scholarly journals Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-κB Signaling Pathway after Spinal Cord Injury in Mice

2022 ◽  
Vol 2022 ◽  
pp. 1-18
Author(s):  
Xiaochu Feng ◽  
Xianghang Chen ◽  
Muhammad Zaeem ◽  
Wanying Zhang ◽  
Liwan Song ◽  
...  

Inflammation is one of the crucial mechanisms mediating spinal cord injury (SCI) progress. Sesamol, a component of sesame oil, has anti-inflammatory activity, but its mechanism in SCI remains unclear. We investigated if the AMPK/SIRT1/NF-κB pathway participated in anti-inflammation of sesamol in SCI. Sesamol could inhibit neuronal apoptosis, reduce neuroinflammation, enhance M2 phenotype microglial polarization, and improved motor function recovery in mice after SCI. Furthermore, sesamol increased SIRT1 protein expression and p-AMPK/AMPK ratio, while it downregulated the p-p65/p65 ratio, indicating that sesamol treatment upregulated the AMPK/SIRT1 pathway and inhibited NF-κB activation. However, these effects were blocked by compound C which is a specific AMPK inhibitor. Together, the study suggests that sesamol is a potential drug for antineuroinflammation and improving locomotor functional recovery through regulation of the AMPK/SIRT1/NF-κB pathway in SCI.

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Song-he Jiang ◽  
Wen-zhan Tu ◽  
En-miao Zou ◽  
Jie Hu ◽  
Sai Wang ◽  
...  

Spinal cord injury (SCI) can induce a series of histological, biochemical, and functional changes. Acupuncture is commonly used for SCI patients. Using male rats of spinal cord injury with the New York University (NYU) Impactor, we investigated the response of electroacupuncture (EA), manual acupuncture (MA), and transcutaneous acupoint electrical stimulation (TAES) at Shuigou (DU26) and Fengfu (DU16) acupoints to understand the effects and mechanisms of acupuncture in neuroprotection and neuronal function recovery after SCI. Histological study showed a restored neural morphology and an increase in the quantity of neurons after EA, MA, and TAES administrations. Acupuncture's antioxidation effects were demonstrated by alleviation of the post-SCI superoxide dismutase (SOD) activity increase and malondialdehyde (MDA) level decrease. The anti-inflammation effect of acupuncture was shown as the reduced expression of inflammatory cytokines including interleukin-1β(IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α) when SCI was treated. And the antiapoptosis role was approved by TUNEL staining. Our data confirmed that the role of acupuncture in neuroprotection and dorsal neuronal function recovery after rat SCI, especially, EA stimulating at Shuigou (DU26) and Fengfu (DU16) can greatly promote neuronal function recovery, which may result from antioxidation, anti-inflammation, and antiapoptosis effects of acupuncture.


2016 ◽  
Vol 54 (9) ◽  
pp. 7471-7482 ◽  
Author(s):  
Gang Li ◽  
Feifei Shen ◽  
Zhongkai Fan ◽  
Yangsong Wang ◽  
Xiangquan Kong ◽  
...  

2015 ◽  
Vol 53 (6) ◽  
pp. 4073-4082 ◽  
Author(s):  
Hao-Tian Li ◽  
Xing-Zhang Zhao ◽  
Xin-Ran Zhang ◽  
Gang Li ◽  
Zhi-Qiang Jia ◽  
...  

2009 ◽  
Vol 26 (11) ◽  
pp. 2057-2069 ◽  
Author(s):  
Venkata Ramesh Dasari ◽  
Krishna Kumar Veeravalli ◽  
Andrew J. Tsung ◽  
Christopher S. Gondi ◽  
Meena Gujrati ◽  
...  

2017 ◽  
Vol 49 (5) ◽  
pp. 589-596 ◽  
Author(s):  
Guanhua Xu ◽  
Jinlong Zhang ◽  
Lingling Wang ◽  
Zhiming Cui ◽  
Xu Sun ◽  
...  

eNeuro ◽  
2018 ◽  
Vol 5 (5) ◽  
pp. ENEURO.0303-18.2018 ◽  
Author(s):  
Shuhei Ito ◽  
Narihito Nagoshi ◽  
Osahiko Tsuji ◽  
Shinsuke Shibata ◽  
Munehisa Shinozaki ◽  
...  

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