scholarly journals Similar Myocardial Perfusion and Vascular Stiffness in Children and Adolescents with High Lipoprotein (a) Levels, in Comparison with Healthy Controls

Pulse ◽  
2021 ◽  
pp. 1-8
Author(s):  
Kyriaki Papadopoulou-Legbelou ◽  
Areti Triantafyllou ◽  
Olga Vampertzi ◽  
Nikolaos Koletsos ◽  
Stella Douma ◽  
...  
Keyword(s):  
Family History ◽  
Children And Adolescents ◽  
Vascular Function ◽  
Augmentation Index ◽  
Positive Family History ◽  
Premature Coronary Artery Disease ◽  
Healthy Children ◽  
Vascular Aging ◽  
Lipoprotein A ◽  
History Of

<b><i>Background and Aims:</i></b> This study investigated the possible correlation between elevated lipoprotein (a) (Lp(a)) levels and early vascular aging biomarkers in healthy children and adolescents. <b><i>Methods:</i></b> Twenty-seven healthy children/adolescents, mean age 9.9 ± 3.7 years, with high Lp(a) levels without other lipid abnormalities and 27 age- and sex-matched controls with normal Lp(a) levels, were included in the study. The investigation of possible early vascular aging was assessed by measuring vascular function indices: carotid intima-media thickness (c-IMT), pulse wave velocity (PWV), augmentation index (AIx), and subendocardial viability ratio (SEVR). <b><i>Results:</i></b> Although serum lipid values were within normal levels, mean values of total cholesterol and apolipoprotein B were higher in the group of children with high Lp(a) levels than controls (<i>p</i> = 0.006 and <i>p</i> &#x3c; 0.001, respectively). Vascular function indices did not show significant differences, neither between the 2 groups nor in the subgroups of children with increased Lp(a) levels. These subgroups were defined by the presence or absence of family history of premature coronary artery disease. Lp(a) levels did not show a significant correlation with the other parameters studied, both regarding the whole sample (patients and controls), as well as in the subgroups of elevated Lp(a) levels. However, in the group of children with high Lp(a) levels, c-IMT and PWV were positively correlated with diastolic blood pressure (<i>r</i> = 0.427, <i>p</i> = 0.026 and <i>r</i> = 0.425, <i>p</i> = 0.030, respectively), while SEVR was negatively correlated with AIx (<i>r</i> = −0.455, <i>p</i> = 0.017). <b><i>Conclusions:</i></b> Healthy children and adolescents with high Lp(a) levels do not yet have impaired vascular indices, compared to controls. However, in order to prevent early atherosclerosis, it is crucial to early identify and follow up children with high Lp(a) levels and positive family history of premature coronary disease or other cardiovascular risk factors.

scholarly journals Risk factors for atherosclerosis in children and adolescents with family history of premature coronary artery disease

10.2223/1153 ◽  
2004 ◽  
Vol 80 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Ceres C. Romaldini ◽  
Hugo Issler ◽  
Ary L. Cardoso ◽  
Jayme Diament ◽  
Neusa Forti
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Family History ◽  
Children And Adolescents ◽  
Premature Coronary Artery Disease ◽  
History Of ◽  
Artery Disease

scholarly journals Prevalence and Family History Characteristics of Type 1 Diabetes Mellitus in Children and Adolescents: A Nigerian Tertiary-Healthcare Based Study

2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Elizabeth Eberechi Oyenusi ◽  
Alphonsus Ndidi Onyiriuka ◽  
Yahaya Saidu Alkali
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Family History ◽  
Children And Adolescents ◽  
Positive Family History ◽  
Risk Category ◽  
Family History Of Diabetes ◽  
Tertiary Healthcare ◽  
History Of

Background: Family history of diabetes mellitus is a useful tool for detecting children and adolescents at risk of the disease. The aim of this study is to determine the prevalence and describe the characteristics of family history of diabetes mellitus in Nigerian children and adolescents with type 1 diabetes. Methods: A retrospective chart review of children and adolescents newly diagnosed with type 1 diabetes was conducted in three tertiary-healthcare institutions in Nigeria. In addition to the review of charts of old patients, other children and adolescents who presented with new-onset diabetes during  the review process were also included. An interviewer-administered questionnaire was used in obtaining information from the patients and their parents. Using the criteria suggested by Scheuner et al, the family history risk category was stratified into average, moderate and high. Results: Out of a total of 65 children and adolescents with type 1 diabetes, 29(44.6%, 95% CI= 32.6-56.7) had a positive family history of diabetes mellitus. Of the affected family members, 42.9% were first-degree relatives. The frequencies of family history risk category were average 65.5%, moderate 27.6% and high 6.9%. Among the affected family members in whom information on their diabetes status was available, 19(86.4%) had type 2 diabetes and only 3(13.6%) had type 1 diabetes. Conclusion: Four out of every ten patients with type 1 diabetes in the paediatric age group, have a first- degree relative with a positive family history of diabetes.

scholarly journals Cardiovascular Risk Factors In 7–13 Years Old Children From Vojvodina (Serbia)

2016 ◽  
Vol 35 (3) ◽  
pp. 293-301 ◽  
Author(s):  
Darko D. Dželajlija ◽  
Slavica S. Spasić ◽  
Jelena M. Kotur-Stevuljevic ◽  
Nataša B. Bogavac-Stanojevic
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Family History ◽  
Positive Family History ◽  
Later Life ◽  
Healthy Children ◽  
Apo B ◽  
Lipid Status ◽  
History Of

