scholarly journals Prescription of Antibiotics to Treat Gonorrhoea in General Practice in Flanders 2009–2013: A Registry-Based Retrospective Cohort Study

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Christoph Schweikardt ◽  
Geert Goderis ◽  
Steven Elli ◽  
Yves Coppieters
Keyword(s):  
General Practice ◽  
Cohort Study ◽  
Combination Therapy ◽  
Electronic Health Record ◽  
General Practitioners ◽  
Guideline Adherence ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Treatment Guidelines ◽  
Health Record

Background. General practitioners (GPs) as a group have been identified as playing an important role in gonorrhoea management in Flanders. Belgian guidelines recommended ceftriaxone or alternatively spectinomycin from 2008 onwards and azithromycin combination therapy since 2012. Objectives. This study investigates to which extent contemporary gonorrhoea treatment guidelines were followed. Methods. A retrospective cohort study (2009–2013) of antibiotic prescriptions for gonorrhoea cases registered in the Flemish Intego general practice database was carried out. The database is based on electronic health record routine registration by over 90 GPs using the software programme Medidoc. Results. Ninety-one gonorrhoea cases with ten chlamydia and one genital trichomonas coinfections in 90 patients were registered between 2009 and 2013. The proportion of cases with ceftriaxone and/or spectinomycin prescriptions rose from 13% (two of 15 cases) in 2009 to 56% (nine of 16 cases) in 2013. Combination therapy of ceftriaxone and/or spectinomycin together with azithromycin rose from 0 of 15 cases (0%) in 2009 to 7 of 16 cases (44%) in 2013. Conclusion. Although numbers are small, the results suggest that gonorrhoea therapy guideline adherence improved between 2009 and 2013.

scholarly journals Stratifying risk for dementia onset using large‐scale electronic health record data: A retrospective cohort study

2020 ◽  
Vol 16 (3) ◽  
pp. 531-540 ◽  
Author(s):  
Thomas H. McCoy ◽  
Larry Han ◽  
Amelia M. Pellegrini ◽  
Rudolph E. Tanzi ◽  
Sabina Berretta ◽  
...  
Keyword(s):  
Cohort Study ◽  
Electronic Health Record ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Large Scale ◽  
Health Record ◽  
Electronic Health Record Data ◽  
Record Data ◽  
Electronic Health ◽  
Dementia Onset

scholarly journals Pediatric BMI changes during COVID-19 pandemic: An electronic health record-based retrospective cohort study

2021 ◽  
Vol 38 ◽  
pp. 101026
Author(s):  
Corinne G. Brooks ◽  
Jessica R. Spencer ◽  
J. Michael Sprafka ◽  
Kimberly A. Roehl ◽  
Junjie Ma ◽  
...  
Keyword(s):  
Cohort Study ◽  
Electronic Health Record ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Health Record ◽  
Electronic Health

scholarly journals Identifying prevalence and risk factors for metformin non-persistence: a retrospective cohort study using an electronic health record

BMJ Open ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. e021505 ◽  
Author(s):  
James H Flory ◽  
Scott Justin Keating ◽  
David Siscovick ◽  
Alvin I Mushlin
Keyword(s):  
Cohort Study ◽  
Electronic Health Record ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Index Date ◽  
Secondary Outcome ◽  
Health Record ◽  
Electronic Health Record Data ◽  
Electronic Health

ObjectivesNon-persistence may be a significant barrier to the use of metformin. Our objective was to assess reasons for metformin non-persistence, and whether initial metformin dosing or use of extended release (ER) formulations affect persistence to metformin therapy.DesignRetrospective cohort study.SettingElectronic health record data from a network of urban academic practices.ParticipantsThe cohort was restricted to individuals receiving a metformin prescription between 2009/1/1 and 2015/9/31, under care for at least 6 months before the first prescription of metformin. The cohort was further restricted to patients with no evidence of any antihyperglycaemic agent use prior to the index date, an haemoglobin A1c measured within 1 month prior to or 1 week after the index date, at least 6 months of follow-up, and with the initial metformin prescription originating in either a general medicine or endocrinology clinic.Primary and secondary outcome measuresThe primary outcome measure was early non-persistence, as defined by the absence of further prescriptions for metformin after the first 90 days of follow-up.ResultsThe final cohort consisted of 1259 eligible individuals. The overall rate of early non-persistence was 20.3%. Initial use of ER and low starting dose metformin were associated with significantly lower rates of reported side effects and non-persistence, but after multivariable analysis, only use of low starting doses was independently associated with improved persistence (adjusted OR 0.54, 95% CI 0.37 to 0.76, for comparison of 500 mg daily dose or less to all higher doses).ConclusionsThese data support the routine prescribing of low starting doses of metformin as a tool to improve persistence. In this study setting, many providers routinely used ER metformin as an initial treatment; while this practice may have benefits, it deserves more rigorous study to assess whether increased costs are justified.

scholarly journals Suspected cow’s milk allergy in everyday general practice: a retrospective cohort study on health care burden and guideline adherence

2014 ◽  
Vol 7 (1) ◽  
pp. 507 ◽  
Author(s):  
Sharayke C T A van den Hoogen ◽  
Alma C van de Pol ◽  
Yolanda Meijer ◽  
Jaap Toet ◽  
Céline van Klei ◽  
...  
Keyword(s):  
Health Care ◽  
General Practice ◽  
Cohort Study ◽  
Guideline Adherence ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Care Burden ◽  
Health Care Burden

scholarly journals The incidence and prevalence of inflammatory bowel disease in UK primary care: a retrospective cohort study of the IQVIA Medical Research Database

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Karoline Freeman ◽  
Ronan Ryan ◽  
Nicholas Parsons ◽  
Sian Taylor-Phillips ◽  
Brian H. Willis ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
General Practice ◽  
Cohort Study ◽  
Medical Research ◽  
Bowel Disease ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Research Database ◽  
Care Providers ◽  
Inflammatory Bowel

Abstract Background Our knowledge of the incidence and prevalence of inflammatory bowel disease (IBD) is uncertain. Recent studies reported an increase in prevalence. However, they excluded a high proportion of ambiguous cases from general practice. Estimates are needed to inform health care providers who plan the provision of services for IBD patients. We aimed to estimate the IBD incidence and prevalence in UK general practice. Methods We undertook a retrospective cohort study of routine electronic health records from the IQVIA Medical Research Database covering 14 million patients. Adult patients from 2006 to 2016 were included. IBD was defined as an IBD related Read code or record of IBD specific medication. Annual incidence and 12-month period prevalence were calculated. Results The prevalence of IBD increased between 2006 and 2016 from 106.2 (95% CI 105.2–107.3) to 142.1 (95% CI 140.7–143.5) IBD cases per 10,000 patients which is a 33.8% increase. Incidence varied across the years. The incidence across the full study period was 69.5 (95% CI 68.6–70.4) per 100,000 person years. Conclusions In this large study we found higher estimates of IBD incidence and prevalence than previously reported. Estimates are highly dependent on definitions of disease and previously may have been underestimated.

scholarly journals Incident somatic comorbidity after psychosis: results from a retrospective cohort study based on Flemish general practice data

2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Carla Truyers ◽  
Frank Buntinx ◽  
Jan De Lepeleire ◽  
Marc De Hert ◽  
Ruud Van Winkel ◽  
...  
Keyword(s):  
General Practice ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Somatic Comorbidity
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