scholarly journals Late Lung Metastasis in a Patient with a Clear Cell Chondrosarcoma: An Indication for a Life-Long Follow-Up?

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Paulien West ◽  
Celine Jacobs ◽  
Michael Saerens ◽  
David Creytens ◽  
Gwen Sys ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Clear Cell ◽  
Wedge Resection ◽  
Lung Nodule ◽  
Complete Removal ◽  
Good Health ◽  
Ct Guided ◽  
Clear Cell Chondrosarcoma ◽  
Lung Lobe

Background. Clear cell chondrosarcoma (CCCS) is a rare subtype of chondrosarcoma and comprises between 1.6% and 2.5% of all chondrosarcoma. They are known to be chemo- and radiotherapy resistant; surgical resection is therefore the therapy of choice. Methods. We present a 63-year-old woman with a progressive lung nodule 20 years after initial diagnosis and treatment of a clear cell chondrosarcoma of the right os naviculare. Results. On serial CT scans of the chest, an asymptomatic, slowly growing nodule in the left upper lung lobe was detected. CT-guided transthoracic biopsy of this nodule confirmed the diagnosis of a chondrosarcoma lung metastasis. Video-assisted thoracoscopic wedge resection was performed with complete removal of the nodule. The patient recovered well from surgery and remains in good health during further follow-up. Conclusion. Given the tendency of clear cell chondrosarcoma to recur and metastasize after extended periods of time, a long-term, possibly life-long follow-up and clinical surveillance is advisable in these patients.

scholarly journals Clinical Application of CT-Guided Percutaneous Microwave Ablation for the Treatment of Lung Metastasis from Colorectal Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-9
Author(s):  
Lin Li ◽  
Ketong Wu ◽  
Haiyang Lai ◽  
Bo Zhang
Keyword(s):  
Colorectal Cancer ◽  
Lung Metastasis ◽  
Microwave Ablation ◽  
Progression Free Survival ◽  
Ct Guided ◽  
Metastatic Lesions ◽  
Local Progression ◽  
Invasive Method ◽  
Percutaneous Microwave Ablation

Objective. The aim of our research is to explore the clinical efficacy and safety of CT-guided percutaneous microwave ablation (MWA) for the treatment of lung metastasis from colorectal cancer. Materials and Methods. CT-guided percutaneous MWA was performed in 22 patients (male 14, female 8, mean age: 56.05 ± 12.32 years) with a total of 36 lung metastatic lesions from colorectal cancer between February 2014 and May 2017. Clinical data were retrospectively analyzed with respect to the efficacy, safety, and outcome. Results. Of the 36 lesions, 34 lesions (94.4%) reduced obviously with small cavitations or fibrous stripes formed and had no evidence of recurrence during follow-up. The volume of the other 2 lesions demonstrated local progression after 6 months by follow-up CT. The primary complications included pneumothorax (28%), chest pain (21%), and fever (5%). These symptoms and signs were obviously relieved or disappeared after several-day conservative treatment. The mean follow-up of the patients was 25.54 ± 12.58 months (range 2–41 months). The estimated progression-free survival rate was 94.4%. Conclusion. Our results demonstrate that CT-guided percutaneous MWA appears to be an effective, reliable, and minimally invasive method for the treatment of lung metastasis from colorectal cancer. This trial is registered with ChiCTR-ORC-17012904.

scholarly journals Clear Cell Chondrosarcoma: Clinical Characteristics and Outcomes in 15 Patients

Sarcoma ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
James H. Flint ◽  
Anthony P. Conley ◽  
M. Laura Rubin ◽  
Lei Feng ◽  
Patrick P. Lin ◽  
...  
Keyword(s):  
Median Time ◽  
Clinical Characteristics ◽  
Clear Cell ◽  
Primary Treatment ◽  
Wide Resection ◽  
Rare Entity ◽  
Clear Cell Chondrosarcoma ◽  
Time To Death ◽  
Time To Recurrence

Background. Clear cell chondrosarcoma (CCC) represents less than 6% of all chondrosarcomas, and thus, our understanding of this rare entity is limited. Analyzing clinical characteristics and treatment patterns, thus increasing our knowledge, may improve treatment strategy. We review our institutional experience with 15 patients, including one case with dedifferentiation. Methods. A retrospective review was conducted in CCC patients treated at our institution from 1996 to 2015, with at least 2-year follow-up. Descriptive statistics and Kaplan–Meier survival analyses were performed. Results. Of 19 patients identified, 15 patients had at least 2-year follow-up and were included. The median age at diagnosis was 43 years. 80% were male. The most common presenting signs were pain (12 patients; 80%) and fracture (2 patients; 13.3%). The most common site was proximal femur (8 patients; 53%). All patients had MSTS Stage I disease. Primary treatment included wide resection in 10 patients (67%) and intralesional or marginal resection in 5 patients (33%). Three patients died of disease during the study period, 1 with dedifferentiation of recurrent CCC. The median time to death from disease was 15.3 years (95% CI: (14.2; NA)). The median time to either recurrence or death was 7.73 years for patients who had intralesional/marginal resection and 16.44 years for patients with wide resection (HR (wide vs. intralesional/marginal) = 0.21, 95% CI: (0.04; 1.18), p = 0.053 ). The median time to recurrence or death was significantly shorter for patients not initially treated at a sarcoma center ( p = 0.01 ). Conclusions. CCC is a rare entity, and our understanding of it is still evolving. We observed a higher recurrence rate for intralesional or marginal resection, and wide resection alone remains the mainstay of treatment. Better outcomes were observed in patients initially treated by trained musculoskeletal oncologists. Due to the propensity of CCC to recur decades after initial resection, lifelong surveillance is recommended.

