scholarly journals Rosai-Dorfman Disease Originating from Nasal Septal Mucosa

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Abdulvahap Akyigit ◽  
Hadice Akyol ◽  
Oner Sakallioglu ◽  
Cahit Polat ◽  
Erol Keles ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Head And Neck ◽  
Nasal Obstruction ◽  
Histopathological Examination ◽  
Neck Region ◽  
Unknown Etiology ◽  
Extranodal Involvement ◽  
Head And Neck Region ◽  
Histiocytic Cell ◽  
Rosai Dorfman Disease

Rosai-Dorfman disease is a rarely seen disease with unknown etiology. Extranodal involvement is most commonly seen in the head and neck region. Histopathologically, it is characterized by histiocytic cell proliferation. This paper presents a case of a 15-year-old male patient who presented with nasal obstruction and was surgically treated for a mass filling in the left nasal meatus that was diagnosed to be Rosai-Dorfman disease by histopathological examination.

scholarly journals Paranasal Rosai-Dorfman Disease with Osseous Destruction

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Kevin Hur ◽  
Changxing Liu ◽  
Jeffrey A. Koempel
Keyword(s):  
Head And Neck ◽  
Histopathological Examination ◽  
Cervical Lymphadenopathy ◽  
Neck Region ◽  
Unknown Etiology ◽  
Extranodal Involvement ◽  
Head And Neck Region ◽  
Left Orbit ◽  
Rosai Dorfman Disease

Rosai-Dorfman disease is a rare histiocytic proliferative disorder of unknown etiology typically characterized by cervical lymphadenopathy. Extranodal involvement often manifests in the head and neck region. We present a 10-year-old male who presented to our hospital with left epiphora from an aggressive paranasal mass invading the left orbit with osseous destruction. The mass was surgically biopsied and debulked with histopathological examination revealing Rosai-Dorfman disease. Although rarely found in the sinuses, Rosai-Dorfman disease should be considered when evaluating sinonasal masses.

scholarly journals The role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region

2019 ◽  
Vol 10 (1) ◽  
pp. 48-53
Author(s):  
Mohammad Sowkat Hossain ◽  
S M Mahbubul Alam ◽  
Sk Md Jaynul Islam ◽  
Wasim Selimul Haque ◽  
Shamoli Yasmin
Keyword(s):  
Head And Neck ◽  
Soft Tissues ◽  
Histopathological Examination ◽  
Malignant Neoplasm ◽  
Cervical Lymphadenopathy ◽  
Neck Region ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Head And Neck Region

Background: Undifferentiated tumours in the head and neck region are not uncommon. They can arise from different sites like in mucosa as well as in salivary glands, soft tissues or lymph nodes. Histopathological examination plays a central role in the diagnosis but difficulties arise with some tumours which are poorlydifferentiated due to their high inter- and intra-observer variability. In those cases, immunohistochemistry has greatly assisted to diagnose the tumours that cannot be accurately identified using routine histopathological procedures. The correct histopathological diagnosis is essential especially in case of malignant tumourwhere subsequent specific therapy is required. The aim of this study was to determine the role of immunohistochemistry for diagnosing undifferentiated malignancy in the head and neck region. Methods: This cross-sectional study was conducted during July 2014 to June 2015. A total of 35 Bangladeshi patient’s specimens of head and neck swelling were collected from two renowned laboratories in Dhaka city.These cases were diagnosed as undifferentiated tumour in histopathological examination.Standard protocol was followed for immunohistochemistry.Then primary immunohistochemical panel which included the markers for Epithelial CK (AE1/AE3),mesenchymal marker (Vimentin) and lymphoid marker (LCA) were used.The cases which were not resolved by primary immunohistochemistry panel, the second panel was applied for further sub classification (Desmin, Chromogranin, CK20, CEA, CD20, CD30, HMB45, NSE). Based on interpretation of immunohistochemical findings final diagnoses were made.Data analysis was performed using the Statistical Package for the Social Sciences for Windows version 22.0 (SPSS, Chicago, Illinois, USA). Results: A total of 35 undifferentiated tumorsof head-neck region were studied.The mean age was 46.3±17.6 years and male to female ratio was 4.8:1. The majority 13 (37.1%) patient had cervical lymphadenopathy, 11 (31.4%) had neck mass and 4(11.4%) had in nasal/sinonasal mass.Regarding histopathologicalcell types, round cell was 21 (60.0%), spindle cell 6 (17.1%), pleomorphic cells 6(17.1%) and epithelioid cells 2(5.7%). In initial histopathological examination, majority 25(71.4%) were undifferentiated malignant neoplasm, 8(22.8%) were metastatic undifferentiated carcinoma, 1(2.9%) was pleomorphic sarcoma and the remaining 1(2.9%) had malignant adnexal tumour. By application of immunohistochemistry, most (33, 94.3%) of the cases were resolved and the two cases remained unresolved. Among the resolved cases majority (15, 45.5%) were lymphoma, 4(12.1%) were metastatic carcinoma, 3(9.1%) were Ewing’s sarcoma and malignant melanoma were found in 3(9.1%) cases. Conclusion: This study supports that the immunohistochemical technique has a fundamental role in the investigation of undifferentiated tumour origin, to determine the correct guidance for treatment and improving the prognosis for head and neck tumour patients. Birdem Med J 2020; 10(1): 48-53

