Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men

2018 ◽  
Vol 78 (21) ◽  
pp. 6134-6145 ◽  
Author(s):  
Marc Gillard ◽  
Rodrigo Javier ◽  
Yuan Ji ◽  
S. Lilly Zheng ◽  
Jianfeng Xu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Cancer Progression ◽  
African American Men ◽  
Prostate Cancer Progression ◽  
Mediators Of Inflammation

scholarly journals Cultural Adaptation of Evidence-Based Lifestyle Interventions for African American Men With Prostate Cancer: A Dyadic Approach

2020 ◽  
Vol 14 (6) ◽  
pp. 155798832094544
Author(s):  
Dalnim Cho ◽  
Karen Basen-Engquist ◽  
Chiara Acquati ◽  
Curtis Pettaway ◽  
Hilary Ma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Cancer Survivors ◽  
Lifestyle Intervention ◽  
Cancer Progression ◽  
Healthy Lifestyle ◽  
African American Men ◽  
Evidence Based ◽  
Lifestyle Interventions ◽  
Intervention Adaptation

Although a number of lifestyle interventions have been developed for cancer survivors, the extent to which they are effective for African American men with cancer is unclear. Given that African American men have the highest prostate cancer burden and the lack of proven interventions, this study developed a culturally-tailored lifestyle intervention for African American men with prostate cancer and their partners that aimed to improve healthy lifestyle behaviors (physical activity and healthy eating) and quality of life. The aim of the present study is to provide a detailed overview of the model-based process of intervention adaptation. Based on the IM Adapt approach (Highfield et al., 2015) and Typology of Adaptation (Davidson et al., 2013), the present study adapted existing, evidence-based interventions to address African American prostate cancer survivors’ and their partners’ potential unmet needs including anxiety/uncertainty about cancer progression, communication between partners, cultural sensitivity, and concordance/discordance of motivation and behaviors between partners. The intervention adaptation was a comprehensive and fluid process. To the best knowledge of the author, this is the first couple-based lifestyle intervention specifically developed for African American men with prostate cancer. The present study will be highly informative to future investigators by providing flexible and detailed information regarding lifestyle intervention adaptation for racial/ethnic minority men with prostate cancer and their partners.

scholarly journals Loss of SELENOF Induces the Transformed Phenotype in Human Immortalized Prostate Epithelial Cells

2021 ◽  
Vol 22 (21) ◽  
pp. 12040
Author(s):  
Lenny K. Hong ◽  
Shrinidhi Kadkol ◽  
Maria Sverdlov ◽  
Irida Kastrati ◽  
Mostafa Elhodaky ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Epithelial Cells ◽  
Cancer Progression ◽  
African American Men ◽  
Soft Agar ◽  
Cancer Tissue ◽  
Prostate Epithelial Cells ◽  
Increased Risk ◽  
Caucasian Men

SELENOF is a member of the class of selenoproteins in which the amino acid selenocysteine is co-translationally inserted into the elongating peptide in response to an in-frame UGA codon located in the 3′-untranslated (3′-UTR) region of the SELENOF mRNA. Polymorphisms in the 3′-UTR are associated with an increased risk of dying from prostate cancer and these variations are functional and 10 times more frequent in the genomes of African American men. SELENOF is dramatically reduced in prostate cancer compared to benign adjacent regions. Using a prostate cancer tissue microarray, it was previously established that the reduction of SELENOF in the cancers from African American men was significantly greater than in cancers from Caucasian men. When SELENOF levels in human prostate immortalized epithelial cells were reduced with an shRNA construct, those cells acquired the ability to grow in soft agar, increased the ability to migrate in a scratch assay and acquired features of energy metabolism associated with prostate cancer. These results support a role of SELENOF loss in prostate cancer progression and further indicate that SELENOF loss and genotype may contribute to the disparity in prostate cancer mortality experienced by African American men.

463: Telomerase Inhibition Prevents Androgen Independent Osseous Prostate Cancer Progression

2005 ◽  
Vol 173 (4S) ◽  
pp. 126-127
Author(s):  
Yingming Li ◽  
Melissa Thompson ◽  
Zhu Chen ◽  
Bahaa S. Malaeb ◽  
David Corey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Telomerase Inhibition ◽  
Androgen Independent

479: Prostate-Specific Membrane Antigen (PSMA) Expression as a Predictor of Prostate Cancer Progression

2006 ◽  
Vol 175 (4S) ◽  
pp. 155-156
Author(s):  
Matthias D. Hofer ◽  
Sven Perner ◽  
Haojie Li ◽  
Rainer Kuefer ◽  
Richard E. Hautmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Progression ◽  
Specific Membrane ◽  
Psma Expression
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