Effect of magnetic nanoparticles containing ropivacaine on ankle nerve block in rats

2021 ◽  
Vol 11 (9) ◽  
pp. 1483-1490
Author(s):  
Ronghua Li ◽  
Yongbo Li ◽  
Xiucai Hu ◽  
Shiqiang Shan ◽  
Lingling Liu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Pain Management ◽  
Management Strategy ◽  
Magnetic Iron Oxide ◽  
Pain Stimulation ◽  
The Central Nervous System ◽  
Clinical Anesthesia ◽  
The Stability ◽  
Pain Management Strategy

Ropivacaine (RVC), a common pain management drug used for clinical anesthesia and postoperative analgesia, inhibits peripheral nociceptive pain stimulation. However, the potential neurological damage resulting from RVC use must be considered. Developing a strategy to enhance the local anesthetic effect of RVC while reducing its potential acute toxicity to the central nervous system is urgently needed. In this study, a novel RVC nanocomposite drug, magnetic iron oxide/polyethylene glycol-carboxymethyl chitosan/ropivacaine nanoparticle (mCMCS-PEG/RVC NPs), was synthesized with magnetic iron oxide. The inherent shell–core structure of mCMCS-PEG retained core magnetic properties, improved the stability and biocompatibility of magnetic nanoparticles, and avoided excessive degradation. Thus, mCMCS-PEG/RVC NPs are expected to provide a new pain management strategy for perioperative patients.

Ropivacaine magnetic nanoparticles: An efficient local anesthetic nerve conduction blocker

2021 ◽  
Vol 11 (11) ◽  
pp. 1819-1825
Author(s):  
Junying Su ◽  
Xiaohu Chen ◽  
Huizhang Liu ◽  
Yuhui Luo
Keyword(s):  
Magnetic Nanoparticles ◽  
Postoperative Analgesia ◽  
Local Anesthetic ◽  
Temperature Response ◽  
Nociceptive Pain ◽  
Nerve Blocks ◽  
Anesthetic Effect ◽  
Field Of Vision ◽  
Clinical Anesthesia ◽  
The Stability

Ropivacaine (Rop) is one of the commonly used local nerve blocks in clinical anesthesia and postoperative analgesia and it inhibits the stimulation of peripheral nociceptive pain. However, Rop alone is not effective enough to exert a controllable anesthetic effect in patients with peripheral nociceptive pain. Therefore, there is an urgent need to improve the targeting of the local anesthetic effect of Rop and reduce its potential chronic or acute toxicity. In this study, a novel Rop nanocomposite hydrogel drug, N-isopropylacrylamide-methacrylic acid/ropivacaine magnetic nanoparticles (NIP-MAA/Rop MNPs), was constructed on magnetic iron oxide. The unique pH and temperature response of NIP-MAA can effectively retain magnetic properties, improve the stability and targeting controllability of magnetic nanoparticles, and avoid excessive drug diffusion. Therefore, the NIP-MAA/Rop MNPs is expected to open a new field of vision for the research of clinical anesthesia and postoperative analgesia.

An audience survey of practice relating to pain in the management of chronic venous leg ulcers

2020 ◽  
Vol 25 (Sup12) ◽  
pp. S20-S24
Author(s):  
Leanne Atkin ◽  
Robin Martin
Keyword(s):  
Pain Management ◽  
Lower Limb ◽  
Management Strategy ◽  
Compression Therapy ◽  
Leg Ulcers ◽  
Venous Leg Ulcers ◽  
Pain Management Strategy

Venous leg ulcers (VLU) respond well to compression, yet many ulcers remain unhealed after 1 year. Practitioners could be reluctant to apply compression to patients with significant ulcer pain. This study aimed to capture the views of practitioners on compression therapy for patients with painful VLU. A survey was conducted at a UK meeting in 2019 using handheld voting pads to capture the anonymous responses to four questions to which a mean of 90 practitioners responded. Nearly 40% of practitioners treat six or more patients a day with painful lower-limb ulcers. Some 80% felt confident in managing patients with painful ulcers; yet, most practitioners suggested they would refer onward for pain management. Some 40% would omit or reduce compression therapy as a pain management strategy. This survey supports the need for technological solutions that reduce VLU pain so that patients receive effective compression therapy.