scholarly journals Tuberculosis in the head and neck: experience in India

2007 ◽  
Vol 121 (10) ◽  
pp. 979-985 ◽  
Author(s):  
Kishore C Prasad ◽  
S Sreedharan ◽  
Y Chakravarthy ◽  
Sampath C Prasad
Keyword(s):  
Head And Neck ◽  
Histopathological Examination ◽  
Neck Region ◽  
Needle Aspiration ◽  
Head And Neck Region ◽  
Mandibular Joint ◽  
Immunodeficiency Virus ◽  
Needle Aspiration Cytology ◽  
Anti Tubercular Therapy ◽  
Tubercular Lymphadenitis

Objective: With improvement in economic and social conditions and the use of effective anti-tubercular therapy, the developed nations, and most developing nations, have enjoyed a decline in tuberculosis for several decades. It is now seen that extra-pulmonary presentations form a major proportion of new cases, especially since the advent of the acquired immunodeficiency syndrome epidemic. Therefore, it is important that otolaryngologists are aware of tuberculosis in the head and neck region and its varied manifestations. We report the increased incidence of isolated head and neck tuberculosis, its various presentations and clinical manifestations over a 10-year period.Materials and methods: A 10-year (1995–2004), retrospective study was undertaken by the department of otolaryngology and head and neck surgery, Kasturba Medical College, and its allied hospitals, Mangalore, South India, involving a group of 165 patients with head and neck tuberculosis. Each patient underwent a detailed clinical examination and a battery of investigations. Most patients were treated with anti-tubercular therapy alone; others required surgical intervention followed by Anti-tubercular therapy (ATT). In addition, those with human immunodeficiency virus infection or malignancy were treated with anti-retroviral therapy and radiotherapy, respectively.Results: Of the 165 cases, 121 (73.3 per cent) had isolated tubercular lymphadenitis, 24 (14.5 per cent) had laryngeal tuberculosis, four (2.4 per cent) had tubercular otitis media, three (1.8 per cent) had tuberculosis of the cervical spine, three (1.8 per cent) had tuberculosis of the parotid, eight (5 per cent) had tuberculosis of the oral cavity, one had tuberculosis of the temporo-mandibular joint and one had tuberculosis of the nose. Fine needle aspiration cytology was highly effective in the diagnosis of tubercular lymphadenitis (92 per cent) but not so for other sites. The purified protein derivative (PPD) test was positive in only 20 per cent of cases. Pus for culture and sensitivity was positive only in caries of the spine and mandibular tuberculosis. Excision biopsy and histopathological examination were required to make a diagnosis in tuberculosis of the oral and nasal cavities, salivary glands, ear, temporo-mandibular joint, and mandible. There were 40 cases (24.2 per cent) with coexisting pulmonary tuberculosis and five cases (3 per cent) with coexisting malignancy. Of the 65 patients who were tested, 30 per cent were found to have coexisting human immunodeficiency virus infection.Conclusion: In addition to cervical lymphadenitis, tuberculosis in the head and neck region can produce isolated disease in the oral cavity, ear, salivary glands, temporo-mandibular joint, nose and larynx. Seventy-five per cent of our head and neck tuberculosis patients did not have pulmonary involvement. Fine needle aspiration cytology was highly effective in the diagnosis of nodal tuberculosis, but histopathological examination was required to make the diagnosis in other head and neck sites. The PPD test was not effective as a diagnostic tool. If the otolaryngologist maintains a high index of suspicion, an early diagnosis can be made with the help of simple investigations. Successful outcome depends upon appropriate chemotherapy and timely surgical intervention when necessary.

scholarly journals Epidermoid cyst of earlobe: a common cyst at an uncommon site

2019 ◽  
Vol 5 (5) ◽  
pp. 1400
Author(s):  
Jayendiran S. ◽  
Jinu Vadakkanethu Iype ◽  
Srinivasa V.
Keyword(s):  
Head And Neck ◽  
Malignant Transformation ◽  
Clinical Diagnosis ◽  
Epidermoid Cyst ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Neck Region ◽  
Head And Neck Region ◽  
Important Concern ◽  
Nylon 4

<p class="abstract">Epidermoid cysts are frequently encountered cutaneous cysts. They are mostly tiny and benign swellings. But rarely they can grow huge in size and malignant transformation can also occur occasionally. Cosmetic disfigurement is also another important concern especially in head and neck region. We report a case of earlobe epidermoid cyst, a location where very few cases have been described in the literature. The cyst was completely excised and the wound was closed with nylon 4/0. Histopathological examination confirmed the diagnosis of an epidermoid cyst. The patient did not have any signs of recurrence even after six months postoperatively. Due to the possibility of malignant transformation and to ensure correct diagnosis, we consider that histopathological examination is necessary for all cysts although the clinical diagnosis could be enough.</p>

scholarly journals Castleman Disease of the Parotid Gland: A Report of a Case

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Fawaz Abo-Alhassan ◽  
Fatemah Faras ◽  
Jassem Bastaki ◽  
Mutlaq K. Al-Sihan
Keyword(s):  
Parotid Gland ◽  
Head And Neck ◽  
Lymphoproliferative Disorder ◽  
Neck Region ◽  
Excisional Biopsy ◽  
Castleman Disease ◽  
Unknown Etiology ◽  
Common Site ◽  
Head And Neck Region ◽  
History Of

