrer ◽  
Francisco José Sánchez-Cuesta ◽  
Yeray González-Zamorano ◽  
María Dolores del Castillo ◽  
Carolina Sastre-Barrios ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Therapy ◽  
Cognitive Processing ◽  
Processing Speed ◽  
Cognitive Rehabilitation ◽  
Neurodegenerative Disorder ◽  
Control Group ◽  
Motor Symptoms ◽  
The Impact

Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder. This disease is characterized by motor symptoms, such as bradykinesia, tremor, and rigidity. Although balance impairment is characteristic of advanced stages, it can be present with less intensity since the beginning of the disease. Approximately 60% of PD patients fall once a year and 40% recurrently. On the other hand, cognitive symptoms affect up to 20% of patients with PD in early stages and can even precede the onset of motor symptoms. There are cognitive requirements for balance and can be challenged when attention is diverted or reduced, linking a worse balance and a higher probability of falls with a slower cognitive processing speed and attentional problems. Cognitive rehabilitation of attention and processing speed can lead to an improvement in postural stability in patients with Parkinson’s. Methods: We present a parallel and controlled randomized clinical trial (RCT) to assess the impact on balance of a protocol based on cognitive rehabilitation focused on sustained attention through the NeuronUP platform (Neuronup SI, La Rioja, Spain) in patients with PD. For 4 weeks, patients in the experimental group will receive cognitive therapy three days a week while the control group will not receive any therapy. The protocol has been registered at trials.gov NCT04730466. Conclusions: Cognitive therapy efficacy on balance improvement may open the possibility of new rehabilitation strategies for prevention of falls in PD, reducing morbidity, and saving costs to the health care system.

scholarly journals Evaluation of Effectiveness of a Toothpaste Containing Tea Tree Oil and Ethanolic Extract of Propolis on the Improvement of Oral Health in Patients Using Removable Partial Dentures

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4071
Author(s):  
Karolina Wiatrak ◽  
Tadeusz Morawiec ◽  
Rafał Rój ◽  
Patryk Kownacki ◽  
Aleksandra Nitecka-Buchta ◽  
...  
Keyword(s):  
Oral Health ◽  
Oral Hygiene ◽  
Ethanolic Extract ◽  
Plaque Index ◽  
Control Group ◽  
Oral Microbiota ◽  
Study Group ◽  
Tea Tree Oil ◽  
Tea Tree ◽  
Ethanolic Extract Of Propolis

The aim of this study was to evaluate the effect of toothpaste containing natural tea tree essential oil (TTO) and ethanolic extract of propolis (EEP), on microflora and selected indicators of oral health in patients using removable acrylic partial dentures. Fifty patients with varying conditions of hygiene were divided into two groups. The study group received the toothpaste with TTO and EEP, while the control group received the same toothpaste but without TTO and EEP. At the first visit, oral hygiene and hygiene of the prostheses were carried out. Control visits took place 7 and 28 days later and compared to baseline. Indexes like API (Approximal Plaque Index), mSBI (modified Sulcus Bleeding Index), OHI-s (simplified Oral Hygiene Index), and DPI (Denture Plaque Index) were assessed in three subsequent stages, and swabs were collected from floor of the mouth area to assess the microbiota. After 7 and 28 days of using the toothpaste with TTO and EEP, a statistically significant decrease of the examined indicator values were observed in the study group as compared to the values upon the initial visit. The number of isolated strains of microorganisms in the study group was decreased or maintained at the same level, whereas in the control group an increase in the number of isolated strains was observed. The observed stabilization of oral microbiota in patients from the study group confirms the beneficial activity of toothpaste containing EEP and TTO compared to the control group.

scholarly journals Palmitate and Stearate are Increased in the Plasma in a 6-OHDA Model of Parkinson’s Disease

Metabolites ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 31 ◽  
Author(s):  
Anuri Shah ◽  
Pei Han ◽  
Mung-Yee Wong ◽  
Raymond Chang ◽  
Cristina Legido-Quigley
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Stearic Acid ◽  
Palmitic Acid ◽  
Neurodegenerative Disorder ◽  
Motor Dysfunction ◽  
Substantia Nigra Pars Compacta ◽  
Control Group ◽  
Sprague Dawley ◽  
Curative Therapy

