scholarly journals Ocular Surface Erosion after Suspected Exposure to Evaporated COVID-19 Vaccine

2021 ◽  
pp. 944-951
Author(s):  
Somporn Chantra ◽  
Pareena Chaitanuwong ◽  
Kasem Seresirikachorm ◽  
Mitchell Brinks ◽  
Onsiri Serirat ◽  
...  
Keyword(s):  
Single Dose ◽  
Skin Rash ◽  
Ocular Surface ◽  
Health Personnel ◽  
Vaccination Campaign ◽  
Surface Erosion ◽  
Closed Space ◽  
Skin Reactions ◽  
The Third ◽  
Symptoms And Signs

The purpose is to report ocular surface erosion of health personnel who were exposed to evaporated CoronaVac during a vaccination campaign. A campaign for CoronaVac vaccination was conducted in a closed space of 11.04 × 5.96 m, partially divided into 6 rooms with interconnected area among the rooms. A total of 20 health personnel worked in the vaccination rooms. On the third day of campaign, a vial, containing a single dose of 0.5 mL, of the vaccine was dropped accidentally onto the floor and broken by an administering nurse. A total of 15 personnel had symptoms and signs of ocular surface erosion at the average time from the accident to the onset of 10.2 ± 7.1 h; 4 personnel also had skin rash. These personnel included all 13 persons who already worked in the rooms when the accident occurred and continued for additional 4–6 h and 2 personnel who presented in the rooms 1–2 h after the accident and stayed for 2–3 h. Proximity and timing suggest CoronaVac correlation with the ocular and skin reactions. Cautions should be taken to avoid broken vials, spills, and aerosolization of CoronaVac during the vaccination.

scholarly journals Self-reported and physiological reactions to the third BNT162b2 mRNA COVID-19 (booster) vaccine dose

2021 ◽  
Author(s):  
Merav Mofaz ◽  
Matan Yechezkel ◽  
Grace Guan ◽  
Margaret L. Brandeau ◽  
Tal Patalon ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Booster Dose ◽  
Vaccination Campaign ◽  
Vaccine Dose ◽  
P Value ◽  
Booster Vaccine ◽  
The Third ◽  
Systemic Reactions ◽  
Physiological Reactions

AbstractBackgroundThe rapid rise in hospitalizations associated with the Delta-driven COVID-19 resurgence, and the imminent risk of hospital overcrowding, led the Israeli government to initialize a national third (booster) COVID-19 vaccination campaign in early August 2021, offering the BNT162b2 mRNA vaccine to individuals who received their second dose over five months ago. However, the safety of the third (booster) dose has not been fully established yet.ObjectiveEvaluate the short-term, self-reported and physiological reactions to the third BNT162b2 mRNA COVID-19 (booster) vaccine dose.DesignA prospective observational study, in which participants are equipped with a smartwatch and fill in a daily questionnaire via a dedicated mobile application for a period of 21 days, starting seven days before the vaccination.SettingAn Israel-wide third (booster) vaccination campaign.ParticipantsA group of 1,609 (18+ years of age) recipients of at least one dose of the BNT162b2 vaccine between December 20, 2020, and September 15, 2021, out of a larger cohort of 2,912 prospective study participants. 1,344 of the participants were recipients of the third vaccine dose.MeasurementsDaily self-reported questionnaires regarding local and systemic reactions, mood level, stress level, sport duration, and sleep quality. Heart rate, heart rate variability and blood oxygen saturation level were continuously measured by Garmin Vivosmart 4 smartwatches.ResultsThe extent of systemic reactions reported following the third (booster) dose administration is similar to that reported following the second dose (p-value=0.305) and considerably greater than that reported following the first dose (p-value<0.001). Our analyses of self-reported well-being indicators as well as the objective heart rate and heart rate variability measures recorded by the smartwatches further support this finding. Focusing on the third dose, reactions were more apparent in younger participants (p-value<0.01), in women (p-value<0.001), and in participants with no underlying medical conditions (p-value<0.001). Nevertheless, reported reactions and changes in physiological measures returned to their baseline levels within three days from inoculation with the third dose.LimitationsParticipants may not adequately represent the vaccinated population in Israel and elsewhere.ConclusionOur work further supports the safety of a third COVID-19 BNT162b2 mRNA (booster) vaccine dose from both a subjective and an objective perspective, particularly in individuals 65+ years of age and those with underlying medical conditions.Primary funding sourceEuropean Research Council (ERC) project #949850

The poet and the poison

2005 ◽  
Author(s):  
John Emsley
Keyword(s):  
Single Dose ◽  
Large Dose ◽  
Corrosive Sublimate ◽  
The Political ◽  
Good Luck ◽  
The Third ◽  
Health Authorities ◽  
Metallic Taste ◽  
Large Single Dose ◽  
To Receive

