Laparoscopy Reveals a Diversity of Peritoneal Change in Patients with Long-Term Vintage of Peritoneal Dialysis

2015 ◽  
Vol 41 (1-3) ◽  
pp. 48-54 ◽  
Author(s):  
Koichi Sasaki ◽  
Hitoshi Mizuno ◽  
Noriyuki Iwamoto ◽  
Masami Imakita ◽  
Keiko Yasuda ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Inflammatory Cell ◽  
Interstitial Fibrosis ◽  
Inflammatory Cell Infiltration ◽  
Fibrin Deposition ◽  
Factors Associated ◽  
The Relationship ◽  
Microvascular Change ◽  
Microscopic Findings

Background: Although laparoscopy may provide more detailed morphological and histological information about peritoneal damage, its significance in patients with long vintage of peritoneal dialysis (PD) is not elucidated. Methods: Findings in 12 patients with PD vintage of 7.3 (5.0-8.4) years who had undergone laparoscopy between 2007 and 2011 were reviewed. Macroscopic (peritoneal change, hypervascular change, adhesion, encapsulation) and histopathological peritoneal findings (interstitial fibrosis, microvascular change, fibrin deposition, inflammatory cell infiltration) were scored and summed as Macro-total score (Macro-TS) and Micro-total score (Micro-TS), respectively. Factors associated with these scores and the relationship between these scores were investigated. Results: Neither Macro-TS nor Micro-TS were related to PD vintage (p = 0.069 and p = 0.769, respectively); moreover, Macro-TS varied from patient to patient regardless of similar PD vintage. However, Macro-TS showed a significant association with duration of acidic dialysate (p = 0.003). Conclusion: Macroscopic and microscopic findings via laparoscopy may help the assessment of peritoneal damage in patients with long PD vintage.

Characteristics and Clinical Outcomes of End-Stage Renal Disease Patients on Peritoneal Dialysis for over 15 Years: A Single-Center Experience

2017 ◽  
Vol 37 (5) ◽  
pp. 535-541 ◽  
Author(s):  
Youn Kyung Kee ◽  
Jung Tak Park ◽  
Chang-Yun Yoon ◽  
Hyoungnae Kim ◽  
Seohyun Park ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Clinical Outcomes ◽  
End Stage Renal Disease ◽  
Short Term ◽  
Factors Associated ◽  
The Mean ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Background Maintaining peritoneal dialysis (PD) for a long time is problematic owing to a number of factors. This study aimed to clarify the characteristics and examine the clinical outcomes of patients who received PD as a long-term dialysis modality. Methods All end-stage renal disease (ESRD) patients who initiated PD at Yonsei University Health System between 1987 and 2000 were screened. Patients who maintained PD for over 15 years were classified as the long-term PD group and those who were treated with PD for less than 5 years were included in the short-term PD group. Demographic and biochemical data and clinical outcomes were compared between the groups. Independent factors associated with long-term PD maintenance were ascertained using multivariate logistic regression analysis. Results Among 1,116 study patients, 87 (7.8%) were included in the long-term group and 293 (26.3%) were included in the short-term group. In the long-term group, the mean patient age at PD initiation was 39.6 ± 11.5 years, 35 patients (40.2%) were male, and the mean PD duration was 205.3 ± 32.7 months. Patients were younger, body weight was lower, the proportion of patients with diabetes or cardiovascular diseases was lower, and the proportion of low to low-average transporters was higher in the long-term group than in the short-term group ( p < 0.001). Multiple logistic regression analysis revealed that age, body mass index (BMI), serum creatinine, type of PD solution, and diabetes were significant independent factors associated with long-term PD maintenance. Conclusion Peritoneal dialysis can be considered as a long-term renal replacement therapy option, especially in non-diabetic, not overweight, and young ESRD patients.

scholarly journals The Effect of Artesunate and Brotowali (Tinospora Crispa) Combination on Histopathological, and Expression of Nuclear Factor Kappa B (NF-kβ) in Renal Tubules of Mice Infected With Plasmodium Berghei

