scholarly journals Diabetic Cystopathy Occurs Independently from Other Atherosclerotic Risks

2021 ◽  
pp. 200-204
Author(s):  
Osamu Takahashi ◽  
Ryuji Sakakibara ◽  
Ayami Shimizu ◽  
Fuyuki Tateno ◽  
Yosuke Aiba
Keyword(s):  
Intima Media Thickness ◽  
Small Fiber Neuropathy ◽  
Stiffness Index ◽  
Plaque Score ◽  
Diabetic Cystopathy ◽  
Duration Of Diabetes ◽  
Small Fiber ◽  
The Relationship ◽  
Doppler Echography

It has not yet been clarified whether atherosclerotic risks other than diabetes are related to bladder small fiber neuropathy (cystopathy) in type 2 diabetes. The aim of this study was to answer this question by urodynamics. This was a retrospective study. The subjects were 44 patients: 27 male, 17 female; mean age 67.0 ± 12.7 years; mean duration of diabetes 16.8 ± 13.1 years; mean HbA1c 7.8 ± 1.2%. We analyzed the relationship between diabetic cystopathy (at least one of the following abnormalities in urodynamics: decreased bladder sensation, post-void residual, detrusor overactivity, low-compliance detrusor) and clinical items, i.e., severity and duration of diabetes, nerve conduction, body mass index, blood pressure, cardio-ankle vascular stiffness index, and ultrasound Doppler echography (plaque score, intima-media thickness) in these patients. As a result, urodynamic diabetic cystopathy was not correlated with any of the above systemic items. In conclusion, the above findings suggest that bladder small fiber neuropathy can occur independently from systemic atherosclerotic risks.

scholarly journals Association of Body Mass Index in Youth With Adult Cardiometabolic Risk

2020 ◽  
Vol 9 (14) ◽  
Author(s):  
Feitong Wu ◽  
Markus Juonala ◽  
Matthew A. Sabin ◽  
Marie‐Jeanne Buscot ◽  
Katja Pahkala ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Lipoprotein Cholesterol ◽  
Stiffness Index ◽  
Overweight Or Obesity

Background Whether long‐term exposure to overweight or obesity from early life to adulthood has a detrimental influence on health outcomes is unknown. We aimed to investigate whether duration of overweight or obesity from youth to adulthood is associated with adult cardiometabolic risk. Methods and Results A population‐based cohort study was performed of 1268 youths, aged 3 to 18 years, with follow‐ups at 3, 6, 9, 12, 21, 27, and 31 years. Duration of overweight or obesity over 31‐year follow‐up was calculated. Adulthood outcomes included type 2 diabetes mellitus, impaired fasting glucose, high insulin levels, high carotid intima‐media thickness, hypertension, low high‐density lipoprotein cholesterol, high low‐density lipoprotein cholesterol and triglycerides, arterial pulse wave velocity, carotid artery compliance, Young elastic modulus, and stiffness index. Rates of overweight/obesity were 7.9% at baseline and 55.9% after 31 years. After adjustment for confounders, longer duration of overweight or obesity was associated with increased risk of all outcomes (relative risk ranged from 1.45–9.06 for type 2 diabetes mellitus, impaired fasting glucose, carotid intima‐media thickness, hypertension, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, and triglycerides; β from 0.370–0.543 m/s for pulse wave velocity; –0.193 to –0.237 %/10 mm Hg for carotid artery compliance; 52.1–136.8 mm Hg·mm for Young elastic modulus; and 0.554–0.882 for stiffness index). When body mass index was further adjusted, these associations disappeared or were substantially reduced. Detrimental associations of adult body mass index with all outcomes were robust to adjustment for confounders and duration of overweight or obesity. Conclusions Overweight or obesity in adulthood rather than childhood appears to be more important for adult cardiometabolic health.

scholarly journals Epicardial fat thickness and carotid intima-media thickness in patients with type 2 diabetes mellitus

2016 ◽  
Vol 7 (6) ◽  
pp. 1-5 ◽  
Author(s):  
Pijush Kanti Mandal ◽  
Subhraprakash Pramanik ◽  
Koushik Mondal ◽  
Shovan Kumar Das ◽  
Arpan Kumar Dey ◽  
...  
Keyword(s):  
Glucose Level ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Plasma Glucose Level ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Fasting Plasma Glucose Level ◽  
Duration Of Diabetes ◽  
Fasting Plasma

Background: Epicardial adipose tissue thickness has been considered to be a possible cardiovascular risk indicator in recent reports. Aim of this study was to evaluate the relationship of echocardiographic epicardial fat thickness (EFT) with carotid intima-media thickness (CIMT), in patients with type 2 diabetes mellitus (T2DM).Materials and Methods: In this hospital based cross sectional observational study a total of 64 patients with T2DM (mean age 54.51±6.60 years and 75.0% male) and 76 age and sex-matched non-diabetic control (mean age 54.97±6.11years and 71.1% male) were evaluated. Echocardiographic EFT and ultrasonographic CIMT were measured in all subjects.Results: Patients with T2DM had significantly increased EFT and CIMT than those of the non-diabetic controls (6.15±0.99 mm versus 4.39±0.61 mm, P< 0.001 and 0.77±0.09 mm versus 0.51±0.05 mm, P< 0.001, respectively). EFT was correlated with CIMT (r = 0.724, P < 0.001), duration of diabetes (r = 0.723, P < 0.001) and fasting plasma glucose level (r = 0.542, P < 0.001). Linear regression analysis showed that CIMT (β = 0.358, t = 3.658, P < 0.001) duration of diabetes (β = 0.324, t = 3.268, P = 0.001) and fasting plasma glucose level (β = 0.210, t = 3.302, P = 0.001) were found to be the independent predictors of EFT.Conclusion: The echocardiographic EFT was significantly higher in patients with T2DM; and it was well correlated with CIMT, duration of diabetes and fasting plasma glucose level as being the independent predictors of EFT.Asian Journal of Medical Sciences Vol.7(6) 2016 1-5

Assessment of small fiber neuropathy to predict future risk of type 2 diabetes

2013 ◽  
Vol 7 (4) ◽  
pp. 269-273 ◽  
Author(s):  
G. Müller ◽  
E. Parfentyeva ◽  
J. Olschewsky ◽  
S.R. Bornstein ◽  
P.E.H. Schwarz
Keyword(s):  
Type 2 Diabetes ◽  
Small Fiber Neuropathy ◽  
Small Fiber ◽  
Future Risk
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