Abstract 16636: Cardiac Microstructural Associations With Metabolic Syndrome Differ by Sex

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Gerran Salto ◽  
Alan C Kwan ◽  
Ewa Osypiuk ◽  
Plamen Stantchev ◽  
Elizabeth H Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiac Disease ◽  
Tissue Level ◽  
Left Ventricular ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
The Metabolic Syndrome ◽  
Tissue Alteration ◽  
Myocardial Fibers

Background: Alterations in the orientation and integrity of myocardial fibers can be assessed using ultrasonic image analysis. The ability to detect such microstructural abnormalities may shed light on sex differences in the progression from metabolic risk factors to overt cardiac disease. Methods: In a community-based cohort of N=2510 adults (age 66±9 years, 56% women) without overt cardiovascular disease, we evaluated whether a novel echocardiography-based assessment of left ventricular myocardial microstructure, the signal intensity coefficient (SIC), could detect tissue-level alterations that are associated with metabolic risk factors, such as body mass index (BMI) and the metabolic syndrome. Results: In multivariable models adjusting for age and BMI, women had a significantly greater degree of cardiac microstructural alteration (coeff 0.15; s.e. 0.06, P=0.007) in the presence of metabolic syndrome, whereas this association was only borderline significant in men (coeff 0.11; s.e. 0.06, P=0.07) ( Figure ). Notably, there was no sex-specificity in the associations of either age or BMI with cardiac microstructure. Conclusion: A novel index of myocardial tissue alteration is significantly associated with presence of metabolic syndrome, even after adjusting for body size, and more prominently in women than in men. Further research is needed to examine the extent to which cardiac microstructural abnormalities may mediate the metabolic risks for cardiac disease, particularly in women.

scholarly journals Metabolic risk factors and ovarian cancer in the Metabolic Syndrome and Cancer project

2011 ◽  
Vol 40 (6) ◽  
pp. 1667-1677 ◽  
Author(s):  
T. Bjorge ◽  
A. Lukanova ◽  
S. Tretli ◽  
J. Manjer ◽  
H. Ulmer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ovarian Cancer ◽  
Metabolic Syndrome ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
The Metabolic Syndrome ◽  
Cancer Project

scholarly journals Case–Control Study of the Metabolic Syndrome and Metabolic Risk Factors for Endometrial Cancer

2011 ◽  
Vol 20 (11) ◽  
pp. 2384-2395 ◽  
Author(s):  
Christine M. Friedenreich ◽  
Rita K. Biel ◽  
David C.W. Lau ◽  
Ilona Csizmadi ◽  
Kerry S. Courneya ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Endometrial Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
The Metabolic Syndrome ◽  
Control Study

scholarly journals Metabolic risk factors and cervical cancer in the metabolic syndrome and cancer project (Me–Can)

2012 ◽  
Vol 125 (2) ◽  
pp. 330-335 ◽  
Author(s):  
Hanno Ulmer ◽  
Tone Bjørge ◽  
Hans Concin ◽  
Annekatrin Lukanova ◽  
Jonas Manjer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cervical Cancer ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
The Metabolic Syndrome ◽  
Cancer Project

scholarly journals Overnutrition, ectopic lipid and the metabolic syndrome

2016 ◽  
Vol 64 (6) ◽  
pp. 1082-1086 ◽  
Author(s):  
Scott M Grundy
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Metabolic Risk Factors ◽  
Atherogenic Dyslipidemia ◽  
Current View ◽  
Metabolic Risk ◽  
Serum Triglycerides ◽  
The Metabolic Syndrome

The metabolic syndrome is a constellation of metabolic risk factors including atherogenic dyslipidemia (elevated serum triglycerides, reduced high-density lipoprotein (HDL) cholesterol), elevated blood pressure, dysglycemia (insulin resistance and elevated serum glucose), a pro-inflammatory state, and a prothrombotic state. Most persons with metabolic syndrome are obese, and usually have abdominal obesity. Generally, obesity is a reflection of overnutrition. A current view is that when adipose tissue fails to store all excess nutrients as triglyceride, lipid begins to accumulate in various tissues (eg, muscle, liver, pancreas, and heart). This accumulation is called ectopic lipid. Various mechanisms have been proposed whereby ectopic lipid is detrimental in different tissues; these derangements induce metabolic risk factors. The foundation of the metabolic syndrome thus appears to be overnutrition, that is, more nutrient intake than can be safely disposed by lipid oxidation. Excess dietary carbohydrate also induces ectopic lipid. Of interest, less than half of obese individuals develop metabolic syndrome. Through various mechanisms they adapt to overnutrition so as to minimize lipid overload in tissues, and consequently, prevent the syndrome.