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Angela Merici ◽  
Loeki Enggar Fitri ◽  
Niniek Budiarti
Keyword(s):  
Plasmodium Berghei ◽  
Inflammatory Cell ◽  
Interstitial Fibrosis ◽  
Tubular Cell ◽  
Inflammatory Cell Infiltration ◽  
Cell Infiltration ◽  
Cell Necrosis ◽  
Group 4 ◽  
Group 5 ◽  
Group 2

Brotowali (BR) extract (Tinospora crispa) can be used as an antimalarial. Aim: to determine the effect of BR extract in histopathological and expression of NFκB in mice tubules infected by Plasmodium berghei treated by artesunate (AR). Method: we used 42 C57BL / 6J strain mice as experimental animals, which were randomly divided into 7 groups : negative control (NC), positive control (PC), treatment group consist of AR 32 mg/kb (group 1); BR 70 mg/kg (group 2), combination of AR+BR 50 mg/kg (group 3), AR+BR 60 mg/kg (group 4), and AR+BR 70 mg/kg (group 5). Histological examination (hematoxylin-eosin (HE) staining) and expression of NFKB (immunohistochemical staining) in the kidneys were performed on 7th and 14th. Result: compared to PC group, BR with doses of 70 mg until 14th day, improved the degree of tubular necrosis, interstitial fibrosis, tubular degeneration, and inflammatory cell infiltration (p <0.001) but did not reach NC group (p <0.05). The combination of AR+BR until the 14th day with dose of 50, 60, 70 mg all of dose improves significantly in-term of degree of tubular cell necrosis and inflammatory cell infiltration. The degree of interstitial fibrosis on 14th day only improved in group 4 and 5 (p<0.001 and p=0.003). The level of NF-kB expression on day 7 and day 14 was reduced in group 2, group 4, and group 5 compared to PC group. There was positive correlation on 7th and 14th between NF-kβ expression and tubular degeneration, tubular cell necrosis, inflammatory cell infiltration, and interstitial fibrosis. Conclusion: the combination of AR+BR extract can improve histopathological features and reduce NF-kβ expression in mice tubules infected by Plasmodium berghei with an optimal dose was 60 mg/day for 7-14 days or 70 mg for 7 days.

scholarly journals Understanding Former Smokers in Canada: Examining Who They are and When, Why and How They Quit

2009 ◽  
Vol 4 (2) ◽  
pp. 79-85
Author(s):  
Rovshan M. Ismailov ◽  
Scott T. Leatherdale
Keyword(s):  
Logistic Regression ◽  
Prevention Programming ◽  
Logistic Regression Models ◽  
Factors Associated ◽  
The Past ◽  
Quit Attempts ◽  
Monitoring Survey ◽  
Former Smokers ◽  
The Relationship

AbstractObjectives: Although the benefits of smoking cessation are well established, long-term abstinence from cigarettes is difficult for many smokers to achieve. We aimed to examine quit attempts, years since quitting and factors associated with long-term abstinence among former smokers.Methods: Data were from the 2006 Canadian Tobacco Use Monitoring Survey. Descriptive analyses were performed and logistic regression models were used to examine factors associated with long-term abstinence (more than 5 years) among former smokers.Results: In 2006, over one in four Canadians (27.1%,n= 7,200,000) aged 15 and older was a former smoker. The prevalence of former smoking was higher among men (30.9%) in comparison to women (23.4%). Former smokers who quit in the past 3 years or earlier were more likely to be older as well as have children younger than 15 in the household. Logistic regression analyses revealed that older age was a significant predictor of long-term abstinence from smoking.Conclusion: Our findings suggest that there are modifiable characteristics associated with long-term smoking abstinence that could be addressed by relapse prevention programming. Longitudinal data are warranted to further clarify the relationship between certain characteristic of former smokers and the duration of abstinence.

scholarly journals Analysis of Long-Term Gravitational and Seismic Measurements in the Pamir - Tien-Shan Region

2020 ◽  
Vol 223 ◽  
pp. 03014
Author(s):  
Leonid Sverdlik ◽  
Ekaterina Lazareva
Keyword(s):  
Tien Shan ◽  
Seismic Process ◽  
Satellite Measurements ◽  
Gravitational Effects ◽  
Factors Associated ◽  
Grace Satellite ◽  
Temporal And Spatial ◽  
The Relationship ◽  
Seismic Measurements

Long-term variations (2003–2015) of the Equivalent Water Height (EWH) above the geoid's contour obtained from GRACE satellite measurements are analyzed to establish the relationship between changes in the gravitational field with the stress-strain state of the geological environment and the seismic process in Central Asia (Pamir and Tien-Shan regions). The earthquakes gravitational effects study, based on the use of various GRACE models allows us to distinguish the component of the gravity field, which may be related to seismic activity. The results of temporal and spatial gravitational anomalies identification, the probable causes of which were tectonic factors associated with the redistribution of masses in the lithosphere as a result of large (M>5.5) regional earthquakes, are presented.

