A Commentary on the “Duration of Oral Antibiotics Administration for Cetuximab-Induced Acneiform Eruption”

Dermatology ◽  
2021 ◽  
pp. 1-4
Author(s):  
Jawaher Tariq A. AlMulhem ◽  
Farah A.O.A. Zuaiter
Keyword(s):  
Oral Antibiotics ◽  
Ongoing Research ◽  
Systemic Corticosteroids ◽  
Prophylactic Drugs ◽  
Acneiform Eruption ◽  
Treatment Measures ◽  
Cutaneous Side Effect ◽  
Prevention Methods ◽  
Dermatological Side Effects

Acneiform eruption is a devastating cutaneous side effect of cetuximab, a monoclonal antibody used to treat a variety of cancers. Despite its effectiveness, many patients avoid or discontinue it after experiencing its dermatological side effects as it negatively impacts their quality of life (QoL). This displays the immense need for multidisciplinary collaboration to prevent and treat cetuximab-induced acneiform eruption (CIAE). Prevention methods include, but are not limited to, education, skin care routines, and prophylactic drugs. The following measures reduce the likelihood of developing CIAE and decrease its severity, making it easier to treat if it were to occur. Ongoing research on the treatment of CIAE continues. Of these treatments, oral tetracyclines and systemic corticosteroids have been shown to be the most effective by far. This commentary aims to evaluate the study by Park et al. [Dermatology. 2021;237(3):457–63], further elaborate on prevention and treatment measures of CIAE, and highlight the implications of CIAE on a patient’s QoL.

Duration of Oral Antibiotics Administration for Cetuximab-Induced Acneiform Eruption

Dermatology ◽  
2020 ◽  
pp. 1-7
Author(s):  
Ji-Hye Park ◽  
YoungHwan Choi ◽  
Hyun Je Kim ◽  
Se Jin Oh ◽  
Dong-Youn Lee ◽  
...  
Keyword(s):  
Antibiotic Use ◽  
Time Interval ◽  
Antibiotic Administration ◽  
Oral Antibiotic ◽  
Oral Antibiotics ◽  
Younger Age ◽  
Acneiform Eruption ◽  
Cutaneous Adverse Event ◽  
The Mean

<b><i>Background:</i></b> Acneiform eruption is the most common cutaneous adverse event associated with cetuximab. As it can affect quality of life and adversely affect chemotherapy schedule, additional medical care is required. <b><i>Objectives:</i></b> To investigate the adherence to and the duration of antibiotic administration to treat cetuximab-induced acneiform eruption. <b><i>Methods:</i></b> Medical data of patients who were referred to the Department of Dermatology were reviewed from January 2013 to June 2018. Dermatologists assessed the severity of acneiform eruption and prescribed tetracycline-class antibiotics according to the severity every 2 or 4 weeks. We investigated the duration and amount of oral antibiotic administration and analyzed the factors that may affect the control of acneiform eruption statistically. <b><i>Results:</i></b> A total of 207 of 267 patients referred to the Department of Dermatology showed acneiform eruption; 124 patients were treated with minocycline, 34 patients with doxycycline, 27 patients with both, and 22 patients with topical agents. The mean duration of oral antibiotic medication was 82.7 days. A statistical analysis of the factors that prolonged the use of antibiotics for more than 90 days showed that male and younger age were risk factors. Shorter time interval from starting cetuximab to starting antibiotics was associated with longer duration of antibiotic use, statistically. <b><i>Conclusions:</i></b> Cetuximab-induced acneiform eruption can be well controlled with tetracycline-class antibiotics in about 3 months. It can last longer in male and younger patients. The sooner and the more severe it appears, the longer it can last.

