scholarly journals Excess Body Weight and Gastroesophageal Reflux Disease

2021 ◽  
pp. 1-6
Author(s):  
Andreas Thalheimer ◽  
Marco Bueter

<b><i>Background:</i></b> Gastroesophageal reflux disease (GERD) is strongly associated with excess body weight. <b><i>Summary:</i></b> GERD is characterized by typical symptoms with or without mucosal damage because of retrograde flow of gastric content into the esophagus. An ineffective esophagogastric junction (EGJ) combined with anatomical abnormalities is considered to be causative. The incidence of GERD is strongly associated with excess body weight, reflecting the pathophysiological relevance of the abdominothoracic pressure gradient. <b><i>Key Message:</i></b> Weight loss has been demonstrated to be an effective therapy for GERD combined with obesity. In cases in which surgical therapy is indicated, traditional antireflux surgery has led to equivocal results, advocating a proximal Roux-en-Y gastric bypass in these patients to correct both GERD and excess body weight.

2001 ◽  
Vol 120 (5) ◽  
pp. A480-A480
Author(s):  
F GRANDERATH ◽  
U SCHWEIGER ◽  
T KAMOLZ ◽  
T BAMMER ◽  
M PASIUT ◽  
...  

Radiology ◽  
2007 ◽  
Vol 243 (2) ◽  
pp. 329-339 ◽  
Author(s):  
Mark E. Baker ◽  
David M. Einstein ◽  
Brian R. Herts ◽  
Erick M. Remer ◽  
Gaspar Alberto Motta-Ramirez ◽  
...  

2021 ◽  
Vol 1 (3) ◽  
pp. 227-233
Author(s):  
Sumeet K. Mittal ◽  
Komeil Mirzaei Baboli

The esophagogastric junction (EGJ) barrier plays an integral role in the prevention of gastroesophageal reflux; however, not much attention has been paid to competency parameters, especially in the era of high-resolution manometry (HRM). HRM provides a unique spatiotemporal pressure profile and measurements of the EGJ. Herein, we discuss the evidence for objective measures of EGJ competency, which should guide the clinical management of gastroesophageal reflux disease. Additionally, we will briefly discuss expected normal values after antireflux surgery.


2012 ◽  
Vol 142 (5) ◽  
pp. S-1033 ◽  
Author(s):  
Brian L. Bello ◽  
Marco Zoccali ◽  
Roberto Gullo ◽  
Arunas E. Gasparaitis ◽  
Mustafa Hussain ◽  
...  

JAMA Oncology ◽  
2018 ◽  
Vol 4 (11) ◽  
pp. 1576 ◽  
Author(s):  
John Maret-Ouda ◽  
Karl Wahlin ◽  
Miia Artama ◽  
Nele Brusselaers ◽  
Martti Färkkilä ◽  
...  

Author(s):  
Jessica Ng ◽  
Florian Friedmacher ◽  
Caroline Pao ◽  
Paul Charlesworth

Abstract Introduction Gastroesophageal reflux disease (GERD) is associated with accelerated decline in lung health in children with cystic fibrosis (CF). Thus, antireflux surgery (ARS) is offered to a selected CF cohort with refractory GERD, but outcomes remain poorly investigated. This study aimed to determine the incidence of GERD in children with CF and to evaluate complications and outcomes of ARS. Materials and Methods A systematic literature-based search was conducted using various online databases according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The number of GERD cases in pediatric CF cohorts who underwent diagnostic investigation(s) was recorded. Data on postoperative complications and outcomes (including symptoms, lung function, and nutritional status) following ARS were analyzed. Results Ten articles (n = 289 patients) met the defined inclusion criteria (51% male; age range, 0.5 month–36 years). The overall incidence of GERD was 46% (range, 19–81%), derived from seven studies (n = 212 patients). Four publications (n = 82 patients) reported on ARS due to uncontrolled GERD. All ARSs were Nissen fundoplication (majority with gastrostomy placement). Major postoperative complications occurred in 15 (18%) patients, two required redo-ARS. Median follow-up time was 2 years (range, 3 months–6 years); 59% showed symptom improvement, and pulmonary exacerbations and decline in lung function were reduced. Nutritional status mainly improved in milder CF cases. There were no deaths related to ARS. Conclusion Approximately half of pediatric CF patients have GERD. Published data for children with CF are limited and heterogeneous in terms of GERD diagnosis and outcomes following ARS. However, ARS has shown to slow the deterioration of lung function in CF.


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