scholarly journals Effect of Prepregnancy Lymphocyte Active Immunotherapy on Unexplained Recurrent Miscarriage, Pregnancy Success Rate, and Maternal-Infant Outcome

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Junxia Li ◽  
Yan Gu ◽  
Shaojing Zhang ◽  
Baohui Ju ◽  
Jianmei Wang

Objective. To evaluate the effect of prepregnancy lymphocyte active immunotherapy on unexplained recurrent miscarriage, pregnancy success rate, and maternal-infant outcome. Methods. A total of 124 patients with recurrent miscarriage admitted to our hospital from January 2018 to December 2020 were selected as the research objects and divided into the experimental group and the control group according to the random number table method, with 62 patients in each group. The experimental group was treated with lymphocyte active immunotherapy, and the control group was given conventional treatment. The pregnancy success rate, estrogen indexes, hemorheology indexes, and psychological state of the two groups were compared. Results. The experimental group garnered a notably higher pregnancy success rate and a prominently lower miscarriage rate than the control group ( P < 0.05 ). Better results of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were observed in the experimental group, as compared to the control group ( P < 0.05 ). The experimental group yielded more desirable results in terms of treatment satisfaction, estrogen indexes, and hemorheology indexes in comparison with the control group ( P < 0.05 ). Conclusion. The use of lymphocyte active immunotherapy for patients with unexplained recurrent miscarriage can significantly increase the pregnancy success rate, optimize the maternal-infant outcome, drive down the miscarriage rate, and ameliorate the patient’s estrogen levels and hemorheology indicators, which is worthy of promotion and application in clinical practice.

Author(s):  
Laetitia Idier ◽  
Aurélie Untas ◽  
Nicole Rascle ◽  
Michèle Koleck ◽  
Maider Aguirrezabal ◽  
...  

Introduction:Psychological impact of Therapeutic Patient Education (TPE) for dialysis patients is rarely evaluated since the focus of many studies is on medical variables (i.e., adherence).Objectives:The aims of this study were: 1) to estimate the impact of a TPE program on knowledge, depression and anxiety, 2) to examine change in knowledge as a mediator of the effects of a TPE program on mental health.Method:This study was conducted in three hemodialysis units and comprised two groups: an experimental group with education and a control group with routine care. The program was based of 5 educative sessions. Knowledge, depressive and anxious symptoms were assessed with self-reported outcomes measured before and 3 months after the program.Results:The sample comprised 125 patients. Knowledge about vascular access and nutrition (p < 0.01) and depressive symptoms increased in the experimental group (p < 0.01). Analysis of mediation showed that changes in knowledge about vascular access were a significant mediator of the effects of the program on depressive symptoms (F = 4.90;p = 0.01).Discussion:Knowledge acquired during an educational program could lead to an emotional change. Improving knowledge often leads to an awareness of the risks that can modify the psychological state of patients by reminding them of their vulnerability. This study shows that it is required to be attentive to the way of transmitting knowledge. It’s necessary adapting this transmission to the needs of patients and promoting the acquisition of psychosocial competence too.Conclusion:This study shows that knowledge acquired during an educational program can lead to an emotional change in the short term. A long-term follow-up of the population should be interesting to observe these emotional effects.


2020 ◽  
Vol 48 (7) ◽  
pp. 030006052094211
Author(s):  
Yuling Sun ◽  
Zhongying Bao ◽  
Yang Guo ◽  
Xiaodong Yuan