Climate impact of an optimised gas treatment on old landfills

2022 ◽  
pp. 0734242X2110701
Author(s):  
Roland Berger ◽  
Joachim Lehner
Keyword(s):  
New Technology ◽  
Landfill Gas ◽  
Calorific Value ◽  
Climate Impact ◽  
Treatment Technology ◽  
Gas Treatment ◽  
Treatment Measures ◽  
Established Fact ◽  
New Treatment

It is a well-established fact that the quality and quantity of landfill gas (LFG) start declining after a landfill is closed to further waste intake. Conventional gas treatment and utilisation systems such as flares and gas-driven engines require a certain quality of LFG: specifically, a sufficient methane concentration. Various measures are utilised to maintain the necessary quality of LFG, including a turn-down of gas extraction rates and a shutdown of low-quality gas wells, resulting in a decline of LFG production. This, however, does not have to be the case. The low calorific value (LCV) LFG capture and treatment technology developed by e-flox and referred to in this article as ‘LCV LFG System’ can significantly increase the collection rate and the amount of treated methane in an old landfill. This article introduces such new treatment measures, describes gas capture calculation methodologies and presents actual results based on a medium-sized landfill in Germany. The study demonstrates, among other things, that the LCV LFG system can reduce the CO2 avoidance costs to roughly 10 €/tCO2eq. We present this new technology as a quick and straightforward measure of dealing with the climate issues related to methane emissions of old landfills.

Comparison of Corticosteroid and Vincristine in Treating Kaposiform Hemangioendothelioma and Tufted Angioma: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 29 (05) ◽  
pp. 401-407 ◽  
Author(s):  
Wei Yao ◽  
Kai Li ◽  
Zuopeng Wang ◽  
Jiahao Pei ◽  
Xiangqi Liu ◽  
...  
Keyword(s):  
Recurrence Rate ◽  
Adverse Reactions ◽  
Meta Analysis ◽  
Case Series ◽  
Research Quality ◽  
Cochrane Library ◽  
Kaposiform Hemangioendothelioma ◽  
Systemic Corticosteroids ◽  
Tufted Angioma

Objective To evaluate the outcome and safety of corticosteroids and vincristine (VCR) in the treatment of kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). Materials and Methods Clinical studies involving corticosteroids and VCR therapies in treating KHE/TA were identified by using PubMed, Cochrane Library, OVID, EBSCO, CNKI, VIP, and Wanfang databases from their establishment date to December 2017. Randomized controlled trials, case–control, or case series with more than five cases were included. The following data were extracted: study sample, demographics, responses rate, recurrence rate, and adverse reactions. Two reviewers completed screening and extraction. Methodological quality was evaluated with quality appraisal tool. Results A total of 266 studies were found, and 27 studies were finally included in this research; quality of all studies was low. Seven studies with a total of 123 participants, which compared the effect of systemic corticosteroids with that of VCR, were performed for the meta-analysis. The results indicated that the effect of VCR was significantly higher than that of corticosteroids (relative risk [RR] = 2.08, 95% confidence interval [CI]: 1.38–3.16). The recurrence rate of VCR (11.1%) was lower than that of corticosteroids (50%), but there was no statistical difference between the two therapies (p = 0.1312). The result of pooled adverse reactions response rate for VCR was 18.2%, significantly lower than that for corticosteroids, which was 52.0%. Conclusion The present profile shows that VCR is relatively more effective and safer in treating KHE/TA than corticosteroids are. So, we believe VCR could be used as a first-line medication agent in the treatment of KHE/TA.

scholarly journals Comparison of Multicast Algorithm Evaluation Results in Low and High Multicast Saturation Environments

2019 ◽  
Vol 3 ◽  
pp. 3-7
Author(s):  
Krzysztof Stachowiak ◽  
Piotr Zwierzykowski
Keyword(s):  
Quality Of Service ◽  
Computational Complexity ◽  
Optimization Methods ◽  
The Other ◽  
Ongoing Research ◽  
Mathematical Problems ◽  
Point To Point ◽  
Difficult Challenge ◽  
Entire Network

