scholarly journals Does Early Cerebral Near-Infrared Spectroscopy Monitoring Predict Outcome in Neonates with Hypoxic Ischaemic Encephalopathy? A Systematic Review of Diagnostic Test Accuracy

Neonatology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Aisling A. Garvey ◽  
Andreea M. Pavel ◽  
Deirdre M. Murray ◽  
Geraldine B. Boylan ◽  
Eugene M. Dempsey
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Objective Assessment ◽  
Brain Mri ◽  
Neurodevelopmental Outcome ◽  
Cochrane Library ◽  
Test Accuracy ◽  
Valuable Insight ◽  
Neurodevelopmental Outcomes

<b><i>Introduction:</i></b> Hypoxic ischaemic encephalopathy (HIE) remains one of the top 10 contributors to the global burden of disease. Early objective biomarkers are required. Near-infrared spectroscopy (NIRS) may provide a valuable insight into cerebral perfusion and metabolism. We aimed to determine whether early NIRS monitoring (&#x3c;6 h of age) can predict outcome as defined by grade of encephalopathy, brain MRI findings, and/or neurodevelopmental outcome at 1–2 years in infants with HIE. <b><i>Methods:</i></b> We searched PubMed, Scopus, Web of Science, Embase, and The Cochrane Library databases (July 2019). Studies of infants born ≥36<sup>+0</sup> weeks gestation with HIE who had NIRS recording commenced before 6 h of life were included. We planned to provide a narrative of all the studies included, and if similar clinically and methodologically, the results would be pooled in a meta-analysis to determine test accuracy. <b><i>Results:</i></b> Seven studies were included with a combined total of 161 infants. Only 1 study included infants with mild HIE. A range of different oximeters and probes were utilized with varying outcome measures making comparison difficult. Although some studies showed a trend towards higher cSO<sub>2</sub> values before 6 h in infants with adverse neurodevelopmental outcomes, in the majority, this was not significant until beyond 24 h of life. <b><i>Conclusion:</i></b> Very little data currently exists to assess the use of early NIRS to predict outcome in infants with HIE. Further studies using a standardized approach are required before NIRS can be evaluated as a potential objective assessment tool for early identification of at-risk infants.

Clinical effect of unilateral transcranial magnetic resonance-guided focused ultrasound thalamotomy in patients with essential tremor as evaluated by functional near-infrared spectroscopy

2020 ◽  
Author(s):  
Dongsheng Kong ◽  
Rui Zong ◽  
Tingyu Zhang ◽  
Longsheng Pan ◽  
Xinguang Yu
Keyword(s):  
Infrared Spectroscopy ◽  
Magnetic Resonance ◽  
Essential Tremor ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Focused Ultrasound ◽  
Objective Assessment ◽  
Functional Near Infrared Spectroscopy ◽  
Cohen’S D ◽  
Cohen's D

Abstract Background: Transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) surgery is a noninvasive thermal ablation therapy for neurological conditions such as essential tremor (ET). However, most studies on the therapeutic mechanisms of this technique are limited to the visualization of brain structure and network activities with resting state functional magnetic resonance imaging. We aimed to investigate the effect of tcMRgFUS on the cortical level of the motor network using functional near-infrared spectroscopy (fNIRS).Results: Two sample paired t-tests revealed that only channel 6 (left primary motor and somatosensory cortices), and channel 45 (right dorsolateral prefrontal cortex) were significantly activated in the writing task after MRgFUS treatment compared to the task before MRgFUS treatment (CH6: t(6) = 3.42, p < 0.05, Cohen's d = 1.29; CH45: t(6) = 2.47, p < 0.05, Cohen's d = 0.93).Conclusions: We identified changes in relevant cortical activity after surgery and found that fNIRS can provide an important supplement to objective assessment of the clinical efficacy of tcMRgFUS.

scholarly journals Spatial Coregistration of Functional Near-Infrared Spectroscopy to Brain MRI

2017 ◽  
Vol 27 (5) ◽  
pp. 453-460 ◽  
Author(s):  
Michelle Chen ◽  
Helena M. Blumen ◽  
Meltem Izzetoglu ◽  
Roee Holtzer
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Brain Mri ◽  
Functional Near Infrared Spectroscopy

scholarly journals The Use of Near-Infrared Spectroscopy and/or Transcranial Doppler as Non-Invasive Markers of Cerebral Perfusion in Adult Sepsis Patients With Delirium: A Systematic Review

2021 ◽  
pp. 088506662199709
Author(s):  
Michael D. Wood ◽  
J. Gordon Boyd ◽  
Nicole Wood ◽  
James Frank ◽  
Timothy D. Girard ◽  
...  
Keyword(s):  
Systematic Review ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Transcranial Doppler ◽  
Cerebral Perfusion ◽  
Near Infrared ◽  
Cochrane Library ◽  
Delirium Assessment ◽  
Non Invasive ◽  
The Impact

