scholarly journals Serum Antithyroglobulin Antibody Levels Are Associated with Diabetic Retinopathy among Euthyroid Type 2 Diabetes Patients: A Hospital-Based, Retrospective Study

2022 ◽  
Vol 2022 ◽  
pp. 1-10
Author(s):  
Xiaotong Gao ◽  
Xichang Wang ◽  
Yifan Zhong ◽  
Lei Liu ◽  
Weiping Teng ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Reference Interval ◽  
Free Triiodothyronine ◽  
Thyroglobulin Antibody ◽  
Fundus Photographs ◽  
Antibody Levels

Background. Previous studies have revealed that the variation of thyroid indicators may be associated with the risk of diabetic retinopathy (DR) among euthyroid type 2 diabetes (T2D) patients. But the specific conclusions are currently inconsistent. Methods. This is a hospital-based retrospective survey. We recruited 1,145 euthyroid T2D patients and checked the thyroid function and fundus photographs. The modified Airlie House classification system was used to categorize the stages of DR. The association between thyroid indicators and different stages of DR was analyzed. Results. We divided free triiodothyronine (FT3) into tertiles and found that the prevalence of mild nonproliferative DR (NPDR) was significantly higher in T2, compared with T1 (32.0% vs. 25.2%, p < 0.05 ). When FT3 was within the level of T2, FT3 could be an independent risk factor for mild NPDR (OR 1.426, 95% CI (1.031, 1.971), p < 0.05 ). In addition, the prevalence of severe NPDR and proliferative DR (PDR) was significantly higher in thyroglobulin antibody (TgAb) positive group (8.8% vs. 4.1%, p < 0.05 ) and vice versa (33.3% vs. 18.4%, p < 0.05 ). TgAb positivity was also an independent risk factor for severe NPDR and PDR (OR 2.212, 95% CI (1.244, 3.934), p < 0.05 ). Conclusions. We hardly observed a significant change in DR risk with the elevation or reduction of serum TSH or thyroid hormone within the reference interval. Although the slightly elevated FT3 may be associated to mild NPDR, the extensibility of this result remains to be seen. For T2D patients with euthyroid function, there may be a significant correlation between serum TgAb positivity and severe NPDR and PDR.

Low bilirubin levels are an independent risk factor for diabetic retinopathy and nephropathy in Japanese patients with type 2 diabetes

2015 ◽  
Vol 41 (5) ◽  
pp. 429-431 ◽  
Author(s):  
S. Hamamoto ◽  
H. Kaneto ◽  
S. Kamei ◽  
M. Shimoda ◽  
K. Tawaramoto ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Japanese Patients

LBPS 03-27 CO-EXISTING HYPERTENSION AS INDEPENDENT RISK FACTOR FOR DIABETIC RETINOPATHY AMONG TYPE-2 DIABETES

2016 ◽  
Vol 34 (Supplement 1) ◽  
pp. e531
Author(s):  
Kazi Rumana Ahmed ◽  
Hasina Akhter Chowdhury ◽  
Jesmin Akter ◽  
Sharmin Hossain ◽  
Mohammad Sadaat Bukht ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Risk Factor ◽  
Independent Risk Factor

scholarly journals The Platelet-to-Lymphocyte Ratio Predicts Diabetic Retinopathy in Type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Jing Zeng ◽  
Min Chen ◽  
Qiu Feng ◽  
Haiyan Wan ◽  
Jianbo Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Inflammatory Responses ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio

Abstract Introduction:Diabetic retinopathy (DR), as a serious and specific neurovascular complication of DM, remains the leading cause of vision loss and preventable blindness in adults aged 20–74 years. Several studies have indicated that chronic inflammation plays an important role in DR. Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are novel potential markers of inflammatory responses. However, only a few articles have evaluated the association between these factors and DR.Patients and Methods: The study included 133 patients diagnosed with type 2 diabetes mellitus (T2DM). Retinopathy was graded using the International Clinical Diabetic Retinopathy Disease Severity Scale.Results:The mean NLR, PLR and MLR were significantly higher in patients with DR than in patients without DR (p < 0.001, p = 0.002, and p = 0.003, respectively). In the post hoc analysis, the PDR group had the highest NLR and MLR values among the three groups. Multiple logistic regression showed that the PLR was an independent risk factor for DR (odds ratio [OR]: 1.022, 95% confidence interval [CI]: 1.005–1.040 p = 0.013). Based on the receiver operating characteristic (ROC) curve, the cutoff value of PLR as an indicator for DR diagnosis was projected to be 78.70 and yielded a sensitivity and specificity of 80.7% and 48.9%, respectively, with an area under the curve of 0.669 (95% CI: 0.572–0.765, P = 0.002).Conclusions:Our results suggest that PLR may be an independent risk factor for evaluating DR in patients with type 2 diabetes.

