scholarly journals Design, Materials, and Mechanobiology of Biodegradable Scaffolds for Bone Tissue Engineering

2015 ◽  
Vol 2015 ◽  
pp. 1-21 ◽  
Author(s):  
Marco A. Velasco ◽  
Carlos A. Narváez-Tovar ◽  
Diego A. Garzón-Alvarado
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Healing ◽  
Computational Models ◽  
Manufacturing Processes ◽  
Scaffold Design ◽  
Biodegradable Scaffolds ◽  
Design Materials

A review about design, manufacture, and mechanobiology of biodegradable scaffolds for bone tissue engineering is given. First, fundamental aspects about bone tissue engineering and considerations related to scaffold design are established. Second, issues related to scaffold biomaterials and manufacturing processes are discussed. Finally, mechanobiology of bone tissue and computational models developed for simulating how bone healing occurs inside a scaffold are described.

scholarly journals 3D-Bioprinting Strategies Based on In Situ Bone-Healing Mechanism for Vascularized Bone Tissue Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 287
Author(s):  
Ye Lin Park ◽  
Kiwon Park ◽  
Jae Min Cha
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Healing ◽  
Critical Size ◽  
Current Knowledge ◽  
3D Bioprinting ◽  
The Past ◽  
Regeneration Processes

Over the past decades, a number of bone tissue engineering (BTE) approaches have been developed to address substantial challenges in the management of critical size bone defects. Although the majority of BTE strategies developed in the laboratory have been limited due to lack of clinical relevance in translation, primary prerequisites for the construction of vascularized functional bone grafts have gained confidence owing to the accumulated knowledge of the osteogenic, osteoinductive, and osteoconductive properties of mesenchymal stem cells and bone-relevant biomaterials that reflect bone-healing mechanisms. In this review, we summarize the current knowledge of bone-healing mechanisms focusing on the details that should be embodied in the development of vascularized BTE, and discuss promising strategies based on 3D-bioprinting technologies that efficiently coalesce the abovementioned main features in bone-healing systems, which comprehensively interact during the bone regeneration processes.

Combination of bone tissue engineering and BMP-2 gene transfection promotes bone healing in osteoporotic rats

2008 ◽  
Vol 32 (9) ◽  
pp. 1150-1157 ◽  
Author(s):  
Youchao Tang ◽  
Wei Tang ◽  
Yunfeng Lin ◽  
Jie Long ◽  
Hang Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Healing ◽  
Gene Transfection

Optimization of scaffold design for bone tissue engineering: A computational and experimental study

2014 ◽  
Vol 36 (4) ◽  
pp. 448-457 ◽  
Author(s):  
Marta R. Dias ◽  
José M. Guedes ◽  
Colleen L. Flanagan ◽  
Scott J. Hollister ◽  
Paulo R. Fernandes
Keyword(s):  
Tissue Engineering ◽  
Experimental Study ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Scaffold Design

New fabrication methods of bioactive and biodegradable scaffolds for bone tissue engineering

2011 ◽  
Vol 47 (3) ◽  
pp. 261-270 ◽  
Author(s):  
Youngmee Jung ◽  
Su Hee Kim ◽  
Sang-Heon Kim ◽  
Soo Hyun Kim
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Porous Polymer ◽  
Cellular Interaction ◽  
Solvent Casting ◽  
Polymer Scaffolds ◽  
Casting Method ◽  
Biodegradable Scaffolds ◽  
Sintering Method

Bioceramic and polymers have been used as matrices for bone tissue engineering, and successful bone regeneration depends on cellular interaction with these matrices. The aim of this study was to fabricate polymer/ceramics composites with a novel sintering method. Also, we prepared homogenous porous poly(lactide-co-glycolide (PLGA) scaffolds in the supercritical CO2. These scaffolds had homogenous porous structure and high tensile and compressive mechanical properties compared to the scaffold prepared by conventional solvent casting method. This study revealed that generating bioactive and porous polymer scaffolds with novel sintering method or supercritical fluid technique could be useful for bone tissue engineering.

scholarly journals Life Cycle Assessment of 3D-Printed Bone Tissue Engineering Scaffolds

2021 ◽  
Author(s):  
Nurul Ainina Nadhirah Tajurahim ◽  
Salwa Mahmood ◽  
Muhamad Zameri Mat Saman ◽  
Nor Hasrul Akhmal Ngadiman
Keyword(s):  
Tissue Engineering ◽  
Life Cycle ◽  
Environmental Impact ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Manufacturing Process ◽  
Manufacturing Processes ◽  
Tissue Engineering Scaffolds ◽  
Printing Technology ◽  
Material Resources

