scholarly journals The Effect of Genetically Modified Food on Infertility Indices: A Systematic Review Study

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Parisa Keshani ◽  
Mohammad Hossein Sharifi ◽  
Mohammad Reza Heydari ◽  
Hassan Joulaei
Keyword(s):  
Systematic Review ◽  
Adverse Effects ◽  
Sperm Motility ◽  
Genetically Modified ◽  
Sperm Head ◽  
Gm Crops ◽  
Control Group ◽  
Gm Crop ◽  
Gm Plants ◽  
Sperm Abnormality

Background and Objectives. With the increase in the growth of genetically modified (GM) crops, concerns as to the adverse effects of GM crops have risen in the community. The present systematic review seeks to assess the GM plants’ potential impacts on the sperm parameters, including sperm head, sperm motility, sperm abnormality, and fertility index. Materials and Methods. A structured literature search was independently performed by three authors on Scopus, Web of Science, PubMed, and Embase in January 2019. A total of 1467 publications were obtained by the search strategy after eliminating the duplicates. Moreover, the review only included articles written in English language. Other pertinent peer-reviewed publications were chosen (“snowballing”) from the reference lists in the selected publications. To assess the GM crop effects on infertility, experimental studies designed with the control group were selected. On the basis of abstract screening and full-text reviewing, 39 relevant publications were selected, seven of which were used in our review. To access the quality of articles, we used the Cochrane checklist. The collected articles were scored independently by three authors, and the publications with the eligibility criteria were included in our review. No article was excluded due to quality assessment. Results and Conclusion. Our findings indicated that GM products had no adverse effects on infertility indices such as the sperm head, sperm motility, sperm abnormality, and fertility indices. Long-term research still seems to be strongly necessary to ensure that the use of GM plants does not cause any harm to consumers, especially in infertility area.

BRAZILIAN GMO REGULATION: DOES IT HAVE AN ENVIRONMENTAL APPROACH?

2012 ◽  
Vol 14 (02) ◽  
pp. 1250013 ◽  
Author(s):  
DENISE GALLO PIZELLA ◽  
MARCELO PEREIRA DE SOUZA
Keyword(s):  
Decision Making ◽  
Risk Analysis ◽  
Environmental Impacts ◽  
Genetically Modified ◽  
Genetically Modified Crops ◽  
Gm Crops ◽  
Gm Crop ◽  
Institutional Issues ◽  
Institutional Aspects ◽  
Biosafety Evaluation

Brazil is the second largest producer of genetically modified crops (GM crops) and the National Technical Commission on Biosafety (CTNBio) the decision making agency on this matter. The country uses Risk Analysis (RA) and project EIA as tools for biosafety evaluation. This paper aims to review the appropriateness of these tools for evaluating the environmental impacts of GM crops, also considering institutional aspects. An overview of the process of release of GM crops in Brazil along with important operational and institutional aspects is provided. The results indicate that project EIA could be applied to GM crops in specific sites and RA could give support to the evaluation of GM crop itself. Regarding institutional issues, it is concluded that decisions should be made by the environmental bodies, and not by the CTNBio.

Vitamin C ameliorates the adverse effects of dexamethasone on sperm motility, testosterone level, and spermatogenesis indexes in mice

2018 ◽  
Vol 38 (4) ◽  
pp. 409-418 ◽  
Author(s):  
F Sadeghzadeh ◽  
MS Mehranjani ◽  
M Mahmoodi
Keyword(s):  
Adverse Effects ◽  
Vitamin C ◽  
Sperm Motility ◽  
Testosterone Level ◽  
Leydig Cells ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Control Group ◽  
The Mean ◽  
Vit C

Background: Dexamethasone (DEX) is a common medicine that is capable of causing malformation in the male reproductive system. The aim of this study was to investigate the effect of vitamin C (Vit-C) on spermatogenesis indexes and daily sperm production (DSP) in adult mice treated with DEX. Methods: Male Naval Medical Research Institute (NMRI) mice were divided into four groups: Control, DEX (7 mg/kg/day), Vit-C (100 mg/kg/day), and DEX +Vit-C and treated for 7 days with intraperitoneal injection. Results: A significant increase in the mean levels of serum and tissue malondialdehyde (MDA) and apoptosis of Leydig cells was found in the DEX group compared to the control group. Sperm motility, DSP, tubular differentiation index, meiotic index, spermatogenesis index, the mean number of spermatocytes, round and long spermatids, and Leydig cells, and also serum testosterone level decreased in the DEX group compared to the control group. The results of this study indicate that Vit-C can significantly prevent the adverse effects of DEX on the mean number of spermatocyte, spermatid, and Leydig cells, tubular differentiation, meiotic and spermatogenesis index, DSP, sperm motility, and the mean levels of serum MDA. Conclusion: In conclusion, our results showed that coadministration of Vit-C and DEX prevents the adverse effects of DEX on the spermatogenesis indexes and DSP.

