Quantitative Parameters of Contrast-Enhanced Ultrasound Combined with Lung Biopsy Were Used to Evaluate the Benign and Malignant Lesions around the Lungs

In recent years, due to the influence of living habits and smoking, the number of lung cancer patients worldwide has increased year by year, and it has gradually developed into one of the common diseases endangering human life. CEUS can observe the lesion and realize the rapid identification of the location of the active area of the lesion. CEUS is the abbreviation of contrast-enhanced ultrasound technology. Contrast-enhanced ultrasound technology is to inject ultrasound contrast agent through a peripheral vein to perform ultrasound exploration to observe the enhancement of the internal nodules. Compared with color ultrasound, it can diagnose more accurately and improve the inspection effect. At present, this technology is used for the diagnosis of many types of space-occupying lesions, but it is rarely used for the diagnosis of lung lesions. The purpose of this study is to explore the role of CEUS quantitative parameters combined with lung biopsy in the assessment of benign and malignant peripheral lung diseases. Based on the relevant theoretical basis of CEUS and lung biopsy, 158 patients with peripheral lung disease were selected as experimental subjects, and they were divided into experimental group and control group for comparative experiments. Experiments proved the effectiveness of CEUS quantitative parameters combined with lung biopsy methods. The experimental results showed that, compared with the benign group, the time-intensity curve, the rise time, and the peak time of the malignant lesions were significantly prolonged. In addition, CEUS combined with the quantitative parameters of lung biopsy can effectively distinguish the activity of lung lesions and the site of necrosis and promote the effective increase of the positive rate of lung biopsy.

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Contrast-enhanced ultrasound (CEUS) for the study of peripheral lung lesions: A preliminary study

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2006.06.018 ◽

2006 ◽

Vol 32 (10) ◽

pp. 1467-1472 ◽

Cited By ~ 27

Author(s):

Marco Sperandeo ◽

Giuseppe Sperandeo ◽

Antonio Varriale ◽

Paola Filabozzi ◽

Marco Decuzzi ◽

...

Keyword(s):

Contrast Enhanced Ultrasound ◽

Lung Lesions ◽

Contrast Enhanced ◽

Peripheral Lung ◽

Preliminary Study

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Quantitative Analysis of the Time–Intensity Curve of Contrast-Enhanced Ultrasound of the Liver: Differentiation of Benign and Malignant Liver Lesions

Diagnostics ◽

10.3390/diagnostics11071244 ◽

2021 ◽

Vol 11 (7) ◽

pp. 1244

Author(s):

Sonja Schwarz ◽

Dirk-André Clevert ◽

Michael Ingrisch ◽

Thomas Geyer ◽

Vincent Schwarze ◽

...

Keyword(s):

Logistic Regression ◽

Diagnostic Accuracy ◽

Late Phase ◽

Focal Liver Lesions ◽

Liver Lesions ◽

Contrast Enhanced Ultrasound ◽

Contrast Enhanced ◽

Malignant Lesions ◽

Benign Liver ◽

Benign Liver Lesions

Background: To evaluate the diagnostic accuracy of quantitative perfusion parameters in contrast-enhanced ultrasound to differentiate malignant from benign liver lesions. Methods: In this retrospective study 134 patients with a total of 139 focal liver lesions were included who underwent contrast enhanced ultrasound (CEUS) between 2008 and 2018. All examinations were performed by a single radiologist with more than 15 years of experience using a second-generation blood pool contrast agent. The standard of reference was histopathology (n = 60), MRI or CT (n = 75) or long-term CEUS follow up (n = 4). For post processing regions of interests were drawn both inside of target lesions and the liver background. Time–intensity curves were fitted to the CEUS DICOM dataset and the rise time (RT) of contrast enhancement until peak enhancement, and a late-phase ratio (LPR) of signal intensities within the lesion and the background tissue, were calculated and compared between malignant and benign liver lesion using Student’s t-test. Quantitative parameters were evaluated with respect to their diagnostic accuracy using receiver operator characteristic curves. Both features were then combined in a logistic regression model and the cumulated accuracy was assessed. Results: RT of benign lesions (14.8 ± 13.8 s, p = 0.005), and in a subgroup analysis, particular hemangiomas (23.4 ± 16.2 s, p < 0.001) differed significantly to malignant lesions (9.3 ± 3.8 s). The LPR was significantly different between benign (1.59 ± 1.59, p < 0.001) and malignant lesions (0.38 ± 0.23). Logistic regression analysis with RT and LPR combined showed a high diagnostic accuracy of quantitative CEUS parameters with areas under the curve of 0.923 (benign vs. malignant) and 0.929 (hemangioma vs. malignant. Conclusions: Quantified CEUS parameters are helpful to differentiate malignant from benign liver lesions, in particular in case of atypical hemangiomas.