Abstract WP212: Association Between Within-visit Blood Pressure Variability and Stroke

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Michelle P Lin ◽  
Bruce Ovbiagele ◽  
Rebecca F Gottesman ◽  
Nerses Sanossian ◽  
Daniela Markovic ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mexican American ◽  
Blood Pressure Variability ◽  
Peripheral Artery ◽  
Factors Associated ◽  
Health And Nutrition ◽  
The Us ◽  
Artery Disease ◽  
The Relationship

Introduction: Long-term variability in systolic blood pressure (SBP) is associated with higher risk of cardiovascular events. Little is known about the association between within-visit SBP variability and stroke. Hypothesis: Higher within-visit SBP variability is associated with higher odds of stroke. Methods: Participants included adults ≥18 years who participated in the US National Health and Nutrition Examination Surveys from 1999 to 2010. Stroke was self-reported. SBP was obtained up to four times by a physician, using a manual sphygmomanometer according standardized procedures. Within-visit SBP variability was defined as standard deviation of the BP measurements, stratified into quartiles. We evaluated the relationship between within-visit SBP variability and odds of having had a stroke using multivariable logistic regression. Results: Of the 27,987 adults, 16.4% were aged ≥ 65 years, 51.3% were female, 71.2% were White, 10.7% were Black and 7.9% were Mexican American. Factors associated with higher mean SBP variability included older age, hypertension, chronic kidney disease, peripheral artery disease, and smoking (all P<0.05). The prevalence of stroke significantly increased across SBP variability quartiles from 2.1% for quartile 1 to 3.7% for quartile 4. High SBP variability was associated with higher odds of stroke (OR 1.8, 95% CI 1.4-2.2). After adjustment for covariates, the odds ratio of stroke comparing highest vs. lowest quartile of SBP variability was 0.9 (p=0.400). Conclusions: Within-visit variability in SBP is associated with increased odds of stroke but the relationship is confounded by age and covariates.

scholarly journals Evaluation of Long-Term Care Insurance Policy in Chinese Pilot Cities

2019 ◽  
Vol 16 (20) ◽  
pp. 3826 ◽  
Author(s):  
Yanzhe Zhang ◽  
Xiao Yu
Keyword(s):  
Long Term Care ◽  
Effective Response ◽  
Term Care ◽  
Factors Associated ◽  
Number Of Children ◽  
Degree Of Disability ◽  
Long Term Care Insurance ◽  
And Performance ◽  
The Relationship

Since 2016, 15 pilot cities in China have implemented a long-term care insurance (LTCI) policy. The aim of this research was to explore the outcomes and evaluate the performance of the LTCI policy in the Chinese pilot cities and estimate the willingness of Chinese citizens to expand the formal implementation of LTCI policy in China. We gathered data from 1500 elderly people aged over 60 years in 15 pilot cities (100 surveys for each city) and the effective response rate was 77.8% (1167/1500). We relied on statistical analysis to elicit the outcomes and performance of LTCI implementation and an ordinal logit regression to analyze the factors associated with the extension of the LTCI policy. We examined factors associated with the perception according to sex, age, degree of disability, choices of care, living location, number of children, and monthly income. Among these factors, the relationship between living location and number of children of the family and the outcomes and performance of the LTCI policy in the pilot cities was significant. The rest of the factors showed no significance with the implementation of the LTCI in Chinese pilot cities. This study is among the first to explore the attitudes of Chinese citizens among those who have benefited from the LTCI policy in the pilot cities and contributes to identifying the outcomes of the LTCI in pilot cities to assist policymakers in their further implementation in China.

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