scholarly journals Effect of Tramadol on Sperm Profile of Male Albino Rats

2019 ◽  
pp. 1-6
Author(s):  
I. S. Esua ◽  
U. U. Uno ◽  
U. B. Ekaluo
Keyword(s):  
Sperm Motility ◽  
Sperm Count ◽  
Sperm Head ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Dependent Manner ◽  
Sperm Viability ◽  
Albino Rat ◽  
Significant Difference

Background and Aim: Tramadol is a potent analgesic effective in the treatment of mild to severe pains. However, the use of the drug can pose a threat to other organs and systems. Therefore, this study evaluated the effect of graded doses of tramadol on sperm profile of male albino rats. Materials and Methods: Eighteen male rats were divided into three groups (A, B and C) using completely randomized design (CRD) with six rats in each group. Rats in group A served as the control group and were given just food and water while groups B and C were given tramadol at 50 and 100 mg/kg body weight (BW) respectively, daily for the period of 65 days. The treatment was administered via oral gavage and at the end of the treatments, the rats were sacrificed. Immediately after sacrifice, a puncture was made in the epididymis with a sterile pin and examined for semen pH. The epididymes were processed for epididymal sperm motility, viability, count and sperm head abnormality. Results: There was no significant difference in the weight of testes and semen pH. Sperm viability, sperm motility, sperm count and weight of epididymes significantly reduced (p<0.05) in tramadol treated animals when compared with the control. Results also indicated statistically significant (p<0.05) increase in sperm head abnormalities in rats treated with tramadol when compared with the control. Conclusion: The results obtained from this study reveal that tramadol has negative effects on weight of epididymes, sperm count, sperm viability, sperm motility and sperm head abnormalities in male albino rat as mammalian models in a dose dependent manner.

Modeling gene flow from genetically modified plants.

2021 ◽  
pp. 103-117
Author(s):  
Wei Wei ◽  
Jun-Ming Wang ◽  
Xiang-Cheng Mi ◽  
Yan-Da Li ◽  
Yan-Ming Zhu
Keyword(s):  
Gene Flow ◽  
Genetically Modified ◽  
Predictive Ability ◽  
Crop Wild Relatives ◽  
Gm Crops ◽  
Wild Plants ◽  
Experimental Conditions ◽  
Flow Models ◽  
Herbicide Resistant ◽  
Gm Plants

Abstract Gene flow from genetically modified (GM) plants is concerning because of its ecological risks. In modeling studies, these risks may be reduced by altering crop management while taking environmental conditions into account. Gene flow modeling should consider many field aspects, both biological and physical. For example, empirical statistical models deduced from experimental data simulate gene flow well only under limited conditions (similar to experimental conditions). Mechanistic models, however, offer a potentially greater predictive ability. Gene flow models from GM crops to non-GM crops are used to simulate field conditions and minimize the adventitious presence of transgenes to meet certain threshold levels. These models can be adapted to simulate gene flow from GM crops to crop wild relatives using parameters of sexual compatibility and growth characteristics of the wild plants. Currently, modeling gene flow from herbicide-resistant weeds has become very important in light of the increased application of herbicides and widely evolved resistance in weeds.

scholarly journals Optimizing the Use of Zebrafish Feeding Trials for the Safety Evaluation of Genetically Modified Crops

2019 ◽  
Vol 20 (6) ◽  
pp. 1472 ◽  
Author(s):  
Isabelle Gabriëls ◽  
Lucia Vergauwen ◽  
Marthe De Boevre ◽  
Stefan Van Dongen ◽  
Ronny Blust ◽  
...  
Keyword(s):  
Genetically Modified ◽  
Safety Evaluation ◽  
Potential Effect ◽  
Gm Crops ◽  
Equivalence Testing ◽  
Oral Toxicity ◽  
Gm Crop ◽  
Natural Response ◽  
Feeding Trials ◽  
Response Variation