The multicast quality of service-enabled routing is a computationally challenging task. Despite ongoing research efforts, the associated mathematical problems are still considered to be NP-hard. In certain applications, computational complexity of finding the optimal connection between a set of network devices may be a particularly difficult challenge. For example, connecting a small group of participants of a teleconference is not much more complex than setting up a set of mutual point-to-point connections. On the other hand, satisfying the demand for such services as IPTV, with their receivers constituting the majority of the network, requires applying appropriate optimization methods in order to ensure real system execution. In this paper, algorithms solving this class of problems are considered. The notion of multicast saturation is introduced to measure the amount of multicast participants relative to the entire network, and the efficiency of the analyzed algorithms is evaluated for different saturation degrees.

Epidemiology of cancer-associated venous thrombosis

Blood ◽  
2013 ◽  
Vol 122 (10) ◽  
pp. 1712-1723 ◽  
Author(s):  
Jasmijn F. Timp ◽  
Sigrid K. Braekkan ◽  
Henri H. Versteeg ◽  
Suzanne C. Cannegieter
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Venous Thrombosis ◽  
Cancer Patients ◽  
Prediction Models ◽  
Related Factors ◽  
Treatment Measures ◽  
Risk Patients ◽  
Cancer Types

Abstract Cancer-associated venous thrombosis is a common condition, although the reported incidence varies widely between studies depending on patient population, start and duration of follow-up, and the method of detecting and reporting thrombotic events. Furthermore, as cancer is a heterogeneous disease, the risk of venous thrombosis depends on cancer types and stages, treatment measures, and patient-related factors. In general, cancer patients with venous thrombosis do not fare well and have an increased mortality compared with cancer patients without. This may be explained by the more aggressive type of malignancies associated with this condition. It is hypothesized that thromboprophylaxis in cancer patients might improve prognosis and quality of life by preventing thrombotic events. However, anticoagulant treatment leads to increased bleeding, particularly in this patient group, so in case of proven benefit of thromboprophylaxis, only patients with a high risk of venous thrombosis should be considered. This review describes the literature on incidence of and risk factors for cancer-associated venous thrombosis, with the aim to provide a basis for identification of high-risk patients and for further development and refinement of prediction models. Furthermore, knowledge on risk factors for cancer-related venous thrombosis may enhance the understanding of the pathophysiology of thrombosis in these patients.

scholarly journals Female Reproductive Health After Childhood, Adolescent, and Young Adult Cancers: Guidelines for the Assessment and Management of Female Reproductive Complications

2013 ◽  
Vol 31 (9) ◽  
pp. 1239-1247 ◽  
Author(s):  
Monika L. Metzger ◽  
Lillian R. Meacham ◽  
Briana Patterson ◽  
Jacqueline S. Casillas ◽  
Louis S. Constine ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Young Adult ◽  
Reproductive Health ◽  
Hormonal Regulation ◽  
Pubertal Development ◽  
Adolescent And Young Adult ◽  
Primary Therapy ◽  
Ongoing Research

Purpose As more young female patients with cancer survive their primary disease, concerns about reproductive health related to primary therapy gain relevance. Cancer therapy can often affect reproductive organs, leading to impaired pubertal development, hormonal regulation, fertility, and sexual function, affecting quality of life. Methods The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancer (COG-LTFU Guidelines) are evidence-based recommendations for screening and management of late effects of therapeutic exposures. The guidelines are updated every 2 years by a multidisciplinary panel based on current literature review and expert consensus. Results This review summarizes the current task force recommendations for the assessment and management of female reproductive complications after treatment for childhood, adolescent, and young adult cancers. Experimental pretreatment as well as post-treatment fertility preservation strategies, including barriers and ethical considerations, which are not included in the COG-LTFU Guidelines, are also discussed. Conclusion Ongoing research will continue to inform COG-LTFU Guideline recommendations for follow-up care of female survivors of childhood cancer to improve their health and quality of life.

