scholarly journals ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Seong-Jong Lee ◽  
Jong-Min Han ◽  
Jin-Seok Lee ◽  
Chang-Gue Son ◽  
Hwi-Jin Im ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Serum Lipid ◽  
Peroxisome Proliferator ◽  
Metabolic Abnormalities ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Peroxisome Proliferator Activated Receptor ◽  
Stress Markers ◽  
And Oxidative Stress

The medicinal plantsArtemisia iwayomogi(A. iwayomogi) andCurcuma longa(C. longa) radix have been used to treat metabolic abnormalities in traditional Korean medicine and traditional Chinese medicine (TKM and TCM). In this study we evaluated the effect of the water extract of a mixture ofA. iwayomogiandC. longa(ACE) on high-fat diet-induced metabolic syndrome in a mouse model. Four groups of C57BL/6N male mice (except for the naive group) were fed a high-fat diet freely for 10 weeks. Among these, three groups (except the control group) were administered a high-fat diet supplemented with ACE (100 or 200 mg/kg) or curcumin (50 mg/kg). Body weight, accumulation of adipose tissues in abdomen and size of adipocytes, serum lipid profiles, hepatic steatosis, and oxidative stress markers were analyzed. ACE significantly reduced the body and peritoneal adipose tissue weights, serum lipid profiles (total cholesterol and triglycerides), glucose levels, hepatic lipid accumulation, and oxidative stress markers. ACE normalized lipid synthesis-associated gene expressions (peroxisome proliferator-activated receptor gamma, PPARγ; fatty acid synthase, FAS; sterol regulatory element-binding transcription factor-1c, SREBP-1c; and peroxisome proliferator-activated receptor alpha, PPARα). The results from this study suggest that ACE has the pharmaceutical potential reducing the metabolic abnormalities in an animal model.

scholarly journals Metabolic and oxidative stress markers in Wistar rats after 2 months on a high-fat diet

2014 ◽  
Vol 6 (1) ◽  
pp. 130 ◽  
Author(s):  
Nathalie Auberval ◽  
Stéphanie Dal ◽  
William Bietiger ◽  
Michel Pinget ◽  
Nathalie Jeandidier ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Stress Markers ◽  
And Oxidative Stress

Effect of a high sucrose and high fat diet in BDNF (+/-) mice on oxidative stress markers in adipose tissues

2019 ◽  
Vol 665 ◽  
pp. 46-56 ◽  
Author(s):  
Akın Bodur ◽  
İmran İnce ◽  
Cemil Kahraman ◽  
İsmail Abidin ◽  
Selcen Aydin-Abidin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Adipose Tissues ◽  
Stress Markers ◽  
High Sucrose

Effect Of Exercise Intensity On Postprandial Lipemia And Oxidative Stress Markers After A High-fat Meal

2016 ◽  
Vol 48 ◽  
pp. 818-819
Author(s):  
Renata L. Krüger ◽  
Bruno C. Teixeira ◽  
Juliano B. Farinha ◽  
Rodrigo C. O. Macedo ◽  
Gabriel A. Fonseca ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exercise Intensity ◽  
Postprandial Lipemia ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Stress Markers ◽  
And Oxidative Stress ◽  
Fat Meal

scholarly journals The Oxidative Stress Markers in the Erythrocytes and Heart Muscle of Obese Rats: Relate to a High-Fat Diet but Not to DJOS Bariatric Surgery

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 183 ◽  
Author(s):  
Bronisława Skrzep-Poloczek ◽  
Jakub Poloczek ◽  
Elżbieta Chełmecka ◽  
Agnieszka Dulska ◽  
Ewa Romuk ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bariatric Surgery ◽  
Heart Muscle ◽  
High Fat Diet ◽  
Glutathione Transferase ◽  
Control Diet ◽  
Oxidative Stress Markers ◽  
High Fat ◽  
Stress Markers ◽  
Gpx Activity

Obesity and high-fat diet (HF) are prevalent causes of oxidative stress (OS). Duodenal-jejunal omega switch (DJOS) is a bariatric procedure used for body mass reduction, extensively tested in animal models. We studied the long-term impact of bariatric surgery and an HF diet on the oxidative stress markers in erythrocytes and heart muscles of rats. We analyzed superoxide dismutase (SOD), catalase (CAT), glutathione transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx) activity and malondialdehyde (MDA) concentration in DJOS or SHAM (control) operated rats fed with different dietary protocols (control diet (CD) and high-fat diet (HF)), before and after the surgery (CD/CD, HF/HF, CD/HF, and HF/CD). We observed higher erythrocytes CAT, GST and GPx activity in DJOS-operated (vs. SHAM) rats fed with an HF/HF diet. For DJOS-operated rats, erythrocytes CAT and GPx activity and MDA concentration were significantly lower in CD/CD group. We observed increased heart muscle GR activity in SHAM-operated rats (vs. DJOS bariatric surgery) fed with an HF/HF diet. Change from HF to CD diet increased heart muscle GPx activity after DJOS bariatric surgery. Heart muscle SOD activity was lower in HF/HF and CD/CD groups after DJOS bariatric surgery (vs. SHAM). DJOS surgery significantly reduced heart muscle MDA concentration in HF/HF and HF/CD groups (vs. SHAM). We conclude that the selected dietary patterns had a stronger impact on oxidative stress markers in erythrocytes and heart muscle than DJOS bariatric surgery.

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