In Europe, the toxicological safety of genetically modified (GM) crops is routinely evaluated using rodent feeding trials, originally designed for testing oral toxicity of chemical compounds. We aimed to develop and optimize methods for advancing the use of zebrafish feeding trials for the safety evaluation of GM crops, using maize as a case study. In a first step, we evaluated the effect of different maize substitution levels. Our results demonstrate the need for preliminary testing to assess potential feed component-related effects on the overall nutritional balance. Next, since a potential effect of a GM crop should ideally be interpreted relative to the natural response variation (i.e., the range of biological values that is considered normal for a particular endpoint) in order to assess the toxicological relevance, we established natural response variation datasets for various zebrafish endpoints. We applied equivalence testing to calculate threshold equivalence limits (ELs) based on the natural response variation as a method for quantifying the range within which a GM crop and its control are considered equivalent. Finally, our results illustrate that the use of commercial control diets (CCDs) and null segregant (NS) controls (helpful for assessing potential effects of the transformation process) would be valuable additions to GM safety assessment strategies.

scholarly journals The perception of genetically modified plants by farmers in Szabolcs-Szatmár-Bereg County, Hungary

2021 ◽  
pp. 73-77
Keyword(s):  
Agricultural Education ◽  
Genetically Modified ◽  
Multiple Choice ◽  
Gm Crops ◽  
Multiple Choice Questions ◽  
Relevant Difference ◽  
Gm Plants ◽  
Gender Education ◽  
The Impact ◽  
Traditional Crops

In this account we report a study that surveyed and quantified the opinion on the acceptability of genetically modified (GM) crops by farmers working in Szabolcs-Szatmár-Bereg County located in North Easter Hungary. Authors answered the question whether there is a difference in perception and reasoning of the county’s agricultural workers regarding GM crops. We evaluated the impact of age, gender, education, and agricultural education of responders on rating GM plants to be more dangerous than traditional crops. Is there a relevant difference when responders are administered multiple choice questions, rather than single choice questions? Can we change farmers’ position on the GM technology by using multiple choice questions?

scholarly journals Well informed Farmers and Consumers are positive about GM Crops in Europe and Africa

Afrika Focus ◽  
2019 ◽  
Vol 32 (2) ◽  
Author(s):  
G. Gheysen ◽  
J. Maes ◽  
M. Valcke ◽  
E.I.R. Sanou ◽  
S. Speelman ◽  
...  
Keyword(s):  
Key Words ◽  
Genetically Modified ◽  
Gm Crops ◽  
The Political ◽  
Policy Makers ◽  
Gm Crop ◽  
Crop Cultivation ◽  
Gm Food ◽  
Public Reaction ◽  
The Eu

Genetically modified (GM) crops are cultivated globally on more than 185 million hectares, but the use of GM crops in Europe and Africa is very limited. Politicians are reluctant to allow such crops because they fear negative public reaction. The political hostility in the EU towards GM crops also has a significant impact on how African policy makers form their opinions for accepting GM crops in their own countries. However, studies reveal that specific types of GM food are welcomed by consumers and that few Europeans avoid GM labels when buying food. Similarly, African farmers and consumers are generally positive about GM crops. Policy makers should take these results into account when a decision needs to be made on whether or not to allow GM crop cultivation in their country. KEY WORDS: ACCEPTANCE, AFRICA, CONSUMERS, EUROPE, FARMERS, GM CROPS

scholarly journals Assessing the Allergenicity of Proteins Introduced into Genetically Modified Crops Using Specific Human IgE Assays

2004 ◽  
Vol 87 (6) ◽  
pp. 1423-1432 ◽  
Author(s):  
Richard E Goodman ◽  
John N Leach
Keyword(s):  
Genetically Modified ◽  
Safety Evaluation ◽  
Genetically Modified Crops ◽  
Specific Ige ◽  
Detection Sensitivity ◽  
Gm Crops ◽  
Enzyme Linked Immunosorbent Assay ◽  
Gm Crop ◽  
Crop Varieties ◽  
Specificity Of Binding

Abstract Global commercial production of genetically modified (GM) crops has grown to over 67 million hectares annually, primarily of herbicide-tolerant and insect protection crop varieties. GM crops are produced by the insertion of specific genes that either encode a protein, or a regulatory RNA sequence. A comprehensive safety evaluation is conducted for each new commercial GM crop, including an assessment of the potential allergenicity of any newly introduced protein. If the gene was derived from an allergenic organism, or the protein sequence is highly similar to a known allergen, immunoassays, e.g., Western blot assays and enzyme-linked immunosorbent assay tests, are performed to identify protein-specific IgE binding by sera of individuals allergic to the gene source, or the source of the sequence-matched allergen. Although such assays are commonly used to identify previously unknown allergens, criteria have not been established to demonstrate that a protein is unlikely to cause allergic reactions. This review discusses factors that affect the predictive value of these tests, including clinical selection criteria for serum donors, selection of blocking reagents to reduce nonspecific antibody binding, inhibition assays to verify specificity of binding, and scientifically justified limits of detection (sensitivity) in the absence of information regarding biological thresholds.