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Incidental nonfunctioning pancreatic neuroendocrine tumors: Contrast enhanced ultrasound features in diagnosis

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-211269 ◽

2021 ◽

pp. 1-10

Author(s):

Daohui Yang ◽

Dansong Wang ◽

Yijie Qiu ◽

Xiaofan Tian ◽

Dan Zuo ◽

...

Keyword(s):

Neuroendocrine Tumors ◽

Clinical Decision Making ◽

Ultrasound Contrast Agents ◽

Arterial Phase ◽

Control Group ◽

Pancreatic Neuroendocrine Tumors ◽

Contrast Enhanced Ultrasound ◽

Color Flow ◽

Color Flow Imaging ◽

Contrast Enhanced

AIM: Preoperative suspicion of malignancy in nonfunctioning pancreatic neuroendocrine tumors (pNETs) is mostly based on tumor size. We retrospectively analyzed the contrast enhanced ultrasound (CEUS) features of a series of histopathologically proved nonfunctioning pNETs. METHODS: In this retrospective study, 37 surgery and histologically proved nonfunctioning pNETs were included. All pNETs lesions were incidentally detected by transabdominal ultrasound. B mode ultrasound (BMUS) and CEUS features were reviewed and analyzed. 52 histopathologically proved pancreatic ductal adenocarcinoma (PDACs) lesions were included as a control group. RESULTS: All nonfunctioning pNETs patients showed no typical clinical symptoms. No significant differences were observed in size, echogenicity or internal color flow imaging signal between pNETs and PDAC patients (P > 0.05). Most of nonfunctioning pNETs showed a well-defined tumor margin. The presence of pancreatic duct dilatation was less frequently observed in nonfunctioning pNETs patients (P < 0.05). After injection of ultrasound contrast agents, homogeneous enhancement was more commonly observed in nonfunctioning pNETs group (P < 0.05). During arterial phase of CEUS, most of nonfunctioning pNETs were hyper- or isoenhanced (32/37, 86.5%), whereas most of PDACs were hypoenhanced (34/52, 65.4%) (P < 0.05). Nonenhanced necrosis area was more commonly detected in PDACs (P = 0.012). CONCLUSIONS: CEUS features are helpful for preoperative non-invasive differential diagnosis of nonfunctioning pNETs, assisting further clinical decision-making process.

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Contrast enhanced ultrasonography (CEUS) in peripheral lung lesions: A study of 60 cases

Journal of Ultrasound ◽

10.1016/j.jus.2008.05.008 ◽

2008 ◽

Vol 11 (3) ◽

pp. 89-96 ◽

Cited By ~ 21

Author(s):

M. Caremani ◽

A. Benci ◽

L. Lapini ◽

D. Tacconi ◽

A. Caremani ◽

...

Keyword(s):

Lung Lesions ◽

Contrast Enhanced ◽

Peripheral Lung ◽

Contrast Enhanced Ultrasonography

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Количественный анализ трансректального ультразвукового исследования с контрастным усилением в диагностике рака предстательной железы (индексы): предварительные результаты

Ultrasound & Functional Diagnostics ◽

10.24835/1607-0771-2020-3-12-25 ◽

2020 ◽

pp. 12-25

Keyword(s):