Mercury is not a particularly promising homicidal poison, but it is possible to dispose of someone by feeding them mercury(II) chloride provided you disguise its metallic taste. In the 1800s solutions of corrosive sublimate, as it was then called, were used as an antiseptic and as an insecticide against bedbugs, and its very availability resulted in thousands of poisonings being reported to the health authorities, although these were mainly accidents or as a result of its being taken deliberately in order to procure an abortion. Mercury was not a poison to feature in many murder cases because it was so easily detectable by the intended victims, especially if they started to vomit, which they almost always did. Then the metallic taste became particularly noticeable, and the presence of mercury could easily be confirmed by simple analytical tests. The poisoners who chose mercury had to use a large dose and this would kill within a day or two. Despite these inherent drawbacks, a few poisoners made use of it. Two of the murderers whose cases we are about to analyse opted for the large single dose approach, but the third murderer achieved her ends by targeting her victim with multiple doses. That murder became famous because of whom she killed and the political repercussions it caused. It was also notorious for the manner in which the final fatal dose of poison was administered. Mary Bateman was known as the Yorkshire Witch and she had a plan that she thought would lead her victims into taking a fatal single dose of mercury. Instead it led her to the gallows. At the time of her crime, Bateman lived in Leeds, Yorkshire, where she earned her living telling fortunes and swindling gullible clients out of their cash and possessions. She claimed to receive her supernatural information from a spirit medium, a Miss Blythe, into whose mouth she put the advice that always seemed to result in her clients handing over their money and saleable goods, with the promise that if they did as Miss Blythe said, then good luck would soon come their way, and they would be more than compensated.

scholarly journals Can Collagenase Be Used in the Treatment of Adhesive Capsulitis?

2019 ◽  
Vol 29 (2) ◽  
pp. 174-180
Author(s):  
Nazım Karahan ◽  
Güzelali Ozdemir ◽  
Duygu Kolukısa ◽  
Serda Duman ◽  
Fatih Arslanoğlu ◽  
...  
Keyword(s):  
Single Dose ◽  
Saline Solution ◽  
Adhesive Capsulitis ◽  
Cartilage Damage ◽  
Male Rats ◽  
Collagenase Clostridium Histolyticum ◽  
Joint Cartilage ◽  
The Third ◽  
Significant Difference ◽  
Shoulder Range

Background: The objective of this study was to evaluate the efficacy of subacromial injections of collagenase and corticosteroid in rats with experimentally induced adhesive capsulitis. Method: Thirty adult Wistar albino male rats were distributed into 3 groups of 10 rats each after stabilization of their shoulders for 3 weeks: the first group received a single dose of 0.002 mg (0.25 mL) subacromial collagenase; the second group received a single dose of 1.60 mg (0.25 mL) subacromial steroid, and the third group received a single dose of 0.25 mL subacromial saline solution. One week later, we investigated shoulder range of motions, collagen content of the shoulder, and joint cartilage structure. Results: There was no statistically significant difference in the cartilage damage between the groups (p > 0.05). Fibrosis measurements were significantly lower in the collagenase group than in the steroid and saline groups. There was no significant difference in fibrosis between the steroid and saline groups (p > 0.05). Abduction measurements were significantly higher in the collagenase group than in the steroid and saline groups (p < 0.001). No significant difference in the abduction measurements was observed between the saline and steroid groups (p > 0.05). Conclusion: We observed that subacromial injections of collagenase Clostridium histolyticum effectively treated adhesive capsulitis. The results suggest that this treatment could be considered for use in patients with an intact rotator cuff.

scholarly journals Sorafenib induced Hand Foot Skin Rash in FLT3 ITD mutated Acute Myeloid leukemia- A case report and review of literature

2014 ◽  
Vol 6 (1) ◽  
pp. e2014016 ◽  
Author(s):  
Jayastu Senapati ◽  
Anup J Devasia ◽  
Abhijeet Ganapule ◽  
Leni George ◽  
Auro Viswabandya
Keyword(s):  
Acute Myeloid Leukemia ◽  
Skin Rash ◽  
Myeloid Leukemia ◽  
Kinase Inhibitor ◽  
Early Stage ◽  
Chemotherapeutic Agents ◽  
Drug Discontinuation ◽  
Skin Reactions ◽  
Palmoplantar Erythrodysesthesia ◽  
Acute Myeloid

Sorafenib is a novel small molecule multiple kinase inhibitor which has been used for metastatic renal cancer, hepatocellular cancer. Sorafenib induced skin rash has been discussed as a side effect in trials in both FLT3 wild type and mutated acute myeloid leukemia (AML) as monotherapy or as combination with other chemotherapeutic agents . We describe a patient with FLT 3 ITD mutated AML who was started on adjunctive Sorafenib therapy. Skin reactions manifested as NCI Grade III palmoplantar erythrodysesthesia (PPE), requiring drug discontinuation. Several pathogenic mechanisms have been implicated in Sorafenib induced skin reactions, but none has been conclusively proven. While treatment options are varied for early stage skin reactions, drug discontinuation remains the only possible therapy presently for severe grade skin reaction. 

