Angiotensinogen Gene Single Nucleotide Polymorphisms A-20C And G-6A Predict Disease Severity In Idiopathic Pulmonary Fibrosis

2012 ◽  
Author(s):  
My-Trang T. Dang ◽  
Chenyang Gu ◽  
Yuehua Cui ◽  
Katherine Jernigan ◽  
Karen H. Friderici ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Single Nucleotide Polymorphisms ◽  
Disease Severity ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Angiotensinogen Gene

Association of Single Nucleotide Polymorphisms inTNFAandIL10Genes with Disease Severity in Influenza A/H1N1pdm09 Virus Infections: A Study from Western India

2018 ◽  
Vol 31 (10) ◽  
pp. 683-688 ◽  
Author(s):  
Manohar Lal Choudhary ◽  
Kalichamy Alagarasu ◽  
Urmila Chaudhary ◽  
Samruddhi Kawale ◽  
Prachi Malasane ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Disease Severity ◽  
Influenza A ◽  
Western India ◽  
Nucleotide Polymorphisms ◽  
Virus Infections ◽  
Single Nucleotide

Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis

2010 ◽  
Vol 16 (6) ◽  
pp. 652-659 ◽  
Author(s):  
Madeleine H Sombekke ◽  
David Arteta ◽  
Mark A van de Wiel ◽  
J Bart A Crusius ◽  
Diego Tejedor ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphisms ◽  
Disease Severity ◽  
Clinical Data ◽  
Severity Score ◽  
Interleukin 2 ◽  
Dna Chip ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Clinical Variables

Multiple sclerosis is a heterogeneous neurological disease with varying degrees of severity. The common hypothesis is that susceptibility to multiple sclerosis and its phenotype are caused by a combination of environmental and genetic factors. The genetic part exerts its effect through several genes, each having modest effects. We evaluated whether disease severity could be predicted by a model based on clinical data and data from a DNA chip. The DNA chip was designed containing several single nucleotide polymorphisms in 44 genes, previously described to be associated with multiple sclerosis. A total of 605 patients with multiple sclerosis were included in this analysis, using gender, onset type and age at onset as clinical covariates. We correlated 80 single nucleotide polymorphisms to the degree of disease severity using the following three outcome measures: linear Multiple Sclerosis Severity Score, dichotomous Multiple Sclerosis Severity Score (using a cut-off point of 2.5) and time to reach Expanded Disability Status Scale score 6. Sixty-nine single nucleotide polymorphisms were included in the analysis. No individual single nucleotide polymorphism showed a significant association; however, a combination of single nucleotide polymorphisms significantly improved the prediction of disease severity in addition to the clinical variables. In all three models the Interleukin 2 gene was included, confirming a previously reported modest effect on disease severity. The highest power was obtained using the dichotomized Multiple Sclerosis Severity Score as outcome. Several single nucleotide polymorphisms showed their added predictive value over the clinical data in the predictive models. These results support our hypothesis that disease severity is determined by clinical variables and genetic influences (through several genes with small effects) in concert.

scholarly journals CLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severity

2004 ◽  
Vol 5 (1) ◽  
Author(s):  
Carol J Blaisdell ◽  
Timothy D Howard ◽  
Augustus Stern ◽  
Penelope Bamford ◽  
Eugene R Bleecker ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Single Nucleotide Polymorphisms ◽  
Disease Severity ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide
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