scholarly journals Clinical Effect of Clarithromycin Combined with Tinidazole on Helicobacter pylori-Related Gastritis and Its Influence on COX-2 Expression

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Chenxi He ◽  
Fanting Kong ◽  
Xinying Zhu ◽  
Fanlei Kong ◽  
Wei Zhao ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Symptom ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Expression Level ◽  
Inflammatory Factors ◽  
Symptom Improvement ◽  
Cox 2

Studies have shown that COX-2 expression is upregulated in gastric cancer (GC) as well as in precancerous lesions and in Helicobacter pylori-induced inflammation, suggesting that cyclooxygenase-2 (COX-2) may play an important role in gastric carcinogenesis. We attempted to investigate the role of clarithromycin with tinidazole on Helicobacter pylori-related gastritis from the aspects of clinical effect and COX-2 expression. From January 2016 to January 2019, 130 patients with Helicobacter pylori-related chronic gastritis were collected and grouped into the observation group (OG) and the control group (CG). Altogether, 80 patients in the OG were treated with clarithromycin with tinidazole, while 50 patients in the CG were treated with amoxicillin with metronidazole. Clinical symptom improvement time, content of COX-2 and B cell lymphoma-2 (BCL-2), content of inflammatory factors interleukin-1 (IL-1), IL-4, and C-reactive protein (CRP), expression level of nutritional indicators serum albumin (ALB), realbumin (PA), and transferrin (TF), clearance of Helicobacter pylori, total effective rate, and incidence of adverse reactions were detected. Compared with the CG, the OG had shorter clinical symptom improvement time, lower COX-2 and Bcl-2, lower expression of inflammatory factors IL-1, IL-4, and CRP, higher expression of nutritional indicators ALB, TF, and PA, higher clearance rate of Helicobacter pylori, higher total effective rate, and lower incidence of adverse reactions. Clarithromycin combined with tinidazole can effectively improve the clinical effect of Helicobacter pylori-related gastritis and reduce the expression level of COX-2.

scholarly journals Analysis of Clinical Effect of Treating Arrhythmia with Stable Heart Granules

2013 ◽  
Vol 2 ◽  
pp. 7
Author(s):  
Li Liu
Keyword(s):  
Clinical Practice ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
The Difference ◽  
And Control ◽  
Group Observation

<p><strong>Objective: </strong>To study the clinical effect on the treatment of cardiac arrhythmia, and further guide the clinical treatment. <strong>Method: </strong>From January 2011 to January 2013, 100 patients with arrhythmia were randomly divided into observation group and control group with 50 cases in each group. Observation group patients given oral Stable heart granule treatment, while control group was treated with oral propafenone treatment. The therapeutic effect and adverse reactions of the two groups were observed and compared. <strong>Results: </strong>The total effective rate of the observation group was higher than control group and incidence of adverse reactions was lower than control group, the difference was statistically significant, <em>p</em> &lt; 0.05. The use of stable heart particles in the treatment of arrhythmia produce significant effect. <strong>Conclusion: </strong>Clinical effect for Stable heart granule on arrhythmia was significant and should widely entrenched in clinical practice.</p>

scholarly journals Analysis and Study of the Treatment of the Toe Defect under the Condi- tional Arrangement of the Toe Artery Skin Flap

1970 ◽  
Vol 1 (1) ◽  
Author(s):  
Zhu Jing Bin
Keyword(s):  
Adverse Reactions ◽  
Clinical Effect ◽  
Total Effective Rate ◽  
Skin Flap ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Curative Effect ◽  
Pedicle Flap ◽  
The Difference

To study on the clinical efficacy of the repairing of the toe defect of the tip of the toe artery with skin flap. 48 patients with tip of toe defects who were admitted to our department from May 2014 to December 2015 were randomly divided into two groups: control group and observation group, 24 cases in each group. The patients in the control group were treated with abdominal pedicle flap while the patients in the observation group were treated with the toe artery skin flap for repair. The clinical curative effect of the two groups was analyzed. The total effective rate of clinical treatment was 23 (95.83%) in the observation group was significantly higher than that in the control group, 19 (79.16%), and the elasticity and texture of the flap were good and no obvious adverse reaction occurred. The difference between the two groups was significant, p<0.05. The use of the toe artery skin flap for the treatment of the tip of toe defect has a significant clinical effect, and no serious adverse reactions occurred, highly safety.

scholarly journals Clinical Observation of Zhuang Medicine Crystal Sugar Ye’An Decoction in Treating Senile Skin Pruritus and Its Effects on Serum IgE

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Yun Zhang ◽  
Yuying Lan
Keyword(s):  
Adverse Reactions ◽  
Clinical Observation ◽  
Skin Lesions ◽  
Effective Rate ◽  
Inflammatory Factors ◽  
Control Group ◽  
Observation Group ◽  
Serum Ige ◽  
The Difference ◽  
Lesion Severity