Effective uranium(vi) sorption from alkaline media using bi-functionalized silica-coated magnetic nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (70) ◽  
pp. 56658-56665 ◽  
Author(s):  
X. T. Chen ◽  
L. F. He ◽  
R. Z. Liu ◽  
C. Zhang ◽  
B. Liu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Sorption Capacity ◽  
Alkaline Media ◽  
Functionalized Silica ◽  
Magnetic Iron Oxide ◽  
Maximum Sorption Capacity ◽  
Oxide Composite ◽  
Maximum Sorption

A bi-functionalized magnetic iron oxide composite has been employed for uranium(vi) sorption from alkaline media. The maximum sorption capacity was observed at pH 9.0 with a capacity of 70.7 mg g−1atcU(vi)initial= 21.7 mg L−1.

A novel pain management strategy for combat casualty care

2004 ◽  
Vol 44 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Russ S. Kotwal ◽  
Kevin C. O'Connor ◽  
Troy R. Johnson ◽  
Dan S. Mosely ◽  
David E. Meyer ◽  
...  
Keyword(s):  
Pain Management ◽  
Management Strategy ◽  
Combat Casualty ◽  
Combat Casualty Care ◽  
Pain Management Strategy

Surface active magnetic iron oxide nanoparticles for extracting metal nanoparticles across an aqueous–organic interface

2019 ◽  
Vol 7 (34) ◽  
pp. 10623-10634 ◽  
Author(s):  
Meenakshi Verma ◽  
Kultar Singh ◽  
Mandeep Singh Bakshi
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Metal Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Gemini Surfactants ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Surface Active

Highly surface active magnetic nanoparticles (Fe3O4 NPs) were synthesized by using tetraalkylammonium and imidazolium Gemini surfactants.

scholarly journals Nanocomposites comprised of homogeneously dispersed magnetic iron-oxide nanoparticles and poly(methyl methacrylate)

2018 ◽  
Vol 9 ◽  
pp. 1613-1622 ◽  
Author(s):  
Sašo Gyergyek ◽  
David Pahovnik ◽  
Ema Žagar ◽  
Alenka Mertelj ◽  
Rok Kostanjšek ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Methyl Methacrylate ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Uniform Loading ◽  
Magnetic Iron Oxide ◽  
Induced Hyperthermia ◽  
Pmma Matrix

Nanocomposites with a high, uniform loading of magnetic nanoparticles are very desirable for applications such as electromagnetic shielding and cancer treatment based on magnetically induced hyperthermia. In this study, a simple and scalable route for preparing nanocomposites with a high, uniform loading of magnetic nanoparticles is presented. The magnetic iron-oxide nanoparticles were functionalized with a methacrylate-based monomer that copolymerized in a toluene solution with the methyl methacrylate (MMA) monomer. The resulting suspension of magnetic nanoparticles decorated with poly(methyl methacrylate) (PMMA) chains in toluene were colloidal, even in the presence of a magnetic field gradient. Nanocomposites were precipitated from these suspensions. The transmission electron microscopy investigation of the prepared nanocomposites revealed that the magnetic nanoparticles were homogeneously dispersed in the PMMA matrix, even in amounts up to 53 wt %. The uniform dispersion of the nanoparticles in the PMMA matrix was attributed to the good solvation of the grafted PMMA chains from the magnetic nanoparticles by the PMMA chains of the matrix. The nanocomposites were superparamagnetic and exhibited large values for the saturation magnetization of up to 36 emu/g. Moreover, the nanocomposite with the largest amount of incorporated nanoparticles exhibited relatively large values for the specific power loss when subjected to alternating magnetic fields, giving this material great potential for the magnetically induced hyperthermia-based treatment of cancer.

scholarly journals Comprehensive pain management strategy for infants with moderate to severe osteogenesis imperfecta in the perinatal period

2021 ◽  
Author(s):  
Ricki S. Carroll ◽  
Perri Donenfeld ◽  
Cristina McGreal ◽  
Jeanne M. Franzone ◽  
Richard W. Kruse ◽  
...  
Keyword(s):  
Pain Management ◽  
Osteogenesis Imperfecta ◽  
Management Strategy ◽  
Perinatal Period ◽  
Pain Management Strategy
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