scholarly journals Pulmonary Metastases from an Undifferentiated Embryonal Sarcoma of the Liver: A Case Report and Review

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Mingxia Shi ◽  
Hongzhi Xu ◽  
Guillermo P. Sangster ◽  
Xin Gu
Keyword(s):  
Adjuvant Chemotherapy ◽  
Lung Tumor ◽  
Lung Metastases ◽  
Wedge Resection ◽  
Lung Nodule ◽  
Lower Lobe ◽  
Complete Removal ◽  
Metastatic Lesion ◽  
Palpable Mass ◽  
Embryonal Sarcoma

Undifferentiated embryonal sarcoma of the liver (UESL) is a rare malignant hepatic tumor that occurs primarily in children. Only a limited number of cases have been reported in the literature due to low incidence of one per million, and reports of metastatic lesion of UESL are even rarer. We hereby describe the case of a 13-year-old male who presented with a palpable mass with imaging findings suggestive of a large complex tumor in the right lobe of the liver. He underwent extended right hepatectomy followed by adjuvant chemotherapy. The tumor was confirmed to be UESL by postoperative pathology and immunohistochemical staining analysis. Four years later, surveillance imaging revealed a small lung nodule in the left lower lobe. Complete removal of the lung tumor by wedge resection was performed, and a histological diagnosis of metastatic UESL was made. The patient also received postoperative adjuvant chemotherapy and is currently in a good general condition and tumor-free in the present eight-month period. This case is presented with emphasis on clinicopathological and immunohistochemical findings of the primary UESL and lung metastases with the aim of collecting more data and expanding our understanding of this rare malignancy.

Clear cell chondrosarcoma of proximal femur: a rare entity with diagnostic dilemma

2020 ◽  
Vol 13 (10) ◽  
pp. e236389
Author(s):  
Manish Pruthi ◽  
Jagandeep Singh Virk ◽  
Anila Sharma ◽  
Vivek Mahawar
Keyword(s):  
Femoral Head ◽  
Clear Cell ◽  
Correct Diagnosis ◽  
Malignant Neoplasm ◽  
Diagnostic Dilemma ◽  
Clear Cell Chondrosarcoma ◽  
High Local Recurrence Rate ◽  
Appropriate Treatment ◽  
Slow Growing

Clear cell chondrosarcoma is an extremely rare malignant neoplasm. The rarity and slow-growing nature of this tumour often lead to prolonged symptoms and also initial misdiagnosis with benign lesions such as chondroblastoma. It can also be confused with avascular necrosis of the femoral head when the lesion is located in the femoral head, as was in the case we report. The patient was kept on observation and conservative treatment for almost 9 years before the correct diagnosis and appropriate treatment. Wide local resection with negative margins forms the mainstay of treatment since intralesional procedures predispose to high local recurrence rate. A prolonged follow-up is recommended since late local recurrences and metastases are common.

Clear cell chondrosarcoma of bone: long time follow-up of 18 cases

2007 ◽  
Vol 128 (2) ◽  
pp. 137-142 ◽  
Author(s):  
Davide Donati ◽  
Jun-qiang Yin ◽  
Marco Colangeli ◽  
Simone Colangeli ◽  
Claudia Di Bella ◽  
...  
Keyword(s):  
Clear Cell ◽  
Clear Cell Chondrosarcoma ◽  
Long Time

scholarly journals A large solitary fibrous tumour of the pleura: a case report and review of the literature

2018 ◽  
Vol 46 (4) ◽  
pp. 1672-1677 ◽  
Author(s):  
Yong-Hao You ◽  
Rong-Ting Liu ◽  
Yi Zhang
Keyword(s):  
Wedge Resection ◽  
Left Lung ◽  
Lower Lobe ◽  
Good Health ◽  
Large Mass ◽  
Solitary Fibrous Tumour ◽  
Endotracheal Anaesthesia ◽  
Tumour Diagnosis ◽  
Local Tumour