scholarly journals Evaluating the costs of cholera illness and cost-effectiveness of a single dose oral vaccination campaign in Lusaka, Zambia

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0215972
Author(s):  
Tannia Tembo ◽  
Michelo Simuyandi ◽  
Kanema Chiyenu ◽  
Anjali Sharma ◽  
Obvious N. Chilyabanyama ◽  
...  
Keyword(s):  
Single Dose ◽  
Cost Effectiveness ◽  
Vaccination Campaign ◽  
Oral Vaccination ◽  
Dose Oral

scholarly journals World Health Organization

1947 ◽  
Vol 1 (3) ◽  
pp. 535-537 ◽  
Keyword(s):  
Public Health ◽  
Health Personnel ◽  
World Health ◽  
Wide Spread ◽  
World Health Assembly ◽  
The Third ◽  
The World ◽  
Health Organization ◽  
First World ◽  
Develop Program

Interim Commission of WHO: The third session of the Interim Commission of WHO, which began on March 30, 1947 at Geneva, closed on April 12, after assigning priority to the various health problems confronting the world. Representatives of sixteen of the eighteen member states (Liberia and the Ukrainian SSR being absent) attended the session. Results of Conference discussions indicated wide-spread agreement on such matters as 1) appointment of expert committees to develop program proposals relating to specific diseases, 2) strengthening of national health services, and 3) facilities for training public health personnel. It was hoped that a practical first year's program could be presented to the first World Health Assembly when that body convenes, probably in February, 1948.

Hematoma from arteriovenous malformation producing hydrocephalus and simulating a thalamic tumor

1971 ◽  
Vol 34 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Larry K. T. Ng ◽  
Gabriel Schwarz ◽  
Mark M. Mishkin
Keyword(s):  
Vascular Malformation ◽  
Obstructive Hydrocephalus ◽  
Third Ventricle ◽  
Intracerebral Hematoma ◽  
Content Type ◽  
The Third ◽  
Brain Substance ◽  
History Of ◽  
The Brain ◽  
Symptoms And Signs

✓ Two patients with a history of progressive unilateral neurological symptoms and signs, and evidence of obstructive hydrocephalus from a mass lesion adjacent to the third ventricle as demonstrated by pneumography, were each found to have an intracerebral hematoma secondary to remote hemorrhage from a small vascular malformation. One patient died shortly after surgical exploration and the other after ventriculography. The pathophysiology of hydrocephalus associated with a vascular malformation is discussed and the need for considering a benign cause for obstructive hydrocephalus from a mass deep in the brain substance is emphasized.

scholarly journals Distributed modeling of soil erosion and sediment transport

2018 ◽  
Vol 34 (2) ◽  
pp. 763
Author(s):  
V. HRISSANTHOU ◽  
A. PSILOVIKOS
Keyword(s):  
Sediment Transport ◽  
River Basin ◽  
Sediment Yield ◽  
Surface Erosion ◽  
Rainfall Runoff ◽  
Distributed Modeling ◽  
The Third ◽  
Nestos River ◽  
Under Construction ◽  
The Individual

A mathematical model is used for the estimation of the annual sediment yield resulting from rainfall and runoff at the outlet of Nestos River basin (Toxotes, Thrace, Greece), where the ecologically interesting Nestos delta exists. The model is applied to that part of Nestos River basin (838 km2) which lies downstream of three dams. Two dams (Thissavros and Platanovryssi) have been already constructed, while the third one (Temenos) is under construction. The model consists of three sub-models: a rainfall-runoff sub-model, a surface erosion sub-model and a sediment transport sub-model for streams. This model is also capable of computing the annual erosion amount and sediment yield in the individual sub-basins

scholarly journals Strong immunogenicity of heterologous prime-boost immunizations with the experimental vaccine GRAd-COV2 and BNT162b2 or ChAdOx1-nCOV19

2021 ◽  
Author(s):  
Chiara Agrati ◽  
Stefania Capone ◽  
Concetta Castilletti ◽  
Eleonora Cimini ◽  
Giulia Matusali ◽  
...  
Keyword(s):  
Immune Response ◽  
Single Dose ◽  
Neutralizing Antibodies ◽  
Small Sample Size ◽  
Phase 1 ◽  
Vaccination Campaign ◽  
Small Sample ◽  
Vaccine Platform ◽  
Ideal Tool ◽  
Cellular Immune

Here we report on the humoral and cellular immune response in eight volunteers who autonomously chose to adhere to the Italian national COVID-19 vaccination campaign more than 3 months after receiving a single administration GRAd-COV2 vaccine candidate in the context of the phase 1 clinical trial. We observed a clear boost of both binding/neutralizing antibodies as well as T cell responses upon receipt of the heterologous BNT162b2 or ChAdOx1-nCOV19 vaccines. These results, despite the limitation of the small sample size, support the concept that a single-dose of an adenoviral vaccine may represent an ideal tool to effectively prime a balanced immune response, which can be boosted to high levels by a single dose of a different vaccine platform.

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