Objective: To discuss the specific application of Zhuang Medicine Crystal Sugar Ye’An Decoction in senile skin pruritus and its effects on serum IgE detection level. Methods: 90 patients with senile skin pruritus admitted to our hospital from February 2019 to April 2020 were randomly grouped. The general treatment effect, itching, secondary skin lesion severity, serum IL-6, IgE level and adverse reactions between 45 patients treated with Chlorcyclizine Hydrochloride Tablets (The control group) and 45 patients treated with Crystal Sugar Ye’An Decoction were compared. Results: The total effective rate of the treatment in the observation group was 93.33%, much higher than that in the control group, 75.56%. The difference was verified and statistically significant (P<0.05). Before the treatment, the itching area, frequency, duration and severity of secondary skin lesions were at the same level (P>0.05). After the treatment, the above data were all reduced, and the reduction of the observation group was more significant than that of the control group, indicating the difference was statistically significant (P<0.05). Before the treatment, there was no difference in serum IL-6 and IgE test data between the two groups (P>0.05). After the treatment, the tendency all declined, and that of the observation group was more obvious, indicating the difference was statistically significant (P<0.05). During the experiment, no obvious adverse reactions were observed in both groups. Conclusion: In the treatment of patients with senile pruritus, the application of Zhuang Medicine Crystal Sugar Ye’An Decoction is not only safe and reliable, but can promote the improvement of patients’ symptoms, adjust the level of inflammatory factors, and enhance clinical efficacy.

scholarly journals Clinical effect of decitabine in the treatment of myelodysplastic syndrome and influencing factors

2020 ◽  
Vol 36 (5) ◽  
Author(s):  
Tangxia Liu ◽  
Jing Wang ◽  
Chunmei Li ◽  
Lingzhi Jia
Keyword(s):  
Myelodysplastic Syndrome ◽  
Influencing Factors ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Progression Free Survival ◽  
Effective Rate ◽  
Good Effect ◽  
Conventional Chemotherapy ◽  
Traditional Group ◽  
The Difference

Objective: To analyze the effect of decitabine combined with conventional chemotherapy on myelodysplastic syndrome (MDS) and its influencing factors. Methods: Eighty patients with MDS who were admitted to our hospital were selected by this study between February 2017 and February 2018. The selected patients were divided into a traditional group (CAG/DA scheme) and the combined group (DAC combined with CAG/DA scheme) according to the random number table method, 40 each. The clinical treatment effects of the two groups were compared, and the influencing factors of the effect were analyzed. Results: After four courses of treatment, the difference in the total effective rate between the two groups were statistically significant (P<0.05); the difference in the incidence of adverse reactions and in the overall survival (OS) rate between the two groups were not statistically significant (P>0.05). However, the progression free survival (PFS) rate of the combined group was significantly higher compared with the traditional group (P<0.05); the Hb level, WHO stage and and karyotype of the patients before treatment had significant influence on the treatment effect (P<0.05). Conclusion: DAC in combination with conventional chemotherapy has good effect in the treatment of MDS, and it will not increase adverse reactions. In addition to treatment scheme, the influencing factors of the effect of treatment for MDS also include Hb, WHO stage and karyotype. doi: https://doi.org/10.12669/pjms.36.5.2289 How to cite this:Liu T, Wang J, Li C, Jia L. Clinical effect of decitabine in the treatment of myelodysplastic syndrome and influencing factors. Pak J Med Sci. 2020;36(5):1084-1088. doi: https://doi.org/10.12669/pjms.36.5.2289 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Efficacy of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Management of Malignant Ascites

2020 ◽  
Author(s):  
Jie Jiao ◽  
Chengzhen Li ◽  
Guanying Yu ◽  
Lei Zhang ◽  
Xiaoyan Shi ◽  
...  
Keyword(s):  
Intraperitoneal Chemotherapy ◽  
Adverse Reactions ◽  
Total Effective Rate ◽  
Malignant Ascites ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Short Term ◽  
Significant Difference ◽  
The Difference

Abstract Objective: The purpose of this study is to compare the difference of clinical efficacy between conventional intraperitoneal chemotherapy and HIPEC, so as to explore the clinical application value and advantages of HIPEC.Design: A retrospective analysis was conducted on 80 patients with malignant ascites admitted to our hospital from June 2017 to June 2019. The general clinical data and qualitative data of the treatment results of 80 patients with malignant ascites were processed by SPSS19.0 using χ2 test and quantitative data were processed by t test. P <0.05, statistical data can be considered statistically significant.Results: 1. There was no significant change in vital signs and temperature in the observation group during the treatment, and the difference was not statistically significant 2. The short-term total effective rate of patients in the observation group was 91.11%, and the short-term total effective rate of the patients in the control group was 40%.3. There was no significant difference in the incidence of adverse reactions between the two groups of patients.Conclusion: Intraperitoneal hyperthermic chemotherapy combined with intravenous chemotherapy can significantly control malignant ascites, and has small adverse reactions, which is worthy of clinical promotion and application.

