Abstract P4-13-04: Estrogen and Avoidance of Invasive Breast Cancer, Coronary Heart Disease and All-cause Mortality. Public Health Impact of Estrogen Guidelines for Women entering Menopause.

2012 ◽  
Author(s):  
J Ragaz ◽  
K Wilson ◽  
S Shakeraneh ◽  
J Budlovsky ◽  
H Wong
Keyword(s):  
Public Health ◽  
Breast Cancer ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Invasive Breast Cancer ◽  
Health Impact ◽  
Public Health Impact ◽  
All Cause Mortality

scholarly journals Randomized Trial Evaluation of Benefits and Risks of Menopausal Hormone Therapy Among Women Aged 50-59

2020 ◽  
Author(s):  
Ross L Prentice ◽  
Aaron K Aragaki ◽  
Rowan T Chlebowski ◽  
Jacques E Rossouw ◽  
Garnet L Anderson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Coronary Heart Disease ◽  
Endometrial Cancer ◽  
Heart Disease ◽  
Hip Fracture ◽  
Global Index ◽  
All Cause Mortality ◽  
Conjugated Equine Estrogens ◽  
Equine Estrogens

Abstract The health benefits and risks of menopausal hormone therapy among women aged 50-59 years are examined in the Women’s Health Initiative randomized, placebo-controlled trials using long-term follow-up data and a parsimonious statistical model that leverages data from older participants to increase precision. These trials enrolled 27,347 healthy post-menopausal women aged 50-79 at 40 U.S. clinical centers during 1993-1998, including 10,739 post-hysterectomy participants in a trial of conjugated equine estrogens, and 16,608 participants with uterus in the trial of these estrogens plus medroxyprogesterone acetate. Over an 18-year (median) follow-up period (1993-2016) risk for a global index, defined as the earliest of coronary heart disease, invasive breast cancer, stroke, pulmonary embolism, colorectal cancer, endometrial cancer, hip fracture, and all-cause mortality, is reduced with conjugated equine estrogens with hazard ratio (95% confidence interval) of 0.82 (0.71, 0.95), and with nominally significant reductions for coronary heart disease, breast cancer, hip fracture and all-cause mortality. Corresponding global index hazard ratio estimates of 1.06 (0.95, 1.19) were non-significant for combined estrogens plus progestin, but increased breast cancer risk and reduced endometrial cancer risk were observed. These results, among women 50-59, substantially agree with the worldwide observational literature, with the exception of breast cancer for estrogens alone.

Evidence-informed physical activity guidelines for Canadian adultsThis article is part of a supplement entitled Advancing physical activity measurement and guidelines in Canada: a scientific review and evidence-based foundation for the future of Canadian physical activity guidelines co-published by Applied Physiology, Nutrition, and Metabolism and the Canadian Journal of Public Health. It may be cited as Appl. Physiol. Nutr. Metab. 32(Suppl. 2E) or as Can. J. Public Health 98(Suppl. 2).

2007 ◽  
Vol 32 (S2E) ◽  
pp. S16-S68 ◽  
Author(s):  
Darren E.R. Warburton ◽  
Peter T. Katzmarzyk ◽  
Ryan E. Rhodes ◽  
Roy J. Shephard
Keyword(s):  
Public Health ◽  
Breast Cancer ◽  
Physical Activity ◽  
Type 2 Diabetes ◽  
Colon Cancer ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Moderate Intensity ◽  
Physical Activity Guidelines

This review of the literature provides an update on the scientific biological and psychosocial bases for Canada’s physical activity guide for healthy active living, with particular reference to the effect of physical activity on the health of adults aged 20–55 years. Existing physical activity guidelines for adults from around the world are summarized briefly and compared with the Canadian guidelines. The descriptive epidemiology of physical activity and inactivity in Canada is presented, and the strength of the relationship between physical activity and specific health outcomes is evaluated, with particular emphasis on minimal and optimal physical activity requirements. Finally, areas requiring further investigation are highlighted. Summarizing the findings, Canadian and most international physical activity guidelines advocate moderate-intensity physical activity on most days of the week. Physical activity appears to reduce the risk for over 25 chronic conditions, in particular coronary heart disease, stroke, hypertension, breast cancer, colon cancer, type 2 diabetes, and osteoporosis. Current literature suggests that if the entire Canadian population followed current physical activity guidelines, approximately one third of deaths related to coronary heart disease, one quarter of deaths related to stroke and osteoporosis, 20% of deaths related to colon cancer, hypertension, and type 2 diabetes, and 14% of deaths related to breast cancer could be prevented. It also appears that the prevention of weight gain and the maintenance of weight loss require greater physical activity levels than current recommendations.

Public Health Impact of Substance Use on Adolescent: A Snapshot of Yenagoa in Bayelsa State. Nigeria

2019 ◽  
Author(s):  
Morufu Raimi ◽  
Abdulraheem Aishat Funmilayo ◽  
Iteimowei Major ◽  
Okoyen Ebikapaye ◽  
Olaolu Oyinlola Bilewu
Keyword(s):  
Public Health ◽  
Substance Use ◽  
Health Impact ◽  
Public Health Impact

Analyzing the FDA Priority Review Voucher Program's Stimulation of Research and Public Health Impact

2016 ◽  
Vol 3 (2) ◽  
pp. 131-141
Author(s):  
Chris Bialas ◽  
Elizabeth Higbee-Dempsey ◽  
Cindy Y. Chen ◽  
Caitlin Ward ◽  
Oscar A Marcos-Contreras ◽  
...  
Keyword(s):  
Public Health ◽  
Health Impact ◽  
Public Health Impact ◽  
Priority Review ◽  
Stimulation Of
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