Macrophages and Uveitis in Experimental Animal Models
Keyword(s):
Resident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In the last few years, experimental animal models of uveitis have enabled us to enhance our understanding of the leading role of macrophages in eye inflammation processes, including macrophage polarization in experimental autoimmune uveoretinitis and the major role of Toll-like receptor 4 in endotoxin-induced uveitis. This improved knowledge should guide advantageous iterative research to establish mechanisms and possible therapeutic targets for human uveitis resolution.
2005 ◽
Vol 4
(3)
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pp. 297-317
2016 ◽
Vol 30
(1)
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pp. 75-85
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Keyword(s):
2016 ◽
Vol 311
(2)
◽
pp. E405-E422
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Keyword(s):
2020 ◽
Vol 10
(1)
◽
pp. 44-58
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2020 ◽
2020 ◽
Vol 318
(2)
◽
pp. L402-L404
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