scholarly journals Pupillary dilation elicited by attending to two disks with different luminance

2021 ◽  
Vol 21 (1) ◽  
pp. 11
Author(s):  
Xiaofei Hu ◽  
Rumi Hisakata ◽  
Hirohiko Kaneko
Keyword(s):  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fang Fang ◽  
Jie Zhang ◽  
Pei Zhuang ◽  
Pingting Liu ◽  
Liang Li ◽  
...  

AbstractRecently, we established silicone oil-induced ocular hypertension (SOHU) mouse model with significant glaucomatous neurodegeneration. Here we characterize two additional variations of this model that simulate two distinct glaucoma types. The first is a chronic model produced by high frequency (HF) pupillary dilation after SO-induced pupillary block, which shows sustained moderate IOP elevation and corresponding slow, mild glaucomatous neurodegeneration. We also demonstrate that although SO removal quickly returns IOP to normal, the glaucomatous neurodegeneration continues to advance to a similar degree as in the HF group without SO removal. The second, an acute model created by no pupillary dilation (ND), shows a greatly elevated IOP and severe inner retina degeneration at an early time point. Therefore, by a straightforward dilation scheme, we extend our original SOHU model to recapitulate phenotypes of two major glaucoma forms, which will be invaluable for selecting neuroprotectants and elucidating their molecular mechanisms.


2021 ◽  
Author(s):  
Yayoi Shigemune ◽  
Akira Midorikawa

Abstract Gambling disorder and problem gambling are characterized by persistent and repetitive problematic gambling behavior. Attentional bias toward gambling-related stimuli such as casino chips, dice, roulette, etc. have been observed in problem gamblers (PGs), but it remains unclear whether stimuli in gambling tasks elicit greater attention and pupillary responses in PGs. To address this issue, we administrated PGs and non-problem gamblers (NPGs) a gambling task accompanied by eye-tracking measurements, in which the participants were required to choose one of the paired pictures to receive monetary rewards and avoid punishments. Concerning attentional allocation, PG showed a greater attentional preference for the right-hand pictures in the decision and feedback phases, and compared to NPGs, PGs’ attention was narrower and more focused on the left-hand pictures in the decision phase. Concerning pupillary dynamics indicative of noradrenergic locus coeruleus activity, pupillary dilation in response to rewards and punishments was observed only in PGs. Studies of unilateral spatial neglect have proposed that asymmetric attention is induced by hemispheric imbalance. Accordingly, asymmetrical allocation of attention by PGs may reflect hemispheric imbalance, and pupillary dynamics may reflect sensitivity to wins and losses.


1974 ◽  
Vol 31 (1) ◽  
pp. 12 ◽  
Author(s):  
Richard N. Edelson ◽  
David E. Levy

Author(s):  
Georges Rey

Unconscious phenomena are those mental phenomena which their possessor cannot introspect, not only at the moment at which the phenomenon occurs, but even when prompted (‘Do you think/want/…?’). There are abundant allusions to many kinds of unconscious phenomena from classical times to Freud. Most notably, Plato in his Meno defended a doctrine of anamnesis according to which a priori knowledge of, for example, geometry is ‘recollected’ from a previous life. But the notion of a rich, unconscious mental life really takes hold in nineteenth-century writers, such as Herder, Hegel, Helmholtz and Schopenhauer. It is partly out of this latter tradition that Freud’s famous postulations of unconscious, ‘repressed’ desires and memories emerged. Partly in reaction to the excesses of introspection and partly because of the rise of computational models of mental processes, twentieth-century psychology has often been tempted by Lashley’s view that ‘no activity of mind is ever conscious’ (1956). A wide range of recent experiments do suggest that people can be unaware of a multitude of sensory cognitive factors (for example, pupillary dilation, cognitive dissonance, subliminal cues to problem-solving) that demonstrably affect their behaviour. And Weiskrantz has documented cases of ‘blindsight’ in which patients with damage to their visual cortex can be shown to be sensitive to visual material they sincerely claim they cannot see. The most controversial cases of unconscious phenomena are those which the agent could not possibly introspect, even in principle. Chomsky ascribes unconscious knowledge of quite abstract principles of grammar to adults and even newborn children that only a linguist could infer. Many philosophers have found these claims about the unconscious unconvincing, even incoherent. However, they need to show how the evidence cited above could be otherwise explained, and why appeals to the unconscious have seemed so perfectly intelligible throughout history.


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