SummaryBackground: Atherosclerosis is a chronic inflammatory disease which starts early in life and depends on many factors, an important one being dyslipoproteinemia. According to several studies, atherosclerotic plaques or their precursors could be seen in children younger than 10 years. During later life, interaction with a sedentary way of life, as well as unhealthy nutrition, smoking, alcohol consumption, obesity and family history of cardiovascular disease cause the burden of atherosclerotic disease.Methods: Study included 624 children (316 boys, 308 girls), aged from 7-13 years. We analysed socio-demographic data (BMI, blood pressure, cardiovascular family history, smoking status), as well as lipid status with lipoprotein little a-Lp(a), and apolipoproteins: Apo AI, Apo B-100 for all children. This enabled us to calculate new atherogenic indices Tg/HDL-c, lipid tetrad index (LTI) and lipid pentad index (LPI). Cardiovascular risk for later life was estimated by using modified Risk Score for Young Individuals (RS), which divided the subjects according to the score level: low, medium and higher risk.Results: The older children (13 y) had better lipid status than the younger children, i.e. significantly lower total cholesterol, LDL-C, triglycerides and non-HDL-C concentration and significantly higher HDL-C concentration than the younger children and this was in accordance with the RS level. Children with a positive family history of CV disease had significantly higher Lp(a) concentration and blood pressure. LPI was significantly higher in children with a higher RS.Conclusions: The results of our work could be used for cardiovascular risk assessment in apparently healthy children to provide preventive measures which could control the change able risk factors.

Clinical and Sociodemographic Characteristics of Ingrown Nails in Children

2019 ◽  
Vol 109 (4) ◽  
pp. 272-276 ◽  
Author(s):  
Ibrahim Etem Arica ◽  
Seher Bostanci ◽  
Pelin Koçyigit ◽  
Deniz Aksu Arica
Keyword(s):  
Family History ◽  
Children And Adolescents ◽  
Daily Living ◽  
Positive Family History ◽  
Sociodemographic Characteristics ◽  
Female Ratio ◽  
Daily Living Activities ◽  
History Of ◽  
Ingrown Nail ◽  
Male To Female

Background: Ingrown nail is a condition frequently seen in children and adolescents, the pain from which can affect their daily living activities and school performances. The purpose of this study was to determine the clinical and sociodemographic characteristics of ingrown nails in children. Methods: The clinical and sociodemographic characteristics of patients aged 0 to 18 years presenting with ingrown nail were evaluated retrospectively from clinic records. Results: Sixty-two patients aged 3 to 18 years (mean age, 15 years; male to female ratio, 1.06) were enrolled. A total of 175 ingrown nails were evaluated (all of them were in the halluces, 54.3% of them were on the lateral margin). A positive family history of ingrown nail was present in 15.7%. High prevalences of incorrect nail cutting (72.1%), trauma (36.1%), poorly fitting shoes (29%), hyperhidrosis (12.9%), obesity (9.7%), and accompanying nail disorders (9.7%) were determined among the patients. Conclusions: This study revealed the clinical and sociodemographic characteristics of ingrown nails in children. These data will be useful in preventing the occurrence of ingrown nail by revealing and then eliminating predisposing factors.

scholarly journals Hashimoto's thyroiditis in children and adolescents

2008 ◽  
Vol 136 (5-6) ◽  
pp. 262-266 ◽  
Author(s):  
Slavica Markovic ◽  
Gordana Kostic ◽  
Zoran Igrutinovic ◽  
Biljana Vuletic
Keyword(s):  
Family History ◽  
Children And Adolescents ◽  
Thyroid Disease ◽  
Hashimoto’S Thyroiditis ◽  
Positive Family History ◽  
Clinical Manifestations ◽  
Hashimoto's Thyroiditis ◽  
Long Term Outcome ◽  
History Of

INTRODUCTION Hashimoto's thyroiditis (HT) is a common cause of goitre and hypothyroidism in children and adolescents. Spontaneous remission may occur in up to 50% patients, but the development of hypothyroidism is possible. OBJECTIVE We investigated the clinical manifestations, course and long-term outcome of HT. METHOD We reviewed charts of 43 children (36 females) with HT, mean age at presentation 12.3 years, and mean follow-up duration 4.6 years. RESULTS HT is five times more common in females. The common complaints leading to referral were goitre in 19 children (44.3%), diffuse in 17 children (89.5%). As to the prevalence of goitre, it accounted for significantly more referrals in females (14 girls, and 5 boys; 73.7% vs 26.3%, t-test; p<0.005). Goitre was either isolated in 15 (34.4%) or associated with other complaints in 4 children: anemia in 7 (16.2%), fatigue in 5 (11.8%), increased appetite in 4 (9.7%), weight gain in 3 (7.0%), growth retardation in 2 children (4.7%), at irregular menses in 3 pubertal girls. Hypothyroidism was present in 18 patients (41.1%), 7 (38.8%) on initial admission, and 11 (61.8%) had the mean follow-up duration of 4.6 years. There were 25 euthyroid HT patients (59.9%). The family history of the thyroid disease was positive in 16 children (37.1%) and 12 of them (71.4%) had hypothyroidism. There were 6 patients (13.9%) in whom the disease was associated with some other autoimmune disease. CONCLUSION HT is five times more common in females. The usual complaints leading to referral were diffuse goitre, which accounted for significantly more referrals in females. A positive family history of autoimmune thyroid disease is associated with a higher risk of hypothyroidism in children with HT. Hypothyroid patients may appear in higher percentage of children and adolescents than previously reported.

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