Abstract The bone tissue engineering scaffolds are one of the methods to repairing bone defects caused by various factors. According to modern tissue engineering technology, three-dimensional (3D) printing technology for bone tissue engineering provides a temporary basis for the creation of biological replacements. Through the generated 3D bone tissue engineering scaffolds from previous studies, the assessment to evaluate the environmental impact has shown less attention in research. Purposes — The main purpose of this research at developing the life cycle assessment (LCA) Model for 3D bone tissue engineering scaffolds of 3D gel-printing technology and present the analysis technique of LCA from cradle-to-gate to assess the environmental impacts from material selection and manufacturing processes. LCA is indeed a valuable tool for conducting a complete environmental impact assessment of 3D bone tissue engineering scaffolds. Method — The methodology of this research is based on the LCA Model through the application of GaBi software according to ISO 14040 standards. The parameters for the developed LCA Model were determined through the system boundaries of 3D gel-printing technology. Acrylamide, citric acid, N,N-Dimethylaminopropyl acrylamide, deionized water, and 2-Hydroxyethyl acrylate were selected as the material resources. Meanwhile, the 3D gel-printing technology was used as the manufacturing processes in the system boundary. Besides, consideration of LCA Model was given to all phases of LCA approach set out in the regulatory framework. The analytical findings are presented through graphs generated by GaBi software based on the inventory of each material and manufacturing process used. Results — The environmental impact was assessed in the 3D gel-printing technology and the result obtained showed the environmental impact of global warming potential (GWP). All of the emissions contribute to GWP have been identified such as emission to air, freshwater, seawater, and industrial soil. The quantity of flows that contributes to GWP comes from electricity consumption, manufacturing process, and material resources. Conclusions — The input data is understood to be resources required whereas, the output is the emission of the different compartments such as emission to air, water, and soil. The issue of GWP is represented by the GWP impacts category. Any emissions to air, water, and soil that contributes to GWP are classified as contributors. Throughout the results, it can be described that the impact category in the system comes from the linking process of specific resources to the specific environmental issue. Thus, it is believed that the development of LCA Model is very helpful to graphically assess the potential environmental impact associated with the material and manufacturing processes of a product’s life cycle. Besides, the data analysis of the results is expected to use for improving the performance at the material and manufacturing process of the product life cycle. Also, it is to makes the production process more environmentally friendly.

scholarly journals A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering

2018 ◽  
Vol 7 (3) ◽  
pp. 232-243 ◽  
Author(s):  
T. Winkler ◽  
F. A. Sass ◽  
G. N. Duda ◽  
K. Schmidt-Bleek
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Bone Defect ◽  
Bone Healing ◽  
Lessons Learned ◽  
Form And Function ◽  
Defect Healing ◽  
Bone Defect Healing

Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be challenged by a multitude of pathological conditions. While innovative approaches have helped to unravel the cascades of bone healing, this knowledge has so far not improved the clinical outcomes of bone defect treatment. Recent findings have allowed us to gain in-depth knowledge about the physiological conditions and biological principles of bone regeneration. Now it is time to transfer the lessons learned from bone healing to the challenging scenarios in defects and employ innovative technologies to enable biomaterial-based strategies for bone defect healing. This review aims to provide an overview on endogenous cascades of bone material formation and how these are transferred to new perspectives in biomaterial-driven approaches in bone regeneration. Cite this article: T. Winkler, F. A. Sass, G. N. Duda, K. Schmidt-Bleek. A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge. Bone Joint Res 2018;7:232–243. DOI: 10.1302/2046-3758.73.BJR-2017-0270.R1.

scholarly journals Optimal mechanical properties of a scaffold for cartilage regeneration using finite element analysis

2019 ◽  
Vol 10 ◽  
pp. 204173141983213 ◽  
Author(s):  
Yong-Gon Koh ◽  
Jin-Ah Lee ◽  
Yong Sang Kim ◽  
Hwa Yong Lee ◽  
Hyo Jeong Kim ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Computational Models ◽  
Cartilage Regeneration ◽  
Cartilage Tissue ◽  
Regulation Theory ◽  
Régulation Theory ◽  
Specific Loading

The development of successful scaffolds for bone tissue engineering requires concurrent engineering that combines different research fields. In previous studies, phenomenological computational models predicted the mechanical properties of a scaffold in a simple loading condition using the mechano-regulation theory. Therefore, the aim of this study is to predict the mechanical properties of an optimum scaffold required for cartilage regeneration using three-dimensional knee joint developed from medical imaging and mechano-regulation theory. It was predicted that the scaffold with optimal mechanical properties would result in greater amounts of cartilage tissue formation than without a scaffold. The results demonstrated the ability of the algorithms to design optimized scaffolds with target properties and confirmed the applicability of set techniques for bone tissue engineering. The scaffolds were optimized to suit the site-specific loading requirements, and the results reveal a new approach for computational simulations in tissue engineering.

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