A hemochromatosis-causing mutation C282Y is a risk factor for proliferative diabetic retinopathy in Caucasians with type 2 diabetes

2004 ◽  
Vol 137 (6) ◽  
pp. 1171-1172
Author(s):  
B. Peterlin ◽  
M. Globočnik Petrovič ◽  
J. Makuc ◽  
M. Hawlina ◽  
D. Petrovič
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Risk Factor ◽  
Proliferative Diabetic Retinopathy

scholarly journals Serum High Lipoprotein(a) Levels in Patients with Type 2 Diabetes May Be an Independent Risk Factor for Hypertension

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Lingfen Zeng ◽  
Jieming Sun ◽  
Ming Cui
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Glycosylated Hemoglobin ◽  
Serum Triglyceride ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Lipoprotein A

Objective — To investigate whether serum lipoprotein(a) [Lp(a)] is an independent risk factor for abnormal blood pressure in patients with type 2 diabetes mellitus. Method — Analyzed data collected from diabetes patients and epidemiological survey from January 1,2020 to May 01,2021, with hypertension as a dependent variable, metabolic index such as glycosylated hemoglobin, serum total cholesterol, serum triglyceride and Lp(a) were independent variables, established logistic regression equation, analyze the influence of their variables on dependent variables. Results — The OR value of Lp(a) is 1.020, 95% confidence intervals (1.006, 1.035), p 0.006; The OR value of age is 1.073, 95% confidence interval (1.028, 1.119); and OR of the remaining parameters were tested no statistically different, p>0.05. Conclusions — The abnormal elevated Lp(a) level in the serum of type 2 diabetic patients may be related to the occurrence of hypertension. For patients with high Lp(a), Monitoring blood pressure may help to better detect and diagnose hypertension. At the same time, it is suggested that reducing serum Lp(a) level may reduce the risk of hypertension.

scholarly journals Microalbuminuria as an independent risk factor for heart failure in the elderly patients with type 2 diabetes mellitus

2020 ◽  
Vol 49 (2) ◽  
Author(s):  
Enisa Karić ◽  
Zumreta Kušljugić ◽  
Enisa Ramić ◽  
Olivera Batić- Mujanović ◽  
Amila Bajraktarević ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Type 2 Diabetes ◽  
Risk Factor ◽  
Diabetes Mellitus Type 2 ◽  
Independent Risk Factor ◽  
The Elderly ◽  
Diabetes Mellitus Type ◽  
Patients With Diabetes

Introduction:The study evaluated of microalbuminuria as a predictor of heart failure in patients with diabetes mellitus type 2.Materials and methods:The prospective study conducted in a period of time from 01-Feb-2007 to 01-Feb-2010.The study included 100 patients with type 2 diabetes, who had diabetes longer than 5 years. All subjects (average age 66 ± 10 years, 33% male, 67% female) were tested for the presence of microalbuminuria, and 50 patients had microalbuminuria. The second group comprised 50 patients without of microalbuminuria with diabetes mellitus type 2.Results:In the patients with microalbuminuria and diabetes mellitus were found 22% of heart failure and 6% in the second group. Average time to the occurance of heart failure in the first group was 32,5 months, in the second group was 35,3 months.Conclusions:The results show that microalbuminuria is an independent risk factor for heart failure in patients with diabetes mellitus type 2 and microalbuminuria. Patients without microalbuminuria had 3,7 less likely to development heart failure compared to patients with microalbuminuria and diabetes mellitus.

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