scholarly journals Brain-Derived Neurotrophic Factor Polymorphism and Aphasia after Stroke

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Nathan T. Lee ◽  
Fatimah Ahmedy ◽  
Natiara Mohamad Hashim ◽  
Khin Nyein Yin ◽  
Kai Ling Chin
Keyword(s):  
Neurotrophic Factor ◽  
Selection Process ◽  
Brain Derived Neurotrophic Factor ◽  
Stroke Recovery ◽  
Bdnf Gene ◽  
Eligibility Criteria ◽  
Val66met Polymorphism ◽  
Language Interventions ◽  
Causes Of Mortality ◽  
Aphasia Recovery

Stroke is one of the most deliberating causes of mortality and disability worldwide. Studies have implicated Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene as a genetic factor influencing stroke recovery. Still, the role of BDNF polymorphism in poststroke aphasia is relatively unclear. This review assesses the recent evidence on the association between the BDNF polymorphism and aphasia recovery in poststroke patients. The article highlights BNDF polymorphism characteristics, speech and language interventions delivered, and the influence of BNDF polymorphism on poststroke aphasia recovery. We conducted a literature search through PubMed and Google Scholar with the following terms: “brain derived-neurotrophic factor” and “aphasia” for original articles from January 2000 until June 2020. Out of 69 search results, a detailed selection process produced a total of 3 articles that met the eligibility criteria. All three studies included Val66Met polymorphism as the studied human BDNF gene. One of the studies demonstrated insufficient evidence to conclude that BDNF polymorphism plays a role in poststroke aphasia recovery. The remaining two studies have shown that Met allele genotype (either single or double nucleotides) was associated with poor aphasia recovery, in either acute or chronic stroke. Carriers of the Val66Met polymorphism of BDNF gave a poorer response to aphasia intervention and presented with more severe aphasia.

The Influence of Val66Met Polymorphism in Brain-Derived Neurotrophic Factor on Stroke Recovery Outcome: A Systematic Review and Meta-analysis

2021 ◽  
pp. 154596832110141
Author(s):  
Xuan Liu ◽  
Jun-Chao Fang ◽  
Xin-Yue Zhi ◽  
Qiu-Yu Yan ◽  
Hong Zhu ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Genetic Model ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Recessive Model ◽  
Stroke Recovery ◽  
Stroke Severity ◽  
Val66met Polymorphism ◽  
Asian Patients ◽  
Caucasian Patients

Background and purpose. A single nucleotide polymorphism at nucleotide 196 (G/A) in the human brain-derived neurotrophic factor ( BDNF) gene produces an amino acid substitution (valine to methionine) at codon 66(Val66Met). It is unclear whether carriers of this substitution may have worse functional outcomes after stroke. We aimed to explore the distribution of Val66Met polymorphism and evaluate the effect of different genotypes on stroke functional recovery. Methods. Several databases were searched using the keywords BDNF or brain-derived neurotrophic factor, codon66, G196A, rs6265, or Val66Met, and stroke. Results. A total of 25 articles were relevant to estimate the distribution of alleles; 5 reports were applied in the meta-analysis to assess genetic differences on recovery outcomes. The genetic model analysis showed that the recessive model should be used; we combined data for AA versus GA+GG (GG—Val/Val, GA—Val/Met, AA—Met/Met). The results showed that stroke patients with AA might have worse recovery outcomes than those with GA+GG (odds ratio = 1.90; 95% CI: 1.17-3.10; P = .010; I2 = 69.2%). Overall, the A allele may be more common in Asian patients (48.6%; 95% CI: 45.8%-51.4%, I2 = 54.2%) than Caucasian patients (29.8%; 95% CI: 7.5%-52.1%; I2 = 99.1%). However, in Caucasian patients, the frequency of the A allele in Iranians (87.9%; 95% CI: 83.4%-92.3%) was quite higher than that in other Caucasians (18.7%; 95% CI: 16.6%-20.9%; I2 = 0.00%). Conclusion. Val66Met AA carriers may have worse rehabilitation outcomes than GA+GG carriers. Further studies are needed to determine the effect of Val66Met polymorphism on stroke recovery and to evaluate this relationship with ethnicity, sex, age, stroke type, observe duration, stroke severity, injury location, and therapies.