Prostate Cancer ◽

Quantitative Analysis ◽

Transit Time ◽

Rise Time ◽

Mean Transit Time ◽

Contrast Enhanced Ultrasound ◽

Time To Peak ◽

Quantitative Parameters ◽

Peak Intensity ◽

Contrast Enhanced

Цель исследования - выявление наиболее информативных относительных количественных показателей (индексов) ТРУЗИ с КУ в диагностике РПЖ с использованием результатов прицельной биопсии под контролем ТРУЗИ. Материал и методы исследования: обследовано 75 пациентов с подозрением на рак предстательной железы по данным пальцевого ректального исследования и (или) повышением уровня общего простатспецифического антигена сыворотки крови. При этом обязательным условием было наличие гипоэхогенных очагов в периферической зоне предстательной железы. Всем пациентам проводилась системная и прицельная биопсия. Прицельная биопсия осуществлялась из гипоэхогенных очагов - зон интереса, которые были предварительно выбраны для количественного анализа контрастного усиления. В соответствии с морфологическими данными были выделены две группы очагов: 30 очагов в группе “РПЖ” (основная группа) и 45 очагов в группе “не РПЖ” (группа сравнения). ТРУЗИ выполнялись на аппарате Epiq 5 (Philips, Нидерланды) внутриполостным микроконвексным датчиком 4-10 МГц. Использовался ультразвуковой контрастный препарат Соновью (Bracco Swiss S.A., Швейцария). При анализе кривой “время-интенсивность” оценивались следующие безразмерностные индексы, представляющие собой отношение соответствующих абсолютных параметров в зоне интереса и эталонной зоне: индекс WIR (wash-in rate), индекс TTP (time to peak), индекс PI (peak intensity), индекс MTT (mean transit time), индекс TPH (time from peak to one half) и индекс RT (rise time). Результаты исследования: достоверные различия между группами получены по индексам WIR (P 0,0001), PI (P 0,0001), TTP (P = 0,0008) и RT (P = 0,0248). Тест “индекс PI > 1,174 - рак предстательной железы” характеризуется чувствительностью 83,3%, специфичностью 88,9%, предсказательной ценностью положительного теста 83,3%, предсказательной ценностью отрицательного теста 88,9%, AUC 0,910. Тест “индекс WIR > 1,432 - рак предстательной железы” характеризуется чувствительностью 76,7%, специфичностью 82,2%, предсказательной ценностью положительного теста 74,2%, предсказательной ценностью отрицательного теста 84,1%, AUC 0,808. Тест “индекс TTP ≤ 0,936 - рак предстательной железы” характеризуется чувствительностью 73,3%, специфичностью 66,7%, предсказательной ценностью положительного теста 59,5%, предсказательной ценностью отрицательного теста 78,9%, AUC 0,729. Определяется достоверная корреляция умеренной силы между суммой Глисона и индексом PI (rS = 0,394, P = 0,0311). Выводы: использование относительных параметров (индексов) количественного анализа трансректального ультразвукового исследования с контрастным усилением может привести к повышению эффективности прицельных биопсий. Индексы отличаются большей информативностью, чем абсолютные параметры. Ключевые слова: ультразвуковое исследование с контрастным усилением, количественный анализ, количественные относительные параметры, индексы, перфузия, предстательная железа, рак предстательной железы, contrast-enhanced ultrasound (CEUS), quantitative analysis, relative quantitative parameters, indices, perfusion, prostate, prostate cancer

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K-Means Clustering Algorithm-Based Detection of Carotid Atherosclerotic Plaque Using Contrast-Enhanced Ultrasound Images

Scientific Programming ◽

10.1155/2021/2223344 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Ruitao Zhou ◽

Ruijie Zhou ◽

Zhibo Zhu

Keyword(s):

Atherosclerotic Plaque ◽

Clustering Algorithm ◽

Detection Method ◽

Control Group ◽

Carotid Atherosclerotic Plaque ◽

Contrast Enhanced Ultrasound ◽

Contrast Enhanced ◽

Group A ◽

Group B ◽

Sensitivity Specificity

The aim of this study was to investigate the diagnostic value of contrast-enhanced ultrasound (CEUS) based on the K-means clustering (KMC) algorithm for the vulnerability of carotid atherosclerotic plaque (CAA). In this study, 90 patients with CAA were enrolled into a control group (group A) and an experimental group (group B). The angiography method and KMC-based ultrasound detection were applied to diagnose the CAA patients from the two groups, respectively. The results showed that the sensitivity, specificity, and positive predictive value of patients from group B (92.3%, 90.1%, and 94.8%) for diagnosing CAA were obviously higher than those of patients from group A (81.4%, 88.6%, and 75.3%) ( P < 0.05 ). The detection rate of patients from group B (83%, 85%) was dramatically higher than that of patients from group A (65%, 71%) in terms of artery bifurcation and CAA ( P < 0.05 ). Besides, patients from group B were more satisfied with their diagnostic method than group A ( P < 0.05 ). In conclusion, the ultrasound detection method based on KMC had high sensitivity, specificity, and accuracy in the detection of CAA. In addition, ultrasound detection was better than angiography in the diagnosis of plaque in different parts, and it was worthwhile to apply the ultrasound detection method based on KMC in clinical practice.