Introduction: Parkinson’s disease (PD) is the second most common neurodegenerative disorder, without any widely available curative therapy. Metabolomics is a powerful tool which can be used to identify unexpected pathway-related disease progression and pathophysiological mechanisms. In this study, metabolomics in brain, plasma and liver was investigated in an experimental PD model, to discover small molecules that are associated with dopaminergic cell loss. Methods: Sprague Dawley (SD) rats were injected unilaterally with 6-hydroxydopamine (6-OHDA) or saline for the vehicle control group into the medial forebrain bundle (MFB) to induce loss of dopaminergic neurons in the substantia nigra pars compacta. Plasma, midbrain and liver samples were collected for metabolic profiling. Multivariate and univariate analyses revealed metabolites that were altered in the PD group. Results: In plasma, palmitic acid (q = 3.72 × 10−2, FC = 1.81) and stearic acid (q = 3.84 × 10−2, FC = 2.15), were found to be increased in the PD group. Palmitic acid (q = 3.5 × 10−2) and stearic acid (q = 2.7 × 10−2) correlated with test scores indicative of motor dysfunction. Monopalmitin (q = 4.8 × 10−2, FC = −11.7), monostearin (q = 3.72 × 10−2, FC = −15.1) and myo-inositol (q = 3.81 × 10−2, FC = −3.32), were reduced in the midbrain. The liver did not have altered levels of these molecules. Conclusion: Our results show that saturated free fatty acids, their monoglycerides and myo-inositol metabolism in the midbrain and enteric circulation are associated with 6-OHDA-induced PD pathology.

scholarly journals Evaluation of quality of life and psychological aspects of Parkinson's disease patients who participate in a support group

2015 ◽  
Vol 9 (3) ◽  
pp. 295-300 ◽  
Author(s):  
Nathalie Ribeiro Artigas ◽  
Vera Lúcia Widniczck Striebel ◽  
Arlete Hilbig ◽  
Carlos Roberto de Mello Rieder
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Social Phobia ◽  
Support Group ◽  
Neurodegenerative Disorder ◽  
Control Group ◽  
Asymmetric Distribution ◽  
Cross Sectional

Parkinson's disease (PD) is a neurodegenerative disorder that can dramatically impair patient quality of life (QoL). Objective: To analyze the QoL, motor capacity, depression, anxiety and social phobia of individuals who attended a patient support group (PSG) compared to non-participants. Methods: A cross-sectional study was performed. The sample consisted of 20 individuals with PD who attended a PSG and another 20 PD patients who did not attend a support group for PD patients, serving as the control group (nPSG). All patients answered questionnaires on motor capacity (UPDRS), QoL (Parkinson's Disease Questionnaire- PDQ-39), depression (Beck Depression Inventory), anxiety (Beck Anxiety Inventory) and social phobia (Liebowitz Social Anxiety Scale). To determine data distribution, the Shapiro-Wilk test was performed. For comparison of means, Student's t-test was applied. In cases of asymmetry, the Mann-Whitney test was employed. To assess the association between the scales, Pearson's correlation coefficient (symmetric distribution) and Spearman's coefficient (asymmetric distribution) were applied. For the association between qualitative variables, Pearson's Chi-squared test was performed. A significance level of 5% (p≤0.05) was adopted. Results: Individuals in the PSG had a significantly better QoL (p=0.002), and lower depression (p=0.026), anxiety (p<0.001) and social phobia (p=0.01) scores compared to the nPSG. Conclusion: The participation of PD patients in social activities such as support groups is associated with better QoL and fewer symptoms of depression, anxiety and social phobia.

scholarly journals Dental Implants: Prevalence, Association with Periodontal Diseases and Awareness of Oral Hygiene among Dental Implant Patients in Saudi Arabia: A Cross-Sectional Study

2020 ◽  
Vol 5 (12) ◽  
pp. 615-619
Author(s):  
Amal Abushal ◽  
Malak Alqudsi ◽  
Nujood Alahmadi ◽  
Mohammed Almalsi ◽  
Haifa Alharbi ◽  
...  
Keyword(s):  
Oral Health ◽  
Periodontal Disease ◽  
Dental Implants ◽  
Oral Hygiene ◽  
Periodontal Diseases ◽  
Public Awareness ◽  
Gingival Recession ◽  
Tooth Brushing ◽  
Cross Sectional ◽  
Health Concepts

Periodontal disease is a broad spectrum that involves different entities and severity levels of the disease. Dental implants, just like normal teeth, can be affected by periodontal disease. This descriptive questionnaire-based study provides a brief shot on the most prevalent periodontal diseases associated with dental implants, associated risk factors, and levels of understanding and awareness about oral hygiene in the Saudi population. Results concluded that 10.5% of population have dental implants. 28.5% the sample confirmed that they have some sort of periodontal disease. Most prevalent symptoms among patients with dental implants are in order: periodontal pockets, redness and blood spitting after tooth brushing, and finally gingival recession. Most associated co-morbidities are cardiovascular disease and diabetes mellitus. Regarding oral hygiene, through assessing two oral health concepts: twice daily tooth brushing, and balanced diet, it is found that more than half of the sample (51.3%) apply these two concepts in their life, while the rest of the sample misses one or both of these two concepts. Focus should be directed toward raising the public awareness about periodontal disease and its symptoms, especially in cases of dental implants, and raising understanding and awareness about different oral health concepts.

