scholarly journals Effect of Early Nutritional Assessment and Nutritional Support on Immune Function and Clinical Prognosis of Critically Ill Children

2022 ◽  
Vol 2022 ◽  
pp. 1-7
Author(s):  
Jie Guo ◽  
Zixuan Jin ◽  
Yibing Cheng ◽  
Jun Su ◽  
Zheng Li ◽  
...  
Keyword(s):  
Immune Function ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Nutritional Support ◽  
Nutritional Assessment ◽  
Nutritional Risk ◽  
Critically Ill Children ◽  
Control Group ◽  
Clinical Prognosis ◽  
Experimental Group

The aim of this study was to study the effect of early nutritional assessment and nutritional support on immune function and clinical prognosis of critically ill children. 90 critically ill children at the same level of severity admitted to the pediatric intensive care unit (PICU) of our hospital (June 2019–June 2020) were chosen as the research objects and were equally separated into the experimental group and the control group by the random number table method. The children in the control group were admitted to the PICU according to the routine process, and the nutritional support was provided to the malnourished ones. After admission to the PICU, the children in the experimental group were given nutritional assessment, nutritional risk screening, and nutritional support according to the screening results. The PICU stay time and total hospitalization time of the experimental group were obviously shorter than those of the control group ( P < 0.05 ), the hospitalization expenses of the experimental group were obviously lower than those of the control group ( P < 0.05 ), the clinical outcomes and immune function of the experimental group were obviously better than those of the control group ( P < 0.05 ), and the nutrition indicators of the experimental group were obviously higher than those of the control group ( P < 0.05 ). Early nutritional assessment and nutritional support can effectively improve the immune function and reduce the incidence of adverse clinical outcomes of critically ill children, which are worthy of clinical application and promotion.

Association of Fluid Overload With Clinical Outcomes in Critically Ill Children With Bronchiolitis

2019 ◽  
Vol 20 (3) ◽  
pp. e130-e136 ◽  
Author(s):  
Jose C. Flores-González ◽  
Cristina Montero Valladares ◽  
Cristina Yun Castilla ◽  
Juan Mayordomo-Colunga ◽  
Sonia Pérez Quesada ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Critically Ill ◽  
Fluid Overload ◽  
Critically Ill Children

scholarly journals Use of body composition and phase angle analysis for the assessment of nutritional status and clinical outcomes in critically ill children

2021 ◽  
Author(s):  
Zi-Hong Xiong ◽  
Xue-Mei Zheng ◽  
Guo-Ying Zhang ◽  
Meng-Jun Wu ◽  
Yi Qu
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Nutritional Status ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Pediatric Intensive Care Unit ◽  
Phase Angle ◽  
Pediatric Intensive Care ◽  
Critically Ill Children ◽  
Duration Time

Abstract BackgroundMalnutrition is highly prevalent in critically ill children in the pediatric intensive care unit .We aimed to investigate the efficiency of bioelectrical impedance analysis (BIA) measurements and phase angle (PhA) analysis for the assessment of nutritional risk and clinical outcomes in critically ill children.MethodsThis single-center observational study included patients admitted to the Pediatric Intensive Care Unit (PICU) of Chengdu Women’s and Children’s Central Hospital. All patients underwent anthropometric measurement in the first 24 h of admission and underwent BIA measurements within 3 days after the admission. The patients were classified into different groups based on body mass index (BMI) for age. Electronic hospital medical records were reviewed to collect clinical data for each patient. All the obtained data were analyzed by the statistics method.ResultsThere were 204 patients enrolled in our study, of which 32.4% were diagnosed with malnutrition. We found that BMI, arm muscle circumference, fat mass, and %body fat were lower in the group with poorer nutritional status (P < 0.05). Evident differences in the score of the Pediatric Risk of Mortality and the duration of mechanical ventilation (MV) among the three groups with different nutritional statuses were observed (P < 0.05). Patients in the severely malnourished group had the longest duration of MV. In the MV groups, there were significant differences (P < 0.05) in albumin level, PhA, and extracellular water/total body water (ECW/TBW ratio). The ECW/TBW ratio and the time for PICU stay had a weak degree of correlation (Pearson correlation coefficient = 0.375). PhA showed a weak degree of correlation with the duration time of medical ventilation (coefficient of correlation = 0.398).ConclusionBIA can be considered an alternative way to assess nutritional status in critically ill children. ECW/TBW ratio and PhA were correlated with PICU stay and duration time of medical ventilation, respectively.

Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children

2015 ◽  
Vol 16 (6) ◽  
pp. 505-514 ◽  
Author(s):  
Pierre Demaret ◽  
Marisa Tucci ◽  
Oliver Karam ◽  
Helen Trottier ◽  
Thierry Ducruet ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Critically Ill ◽  
Critically Ill Children

scholarly journals Early Enteral Nutrition Is Associated With Improved Clinical Outcomes in Critically Ill Children

2020 ◽  
Vol 21 (3) ◽  
pp. 213-221 ◽  
Author(s):  
Vijay Srinivasan ◽  
Natalie R. Hasbani ◽  
Nilesh M. Mehta ◽  
Sharon Y. Irving ◽  
Sarah B. Kandil ◽  
...  
Keyword(s):  
Enteral Nutrition ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Critically Ill Children ◽  
Early Enteral Nutrition

scholarly journals The Effect of Dietary and Exercise Self-Management Support Program on Dietary Behavior Exercise Behavior and Clinical Outcomes in Muslim Patients with Poorly Controlled Type 2 DM in a Community Setting in Indonesia

2015 ◽  
Vol 5 (1) ◽  
pp. 1 ◽  
Author(s):  
Rian Adi Pamungkas ◽  
Tippamas Chinnawong ◽  
Charuwan Kritpracha
Keyword(s):  
Clinical Outcomes ◽  
Dietary Behavior ◽  
Exercise Behavior ◽  
Support Program ◽  
Self Management ◽  
Control Group ◽  
Management Support ◽  
Type 2 Dm ◽  
Experimental Group

Purpose: The objective of this study was to examine the effect of dietary and exercise self-management support program on the dietary behavior, exercise behavior, and clinical outcomes of Muslim patients with poorly controlled type 2 DM in Indonesia. Methods: This study was a quasi-experimental, two group, pre-test and post-test design. The experimental group received the dietary and exercise self-management support program and usual care, whereas the control group only received the usual nursing care.Result: 35 subjects in the experimental group and 35 subjects in the control group completed the program, respectively. The findings indicated that there are significantly differences in dietary behavior (p=.00), exercise behavior (p=.00) and clinical outcomes: fasting blood glucose (FBG) (p=.00), cholesterol total level (p=.01) and systolic blood pressure (p=.00) between the experimental group and control group. However, for the BMI status (p=.84) and diastolic blood pressure (BP) (p=.32) were no significant differences between two groups. Conclusion: The dietary and exercise self-management support program was effective for improving the dietary behavior, exercise behavior, FBG, and total cholesterol level for individuals with poorly controlled type 2 diabetes mellitus. Further studies should be replicated using larger groups over a longer time frame.

scholarly journals Impact of balanced versus unbalanced fluid resuscitation on clinical outcomes in critically ill children: protocol for a systematic review and meta-analysis

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Anab Rebecca Lehr ◽  
Soha Rached-d’Astous ◽  
Melissa Parker ◽  
Lauralyn McIntyre ◽  
Margaret Sampson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Fluid Resuscitation ◽  
Meta Analysis ◽  
Critically Ill Children

Clinical Outcomes in Critically Ill Children With Excess Weight: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Caroline Abud Drumond Costa ◽  
Rita Mattiello ◽  
Gabriele Carra Forte ◽  
Gabriela Rupp Hanzen Andrades ◽  
Francielly Crestani ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Excess Weight ◽  
Critically Ill Children

scholarly journals Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

Critical Care ◽  
2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Emma J. Kooistra ◽  
◽  
Nicole J. B. Waalders ◽  
Inge Grondman ◽  
Nico A. F. Janssen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Plasma Levels ◽  
Prospective Cohort ◽  
Sensitivity Analyses ◽  
Control Group ◽  
Clinical Parameters ◽  
Inflammatory Parameters ◽  
Anakinra Treatment

Abstract Background A subset of critically ill COVID-19 patients develop a hyperinflammatory state. Anakinra, a recombinant interleukin-1 receptor antagonist, is known to be effective in several hyperinflammatory diseases. We investigated the effects of anakinra on inflammatory parameters and clinical outcomes in critically ill, mechanically ventilated COVID-19 patients with clinical features of hyperinflammation. Methods In this prospective cohort study, 21 critically ill COVID-19 patients treated with anakinra were compared to a group of standard care. Serial data of clinical inflammatory parameters and concentrations of multiple circulating cytokines were determined and aligned on start day of anakinra in the treatment group, and median start day of anakinra in the control group. Analysis was performed for day − 10 to + 10 relative to alignment day. Clinical outcomes were analyzed during 28 days. Additionally, three sensitivity analyses were performed: (1) using propensity score-matched groups, (2) selecting patients who did not receive corticosteroids, and (3) using a subset of the control group aimed to match the criteria (fever, elevated ferritin) for starting anakinra treatment. Results Baseline patient characteristics and clinical parameters on ICU admission were similar between groups. As a consequence of bias by indication, plasma levels of aspartate aminotransferase (ASAT) (p = 0.0002), ferritin (p = 0.009), and temperature (p = 0.001) were significantly higher in the anakinra group on alignment day. Following treatment, no relevant differences in kinetics of circulating cytokines were observed between both groups. Decreases of clinical parameters, including temperature (p = 0.03), white blood cell counts (p = 0.02), and plasma levels of ferritin (p = 0.003), procalcitonin (p = 0.001), creatinine (p = 0.01), and bilirubin (p = 0.007), were more pronounced in the anakinra group. No differences in duration of mechanical ventilation or ICU length of stay were observed between groups. Sensitivity analyses confirmed these results. Conclusions Anakinra is effective in reducing clinical signs of hyperinflammation in critically ill COVID-19 patients. A randomized controlled trial is warranted to draw conclusion about the effects of anakinra on clinical outcomes.

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