scholarly journals Apatinib, S-1 Combined with Paclitaxel Perfusion in the Treatment of Malignant Seroperitoneum of Gastric Cancer

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Zhiyu Wang ◽  
Dan Hong ◽  
Zhuoqi Zhang ◽  
Shenyong Su ◽  
Yan Shi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Resistance ◽  
Treatment Effect ◽  
Adverse Reactions ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Good Prognosis ◽  
Control Group ◽  
Observation Group ◽  
And Control

Objective: To analyze the effect of apatinib, S-1 combined with paclitaxel perfusion on malignant seroperitoneum of gastric cancer. Methods: From December 2019 to May 2020, 172 patients with gastric cancer treated in our hospital were randomly divided into two groups: observation group and control group, 86 cases each. The control group adopted the method of S-1 combined with paclitaxel perfusion therapy in the treatment of malignant seroperitoneum of gastric cancer. The observation group was given oral apatinib on the basis of S-1 combined with paclitaxel perfusion therapy, and the dosage was 500 mg/d. Results: The total effective rate of treatment in the control group was 43.02%, while the total effective rate in the observation group was 69.77%; the drug resistance of the two groups of patients increased and the adverse reactions were low. Conclusion: Apatinib and S-1 combined with paclitaxel perfusion therapy can effectively improve the treatment effect, stabilize the patient's condition, increase the patient's drug resistance to adverse reactions, and have a good prognosis.

scholarly journals Clinical Observation of Self-Made Yin-Tonifying Ophiopogonis Decoction Combined with Rehabilitation New Liquid in the Treatment of Reflux Esophagitis with Deficiency of Stomach Yin

2021 ◽  
Vol 5 (4) ◽  
pp. 112-116
Author(s):  
Liang Wang ◽  
Li Liu ◽  
Zhenghui Liu
Keyword(s):  
Reflux Esophagitis ◽  
Clinical Effect ◽  
Clinical Observation ◽  
Random Number ◽  
Clinical Symptoms ◽  
Total Effective Rate ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Random Number Table

Objective: To observe the efficacy of Yin-tonifying Ophiopogonis Decoction combined with Rehabilitation New Liquid in the treatment of reflux esophagitis (RE). Methods: Seventy-four patients with RE were included in the study and they were divided into an observation group and a control group using the random number table method with 37 cases in each group. The patients in the control group were given oral Yin-tonifying Ophiopogonis Decoction whereas the patients in the observation group were additionally treated with the Rehabilitation New Liquid. The clinical efficacy, traditional Chinese medicine (TCM) symptoms, and the efficiency of gastroscopy were compared between the two groups. Results: The total effective rate of clinical symptoms, TCM symptoms, and gastroscopy results between the observation group and the control group were significantly different (P < 0.05) and were statistically significant. Conclusion: The clinical effect of Yin-tonifying Ophiopogonis Decoction combined with the Rehabilitation New Liquid in the treatment of RE is significant.

scholarly journals Clinical Effect of Knee Arthroscopy Combined with Liuwei Gubi Pill in Treating Middle-aged and Elderly Patients with Degenerative Meniscus Injury

2020 ◽  
Vol 185 ◽  
pp. 03019
Author(s):  
Zike He ◽  
Kaifei He ◽  
Shangzeng Wang
Keyword(s):  
Elderly Patients ◽  
Clinical Effect ◽  
Knee Arthroscopy ◽  
Total Effective Rate ◽  
Reference Group ◽  
Effective Rate ◽  
Middle Aged ◽  
Joint Function ◽  
Meniscus Injury ◽  
Experimental Group

Objective: To study the effect of knee arthroscopy combined with Liuwei Gubi Pill on degenerative meniscus injury in middle-aged and elderly patients. Methods: A total of 92 middle-aged and elderly patients with degenerative meniscus injury who were treated in our hospital from August 2018 to February 2020 were collected. They were divided into two groups by envelope lottery. Knee arthroscopy was used for the reference group of 46 patients, and they were guided to perform joint function exercises after surgery; 46 patients in the experimental group took Liuwei Gubi Pill on the basis of the reference group, and compared the efficacy of the two groups. Results: The total effective rate of treatment in the experimental group was 97.83%, which was higher than the reference group’s 84.78%. The experimental group’s VAS score at 1st month, 2nd month, and 3rd month after surgery was lower than that in the reference group. The Lysholm score of the experimental group at 1st month, 2nd month, and 3rd month after operation was significantly higher than that of the reference group, and the data of the two groups was compared by P<0.05. Conclusion: The treatment of middle-aged and elderly patients with degenerative meniscus injury by knee arthroscopy combined with Liuwei Gubi Pill has an ideal effect, which can alleviate postoperative pain and benefit the recovery of knee function.