We report a clinical case of a solitary fibrous tumour of the pleura (SFTP) in a 67-year-old female patient complaining of chest pain for 2 months. A localized large mass was found in the left inferior hemithorax by computed tomography scan. The patient underwent a thoracotomy at the left side with endotracheal anaesthesia. During surgical resection, the tumour was located in the left inferior hemithorax and was attached to the inferior lobe of the left lung and diaphragmatic pleura by a fibrous pedicle. A wedge resection of the left lower lobe was undertaken to completely remove the tumour. Diagnosis of the SFTP was confirmed by the surgical findings and subsequent histological and immunohistochemical examinations. At the 6-month follow-up, no signs of local tumour recurrence or metastasis were documented. After a 3-year follow-up, this patient remains in good health.

scholarly journals Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib

2020 ◽  
Vol 13 (2) ◽  
pp. 789-792
Author(s):  
Layla G. Landgraf ◽  
Mark A. Malias ◽  
Stephen J. Patterson
Keyword(s):  
Malignant Melanoma ◽  
Wedge Resection ◽  
Lung Nodule ◽  
Primary Melanoma ◽  
Molecular Testing ◽  
Ct Guided ◽  
Dna Mutation ◽  
Tumor Specimen ◽  
Atypical Cells ◽  
Full Body

This is a case report on a 69-year-old woman who was diagnosed with malignant melanoma presenting in the lung. A complete staging workup was performed by her oncologist, with no skin lesion identified as a primary. CT-guided needle biopsy of the lung nodule was completed, with pathology revealing atypical cells consistent with malignant melanoma. Following full body examination by the cutaneous oncologist, a robotic wedge resection and lymph node dissection accompanied by bronchoscopy were performed. Molecular testing (Caris Life Sciences) of the surgical tumor specimen revealed pathological BRAF DNA mutation in exon 15/p.V600K. The patient was initially treated with nivolumab, then treated with a combination of dabrafenib and trametinib at recurrence.

scholarly journals Methylene Blue versus Coil-Based Computed Tomography-Guided Localization of Lung Nodules

2020 ◽  
Vol 68 (06) ◽  
pp. 540-544 ◽  
Author(s):  
Ze-Dong Zhang ◽  
Hua-Long Wang ◽  
Xian-Yan Liu ◽  
Feng-Fei Xia ◽  
Yu-Fei Fu
Keyword(s):  
Computed Tomography ◽  
Methylene Blue ◽  
Thoracoscopic Surgery ◽  
Wedge Resection ◽  
Lung Nodule ◽  
Lung Nodules ◽  
Complication Rates ◽  
Success Rates ◽  
Technical Success ◽  
Ct Guided

Abstract Background Preoperative computed tomography (CT)-guided localization has been shown to significantly improve lung nodule video-assisted thoracoscopic surgery (VATS)-based wedge resection technical success rates. However, at present, there was insufficient research regarding the optimal approaches to localization of these nodules prior to resection. We aimed to compare the relative clinical efficacy of preoperative CT-guided methylene blue and coil-based lung nodule localization. Methods In total, 91 patients with lung nodules were subjected to either CT-guided methylene blue (n = 34) or coil (n = 57) localization and VATS resection from January 2014 to December 2018. We compared baseline data, localization-associated complication rates, as well as the technical success of localization and resection between these two groups of patients. Results In total, 42 lung nodules in 34 patients underwent methylene blue localization, with associated localization and wedge resection technical success rates of 97.6 and 97.6%, respectively. A total of 71 lung nodules in 57 patients underwent coil localization, with associated localization and wedge resection technical success rates of 94.4 and 97.2%, respectively. There were no significant differences in technical success rates of localization or wedge resection between these groups (p = 0.416 and 1.000, respectively). The coil group sustained a longer duration between localization and VATS relative to the methylene blue group (13.2 vs. 2.5 hours, p = 0.003). Conclusion Both methylene blue and coil localization can be safely and effectively implemented for conducting the diagnostic wedge resection of lung nodules. The coil-based approach is compatible with a longer period of time between localization and VATS procedures.

Delayed Pancreatic Metastasis of Renal Clear Cell Carcinoma

2013 ◽  
Vol 13 (2) ◽  
pp. 79-80
Author(s):  
Zane Simtniece ◽  
Gatis Kirsakmens ◽  
Ilze Strumfa ◽  
Andrejs Vanags ◽  
Maris Pavars ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Surgical Treatment ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Primary Tumour ◽  
Renal Clear Cell Carcinoma ◽  
Pancreatic Metastasis ◽  
Distal Pancreatic Resection

Abstract Here, we report surgical treatment of a patient presenting with pancreatic metastasis (MTS) of renal clear cell carcinoma (RCC) 11 years after nephrectomy. RCC is one of few cancers that metastasise in pancreas. Jaundice, abdominal pain or gastrointestinal bleeding can develop; however, asymptomatic MTS can be discovered by follow-up after removal of the primary tumour. The patient, 67-year-old female was radiologically diagnosed with a clinically silent mass in the pancreatic body and underwent distal pancreatic resection. The postoperative period was smooth. Four months after the surgery, there were no signs of disease progression.

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