Objective This study was performed to evaluate the effect of care bundles on the prevention of central venous catheter-related bloodstream infection (CRBSI) and improvement of patients’ experience. Methods In total, 212 patients with central venous catheter insertions were enrolled in this study. All patients were matched by sex, age, Acute Physiology and Chronic Health Evaluation II score, body mass index, department, and catheter insertion site and were randomly divided into case and control groups (n = 106 each). The control group was given conventional care, and the case group was given care bundles including nurse education, hand hygiene, maximal sterile barrier precautions, bedside observation, and evaluation. The anxiety scores, hospitalization days, CRBSI rate, and degree of satisfaction with hospitalization were compared between the two groups. Results The patients’ mean self-rating anxiety scale score and self-rating depression scale score after nursing intervention were significantly lower in the case group than in the control group. The mean number of hospitalization days and CRBSI rate were significantly lower and the satisfaction rate was significantly higher in the case group. Conclusion Care bundles are essential for preventing CRBSI. They can improve patients’ psychological state and hospitalization satisfaction and reduce the hospitalization days.


Author(s):  
Ling PANG ◽  
Yunxia WANG ◽  
Yuexin XING ◽  
Chunxia ZHAO

Background: To explore the application effects of whole course high-quality nursing on patients with liver cancer during radiotherapy. Methods: One hundred and five patients with liver cancer who received radiotherapy in Liaocheng People’s Hospital, Liaocheng, China from March 2010 to February 2012 were selected and divided into a control group (42 cases with routine nursing) and an experimental group (63 cases with whole course high-quality nursing). The two groups of patients were observed and compared in terms of clinical data and the Activity of Daily Living (ADL) score before and after nursing (1 course of treatment/6 week). The Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to evaluate and compare the patients’ anxiety and depression before and after nursing. Adverse reactions during radiotherapy and nursing satisfactory of patients were observed and compared between the two groups. Results: After nursing, the ADL score and the nursing satisfaction in the experimental group was significantly higher than that in the control group (P<0.05). The SDS and SAS scores in the 2 groups before nursing were significantly higher than those after nursing (P<0.05). The total incidence of adverse reactions in the control group was significantly higher than that in the experimental group (P<0.05). Conclusion: Whole course high-quality nursing can improve the negative emotions, quality of life and nursing satisfaction, and reduce adverse reactions of patients with liver cancer during radiotherapy.


2018 ◽  
Vol 46 (8) ◽  
pp. 3124-3130 ◽  
Author(s):  
Han Joon Kim ◽  
Su In Park ◽  
Sang Yun Cho ◽  
Min Jae Cho

Objective Insertion of a nasogastric tube (NGT) in patients who have been intubated with an endotracheal tube while under general anesthesia can cause difficulties and lead to complications, including hemorrhage. A visualization-aided modality was recently used to facilitate NGT insertion. Some studies have focused on the role of modified Magill forceps, which have angles similar to those of the GlideScope blade (Verathon, Bothell, WA, USA). Methods Seventy patients were divided into a control group (Group C) and an experimental group (GlideScope and modified Magill forceps, Group M). Results The total NGT insertion time was significantly shorter in Group M than C (71.3 ± 22.6 vs. 96.7 ± 57.5 s; mean difference, –25.3 s; 95% confidence interval [CI], 20.8–71.5). There were also significantly fewer mean insertion attempts in Group M than C (1.0 ± 0.0 vs. 2.11 ± 0.93). The success rate for the first attempt in Group C was 37.1%, while that in Group M was 100% (relative risk, 2.7; 95% CI, 1.7–4.1). Conclusion The use of the GlideScope with modified Magill forceps for insertion of an NGT in patients who are already intubated and under general anesthesia will shorten the insertion time and improve the success rate.


2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Yanjie Han

Objective — To conduct studies on the application effect of humanistic care in the operation room. Methods — A total of 90 patients who received surgical treatment in our hospital from January 2021 to May 2021 were selected and divided into experimental group and control group based on the order of admission, with 45 patients in each group. The patients in the control group were treated with routine surgical nursing, and the patients in the experimental group were treated with humanistic care on the basis of routine surgical nursing. Comparison was made in the application effect of the two groups. Results — The scores of Self-Rating Depression Scale and Self-Rating Anxiety Scale in two groups demonstrated significant decreasing. The scores of the Self-Rating Depression Scale and Self-Rating Anxiety Scale were significantly reduced in the two groups after psychological nursing intervention. Conclusions — Effective humanistic care can not only contributes to the relief of anxiety or depression and other unhealthy emotions of patients, but also serves as an important way to maintain a good doctor-patient relationship. Humanistic care has certain application value in clinical applications.