Background: Several studies have previously reported the presence of altered cerebral perfusion during sepsis. However, the role of non-invasive neuromonitoring, and the impact of altered cerebral perfusion, in sepsis patients with delirium remains unclear. Methods: We performed a systematic review of studies that used near-infrared spectroscopy (NIRS) and/or transcranial Doppler (TCD) to assess adults (≥18 years) with sepsis and delirium. From study inception to July 28, 2020, we searched the following databases: Ovid MedLine, Embase, Cochrane Library, and Web of Science. Results: Of 1546 articles identified, 10 met our inclusion criteria. Although NIRS-derived regional cerebral oxygenation was consistently lower, this difference was only statistically significant in one study. TCD-derived cerebral blood flow velocity was inconsistent across studies. Importantly, both impaired cerebral autoregulation during sepsis and increased cerebrovascular resistance were associated with delirium during sepsis. However, the heterogeneity in NIRS and TCD devices, duration of recording (from 10 seconds to 72 hours), and delirium assessment methods (e.g., electronic medical records, confusion assessment method for the intensive care unit), precluded meta-analysis. Conclusion: The available literature demonstrates that cerebral perfusion disturbances may be associated with delirium in sepsis. However, future investigations will require consistent definitions of delirium, delirium assessment training, harmonized NIRS and TCD assessments (e.g., consistent measurement site and length of recording), as well as the quantification of secondary and tertiary variables (i.e., Cox, Mxa, MAPOPT), in order to fully assess the relationship between cerebral perfusion and delirium in patients with sepsis.

An objective assessment of intermittent claudication by near-infrared spectroscopy

1994 ◽  
Vol 8 (3) ◽  
pp. 294-296 ◽  
Author(s):  
Takashi Komiyama ◽  
Hiroshi Shigematsu ◽  
Hiroshi Yasuhara ◽  
Tetsuichiro Muto
Keyword(s):  
Infrared Spectroscopy ◽  
Intermittent Claudication ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Objective Assessment

scholarly journals Fetal Hemoglobin and Tissue Oxygenation Measured With Near-Infrared Spectroscopy—A Systematic Qualitative Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Ena Pritišanac ◽  
Berndt Urlesberger ◽  
Bernhard Schwaberger ◽  
Gerhard Pichler
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Tissue Oxygenation ◽  
Fetal Hemoglobin ◽  
Cochrane Library ◽  
Term Neonates ◽  
Qualitative Review ◽  
Peripheral Muscle ◽  
The Impact

Fetal hemoglobin (HbF) is a principal oxygen carrier in the blood of preterm and term neonates. Compared to adult hemoglobin, it has a significantly higher affinity for oxygen and its oxyhemoglobin dissociation curve (ODC) is left-shifted accordingly. Tissue oxygenation measured with near-infrared spectroscopy (NIRS) during neonatal intensive care is directly affected by hemoglobin concentration. We performed a systematic qualitative review regarding the impact of HbF on tissue oxygenation monitoring by NIRS. The PubMed/Medline, EMBASE, Cochrane library and CINAHL databases were searched from inception to May 2021 for studies relating to HbF and NIRS in preterm and term neonates in the first days and weeks after birth. Out of 1,429 eligible records, four observational studies were included. Three studies found no effect of HbF on cerebral tissue oxygenation. One peripheral NIRS study found a positive correlation between HbF and peripheral fractional oxygen extraction (FOE). Currently available limited data suggest that FHbF could affect peripheral muscle FOE, but seems not to affect cerebral oxygenation in preterm neonates. More studies are needed to draw a final conclusion on this matter, especially concerning the oxygenation changes driven by adult RBC transfusions.

Near-Infrared Spectroscopy Monitoring, Superior Vena Cava Flow, and Neurodevelopmental Outcome at 2 years in a Cohort of Very Low-Birth-Weight Infants

2016 ◽  
Vol 33 (11) ◽  
pp. 1093-1098 ◽  
Author(s):  
Rosa Cerbo ◽  
Simona Orcesi ◽  
Luigia Scudeller ◽  
Martina Borellini ◽  
Carolina Croci ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Very Low Birth Weight ◽  
Superior Vena ◽  
Neurodevelopmental Outcome ◽  
Vena Cava ◽  
Low Birth Weight Infants

Objective We aimed at assessing the association between superior vena cava flow (SVCf), regional (cerebral) tissue oxygen saturation (rSO2), and cerebral fractional oxygen extraction (CFOE) during the first 48 hours of life and 2-years neurodevelopmental outcome of very low-birth-weight infants (VLBW). Methods We prospectively studied 60 VLBW infants admitted to our neonatal intensive care unit; rSO2 was continuously monitored with near-infrared spectroscopy during the first 48 hours of life, SVCf was measured at 4 to 6, 12, 24, and 48 hours, and CFOE was calculated. Neurodevelopmental outcome was assessed at 24 months corrected age. Results The mean gestational age at birth was 27.9 weeks (standard deviation: 2.4); 8 infants died in the first 3 months of life, 6 were lost to follow-up, 46 survived and were followed up. At 24 months, 6 (13%) and 7 (15.2%) infants developed minor and major sequelae, respectively. Infants who died had higher CFOE (p < 0.001) and lower SVCf (p < 0.001) than infants surviving with sequelae. In turn, these had higher SVCf between 24 and 48 hours than those without sequelae (p < 0.001). Conclusion SVCf, rSO2, and CFOE patterns in the first days of life suggest cerebral hyperperfusion, related to loss of autoregulation and/or use of inotropic drugs, as a potential mechanism of cerebral injury.

Sign in / Sign up

Export Citation Format

Share Document