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CT guided lung biopsy complications: a single centre prospective study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20183416 ◽

2018 ◽

Vol 6 (9) ◽

pp. 2943

Author(s):

Mohd Farooq Mir ◽

Muzafar Ahmed Naik ◽

Javid Ahmed Malik

Keyword(s):

Prospective Study ◽

Needle Biopsy ◽

Lung Biopsy ◽

Pulmonary Haemorrhage ◽

Complication Rates ◽

Transthoracic Needle Biopsy ◽

Ct Guided ◽

Lung Lesions ◽

Peripheral Lung ◽

Percutaneous Transthoracic Needle Biopsy

Background: Computed tomography (CT) guided percutaneous transthoracic needle biopsy of lung is a routine procedure in patients with suspected malignant lung lesions which are either peripheral or not amenable to biopsy on fibreoptic bronchoscopy.Methods: This prospective study was conducted to obtain complication rates based on patient and physician experience after CT guided lung biopsy of central and peripheral lung lesions.Results: In our study 96 patients were included with 78 patients with peripheral and 18 patients having central lung lesions. The reported post procedural complication rates of CT guided lung biopsy were pulmonary haemorrhage 33.3 %, pneumothorax 21.9%, haemoptysis 15.6%, cough 6.3%, haemothorax 3.1% and fever 3.1%. Two patients required inter costal tube drainage. There was no reported mortality of CT guided lung biopsy in our centre.Conclusions: Pulmonary haemorrhage and pneumothorax are the most common complications of percutaneous transthoracic needle biopsy of the lung, the former one is common with central and the latter one with peripheral lung lesions.

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Contrast-enhanced ultrasound algorithm (ACR CEUS LI-RADSv 2017)– a valuable tool for the noninvasive diagnosis of hepatocellular carcinoma in patients with chronic liver disease

Medical Ultrasonography ◽

10.11152/mu-2887 ◽

2021 ◽

Author(s):

Ana Maria Ghiuchici ◽

Mirela Dănilă ◽

Alina Popescu ◽

Roxana Șirli ◽

Tudor Moga ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

High Risk ◽

Predictive Value ◽

Real Life ◽

Reference Method ◽

Focal Liver Lesions ◽

Noninvasive Diagnosis ◽

Contrast Enhanced Ultrasound ◽

Contrast Enhanced ◽

Malignant Lesions

Aims: to evaluate the accuracy of LR-5 category from the latest Contrast-Enhanced Ultrasound algorithm (ACR CEUS LI-RADSv 2017) for the noninvasive diagnosis of hepatocellular carcinoma (HCC), in a real-life cohort of high-risk patients. Material and methods: We retrospectively re-analysed the CEUS studies of 464 focal liver lesions (FLL) in 382 patients at high-risk for HCC (liver cirrhosis of any aetiology, chronic B or C hepatitis with severe fibrosis) using the ACR CEUS LI-RADSv 2017 algorithm. CEUS LI-RADS categories used for the diagnosis of HCC were: CEUS LR-5 (definitely HCC) and CEUS LR-TIV (HCC with macrovascular invasion). Contrast-enhanced CT, contrast-enhanced MRI, or histology were used as diagnostic reference methods to evaluate the CEUS LI-RADS classification of the 464 lesions. Results: According to the reference method, the 464 lesions were classified as follows: 359 HCCs, 68 non-HCC-non-malignant lesions and 37 non-HCC malignant lesions. The diagnostic accuracy of LR-5 category for the diagnosis of hepatocellular carcinoma was 76.9%. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 71.9%, 94.3 %, 97.7% and 49.5%, respectively. Conclusions: LR-5 category from ACR CEUS LI-RADSv 2017 algorithm, has good sensitivity, excellent specificity, and PPV for the diagnosis of HCC. The HCC rate increases from LR-3 to LR-5.