Genetically Modified Crops in Asia Pacific

2021 ◽  
Keyword(s):  
Cropping Systems ◽  
Genetically Modified ◽  
Genetically Modified Crops ◽  
Asia Pacific ◽  
Gm Crops ◽  
Bt Cotton ◽  
Pacific Region ◽  
Asia Pacific Region ◽  
Gm Crop ◽  
Food Needs

Meeting future food needs without compromising environmental integrity is a central challenge for agriculture globally but especially for the Asia Pacific region – where 60% of the global population, including some of the world’s poorest, live on only 30% of the land mass. To guarantee the food security of this and other regions, growers worldwide are rapidly adopting genetically modified (GM) crops as the forerunner to protect against many biotic and abiotic stresses. Asia Pacific countries play an important role in this, with India, China and Pakistan appearing in the top 10 countries with acreage of GM crops, primarily devoted to Bt cotton. Genetically Modified Crops in Asia Pacific discusses the progress of GM crop adoption across the Asia Pacific region over the past two decades, including research, development, adoption and sustainability, as well as the cultivation of insect resistant Bt brinjal, drought-tolerant sugarcane, late blight resistant potato and biotech rice more specific to this region. Regulatory efforts of the Asia Pacific member nations to ensure the safety of GM crops to both humans and the environment are also outlined to provide impetus in other countries initiating biotech crops. The authors also probe into some aspects of gene editing and nanobiotechnology to expand the scope into next generation GM crops, including the potential to grow crops in acidic soil, reduce methane production, remove poisonous elements from plants and improve overall nutritional quality. Genetically Modified Crops in Asia Pacific provides a comprehensive reference not only for academics, researchers and private sectors in crop systems but also policy makers in the Asia Pacific region. Beyond this region, readers will benefit from understanding how GM crops have been integrated into many different countries and, in particular, the effects of the take-up of GM cropping systems by farmers with different socioeconomic backgrounds.

scholarly journals Energy Drinks and Their Adverse Health Effects: A Systematic Review and Meta-analysis

2020 ◽  
pp. 194173812094918
Author(s):  
Ibrahim M. Nadeem ◽  
Ajaykumar Shanmugaraj ◽  
Seaher Sakha ◽  
Nolan S. Horner ◽  
Olufemi R. Ayeni ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Effects ◽  
Adverse Events ◽  
Pediatric Population ◽  
Adult Population ◽  
Energy Drinks ◽  
Energy Drink ◽  
Control Group ◽  
Pertinent Data ◽  
Energy Drink Consumption

Context: Energy drinks are the fastest growing product in the beverage industry. However, there is concern regarding potential for adverse effects with use. Objective: To evaluate the reported adverse effects of energy drink consumption. Data Sources: The electronic databases MEDLINE, EMBASE, and PubMed were searched for relevant studies from inception to November 2019, and pertinent data were abstracted. Study Selection: Only clinical studies reporting adverse events after energy drink consumption were included. Study Design: Systematic review. Level of Evidence: Level 4. Data Extraction: Data regarding sample size characteristics, energy drink characteristics, comparators, and all adverse events were extracted in duplicate and recorded. Results: A total of 32 studies and 96,549 individuals were included. Frequently reported adverse events in the pediatric population were insomnia (35.4%), stress (35.4%), and depressive mood (23.1%). Frequently reported adverse events in the adult population were insomnia (24.7%), jitteriness/restlessness/shaking hands (29.8%), and gastrointestinal upset (21.6%). Alcohol mixed with energy drinks significantly reduced the likelihood of sedation effects but increased the likelihood of stimulatory effects. Energy drink consumption significantly increased the odds of insomnia (OR, 5.02; 95% CI, 1.72-14.63) and jitteriness/activeness (OR, 3.52; 95% CI, 1.28-9.67) compared with the control group. Conclusion: The authors recommend that individuals avoid frequent energy drink consumption (5-7 energy drinks/week) and avoid co-consumption with alcohol; increased regulatory standards should be placed in the sale of energy drinks, particularly with regard to the pediatric population.

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