scholarly journals Restorative yoga and metabolic risk factors: The Practicing Restorative Yoga vs. Stretching for the Metabolic Syndrome (PRYSMS) randomized trial

2014 ◽  
Vol 28 (3) ◽  
pp. 406-412 ◽  
Author(s):  
Alka M. Kanaya ◽  
Maria Rosario G. Araneta ◽  
Sarah B. Pawlowsky ◽  
Elizabeth Barrett-Connor ◽  
Deborah Grady ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Randomized Trial ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
The Metabolic Syndrome

scholarly journals Trends in known and undiagnosed diabetes, HbA1c levels, cardio-metabolic risk factors and diabetes treatment target achievement in repeated cross-sectional surveys – The Tromsø Study 1994-2016

2020 ◽  
Author(s):  
Petja Lyn Langholz ◽  
Tom Wilsgaard ◽  
Inger Njølstad ◽  
Rolf Jorde ◽  
Laila Arnesdatter Hopstock
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Metabolic Risk Factors ◽  
Undiagnosed Diabetes ◽  
Metabolic Risk ◽  
Diabetes Treatment ◽  
Cross Sectional ◽  
Treatment Target ◽  
The Metabolic Syndrome ◽  
Hba1c Levels

AbstractObjectivesThe aim of this study was to investigate time trends in known and undiagnosed diabetes, HbA1c levels, and other cardio-metabolic risk factors in the general population as well as treatment target achievement among those with diabetes.Design and settingRepeated cross-sectional surveys in the population-based Tromsø Study.MethodsWe used age-adjusted generalized estimating equation models to study trends in self-reported and undiagnosed (HbA1c ≥6.5%) diabetes, cardio-metabolic risk factors and the metabolic syndrome in 27281 women and men aged 40-84 years examined in up to four surveys of the Tromsø Study between 1994 and 2016. Further, we analyzed trends in diabetes treatment target achievement.ResultsDuring 1994-2016 diabetes prevalence increased in women (2.3% to 3.9%) and men (2.4% to 5.3%) and in all age-groups, while the proportion of undiagnosed diabetes in women (33% to 20%) and men (37% to 27%) decreased. Blood pressure and total cholesterol decreased, while waist circumference increased in participants with and without diabetes, leading to a relatively stable prevalence of the metabolic syndrome throughout the study period. There was a marginal increase in HbA1c levels among participants without diabetes. Only half of those with diabetes achieved the treatment target of HbA1c ≤7.0%.ConclusionIn the last two decades diabetes prevalence increased, while the proportion of undiagnosed diabetes declined. The prevalence of the metabolic syndrome remained stable throughout, driven by opposing trends with an increase in obesity and a decrease in other cardio-metabolic risk factors. HbA1c treatment target achievement did not improve.

Microvascular dysfunction: causative role in the association between hypertension, insulin resistance and the metabolic syndrome?

2006 ◽  
Vol 42 ◽  
pp. 163-176 ◽  
Author(s):  
Erik H. Serné ◽  
Renate T. de Jongh ◽  
Etto C. Eringa ◽  
Richard G. Ijzerman ◽  
Michiel P. de Boer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Microvascular Dysfunction ◽  
Metabolic Risk Factors ◽  
Causative Role ◽  
Metabolic Risk ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Potential Factor

The metabolic syndrome defines a clustering of metabolic risk factors that confers an increased risk for type 2 diabetes and cardiovascular disease. The metabolic syndrome seems to have multiple etiological factors and microvascular dysfunction may be one potential factor explaining the clustering of multiple metabolic risk factors including hypertension, obesity, insulin resistance and glucose intolerance. Microvascular dysfunction may increase not only peripheral vascular resistance and blood pressure, but may also decrease insulin-mediated glucose uptake in muscle. The present article summarizes some of the data concerning the role of microvascular dysfunction in the metabolic syndrome.

scholarly journals Multimarker Approach to Evaluate the Incidence of the Metabolic Syndrome and Longitudinal Changes in Metabolic Risk Factors

Circulation ◽  
2007 ◽  
Vol 116 (9) ◽  
pp. 984-992 ◽  
Author(s):  
Erik Ingelsson ◽  
Michael J. Pencina ◽  
Geoffrey H. Tofler ◽  
Emelia J. Benjamin ◽  
Katherine J. Lanier ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Longitudinal Changes ◽  
The Metabolic Syndrome
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