scholarly journals Orofacial Functions and Chewing Effiency in Elderly Patients with Parkinson’s Disease Rehabilitated with Removable Prostheses

2020 ◽  
Vol 14 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Corsalini Massimo ◽  
Rapone Biagio ◽  
Cagnetta Giovanni ◽  
Carossa Massimo ◽  
Sportelli Pasquale ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Age Of Onset ◽  
The Elderly ◽  
Control Group ◽  
Study Group ◽  
Dental Prostheses ◽  
Masticatory Efficiency ◽  
Masticatory Ability ◽  
Significant Difference

Background: Parkinson’s Disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. It is one of the movement disorders that can affect oro-facial conditions. It is more common in the elderly, having an average age of onset of around 60 years. Objective: The aim was to study orofacial functions in patients suffering from PD with partial or total edentulism, wearing removable prostheses. Methods: Forty-eight (48) elders, rehabilitated with removable dentures, were included: 24 patients suffering from Parkinson's disease constitute the Study Group (SG), and 24 subjects not suffering from Parkinson's disease or neurological degenerative diseases represent the Control Group (CG). In SG, the severity of Parkinson's disease was assessed according to the Unified Parkinson's Disease Rating objective motor scale III, and oro-facial dysfunctions were evaluated using Nordic Orofacial Test-Screening (NOT-S). The duration of the use of dental prostheses expressed in years has been reported. In both the groups, the subjective chewing index for the analysis of masticatory ability and the two-color chewing gum test for the analysis of masticatory efficiency were conducted . Results: There was a statistically significant difference between the SG and CG compared to the NOT-S (P = 0.001). Analyzing the study group, a statistically significant correlation was found between the masticatory efficiency and prosthetic years of use (rs = 0.436; P <0.05); instead, no statistically significant correlation was found between the masticatory efficiency and the severity of Parkinson's disease. Conclusion: In our study, we did not find differences between SG and CG in terms of the degree of masticatory efficiency; therefore, only a correlation between the duration of use of dental prostheses and the degree of masticatory efficiency was found.

scholarly journals EFFECT OF SESAMOL IN ASSOCIATION WITH FOLIC ACID ON 6-OHDA INDUCED PARKINSONIAN ANIMALS- BIOCHEMICAL, NEUROCHEMICAL AND HISTOPATHOLOGICAL EVIDENCE

2017 ◽  
Vol 10 (4) ◽  
pp. 46 ◽  
Author(s):  
Khadira Sereen ◽  
Vijayalakshmi K ◽  
Priya Nagappan ◽  
Shinu Balima
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Folic Acid ◽  
Neurodegenerative Disorder ◽  
Neuroprotective Effect ◽  
Biochemical Parameter ◽  
Lesion Group ◽  
Control Group ◽  
Tbars Level ◽  
6 Hydroxydopamine

Objective: Parkinson’s disease (PD) is the world’s second neurodegenerative disorder. Degeneration of dopaminergic neurons is the hallmark of the disease. Here is a novel approach to treat PD with a phenolic compound Sesamol (SA) and in combination with Folic acid (FA).Methods: The study was designed with five groups of animals and 6 rats in each group. The rats was infused with 6-hydroxydopamine (10μg/2μl in 0.1% ascorbic acid saline) once for the development of PD, Group 1(control), Group 2(Lesion), Group 3(Lesion+ SA), Group 4(Lesion + SA+ FA) and Group 5(Lesion+ L-dopa). The biochemical parameter like glucose, triglycerides, protein, folic acid, TBARS and antioxidant profile in serum were estimated. The neurotransmitters level in striatum was estimated and histopathology of striatum and mid-brain tissues was carried out.Results: The results showed that 6-hydroxydopamine induced lesion has a significant alteration in the level of glucose, triglycerides, protein and folic acid where as TBARS level was elevated and the activities of antioxidants and neurotransmitters level were reduced. This was significantly restored on SA+FA treatment. The lesion group shows an abnormal architecture of striatum and mid-brain, whereas on SA+FA treatment there was minimal abnormality.Conclusion: Thus our study demonstrates that Sesamol has neuroprotective effect against 6-hydroxy dopamine insult and showed a synergic effect when combined with Folic acid.Keywords: Parkinson’s disease, Sesamol, Folic acid, 6-Hydroxy dopamine, Neurotransmitter, Antioxidant

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