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Contrast enhanced ultrasound quantitative parameters for assessing neoadjuvant chemotherapy response in patients with locally advanced breast cancer

British Journal of Radiology ◽

10.1259/bjr.20201160 ◽

2021 ◽

Vol 94 (1121) ◽

pp. 20201160

Author(s):

Anant Sharma ◽

Shabnam Bhandari Grover ◽

Chinta Mani ◽

Charanjeet Ahluwalia

Keyword(s):

Breast Cancer ◽

Neoadjuvant Chemotherapy ◽

Advanced Breast Cancer ◽

Locally Advanced Breast Cancer ◽

Locally Advanced ◽

Advanced Breast ◽

Contrast Enhanced Ultrasound ◽

Mean Values ◽

Quantitative Parameters ◽

Contrast Enhanced

Objectives: To evaluate the role of contrast-enhanced ultrasound (CEUS) quantitative parameters in predicting neoadjuvant chemotherapy (NACT) response in patients with locally advanced breast cancer (LABC). Methods: 30 patients with histologically proven LABC scheduled for NACT were recruited. CEUS was performed using a contrast bolus of 4.8 ml and time intensity curves (TICs) were obtained by contrast dynamics software. CEUS quantitative parameters assessed were peak enhancement (PE), time-to-peak (TTP), area under the curve (AUC) and mean transit time (MTT). The parameters were documented on four consecutive instances: before NACT and 3 weeks after each of the three cycles. The gold-standard was pathological response using Miller Payne Score obtained pre NACT and post-surgery. Results: A decrease in mean values of PE and an increase in mean values of TTP and MTT was observed with each cycle of NACT among responders. Post each cycle of NACT (compared with baseline pre-NACT), there was a statistically significant difference in % change of mean values of PE, TTP and MTT between good responders and poor responders (p-value < 0.05). The diagnostic accuracy of TTP post-third cycle was 87.2% (p = 0.03), and MTT post--second and third cycle was 76.7% (p = 0.004) and 86.7% (p = 0.006) respectively. Conclusion: In responders, a decrease in the tumor vascularity was reflected in the CEUS quantitative parameters as a reduction in PE, and a prolongation in TTP, MTT. Advances in knowledge: Prediction of NACT response by CEUS has the potential to serve as a diagnostic modality for modification of chemotherapy regimens during ongoing NACT among patients with LABC, thus affecting patient prognosis.

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The Value of Contrast-Enhanced Ultrasound in the Diagnosis of Cesarean Scar Pregnancy

BioMed Research International ◽

10.1155/2016/4762785 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 9

Author(s):

Xi Xiong ◽

Ping Yan ◽

Chunyan Gao ◽

Qiulei Sun ◽

Fenglian Xu

Keyword(s):

Predictive Value ◽

Lower Uterine Segment ◽

Youden Index ◽

Peak Time ◽

Contrast Enhanced Ultrasound ◽

Cesarean Scar Pregnancy ◽

Cesarean Scar ◽

Contrast Enhanced ◽

Significant Difference ◽

Conventional Ultrasound

Objective. To evaluate the value of contrast-enhanced ultrasound (CEUS) in the cesarean scar pregnancy (CSP).Methods. Clinical data from 92 patients with lower uterine segment pregnancy, who underwent conventional ultrasound and CEUS examination in the Department of Obstetrics and Gynecology, were collected by Xinqiao Hospital Third Military Medical University from March 2014 to March 2015. The parameters of ultrasound contrast time-intensity curve (TIC), including arrival time, time to peak, time from peak to one half, basic intensity, peak intensity, and wash-in slope, were analyzed.Results. Of the 92 cases of patients with pregnancy in the lower uterine segment, 52 cases were CSP, and 40 cases were intrauterine pregnancy. CEUS was significantly better than conventional ultrasound in terms of sensitivity, negative predictive value, Youden index, and diagnostic accuracy (P<0.05). There was no significant difference in specificity and positive predictive value (P>0.05).Conclusion. CEUS has a higher accuracy than conventional ultrasound in diagnosis of CSP.

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