scholarly journals Intravenous thrombolysis with alteplase in the treatment of acute cerebral infarction

2022 ◽  
Vol 38 (3) ◽  
Author(s):  
Lilin Gao ◽  
Shaojie Zhang ◽  
Xuewen Wo ◽  
Xiangpeng Shen ◽  
Qiangyuan Tian ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Total Effective Rate ◽  
Intravenous Thrombolysis ◽  
Effective Rate ◽  
Acute Cerebral Infarction ◽  
Inflammatory Factors ◽  
Control Group ◽  
Observation Group ◽  
Efficacy And Safety ◽  
Monocyte Chemoattractant Protein 1

Objectives: To compare the efficacy and safety of intravenous thrombolysis with alteplase and intravenous thrombolysis with urokinase for patients with acute cerebral infarction. Methods: This prospective study included 140 patients with acute cerebral infarction who were admitted to our hospital between June 2018 and June 2019. They were randomly divided into two groups. The control group (70 cases) was treated with urokinase intravenous thrombolysis, and the observation group (70 cases) was given alteplase intravenous thrombolytic therapy. The treatment efficacy and safety of the two groups were compared. Results: The total effective rate of the observation group was 95.7%, and that of the control group was 78.6%, i.e., the total effective rate of the observation group was significantly superior to the that of the control group (P < 0.05). After treatment, the observation group had significantly lower National Institutes of Health Stroke Scale (NIHSS) score and significantly higher mini-mental state examination (MMSE) score than the control group; the difference was statistically significant (P<0.05). After treatment, the levels of inflammatory factors of both groups significantly decreased compared to before treatment, and the decrease in the observation group was larger than that in the control group (P<0.05). The levels of serum homocysteine (Hcy) and monocyte chemoattractant protein-1 (MCP-1) in the observation group were significantly lower than those in the control group after treatment, and the differences were statistically significant (P<0.05). The incidence of hemorrhagic adverse reaction in the observation group was lower than that in the control group (P<0.05). Conclusion: In the treatment of acute cerebral infarction, ccompared with urokinase, alteplase can further relieve cognitive impairment and promote the recovery of nerve function through inhibiting levels of inflammatory factors and levels of serum Hcy and MCP-1. doi: https://doi.org/10.12669/pjms.38.3.4521 How to cite this:Gao L, Zhang S, Wo X, Shen X, Tian Q, Wang G. Intravenous thrombolysis with alteplase in the treatment of acute cerebral infarction. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.4521 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Clinical Effect Analysis of Jianpi Bushen Yiqi Decoction on Patients with Chronic Nephritis

2021 ◽  
Vol 7 (5) ◽  
pp. 1383-1388
Author(s):  
Shujuan Mu ◽  
Jun Chen ◽  
Jing Chen ◽  
Xue Li ◽  
Yingxu Chen ◽  
...  
Keyword(s):  
Renal Function ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Effective Rate ◽  
Urinary Protein ◽  
Control Group ◽  
Observation Group ◽  
Chronic Nephritis ◽  
Tcm Syndrome ◽  
Better Than

Select the actual clinical effect of Jianpi Bushen Yiqi Decoction on patients with chronic nephritis. Methods: A total of 60 patients with chronic nephritis who were admitted to our hospital from January 2018 to January 2019 were selected. They were divided into 2 groups according to the admission order, 30 cases each. The control group was treated with conventional western medicine, and the observation group was treated with Jianpi Bushen Yiqi Decoction on the basis of the control group. The renal function indexes and urinary protein index, clinical efficacy, TCM syndrome scores, and adverse reactions were compared between the two groups. Result: There was no difference in renal function and urinary protein indexes between the two groups before treatment (P> 0.05). After treatment, the indicators in the observation group were better than those in the control group (P <0.05). The total effective rate of treatment in the observation group was higher than that in the control group (P <0.05). There was no difference in TCM syndrome scores between the first two groups (P> 0.05). After treatment, the indicators in the observation group were better than those in the control group (P <0.05). The overall incidence of adverse reactions in the observation group was lower than that in the control group (P <0.05). Conclusion: Jianpi Bushen Yiqi Decoction has a significant effect on chronic nephritis, which can effectively improve the renal function and urinary protein index of patients, with few adverse reactions and great application value.

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