scholarly journals GSH Levels Serve As a Biological Redox Switch Regulating Sulforaphane-Induced Cell Fate in Human Lens Cells

2021 ◽  
Vol 62 (15) ◽  
pp. 2
Author(s):  
Thao Phuong Ngoc Huynh ◽  
Richard P. Bowater ◽  
Federico Bernuzzi ◽  
Shikha Saha ◽  
I. Michael Wormstone
Keyword(s):  
Cell Fate ◽  
Human Lens ◽  
Lens Cells ◽  
Redox Switch

MMP and TIMP Expression in Quiescent, Dividing, and Differentiating Human Lens Cells

2007 ◽  
Vol 48 (9) ◽  
pp. 4192 ◽  
Author(s):  
Lisa M. Hodgkinson ◽  
George Duncan ◽  
Lixin Wang ◽  
Caroline J. Pennington ◽  
Dylan R. Edwards ◽  
...  
Keyword(s):  
Human Lens ◽  
Lens Cells

Particle radiation alters expression of matrix metalloproteases resulting in ECM remodeling in human lens cells

2007 ◽  
Vol 46 (2) ◽  
pp. 187-194 ◽  
Author(s):  
P. Y. Chang ◽  
K. A. Bjornstad ◽  
C. J. Rosen ◽  
S. Lin ◽  
E. A. Blakely
Keyword(s):  
Matrix Metalloproteases ◽  
Human Lens ◽  
Particle Radiation ◽  
Ecm Remodeling ◽  
Lens Cells

Growth factor receptor signalling in human lens cells: role of the calcium store

2005 ◽  
Vol 80 (6) ◽  
pp. 885-895 ◽  
Author(s):  
Lixin Wang ◽  
I. Michael Wormstone ◽  
John R. Reddan ◽  
George Duncan
Keyword(s):  
Growth Factor ◽  
Growth Factor Receptor ◽  
Human Lens ◽  
Calcium Store ◽  
Receptor Signalling ◽  
Lens Cells

Particle Irradiation Induces FGF2 Expression in Normal Human Lens Cells

2000 ◽  
Vol 154 (5) ◽  
pp. 477-484 ◽  
Author(s):  
P. Y. Chang ◽  
K. A. Bjornstad ◽  
E. Chang ◽  
M. McNamara ◽  
M. H. Barcellos-Hoff ◽  
...  
Keyword(s):  
Human Lens ◽  
Particle Irradiation ◽  
Lens Cells ◽  
Fgf2 Expression ◽  
Normal Human

TGFbeta signalling through Smad-independent mechanisms in human lens cells

2008 ◽  
Vol 86 ◽  
pp. 0-0 ◽  
Author(s):  
IM WORMSTONE ◽  
JA ELDRED ◽  
LJ DAWES ◽  
JR REDDAN ◽  
L WANG
Keyword(s):  
Human Lens ◽  
Lens Cells

scholarly journals Use of Human Pluripotent Stem Cells to Define Initiating Molecular Mechanisms of Cataract for Anti-Cataract Drug Discovery

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1269
Author(s):  
Dewi ◽  
O’Connor
Keyword(s):  
Pluripotent Stem Cells ◽  
Molecular Mechanisms ◽  
Cell Types ◽  
Light Transmittance ◽  
Human Lens ◽  
Surgical Removal ◽  
Large Numbers ◽  
Different Types ◽  
Lens Cells ◽  
Cataract Patients

Cataract is a leading cause of blindness worldwide. Currently, restoration of vision in cataract patients requires surgical removal of the cataract. Due to the large and increasing number of cataract patients, the annual cost of surgical cataract treatment amounts to billions of dollars. Limited access to functional human lens tissue during the early stages of cataract formation has hampered efforts to develop effective anti-cataract drugs. The ability of human pluripotent stem (PS) cells to make large numbers of normal or diseased human cell types raises the possibility that human PS cells may provide a new avenue for defining the molecular mechanisms responsible for different types of human cataract. Towards this end, methods have been established to differentiate human PS cells into both lens cells and transparent, light-focusing human micro-lenses. Sensitive and quantitative assays to measure light transmittance and focusing ability of human PS cell-derived micro-lenses have also been developed. This review will, therefore, examine how human PS cell-derived lens cells and micro-lenses might provide a new avenue for development of much-needed drugs to treat human cataract.

Regulation of Sarco/Endoplasmic Ca2+-ATPase Expression by Calcium in Human Lens Cells

2002 ◽  
Vol 75 (5) ◽  
pp. 583-590 ◽  
Author(s):  
L Liu ◽  
C.A Paterson ◽  
D Borchman
Keyword(s):  
Human Lens ◽  
Lens Cells
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