scholarly journals Investigation of intracochlear dual actuator stimulation in a scaled test rig

2017 ◽  
Vol 3 (2) ◽  
pp. 119-122
Author(s):  
Wouter J. van Drunen ◽  
Sarra Kacha Lachheb ◽  
Anatoly Glukhovskoy ◽  
Jens Twiefel ◽  
Marc C. Wurz ◽  
...  
Keyword(s):  
Low Frequency ◽  
Acoustic Stimulation ◽  
Residual Hearing ◽  
Frequency Range ◽  
Test Rig ◽  
Profound Hearing Loss ◽  
Ongoing Research ◽  
Electric Acoustic Stimulation ◽  
Single Implant

AbstractFor patients suffering from profound hearing loss or deafness still having respectable residual hearing in the low frequency range, the combination of a hearing aid with a cochlear implant results in the best quality of hearing perception (EAS – electric acoustic stimulation). In order to optimize EAS, ongoing research focusses on the integration of these stimuli in a single implant device. Within this study, the performance of piezoelectric actuators, particularly the dual actuator stimulation, in a scaled uncoiled test rig was investigated.

Reinforcement Contingencies in Language Acquisition

2016 ◽  
Vol 4 (1) ◽  
pp. 25-32
Author(s):  
Anna Ingeborg Petursdottir ◽  
James R. Mellor
Keyword(s):  
Language Acquisition ◽  
Language Impairment ◽  
Educational Outcomes ◽  
Ongoing Research ◽  
Service Delivery Models ◽  
Naturally Occurring ◽  
Effective Reinforcement ◽  
Delivery Models ◽  
Contrary Evidence

Childhood language delays and language impairments negatively impact educational outcomes and quality of life. In spite of previously prevailing views to the contrary, evidence suggests that children’s language acquisition is affected by contingent responses of caregivers and conversation partners, as well as by the other consequences of speaking. In other words, reinforcement contingencies play a role in language acquisition. Decades of ongoing research have documented how to arrange reinforcement contingencies to support acquisition of language and communication skills in children with varying degrees of language impairment. The existing expertise in this area should be leveraged in the design of service delivery models that provide opportunities for effective reinforcement contingencies to operate throughout the day and support acquisition of skills that have failed to develop through naturally occurring interactions.

Issues in Remote Pilotage

1999 ◽  
Vol 52 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Mike Hadley
Keyword(s):  
Traffic Management ◽  
International Association ◽  
Public Awareness ◽  
The European Union ◽  
Differential Gps ◽  
Ongoing Research ◽  
Motion Data ◽  
Downward Pressure ◽  
Automatic Docking

This paper was presented at the World Congress of the International Association of Institutes of Navigation (IAIN) held in Amsterdam, The Netherlands, 17–21 November 1997.Remote, or shore-based, pilotage means different things to different people, despite a definition being produced by the European and International Maritime Pilots Associations. The debate about it is set in the context of increasing public awareness of the environment and a downward pressure on costs; these in themselves make for uncomfortable bedfellows. However, this sets the scene for the current aspirations within the European Union for vessel traffic management and the ongoing research into Vessel Traffic Services (VTS) and Vessel Traffic Management and Information Services (VTMIS). The technology to implement navigational assistance of a fairly high order is already in place, but there are still problems to be overcome before the concept can be taken further. Commonly recurring concerns over remote pilotage are the inadequacies of radar, difficulties with language, lack of ‘feel’ for the ship, which includes the on-board pilot's assessment of the quality of the vessel's crew, and the lack of ship motion data. Differential GPS is now capable of aiding automatic docking of some specialized vessels, but it has emerged, most recently at the IALA VTS Committee meeting, that ECDIS has shortcomings when being considered as the geographic information system of a VTS. Transponders are the subject of yet another debate, but will the data that they can convey be able to replace an on-board pilot?

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