Castleman disease is an extremely rare benign lymphoproliferative disorder of unknown etiology. It affects the lymphatic chain in anybody region, although the commonest site is the mediastinum. The head and neck region is the second most common site; however, the salivary glands are rarely affected. We report a case of a 29-year-old Asian lady who presented with a 2-year history of an enlarging left parotid mass. Histopathology of the excisional biopsy confirmed the diagnosis of Castleman disease.

scholarly journals Dermoid cyst over the left sphenoid in a child: a rare case report

2019 ◽  
Vol 5 (6) ◽  
pp. 1688
Author(s):  
Andrews Navin Kumar ◽  
Anubhav Shivpuri ◽  
Sandeep Mehta ◽  
Shanender Singh Sambyal
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Dermoid Cyst ◽  
Rare Case ◽  
Histopathological Examination ◽  
Neck Region ◽  
Surgical Removal ◽  
Cystic Lesions ◽  
Head And Neck Region ◽  
Rare Case Report

<p class="abstract">In this case report a bony swelling was noticed clinically which had a cystic presentation in CT imaging. After surgical removal it was sent for histopathological examination and was diagnosed as dermoid cyst. Dermoid cyst is rarely encountered lesions of head and neck region so most frequently misdiagnosed. Though this lesion is very rare but should be considered as a differential diagnosis while evaluation cystic lesions of head and neck region.</p>

scholarly journals Pilomatricoma in the pinna: a case report

2018 ◽  
Vol 5 (1) ◽  
pp. 199
Author(s):  
C. J. Timna ◽  
D. Chandrika
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Hair Follicle ◽  
Histopathological Examination ◽  
Neck Region ◽  
Excision Biopsy ◽  
Skin Tumours ◽  
Head And Neck Region ◽  
Medial Surface ◽  
The Past

<p class="abstract">Benign calcifying epithelioma of Malherbe or pilomatricoma is rare benign skin tumours, typically seen in head and neck region. This is supposed to arise from hair follicle matrix cells. Though head and neck is the commonest area involved by this tumour, only 4.5% cases have been reported in the pinna. Neck is most commonly involved followed by cheek, scalp, pre auricular and peri orbital areas. Here we report a case of pilomatricoma over medial surface of pinna in a 20 years old female. She had the swelling which was gradually increasing for the past 5 years. Histopathological examination following excision biopsy confirmed the diagnosis.</p><p class="abstract"> </p>

Our Experience in Treating a Rare Clinical Case Angiomyomatous Hamartomas of Head and Neck Region; Case Report

2021 ◽  
Vol 1 (4) ◽  
Author(s):  
Hakobyan Gagik
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Surgical Excision ◽  
Final Diagnosis ◽  
External Carotid Artery ◽  
Unknown Etiology ◽  
External Carotid ◽  
Head And Neck Region ◽  
Neck Masses ◽  
Head And Neck Masses

Angiomyomatous hamartoma of head and neck region is very are disease, of unknown etiology and more often than not it can be misdiagnosed preoperatively. Materials and Methods: In a study we present a case of angiomyomatous hamartoma in the carotid triangle, a site where a tumor has an invasion to external carotid artery, treatment carried out by surgical excision, after histological examination, the final diagnosis was made. The patient was under observation for 3 years, there were no relapses. Conclusion: The diagnosis of angiomyomatous hamartoma is based on histologic examination. Although this entity is rare, we believe that head and neck surgeons should include it in the differential diagnosis of head and neck masses.

scholarly journals Giant Plexiform Schwannoma of the Tongue

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Lluís Nisa ◽  
Toni von Büren ◽  
Amine Tiab ◽  
Roland Giger
Keyword(s):  
Differential Diagnosis ◽  
Head And Neck ◽  
Benign Tumor ◽  
Histopathological Examination ◽  
Neck Region ◽  
Large Mass ◽  
Complete Resection ◽  
Head And Neck Region ◽  
Plexiform Schwannoma ◽  
Common Location

We present the case of a 38-year-old woman that presented with a very slowly enlarging mass of the tongue. MRI revealed a large mass originating in the tongue base and extending to the supraglottic space. Biopsy of this tumor confirmed the diagnosis of schwannoma. An endaural approach allowed complete resection of the tumor. Definitive histopathological examination showed a plexiform schwannoma. Schwannoma or neurilemoma represents a benign tumor potentially affecting any nerve. The head and neck region is a relatively common location for schwannomas, but tongue schwannomas are considered to be rare and pose the problem of both clinical and histological differential diagnosis of tongue masses.

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