Effects of Amlodipine on Bone Metabolism in Orchidectomised Spontaneously Hypertensive Rats

Pharmacology ◽  
2018 ◽  
Vol 102 (1-2) ◽  
pp. 67-73
Author(s):  
Helena Zivna ◽  
Iveta Gradošová ◽  
Pavel Zivny ◽  
Eva Cermakova ◽  
Vladimir Palicka
Keyword(s):  
Bone Metabolism ◽  
Spontaneously Hypertensive Rats ◽  
Negative Impact ◽  
Biomechanical Testing ◽  
Biomechanical Properties ◽  
Hypertensive Rats ◽  
Mineral Density ◽  
Spontaneously Hypertensive ◽  
Osteopenic Bone

Spontaneously hypertensive rats (SHR) represent a model of essential hypertension. We studied the effect of amlodipine (AML) on bone markers, bone mineral density (BMD), and biomechanical properties of osteopenic bone induced by orchidectomy in male SHR. Rats were allocated to 3 groups and were sacrificed after 12 weeks: sham-operated control; orchidectomised control; and orchidectomised receiving a diet supplemented with AML. Indicators of bone turnover were assessed in bone homogenate, BMD was measured by dual energy X-ray absorptiometry, and the femurs were subjected to biomechanical testing. Long-term AML administration does not have a negative impact on bone metabolism and density in male SHR.

Long-term administration of prazosin improves bladder storage function: Results from a study in spontaneously hypertensive rats

2011 ◽  
Vol 18 (11) ◽  
pp. 785-791 ◽  
Author(s):  
Nobuhiro Haga ◽  
Ken Aikawa ◽  
Kei Ishibashi ◽  
Tomohiko Yanagida ◽  
Masanori Nomiya ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Storage Function ◽  
Term Administration

scholarly journals Enhancement of arterial relaxation by long-term atenolol treatment in spontaneously hypertensive rats

1994 ◽  
Vol 112 (3) ◽  
pp. 925-933 ◽  
Author(s):  
Mika Kähönen ◽  
Heikki Mäkynen ◽  
Pertti Arvola ◽  
Ilkka Pörsti
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Arterial Relaxation

ASSA13-14-2 The Influence of Long-Term Regular Vitamin D Intervention to Renin and Renin Receptor in Spontaneously Hypertensive Rats

Heart ◽  
2013 ◽  
Vol 99 (Suppl 1) ◽  
pp. A59.1-A59
Author(s):  
Xu Xinjuan ◽  
Qin Xiaowei ◽  
Han Lu ◽  
Lei Hong
Keyword(s):  
Vitamin D ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Long‐term Treatment with Kefir Probiotics Ameliorates Cardiac Function in Spontaneously Hypertensive Rats

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Mirian Almeida Silva‐Cutini ◽  
Simone Alves Almeida ◽  
Andrews Marques Nascimento ◽  
Glaucia Rodrigues Abreu ◽  
Nazaré Souza Bissoli ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Spontaneously Hypertensive Rats ◽  
Term Treatment ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Long Term Treatment

scholarly journals The effect of long-term antihypertensive treatment on medial hypertrophy of cerebral arteries in spontaneously hypertensive rats.

Stroke ◽  
1986 ◽  
Vol 17 (3) ◽  
pp. 515-519 ◽  
Author(s):  
S Ibayashi ◽  
J Ogata ◽  
S Sadoshima ◽  
K Fujii ◽  
H Yao ◽  
...  
Keyword(s):  
Antihypertensive Treatment ◽  
Spontaneously Hypertensive Rats ◽  
Cerebral Arteries ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Medial Hypertrophy

Effect of the long-term intake of an egg white hydrolysate on the oxidative status and blood lipid profile of spontaneously hypertensive rats

2008 ◽  
Vol 109 (2) ◽  
pp. 361-367 ◽  
Author(s):  
María A. Manso ◽  
Marta Miguel ◽  
Jeanne Even ◽  
Rosario Hernández ◽  
Amaya Aleixandre ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Spontaneously Hypertensive Rats ◽  
Blood Lipid ◽  
Egg White ◽  
Oxidative Status ◽  
Hypertensive Rats ◽  
Blood Lipid Profile ◽  
Spontaneously Hypertensive
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