Clinical Significance of Epidermal Growth Factor Receptor Protein Overexpression and Gene Copy Number Gains in Prostate Cancer

2007 ◽  
Vol 13 (22) ◽  
pp. 6579-6584 ◽  
Author(s):  
Thorsten Schlomm ◽  
Patrick Kirstein ◽  
Liv Iwers ◽  
Birte Daniel ◽  
Thomas Steuber ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Copy Number ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Receptor Protein ◽  
Gene Copy ◽  
Protein Overexpression ◽  
Epidermal Growth

Prognostic value of epidermal growth factor receptor gene amplification in surgically resected non-adenocarcinoma lung cancer patients.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e18553-e18553
Author(s):  
Yaewon Yang ◽  
Hyun Chang ◽  
Jong-Seok Lee ◽  
YuJung Kim ◽  
Sang-hoon Jheon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Copy Number ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Gene Copy ◽  
Egfr Gene ◽  
Epidermal Growth

e18553 Background: The purpose of this study is to investigate the prognostic role of genomoic gain and expression for epidermal growth factor receptor (EGFR) gene in surgically resected non-adenocarcinoma of non-small-cell lung cancer (NA-NSCLC). Methods: This retrospective study included 115 NA-NSCLC consecutive patients with available tumor tissue and survival data, median follow up period of 6.4 years. EGFR gene copy number and protein expression was evaluated using by fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) in tissue microarray sections, respectively. Results: Among 115 patients, 99 patients (86.1 %) were with squamous cell carcinoma histology. EGFR gene amplification and high polysomy (EGFR FISH+) were observed in 57 (49.6%) and 45 (39.1%) patients, respectively. Patients with EGFR FISH+ had significantly shorter overall survival [median, 41 months vs. not reached (>70 months), P = 0.011]. Multivariable model confirmed that patients with EGFR FISH+ had a significantly greater risk of death than those with EGFR FISH-negative after adjusting pathologic staging, presence of pleural invasion, venous invasion and adjuvant chemotherapy (hazard ratio = 2.11, 95% confidence interval 1.23-3.61, P = 0.006). EGFR IHC expression did not associate with overall survival in same group. Conclusions: EGFR increased gene copy number is an independent negative prognostic factor in surgically resected NA-NSCLC.

Epidermal growth factor receptor in glioblastomas: correlation between gene copy number and protein expression

2010 ◽  
Vol 41 (6) ◽  
pp. 815-823 ◽  
Author(s):  
Béma Coulibaly ◽  
Isabelle Nanni ◽  
Benoit Quilichini ◽  
Jean Gaudart ◽  
Philippe Metellus ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Protein Expression ◽  
Copy Number ◽  
Gene Copy Number ◽  
Growth Factor Receptor ◽  
Gene Copy ◽  
Epidermal Growth
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