2021 ◽  
Vol 7 (5) ◽  
pp. 4341-4348
Author(s):  
Qi Chen ◽  
Ling Xu ◽  
Hui Liang

Objective. To explore the impact of whole interventional psychological intervention combined with action-oriented teaching on the incidence of postoperative complications and negative emotion in patients with malignant glioma (MG). Methods. 96 MG patients admitted to our hospital (January 2020 - January 2021) were selected, and equally split into the control group (CG) treated with routine nursing and the study group (SG) treated with whole interventional psychological intervention combined with action-oriented approach on the basis of routine nursing. The impact of the two nursing patterns on the incidence of postoperative complications and negative emotion of patients was scientifically evaluated. Results. The patients of CG and SG showed no statistical difference in general data (P>0.05). Compared with CG, the proportion of patients with severe and extreme pain, and the scores of Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) in SG were notably lower (P<0.05). According to statistics, intracranial hemorrhage occurred in 4 cases of CG and 0 case of SG, diarrhea occurred in 5 cases of CG and 1 case of SG, hyperpyrexia occurred in 4 cases of CG and 1 case of SG, and nausea and vomiting occurred in 2 cases of CG and 2 cases of SG, so it could be seen that the incidence of adverse reactions in SG was notably lower compared with CG (P<0.05). The scores of 36-item short-form health survey scale (SF-36) and nursing quality in SG were notably higher compared with CG (P<0.05). Conclusion. The combination of whole interventional psychological intervention and action-oriented teaching can effectively reduce the incidence of postoperative complications, relieve postoperative pain, improve psychological state and further improve quality of life of MG patients. Therefore, it is an effective intervention program that can improve nursing Quality.


2017 ◽  
Vol 37 (2) ◽  
Author(s):  
Yan Wang ◽  
Gang Li ◽  
Man-Zhen Zuo ◽  
Jun-Hua Fang ◽  
Hai-Rong Li ◽  
...  

The present study aims to explore the relationship between the Y chromosome polymorphisms (1qh+, inv(9), 9qh+, 16qh+, group D/G, Yqh– and Yqh+) and the risk of unexplained recurrent miscarriage (URM). A total of 507 couples with URM were recruited as case group and 465 healthy couples as control group. The Y chromosome polymorphisms of the male individuals were analysed with the G-banding technique, and the results of the chromosome G-banding analysis were determined using the International Naming Standards of Human Genetics (ISCN). Logistic regression analysis was used to analyse the risk factors for URM. The detection rate of Y chromosome polymorphisms in the case group (12.03%) was higher than that in the control group (2.15%). Y chromosome polymorphisms were detected at significantly higher rates in the case group than in the control group. Using the normal Y chromosomes in individuals of the case group as reference, the partners of their counterparts were more likely to experience miscarriage. The couples who were Y chromosome-polymorphism carriers had shorter gestational age, increased frequency of URM and longer average interval between pregnancies. The results of logistic regression analysis revealed that Y chromosome polymorphisms, shorter gestational age, a higher frequency of miscarriage and longer pregnancy interval were independent risk factors for URM. Y chromosome polymorphisms may be associated with the risk of URM and may play an important role in the development of URM.