scholarly journals The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

2017 ◽  
Vol 39 (2) ◽  
pp. 90-94 ◽  
Author(s):  
Lucas A. de Azeredo ◽  
Tatiana De Nardi ◽  
Mateus L. Levandowski ◽  
Saulo G. Tractenberg ◽  
Julia Kommers-Molina ◽  
...  
Keyword(s):  
Older Adults ◽  
Neurotrophic Factor ◽  
Memory Performance ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
Val66met Polymorphism ◽  
The Brain

Quadri-pulse stimulation (QPS) induced LTP/LTD was not affected by Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene

2011 ◽  
Vol 487 (3) ◽  
pp. 264-267 ◽  
Author(s):  
Koichiro Nakamura ◽  
Hiroyuki Enomoto ◽  
Ritsuko Hanajima ◽  
Masashi Hamada ◽  
Eiji Shimizu ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
Val66met Polymorphism ◽  
The Brain ◽  
Pulse Stimulation

scholarly journals Brain-Derived Neurotrophic Factor Genotype–Specific Differences in Cortical Activation in Chronic Aphasia

2019 ◽  
Vol 62 (11) ◽  
pp. 3923-3936 ◽  
Author(s):  
Sigfus Kristinsson ◽  
Grigori Yourganov ◽  
Feifei Xiao ◽  
Leonardo Bonilha ◽  
Brielle C. Stark ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Right Hemisphere ◽  
Brain Activation ◽  
Naming Task ◽  
Brain Derived Neurotrophic Factor ◽  
Stroke Recovery ◽  
Bdnf Gene ◽  
Functional Brain ◽  
Link Type ◽  
Chronic Aphasia

Purpose The brain-derived neurotrophic factor (BDNF) gene has been shown to be important for synaptic plasticity in animal models. Human research has suggested that BDNF genotype may influence stroke recovery. Some studies have suggested a genotype-specific motor-related brain activation in stroke recovery. However, recovery from aphasia in relation to BDNF genotype and language-related brain activation has received limited attention. We aimed to explore functional brain activation by BDNF genotype in individuals with chronic aphasia. Consistent with findings in healthy individuals and individuals with poststroke motor impairment, we hypothesized that, among individuals with aphasia, the presence of the Met allele of the BDNF gene is associated with reduced functional brain activation compared to noncarriers of the Met allele. Method Eighty-seven individuals with chronic stroke-induced aphasia performed a naming task during functional magnetic resonance imaging scanning and submitted blood or saliva samples for BDNF genotyping. The mean number of activated voxels was compared between groups, and group-based activation maps were directly compared. Neuropsychological testing was conducted to compare language impairment between BDNF genotype groups. The Western Aphasia Battery Aphasia Quotient ( Kertesz, 2007 ) was included as a covariate in all analyses. Results While lesion size was comparable between groups, the amount of activation, quantified as the number of activated voxels, was significantly greater in noncarriers of the Met allele (whole brain: 98,500 vs. 28,630, p < .001; left hemisphere only: 37,209 vs. 7,000, p < .001; right hemisphere only: 74,830 vs. 30,630, p < .001). This difference was most strongly expressed in the right hemisphere posterior temporal area, pre- and postcentral gyrus, and frontal lobe, extending into the white matter. Correspondingly, the atypical BDNF genotype group was found to have significantly less severe aphasia (Western Aphasia Battery Aphasia Quotient of 64.2 vs. 54.3, p = .033) and performed better on a naming task (Philadelphia Naming Test [ Roach, Schwartz, Martin, Grewal, & Brecher, 1996 ] score of 74.7 vs. 52.8, p = .047). A region of interest analysis of intensity of activation revealed no group differences, and a direct comparison of average activation maps across groups similarly yielded null results. Conclusion BDNF genotype mediates cortical brain activation in individuals with chronic aphasia. Correspondingly, individuals carrying the Met allele present with more severe aphasia compared to noncarriers. These findings warrant further study into the effects of BDNF genotype in aphasia. Supplemental Material https://doi.org/10.23641/asha.10073147 Presentation Video https://doi.org/10.23641/asha.10257581

scholarly journals Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory

2010 ◽  
Vol 13 (8) ◽  
pp. 975-980 ◽  
Author(s):  
Flurin Cathomas ◽  
Christian Vogler ◽  
Jessica C. Euler-Sigmund ◽  
Dominique J.-F. de Quervain ◽  
Andreas Papassotiropoulos
Keyword(s):  
Episodic Memory ◽  
Fine Mapping ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
Val66met Polymorphism ◽  
The Brain
Sign in / Sign up

Export Citation Format

Share Document