2018 ◽  
Vol 7 (4) ◽  
pp. 131-149 ◽  
Author(s):  
A.E. Khain ◽  
A.B. Kholmogorova ◽  
V.A. Ababkov

The article presents data on the study of emotional state characteristics and coping strategies of adolescents in the stressful situation of oncohematological diseases treatment. Two equalized by socio-demographic and clinical parameters groups of patients 11-18 were examined. The experimental group consisted of 28 adolescents undergoing treatment with hemopoietic stem cell transplantation (HSCT) (M = 14.25, SD = 2.20, M: 57.1%, F: 42.9%). The control group consisted of 30 adolescents undergoing chemotherapy (M = 13.71, SD = 2.12, M: 53.3%, F: 46.7%). The psychological state of adolescents in the course of treatment by НSCТ, in comparison with the state of adolescents of the control group, which is characterized by a significantly higher level of distress and anxiety. Significant differences in the use of coping strategies with stress in patients of the two groups were obtained. Adolescents of the experimental group use a less extensive repertoire of productive coping strategies, often use such an ineffective strategy as "discharge" These differences may be associated with less availability, as well as an increase in depletion of various coping resources under special treatment conditions by the НSCТ. The results of the study confirmed that НSCТ is objectively and subjectively more stressful, which indicates the need for additional monitoring of both the psychological state and the need for psychological care for patients in this group, the development of specialized programs for psychological support for transplantation.


1970 ◽  
Vol 1 (1) ◽  
Author(s):  
Kang Yuehua

Objective: To explore the impact of human nursing on emergency success rate and satisfaction in emergency department nursing. Methods: 146 cases of emergency patients were collected from February 2015 to July 2016 in our hospital. The patients were randomly divided into control group and experimental group (73 cases). The patients in the control group were treated by routine nursing method. The patients in the experimental group nursing intervention was performed on the basis of humanized care in the control group, and the success rate and satisfaction of the two groups were observed. Results: The success rate of emergency treatment (93.2%) in the experimental group was significantly higher than that in the control group (79.5%), the difference was statistically significant (P < 0.05).After the nursing group, the satisfaction rate 91.8%) was significantly higher than that of the control group (65.8%), which was statistically significant (P < 0.05). Conclusion: Human care in emergency department nursing can effectively improve the success rate of emergency and patient satisfaction.


2016 ◽  
Vol 35 (2) ◽  
pp. 166-174 ◽  
Author(s):  
Fatimah Basil Al-Mukaynizi ◽  
Afrah AlKhuriji ◽  
Zaineb Babay ◽  
Mohammad Addar ◽  
Sooad AlDaihan ◽  
...  

Summary Background: An insertion/deletion (I/D) polymorphism in the angiotensin converting enzyme (ACE) gene has been associated with recurrent miscarriage (RM) in several populations. We initiated this study to determine the association, if any, between the I/D polymorphism of ACE gene and RM in Saudi females. Method: This study was conducted on 61 Saudi females suffering from RM (mean age: 34.1±6.2 years; range 15–45) attending clinics at King Khalid University Hospital, and 59 age matched females who had at least 2 children, as controls. Blood samples were drawn in EDTA tubes by venipuncture. DNA was extracted using the Puregene DNA purification kits. Insertion/Deletion (I/D) polymorphism of ACE gene was investigated by amplifying the genomic DNA by PCR using gene-specific primers. A single 190 bp or 490 bp band was obtained in the homozygous cases for the D allele or I allele, respectively, while the presence of both 190 and 490 bp bands indicated heterozygosity (ID). Statistical analysis: Deviation from Hardy-Weinberg equilibrium was determined (http://ihg.gsf.de/cgi-bin/hw/hwa1.pl). A standard chi-square (χ2) test was used for comparing the genotype and allele frequencies in the two groups and Students‘t’ test and χ2 test were employed to compare values between the two groups. P<0.05 was considered statistically significant. Results: The frequencies of DD, ID, and II genotypes were 56.7%, 29.5% and 4.9%, respectively, in females with RM and 54.2%, 42.3% and 3.3% respectively in the control group, but the difference was not statistically significant. Conclusion: In some populations, meta-analyses showed an association between I/D polymorphism and RM risk, and the D allele was implicated as an increased risk factor for RM. However, this association was not apparent in the Saudi females.


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